Troponin C

AltitudeomicsDB
Protein Official symbol TNNC1
Aliases TNNC1 TNNC
Chromosomal Location 3
Length 161
Uniprot ID P63316
EC number None
Protein family Information(Pfam) PF13499;
PDB id 1AP4;1IH0;1J1D;1J1E;1LXF;1MXL;1OZS;1SPY;1WRK;1WRL;2JT0;2JT3;2JT8;2JTZ;2JXL;2KDH;2KFX;2KGB;2KRD;2L1R;2L98;2MKP;2MLE;2MLF;2MZP;2N79;2N7L;3RV5;3SD6;3SWB;4GJE;4GJF;4GJG;4Y99;5VLN;5W88;5WCL;6KN7;6KN8;6MV3;
InterPro ID IPR011992;IPR018247;IPR002048;
dbSNP rs267607125 rs267607123 rs267607126 rs397516847 rs267607124

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
TNNI2 TNNT3 0.999
NEB TTN 0.999
TNNI2 TNNC2 0.997
TNNC2 TNNT3 0.997
TNNI3 TNNT2 0.996
NEB MYL1 0.996
MYL1 TNNT3 0.994
TTN TNNC2 0.993
TNNC2 MYL1 0.993
TNNI2 MYL1 0.993
MYBPC3 TNNT2 0.992
TNNI1 TNNT3 0.992
NEB TNNC2 0.992
TTN MYL1 0.992
TNNI1 TNNT2 0.991
TTN TCAP 0.99
MYH6 TNNT2 0.99
TNNT1 TNNI1 0.989
MYBPC3 MYH6 0.989
MYH6 MYL2 0.989
TNNT1 TNNI3 0.988
TNNI3 TNNT3 0.987
ACTN2 TNNT2 0.986
MYBPC3 TNNI3 0.986
TNNT1 TNNI2 0.985
MYH6 MYL3 0.985
MYH6 TNNI3 0.985
TPM1 TNNT2 0.984
TPM1 MYL2 0.983
MYBPC3 MYL2 0.983
TNNT2 MYL2 0.983
MYH8 MYL1 0.982
TPM1 TNNI3 0.982
MYL3 TNNT2 0.981
MYBPC3 MYL3 0.981
MYL3 TNNI3 0.981
TNNI2 TPM2 0.981
TPM2 TNNT3 0.98
MYBPC2 TNNT3 0.98
MYBPC3 TPM1 0.98
TTN ACTN2 0.98
TNNI1 TNNC1 0.978
TNNI3 MYL2 0.978
MYH6 TPM1 0.977
TPM3 TMOD1 0.977
TTN MYH6 0.977
MYL3 TNNI1 0.977
TNNI2 TNNT2 0.977
MYH6 MYL1 0.977
TPM1 TMOD1 0.976
MYBPC1 TNNI2 0.976
MYH3 MYL1 0.976
MYBPC1 TNNT3 0.976
MYH3 TNNI2 0.976
MYH6 MYL4 0.975
ACTN3 TNNT3 0.975
ACTN2 MYH6 0.975
TNNT1 TNNC1 0.975
MYL3 TPM1 0.975
ACTN2 TNNT3 0.974
NEB TMOD4 0.974
TPM3 TMOD3 0.974
TTN TNNT2 0.974
MYH8 MYL2 0.974
TNNT2 TNNC1 0.974
TTN TNNI3 0.974
MYH3 TNNT3 0.973
NEB TMOD1 0.973
MYH3 MYL4 0.973
MYH6 TNNI1 0.973
MYH8 MYL4 0.973
MYH8 MYL3 0.973
TNNI2 TNNC1 0.972
MYH3 MYL2 0.972
MYH3 MYL3 0.972
TNNC2 MYBPC2 0.972
TTN TNNT3 0.971
TNNT1 TPM3 0.97
TNNC2 TNNT2 0.97
TNNT1 TPM2 0.97
MYBPC3 TCAP 0.97
TTN MYL2 0.97
