Prothrombin

AltitudeomicsDB
Protein Official symbol THRB
Aliases THRB ERBA2 NR1A2 THR1
Chromosomal Location 3
Length 461
Uniprot ID P10828
EC number None
Protein family Information(Pfam) PF00104;PF00105;
PDB id 1BSX;1N46;1NAX;1NQ0;1NQ1;1NQ2;1NUO;1Q4X;1R6G;1XZX;1Y0X;2J4A;2NLL;2PIN;3D57;3GWS;3IMY;3JZC;4ZO1;6KKB;6KKE;6KNU;6KNV;6KNW;
InterPro ID IPR035500;IPR000536;IPR001723;IPR001728;IPR001628;IPR013088;
dbSNP rs9865746 rs121918694 rs121918707 rs121918695 rs121918690 rs121918696 rs121918693 rs28999969 rs1054624 rs121918697 rs121918688 rs121918686 rs121918686 rs28999970 rs28999971 rs1553609210 rs1553609195 rs121918698 rs121918691 rs121918692 rs121918703 rs121918687 rs28933408 rs28933408 rs121918702

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SUMO1 UBE2I 0.997
UBE2I PIAS1 0.987
SUMO1 PIAS1 0.983
SUMO3 UBE2I 0.982
NCOA1 NCOR2 0.968
NCOA1 MED1 0.966
SUMO3 PIAS1 0.961
NCOR2 MED1 0.953
NCOR2 RARA 0.944
NCOR2 THRA 0.94
NCOA1 THRB 0.939
NCOR2 THRB 0.935
MED1 THRA 0.933
RARG NCOR2 0.929
NCOA1 THRA 0.927
NCOR2 RARB 0.926
NCOR2 SUMO1 0.925
UBE2I RARA 0.923
MED1 RARA 0.923
THRB MED1 0.923
NCOA1 RARA 0.922
NCOR2 UBE2I 0.921
NCOA1 SUMO1 0.917
SUMO3 SUMO1 0.914
NCOA1 RARB 0.913
THRA RARA 0.913
NCOA1 UBE2I 0.911
RARG NCOA1 0.911
THRB RARB 0.908
THRB RARA 0.908
RARG THRA 0.907
RARG THRB 0.907
RARG RARA 0.906
RARB THRA 0.906
RARG MED1 0.905
SUMO3 THRB 0.905
THRB THRA 0.905
RARG RARB 0.902
RARB RARA 0.901
THRB SUMO1 0.901
THRB PIAS1 0.9
THRB UBE2I 0.9
RARB MED1 0.9
Gene Ontology Semantic Similarity
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# 7329 (UBE2I) 8554 (PIAS1) 9612 (NCOR2) 5469 (MED1) 5914 (RARA) 7067 (THRA) 7068 (THRB) 5915 (RARB) 7341 (SUMO1) 8648 (NCOA1) 6612 (SUMO3) 5916 (RARG)
7329 (UBE2I) 1.00 0.74 0.61 0.54 0.56 0.56 0.56 0.49 0.83 0.60 0.68 0.54
8554 (PIAS1) 0.74 1.00 0.65 0.64 0.60 0.51 0.57 0.44 0.71 0.76 0.57 0.50
9612 (NCOR2) 0.61 0.65 1.00 0.78 0.74 0.72 0.76 0.67 0.63 0.78 0.59 0.74
5469 (MED1) 0.54 0.64 0.78 1.00 0.80 0.80 0.79 0.75 0.58 0.81 0.50 0.81
5914 (RARA) 0.56 0.60 0.74 0.80 1.00 0.86 0.87 0.81 0.58 0.72 0.52 0.86
7067 (THRA) 0.56 0.51 0.72 0.80 0.86 1.00 0.94 0.89 0.57 0.69 0.49 0.91
7068 (THRB) 0.56 0.57 0.76 0.79 0.87 0.94 1.00 0.91 0.59 0.71 0.49 0.93
5915 (RARB) 0.49 0.44 0.67 0.75 0.81 0.89 0.91 1.00 0.51 0.62 0.38 0.96
7341 (SUMO1) 0.83 0.71 0.63 0.58 0.58 0.57 0.59 0.51 1.00 0.65 0.74 0.57
8648 (NCOA1) 0.60 0.76 0.78 0.81 0.72 0.69 0.71 0.62 0.65 1.00 0.63 0.71
6612 (SUMO3) 0.68 0.57 0.59 0.50 0.52 0.49 0.49 0.38 0.74 0.63 1.00 0.46
5916 (RARG) 0.54 0.50 0.74 0.81 0.86 0.91 0.93 0.96 0.57 0.71 0.46 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
THRB Bird Lungs - 4000 m Native upregulated 2.73 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
THRB 7068 CGA 1081 Activation 15361832 TRUSST
THRB 7068 POR 5447 Unknown 10528225 TRUSST
THRB 7068 APOA2 336 - - OregAnno
THRB 7068 APOC4-APOC2 344 - - OregAnno
THRB 7068 EGFR 1956 - - OregAnno
THRB 7068 TSHB 7252 - - OregAnno
THRB 7068 APOA5 116519 - - OregAnno
THRB 7068 CGA 1081 Activation 15361832 TRUSST
THRB 7068 POR 5447 Unknown 10528225 TRUSST
THRB 7068 APOA2 336 - - OregAnno
THRB 7068 APOC4-APOC2 344 - - OregAnno
THRB 7068 EGFR 1956 - - OregAnno
THRB 7068 TSHB 7252 - - OregAnno
THRB 7068 APOA5 116519 - - OregAnno
THRB 7068 CGA 1081 Activation 15361832 TRUSST
THRB 7068 POR 5447 Unknown 10528225 TRUSST
THRB 7068 APOA2 336 - - OregAnno
THRB 7068 APOC4-APOC2 344 - - OregAnno
THRB 7068 EGFR 1956 - - OregAnno