ACTN3 MYBPC2 0.969
ACTN2 MYL2 0.969
MYL1 TNNT2 0.969
ACTN2 TCAP 0.969
TNNC2 TNNI1 0.969
TTN ACTN3 0.969
NEB TPM3 0.969
ACTN2 TPM1 0.969
TNNI3 TNNC1 0.969
TTN MYL3 0.969
TPM1 TNNT3 0.969
TPM4 TMOD3 0.968
MYH6 TCAP 0.968
TCAP TNNT2 0.968
ACTN3 TNNI2 0.968
MYL3 TCAP 0.968
TPM2 TNNI1 0.967
TTN DMD 0.967
NEB TPM2 0.967
TPM2 MYL1 0.967
TNNT1 TPM1 0.966
TPM3 MYL1 0.966
TPM2 TMOD1 0.966
MYH8 TNNT3 0.966
TNNI3 MYL1 0.966
TNNI2 MYBPC2 0.966
MYL3 TNNT3 0.966
TCAP MYL2 0.966
MYBPC1 MYL1 0.965
ACTN2 MYL3 0.965
ACTN3 TNNC2 0.965
TNNT3 TNNC1 0.965
TNNI3 TCAP 0.965
TNNT1 MYL2 0.965
TTN TPM1 0.964
ACTN2 TNNI3 0.964
TPM3 TNNI1 0.964
ACTN2 MYBPC3 0.964
TNNI1 MYL1 0.964
TPM2 TMOD3 0.963
MYL4 TNNT2 0.963
TPM3 TNNT2 0.963
MYH6 TNNT3 0.963
TNNT1 MYL3 0.963
TNNI1 MYL4 0.963
ACTN3 TNNT2 0.963
TTN MYH3 0.962
NEB TCAP 0.962
MYL3 TNNI2 0.962
MYH3 TPM2 0.962
TNNI1 MYL2 0.962
ACTN2 TNNC2 0.962
TTN MYH8 0.962
TPM4 TMOD1 0.962
TPM1 MYL1 0.962
TPM3 TNNT3 0.962
MYL4 TNNI3 0.961
TNNC2 TPM4 0.961
TNNT3 MYL2 0.961
MYH6 TNNC1 0.961
TPM4 MYL1 0.961
TNNT1 TTN 0.96
TTN MYL4 0.96
ACTN2 TPM2 0.96
TNNT1 MYL4 0.96
TNNT1 TNNC2 0.96
TPM1 TMOD3 0.96
TNNI1 TPM1 0.96
ACTN3 TPM2 0.96
ACTN2 MYL1 0.959
TPM1 TCAP 0.959
TTN TNNI1 0.959
MYL3 MYL2 0.959
MYBPC1 TNNI1 0.959
MYL3 TPM2 0.959
MYH6 DMD 0.959
TNNT1 MYL1 0.958
ACTN3 MYH6 0.958
TNNI2 TPM1 0.958
ACTN3 TPM1 0.958
MYH6 TNNI2 0.957
MYH3 TNNC2 0.957
MYH3 TNNT2 0.957
TNNT1 MYH6 0.957
NEB TNNT3 0.957
NEB TNNT1 0.957
MYH8 TNNI3 0.957
MYH8 TPM2 0.956
TNNI2 MYL4 0.956
TPM2 TMOD2 0.956
TNNC1 MYL2 0.956
MYH6 TPM2 0.956
MYBPC3 TPM3 0.956
TPM2 TNNT2 0.956
TPM4 TMOD2 0.955
MYH8 TNNI2 0.955
MYH3 TNNI1 0.955
MYL3 TPM3 0.955
NEB MYH8 0.955
TPM2 TMOD4 0.955
MYH8 MYBPC2 0.954
MYH3 TNNI3 0.954
NEB DMD 0.954
TPM4 TNNT3 0.954
MYBPC1 MYL3 0.954
TTN TPM2 0.954
TNNT1 TPM4 0.954
TPM2 TNNC2 0.954
MYH6 TPM3 0.954
NEB MYH6 0.954
TPM3 TMOD4 0.954
TPM3 TMOD2 0.954
ACTN3 MYL1 0.954
DMD TCAP 0.954
TTN TNNI2 0.954
MYH6 TNNC2 0.953
TNNC2 TNNI3 0.953
MYH3 ACTN2 0.953
TNNI2 MYL2 0.953
MYH8 TNNI1 0.953
TNNC2 TPM1 0.953
TPM1 TMOD2 0.953
ACTN3 MYH8 0.953
MYL4 TNNT3 0.953
TNNI2 TPM4 0.953
MYBPC1 TNNC2 0.952
NEB MYBPC2 0.952
TPM2 MYL2 0.952
TPM2 TNNI3 0.952
ACTN2 TNNI1 0.952
TPM3 MYL2 0.952
ACTN3 TPM4 0.952
TPM2 MYL4 0.952
MYBPC3 MYL4 0.951
MYH8 TNNT2 0.951
NEB MYH3 0.951
MYH8 TNNC2 0.951
ACTN2 TPM3 0.951
ACTN3 TPM3 0.951
ACTN2 TPM4 0.951
TNNI2 TPM3 0.95
NEB ACTN2 0.95
TNNT1 ACTN2 0.95
ACTN2 TNNI2 0.95
TNNI1 MYBPC2 0.95
MYH6 TPM4 0.95
TNNT1 MYBPC1 0.95
MYL3 TPM4 0.949
MYL4 TPM4 0.949
TPM4 TMOD4 0.949
TPM4 MYL2 0.949
TPM3 TNNI3 0.949
TTN DES 0.949
MYBPC1 TPM2 0.949
TTN TPM3 0.949
TPM3 MYL4 0.949
NEB TPM1 0.948
TTN TNNC1 0.948
TPM1 TMOD4 0.948
NEB TMOD3 0.948
TPM4 TNNT2 0.948
MYH3 DMD 0.948
TNNI1 TPM4 0.947
TPM1 MYL4 0.947
MYH3 ACTN3 0.947
MYBPC2 MYL1 0.946
NEB TPM4 0.946
MYBPC1 MYH8 0.946
DES TCAP 0.946
MYH6 MYBPC2 0.946
MYH8 TPM1 0.946
NEB ACTN3 0.946
MYBPC3 TNNI1 0.945
TPM4 TNNI3 0.945
TNNT1 MYBPC2 0.945
MYBPC3 TNNC1 0.945
MYH8 DMD 0.945
TTN TPM4 0.945
MYH3 TPM1 0.945
ACTN2 DES 0.945
TNNT1 MYBPC3 0.944
ACTN2 MYH8 0.944
TCAP MYL1 0.944
MYBPC3 DES 0.944
TNNT1 ACTN3 0.944
MYBPC1 TNNT2 0.943
MYH8 TPM3 0.943
TNNT1 MYH8 0.943
TTN TMOD1 0.943
MYH8 TPM4 0.943
TNNT1 MYH3 0.943
TTN MYBPC3 0.942
TPM1 TNNC1 0.942
NEB MYBPC1 0.942
MYL3 TNNC1 0.942
ACTN2 MYL4 0.942
MYH3 MYBPC1 0.942
ACTN3 TMOD4 0.942
NEB MYL2 0.941
MYH3 TPM3 0.941
MYBPC3 TNNT3 0.941
MYH3 TPM4 0.941
ACTN2 MYBPC2 0.941
MYL4 TCAP 0.94
MYBPC3 MYL1 0.94
MYBPC2 TNNC1 0.94
DES TNNI3 0.94
DMD TNNI3 0.94
DES TPM1 0.94
NEB MYL3 0.94
ACTN3 MYL2 0.94
ACTN2 MYBPC1 0.939
DES TNNT2 0.939
NEB MYL4 0.939
MYBPC1 TMOD4 0.939
TNNC2 TCAP 0.939
MYBPC2 MYL2 0.938
MYL1 MYL2 0.938
ACTN3 MYL3 0.938
MYL3 MYBPC2 0.938
DES TNNC2 0.938
TMOD4 TNNT3 0.938
TPM2 MYBPC2 0.938
DMD TNNT2 0.938
DES MYL1 0.937
ACTN2 TNNC1 0.937
TPM3 DMD 0.937
MYBPC2 TNNT2 0.937
DMD TPM1 0.937
MYBPC1 MYL4 0.937
ACTN3 TNNI1 0.937
TNNT1 TMOD4 0.936
TNNI2 TMOD1 0.936