THRB 7068 TSHB 7252 - - OregAnno
THRB 7068 APOA5 116519 - - OregAnno
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT005425 hsa-miR-27a-3p Homo sapiens THRB 7068 Homo sapiens Luciferase reporter assay//Northern blot//Western blot Functional MTI 21149577
MIRT005425 hsa-miR-27a-3p Homo sapiens THRB 7068 Homo sapiens qRT-PCR Functional MTI (Weak) 25156012
MIRT005524 hsa-miR-204-5p Homo sapiens THRB 7068 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 20691260
MIRT054752 hsa-miR-155-5p Homo sapiens THRB 7068 Homo sapiens Luciferase reporter assay//Real time PCR Functional MTI 24849932
MIRT054753 hsa-miR-425-5p Homo sapiens THRB 7068 Homo sapiens Luciferase reporter assay//Real time PCR Functional MTI 24849932
MIRT054841 hsa-miR-452-5p Homo sapiens THRB 7068 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 24440748
MIRT306961 hsa-miR-4677-3p Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT306962 hsa-miR-4679 Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT443048 hsa-miR-3161 Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT443049 hsa-miR-3689f Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT443050 hsa-miR-3689e Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT443051 hsa-miR-3689b-5p Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT443052 hsa-miR-3689a-5p Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT443053 hsa-miR-3926 Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT443054 hsa-miR-4778-5p Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT443055 hsa-miR-4753-5p Homo sapiens THRB 7068 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT713128 hsa-miR-6794-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT713129 hsa-miR-3152-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT713130 hsa-miR-6836-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT713131 hsa-miR-15b-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT713132 hsa-miR-4264 Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT713133 hsa-miR-4797-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT721494 hsa-miR-6809-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT721495 hsa-miR-4753-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT721496 hsa-miR-4436b-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT721497 hsa-miR-6509-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT721498 hsa-miR-1236-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT721499 hsa-miR-6515-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT733400 hsa-miR-101-3p Homo sapiens THRB 7068 Homo sapiens Microarray Functional MTI (Weak) 28416776
MIRT733513 hsa-miR-200a-3p Homo sapiens THRB 7068 Homo sapiens Luciferase reporter assay//Next Generation Sequencing (NGS)//RISC-IP//qRT-PCR//Western blot Functional MTI 27734462
MIRT783193 hsa-miR-1238-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783612 hsa-miR-129-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785050 hsa-miR-3659 Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786324 hsa-miR-4658 Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786635 hsa-miR-4758-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787886 hsa-miR-574-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788744 hsa-miR-6790-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789740 hsa-miR-8055 Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789820 hsa-miR-8081 Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT790128 