MYL3 DMD 0.936
MYBPC3 TMOD1 0.936
TPM2 DMD 0.936
MYBPC1 MYH6 0.936
TPM1 MYBPC2 0.935
TTN TMOD4 0.935
MYL1 TMOD4 0.935
MYBPC3 TNNI2 0.935
MYH6 DES 0.935
ACTN3 TCAP 0.935
MYBPC1 MYL2 0.935
MYH3 TCAP 0.935
MYBPC1 DMD 0.935
NEB DES 0.935
TCAP TMOD4 0.935
TNNT3 TMOD1 0.934
NEB TNNI2 0.934
TNNI2 TCAP 0.934
MYH3 MYBPC2 0.934
MYBPC1 TNNI3 0.933
TPM3 TNNC1 0.932
TCAP TNNT3 0.932
ACTN3 MYL4 0.932
ACTN3 TMOD1 0.931
MYBPC1 TNNC1 0.931
DMD MYL1 0.931
TPM2 TNNC1 0.931
TMOD4 TNNC1 0.93
NEB TMOD2 0.93
TPM3 TCAP 0.93
NEB MYBPC3 0.93
TNNI2 TMOD4 0.93
ACTN3 MYBPC1 0.93
TMOD1 TNNT2 0.93
DMD TNNT3 0.93
TCAP TNNC1 0.93
TNNI1 TCAP 0.929
MYBPC3 DMD 0.929
NEB TNNT2 0.928
DMD TNNI1 0.928
VIM TPM2 0.928
MYH8 TCAP 0.928
TTN MYBPC1 0.928
MYL3 TMOD4 0.928
DMD MYL2 0.927
MYBPC1 TPM1 0.927
TPM3 MYBPC2 0.927
MYBPC1 TPM3 0.927
DMD TPM4 0.926
MYL3 DES 0.926
TNNC2 TPM3 0.926
TNNC2 TMOD4 0.926
DMD TMOD1 0.926
ACTN2 DMD 0.926
MYL1 TNNC1 0.926
NEB TNNI1 0.925
VIM TPM4 0.925
ACTN3 TNNC1 0.925
MYBPC3 MYH8 0.925
MYL4 TMOD1 0.925
MYH3 TMOD1 0.925
VIM TPM1 0.925
MYBPC2 TMOD4 0.925
TTN MYBPC2 0.925
TPM2 TCAP 0.924
TNNI1 TMOD1 0.924
DES TNNC1 0.924
ACTN2 TMOD4 0.924
TCAP TMOD1 0.924
TNNT1 TMOD1 0.924
MYH6 TMOD1 0.924
TNNT1 TCAP 0.923
TNNT1 DMD 0.923
MYL4 MYL2 0.923
TMOD4 MYL2 0.923
ACTN3 DMD 0.922
MYH8 TMOD4 0.922
MYL4 TNNC1 0.922
MYL3 TMOD1 0.922
MYH8 TNNC1 0.921
TNNI2 DMD 0.921
TNNT1 DES 0.921
ACTN3 TMOD3 0.921
DMD MYL4 0.921
MYBPC3 TPM2 0.921
TNNI3 TMOD1 0.921
NEB TNNI3 0.92
MYL3 TNNC2 0.92
MYH6 TMOD4 0.92
MYBPC2 TCAP 0.92
TTN VIM 0.92
ACTN2 TMOD1 0.92
MYL3 MYL1 0.92
DES DMD 0.919
MYBPC3 TPM4 0.919
VIM TPM3 0.919
MYH3 MYBPC3 0.919
TNNI2 TMOD3 0.919
DES MYL2 0.919
MYBPC2 TNNI3 0.919
ACTN2 TMOD2 0.919
MYL4 TMOD4 0.919
MYBPC3 TNNC2 0.918
TTN TMOD3 0.918
NEB VIM 0.918
ACTN3 TNNI3 0.918
TNNC2 MYL2 0.918
MYBPC3 ACTN3 0.918
MYBPC2 TMOD1 0.917
MYH8 TMOD1 0.917
TMOD1 TNNC1 0.917
DMD TMOD3 0.917
ACTN2 TMOD3 0.916
MYL1 TMOD1 0.916
ACTN3 TMOD2 0.916