hsa-miR-1537-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790269 hsa-miR-320a Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790270 hsa-miR-320b Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790271 hsa-miR-320c Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790272 hsa-miR-320d Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790306 hsa-miR-3607-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790439 hsa-miR-4429 Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790528 hsa-miR-4633-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790647 hsa-miR-4793-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790669 hsa-miR-5002-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790720 hsa-miR-5196-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT790854 hsa-miR-6500-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT791060 hsa-miR-6870-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT791071 hsa-miR-6874-5p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
MIRT791169 hsa-miR-9-3p Homo sapiens THRB 7068 Homo sapiens HITS-CLIP Functional MTI (Weak) 28735896
Gene Ontology
ID GO ID GO Term GO Type
7068 GO:0000122 negative regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
7068 GO:0000790 nuclear chromatin GOTERM_CC_DIRECT
7068 GO:0003677 DNA binding GOTERM_MF_DIRECT
7068 GO:0003700 transcription factor activity GOTERM_MF_DIRECT
7068 GO:0003707 steroid hormone receptor activity GOTERM_MF_DIRECT
7068 GO:0003714 transcription corepressor activity GOTERM_MF_DIRECT
7068 GO:0004887 thyroid hormone receptor activity GOTERM_MF_DIRECT
7068 GO:0005515 protein binding GOTERM_MF_DIRECT
7068 GO:0005634 nucleus GOTERM_CC_DIRECT
7068 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
7068 GO:0006351 transcription GOTERM_BP_DIRECT
7068 GO:0006355 regulation of transcription GOTERM_BP_DIRECT
7068 GO:0006367 transcription initiation from RNA polymerase II promoter GOTERM_BP_DIRECT
7068 GO:0007605 sensory perception of sound GOTERM_BP_DIRECT
7068 GO:0007621 negative regulation of female receptivity GOTERM_BP_DIRECT
7068 GO:0008016 regulation of heart contraction GOTERM_BP_DIRECT
7068 GO:0008050 female courtship behavior GOTERM_BP_DIRECT
7068 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
7068 GO:0009887 organ morphogenesis GOTERM_BP_DIRECT
7068 GO:0019899 enzyme binding GOTERM_MF_DIRECT
7068 GO:0030522 intracellular receptor signaling pathway GOTERM_BP_DIRECT
7068 GO:0031490 chromatin DNA binding GOTERM_MF_DIRECT
7068 GO:0043401 steroid hormone mediated signaling pathway GOTERM_BP_DIRECT
7068 GO:0043565 sequence-specific DNA binding GOTERM_MF_DIRECT
7068 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
7068 GO:0060509 Type I pneumocyte differentiation GOTERM_BP_DIRECT
7068 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
7068 GO:0070324 thyroid hormone binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
7068 hsa04080 Neuroactive ligand-receptor interaction
7068 hsa04919 Thyroid hormone signaling pathway
7068 hsa04080 Neuroactive ligand-receptor interaction
7068 hsa04919 Thyroid hormone signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
THRB 7068 Diaphragmatic Hernia C0019284 Anatomical Abnormality 0.3 0.584 0.69 phenotype
THRB 7068 Follicular thyroid carcinoma C0206682 Neoplastic Process 0.53 0.584 0.69 disease
THRB 7068 Craniofacial Abnormalities C0376634 Congenital Abnormality 0.3 0.584 0.69 group
THRB 7068 Thyroid Hormone Resistance Syndrome C2940786 Disease or Syndrome 1.0 0.584 0.69 disease
THRB 7068 Thyroid Hormone Resistance, Generalized, Autosomal Recessive C3489796 Disease or Syndrome 0.7 0.584 0.69 disease
THRB 7068 THYROID HORMONE RESISTANCE, SELECTIVE PITUITARY C1840364 Disease or Syndrome 0.7 0.584 0.69 disease
THRB 7068 THYROID HORMONE RESISTANCE, GENERALIZED, AUTOSOMAL DOMINANT C2937288 Disease or Syndrome 0.7 0.584 0.69 disease
THRB 7068 Osteogenesis Imperfecta C0029434 Congenital Abnormality; Disease or Syndrome 0.3 0.584 0.69 disease
THRB 7068 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.584 0.69 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
THRB 7068 DEXTROTHYROXINE DEXTROTHYROXINE CHEMBL559 agonist
THRB 7068 DEXTROTHYROXINE SODIUM DEXTROTHYROXINE SODIUM CHEMBL3545058 agonist
THRB 7068 EPROTIROME EPROTIROME CHEMBL2035874 None
THRB 7068 EPROTIROME EPROTIROME CHEMBL2035874 agonist
THRB 7068 LEVOTHYROXINE LEVOTHYROXINE CHEMBL1624 None
THRB 7068 LEVOTHYROXINE LEVOTHYROXINE CHEMBL1624 None
THRB 7068 LEVOTHYROXINE SODIUM LEVOTHYROXINE SODIUM CHEMBL2103741 agonist
THRB 7068 LIOTHYRONINE LIOTHYRONINE CHEMBL1544 None
THRB 7068 LIOTHYRONINE LIOTHYRONINE CHEMBL1544 agonist
THRB 7068 LIOTHYRONINE LIOTHYRONINE CHEMBL1544 None
THRB 7068 LIOTHYRONINE SODIUM LIOTHYRONINE SODIUM CHEMBL1201119 agonist
THRB 7068 MB07811 MB07811 CHEMBL457748 agonist
THRB 7068 MB07811 MB07811 CHEMBL457748 None
THRB 7068 MGL-3196 MGL-3196 CHEMBL3261331 agonist
THRB 7068 SOBETIROME SOBETIROME CHEMBL107400 None
THRB 7068 TRIIODOTHYRONINE (T3) LIOTHYRONINE CHEMBL1544 None
THRB 7068 VIA-3196 MGL-3196 CHEMBL3261331 None
THRB 7068 DEXTROTHYROXINE DEXTROTHYROXINE CHEMBL559 agonist
THRB 7068 DEXTROTHYROXINE SODIUM DEXTROTHYROXINE SODIUM CHEMBL3545058 agonist
THRB 7068 EPROTIROME EPROTIROME CHEMBL2035874 None
THRB 7068 EPROTIROME EPROTIROME CHEMBL2035874 agonist
THRB 7068 LEVOTHYROXINE LEVOTHYROXINE CHEMBL1624 None
THRB 7068 LEVOTHYROXINE LEVOTHYROXINE CHEMBL1624 None
THRB 7068 LEVOTHYROXINE SODIUM LEVOTHYROXINE SODIUM CHEMBL2103741 agonist
THRB 7068 LIOTHYRONINE LIOTHYRONINE CHEMBL1544 None
THRB 7068 LIOTHYRONINE LIOTHYRONINE CHEMBL1544 agonist
THRB 7068 LIOTHYRONINE LIOTHYRONINE CHEMBL1544 None
THRB 7068 LIOTHYRONINE SODIUM LIOTHYRONINE SODIUM CHEMBL1201119 agonist
THRB 7068 MB07811 MB07811 CHEMBL457748 agonist
THRB 7068 MB07811 MB07811 CHEMBL457748 None
THRB 7068 MGL-3196 MGL-3196 CHEMBL3261331 agonist
THRB 7068 SOBETIROME SOBETIROME CHEMBL107400 None
THRB 7068 TRIIODOTHYRONINE (T3) LIOTHYRONINE CHEMBL1544 None
THRB 7068 VIA-3196 MGL-3196 CHEMBL3261331 None
THRB 7068 DEXTROTHYROXINE DEXTROTHYROXINE CHEMBL559 agonist
THRB 7068 DEXTROTHYROXINE SODIUM DEXTROTHYROXINE SODIUM CHEMBL3545058 agonist
THRB 7068 EPROTIROME EPROTIROME CHEMBL2035874 None
THRB 7068 EPROTIROME EPROTIROME CHEMBL2035874 agonist
THRB 7068 LEVOTHYROXINE LEVOTHYROXINE CHEMBL1624 None
THRB 7068 LEVOTHYROXINE LEVOTHYROXINE CHEMBL1624 None
THRB 7068 LEVOTHYROXINE SODIUM LEVOTHYROXINE SODIUM CHEMBL2103741 agonist
THRB 7068 LIOTHYRONINE LIOTHYRONINE CHEMBL1544 None
THRB 7068 LIOTHYRONINE LIOTHYRONINE CHEMBL1544 agonist
THRB 7068 LIOTHYRONINE LIOTHYRONINE CHEMBL1544 None
THRB 7068 LIOTHYRONINE SODIUM LIOTHYRONINE SODIUM CHEMBL1201119 agonist
THRB 7068 MB07811 MB07811 CHEMBL457748 agonist
THRB 7068 MB07811 MB07811 CHEMBL457748 None
THRB 7068 MGL-3196 MGL-3196 CHEMBL3261331 agonist
THRB 7068 SOBETIROME SOBETIROME CHEMBL107400 None
THRB 7068 TRIIODOTHYRONINE (T3) LIOTHYRONINE CHEMBL1544 None
THRB 7068 VIA-3196 MGL-3196 CHEMBL3261331 None