MYBPC2 MYL4 0.916
VIM TNNC2 0.916
TPM4 TCAP 0.916
VIM MYH6 0.916
TMOD1 MYL2 0.915
DMD MYBPC2 0.915
VIM TNNT2 0.915
DMD TMOD4 0.915
TNNT1 VIM 0.915
TPM4 TNNC1 0.915
DES TNNT3 0.914
DES TNNI1 0.914
VIM TNNI2 0.914
TPM2 TPM1 0.914
TNNC2 DMD 0.913
TMOD2 TNNT2 0.913
TMOD3 MYL1 0.913
TMOD4 TNNT2 0.913
TMOD3 TNNT3 0.913
MYH3 TMOD4 0.913
TNNT3 TMOD2 0.913
TNNI2 TMOD2 0.913
TPM2 DES 0.913
MYBPC2 TPM4 0.913
TMOD3 TNNT2 0.913
VIM MYL1 0.912
TNNI3 TMOD2 0.912
MYH3 TNNC1 0.912
TNNI1 TMOD2 0.912
MYBPC1 MYBPC2 0.912
MYBPC3 TMOD2 0.912
TNNI3 TMOD3 0.912
MYBPC3 TMOD3 0.912
TNNI1 TMOD3 0.912
DMD TMOD2 0.911
TTN TMOD2 0.911
VIM ACTN2 0.911
VIM TNNT3 0.911
TNNI2 TNNI1 0.911
NEB TNNC1 0.911
VIM ACTN3 0.91
TNNI2 TNNI3 0.91
VIM TNNI3 0.91
TNNT1 TMOD3 0.91
TNNC2 TNNC1 0.91
ACTN3 DES 0.91
TNNC2 MYL4 0.91
MYL4 MYL1 0.91
DES TPM3 0.909
VIM MYBPC3 0.909
DMD TNNC1 0.909
DES TMOD1 0.909
DES TPM4 0.909
MYH3 TMOD2 0.908
VIM MYL2 0.908
MYH6 MYH8 0.908
TNNT1 TMOD2 0.908
VIM MYL4 0.908
TNNI3 TMOD4 0.908
MYH3 TMOD3 0.908
TNNT1 TNNT3 0.907
MYH6 TMOD3 0.907
MYH8 TMOD3 0.907
TNNI2 DES 0.907
MYL1 TMOD2 0.907
TNNI1 TMOD4 0.907
ACTN2 ACTN3 0.907
MYH8 DES 0.907
MYH8 TMOD2 0.907
MYBPC3 TMOD4 0.907
MYH6 TMOD2 0.907
MYBPC1 TMOD2 0.906
VIM TNNI1 0.906
MYBPC1 DES 0.906
MYBPC1 TCAP 0.906
VIM TMOD4 0.906
TMOD2 TNNC1 0.906
MYL3 TMOD3 0.905
MYBPC1 TPM4 0.905
TPM2 TPM3 0.905
TNNT3 TNNT2 0.905
DES MYBPC2 0.905
TMOD4 TMOD1 0.905
MYH3 DES 0.905
VIM TMOD1 0.905
TMOD3 TNNC1 0.905
MYBPC3 MYBPC1 0.905
TPM2 TPM4 0.905
TNNT1 TNNT2 0.905
MYH3 MYH8 0.905
TPM3 TPM4 0.904
DES TMOD4 0.904
VIM TNNC1 0.904
VIM DMD 0.904
MYBPC3 MYBPC2 0.904
MYBPC1 TMOD1 0.904
VIM MYL3 0.904
VIM TCAP 0.904
TMOD3 TMOD4 0.903
DES TMOD2 0.903
VIM MYBPC1 0.903
TMOD4 TMOD2 0.903
TNNI1 TNNI3 0.903
MYBPC1 TMOD3 0.903
MYL3 TMOD2 0.903
DES TMOD3 0.903
MYL4 TMOD3 0.903
MYH3 VIM 0.903
DES MYL4 0.903
MYH3 MYH6 0.903
MYL3 MYL4 0.903
VIM TMOD3 0.903
VIM TMOD2 0.903
TMOD1 TMOD2 0.902
TMOD3 MYL2 0.902
MYBPC2 TMOD2 0.902
TCAP TMOD2 0.902
TMOD2 MYL2 0.902
TNNC2 TMOD1 0.902
TMOD3 TMOD1 0.902
MYBPC2 TMOD3 0.902
MYL4 TMOD2 0.902
TCAP TMOD3 0.902
VIM MYH8 0.902
VIM DES 0.902
TPM3 TPM1 0.902
VIM MYBPC2 0.902
TMOD3 TMOD2 0.901
TPM1 TPM4 0.901
TNNC2 TMOD2 0.9
TNNC2 TMOD3 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 7140 (TNNT3) 7273 (TTN) 7125 (TNNC2) 7139 (TNNT2) 4632 (MYL1) 8557 (TCAP) 7135 (TNNI1) 4624 (MYH6) 4633 (MYL2) 7137 (TNNI3) 7136 (TNNI2) 4634 (MYL3) 7169 (TPM2) 7168 (TPM1) 88 (ACTN2) 7134 (TNNC1) 7111 (TMOD1) 4635 (MYL4) 29765 (TMOD4) 29766 (TMOD3) 4606 (MYBPC2) 7170 (TPM3) 89 (ACTN3) 1756 (DMD) 4607 (MYBPC3) 4621 (MYH3) 4626 (MYH8) 7171 (TPM4) 7138 (TNNT1) 29767 (TMOD2) 4604 (MYBPC1) 1674 (DES) 7431 (VIM) 4703 (NEB)
7140 (TNNT3) 1.00 0.66 0.84 0.99 0.26 0.67 1.00 0.50 0.74 0.76 0.74 0.52 0.65 0.71 0.67 0.82 0.70 0.55 1.00 0.62 0.63 0.67 0.63 0.66 0.62 0.62 0.52 0.72 0.89 1.00 0.64 0.71 0.65 0.64
7273 (TTN) 0.66 1.00 0.71 0.65 1.00 0.69 1.00 0.38 0.72 0.68 0.62 0.51 0.69 0.75 0.70 0.71 0.48 0.46 0.70 0.46 0.76 0.67 0.68 0.69 0.74 0.51 0.48 0.78 0.63 0.70 0.76 0.70 0.66 0.72
7125 (TNNC2) 0.84 0.71 1.00 0.81 0.26 0.69 1.00 0.31 0.80 0.81 0.82 0.55 0.74 0.76 0.67 0.90 0.70 0.69 0.70 0.56 0.74 0.80 0.66 0.70 0.69 0.57 0.45 0.83 0.76 0.70 0.74 0.73 0.68 0.77
7139 (TNNT2) 0.99 0.65 0.81 1.00 0.26 0.66 1.00 0.50 0.73 0.73 0.73 0.52 0.65 0.70 0.66 0.79 0.71 0.56 1.00 0.62 0.62 0.66 0.62 0.65 0.61 0.62 0.52 0.71 0.90 1.00 0.63 0.71 0.64 0.62
4632 (MYL1) 0.26 1.00 0.26 0.26 1.00 1.00 0.26 0.16 1.00 0.26 0.26 1.00 1.00 1.00 1.00 0.26 0.18 0.16 0.18 0.18 1.00 0.48 1.00 1.00 1.00 0.21 1.00 1.00 0.26 0.18 1.00 0.59 0.59 1.00
8557 (TCAP) 0.67 0.69 0.69 0.66 1.00 1.00 1.00 0.34 0.76 0.69 0.73 0.60 0.71 0.79 0.83 0.69 0.57 0.48 0.70 0.55 0.78 0.71 0.81 0.77 0.76 0.48 0.48 0.75 0.65 0.70 0.82 0.79 0.74 0.80
7135 (TNNI1) 1.00 1.00 1.00 1.00 0.26 1.00 1.00 0.60 1.00 1.00 1.00 0.60 0.82 1.00 1.00 1.00 0.69 0.60 0.69 0.69 1.00 1.00 1.00 1.00 1.00 0.82 0.60 1.00 1.00 0.69 1.00 1.00 1.00 1.00
4624 (MYH6) 0.50 0.38 0.31 0.50 0.16 0.34 0.60 1.00 0.27 0.40 0.31 0.20 0.28 0.32 0.34 0.32 0.21 0.19 0.40 0.20 0.27 0.33 0.30 0.32 0.30 0.79 0.67 0.30 0.52 0.40 0.28 0.31 0.33 0.27
4633 (MYL2) 0.74 0.72 0.80 0.73 1.00 0.76 1.00 0.27 1.00 0.67 0.70 0.80 0.74 0.78 0.71 0.74 0.59 0.65 0.69 0.50 0.75 0.65 0.75 0.80 0.76 0.42 0.50 0.83 0.70 0.69 0.74 0.74 0.68 0.78
7137 (TNNI3) 0.76 0.68 0.81 0.73 0.26 0.69 1.00 0.40 0.67 1.00 0.82 0.53 0.70 0.75 0.71 0.79 0.65 0.62 0.70 0.56 0.71 0.76 0.66 0.69 0.69 0.55 0.46 0.70 0.68 0.70 0.72 0.73 0.69 0.73
7136 (TNNI2) 0.74 0.62 0.82 0.73 0.26 0.73 1.00 0.31 0.70 0.82 1.00 0.61 0.74 0.75 0.69 0.79 0.82 0.69 0.70 0.66 0.71 0.77 0.70 0.72 0.66 0.50 0.40 0.69 0.73 0.70 0.71 0.80 0.71 0.73
4634 (MYL3) 0.52 0.51 0.55 0.52 1.00 0.60 0.60 0.20 0.80 0.53 0.61 1.00 0.67 0.67 0.54 0.48 0.60 0.80 0.60 0.43 0.68 0.55 0.60 0.69 0.65 0.34 0.49 0.58 0.43 0.60 0.67 0.61 0.48 0.72
7169 (TPM2) 0.65 0.69 0.74 0.65 1.00 0.71 0.82 0.28 0.74 0.70 0.74 0.67 1.00 0.95 0.75 0.74 0.63 0.62 0.70 0.49 0.82 0.73 0.80 0.77 0.78 0.52 0.54 0.91 0.57 0.70 0.81 0.77 0.68 0.85
7168 (TPM1) 0.71 0.75 0.76 0.70 1.00 0.79 1.00 0.32 0.78 0.75 0.75 0.67 0.95 1.00 0.82 0.78 0.63 0.60 0.84 0.54 0.84 0.76 0.82 0.86 0.82 0.54 0.57 0.91 0.63 0.84 0.84 0.88 0.79 0.85
88 (ACTN2) 0.67 0.70 0.67 0.66 1.00 0.83 1.00 0.34 0.71 0.71 0.69 0.54 0.75 0.82 1.00 0.71 0.54 0.48 0.84 0.52 0.72 0.68 0.83 0.74 0.77 0.49 0.48 0.77 0.64 0.84 0.76 0.76 0.73 0.73
7134 (TNNC1) 0.82 0.71 0.90 0.79 0.26 0.69 1.00 0.32 0.74 0.79 0.79 0.48 0.74 0.78 0.71 1.00 0.61 0.60 0.70 0.56 0.72 0.76 0.73 0.66 0.69 0.55 0.45 0.85 0.79 0.70 0.72 0.74 0.68 0.74
7111 (TMOD1) 0.70 0.48 0.70 0.71 0.18 0.57 0.69 0.21 0.59 0.65 0.82 0.60 0.63 0.63 0.54 0.61 1.00 0.70 1.00 0.76 0.59 0.63 0.51 0.61 0.57 0.40 0.35 0.52 0.63 1.00 0.61 0.66 0.51 0.60
4635 (MYL4) 0.55 0.46 0.69 0.56 0.16 0.48 0.60 0.19 0.65 0.62 0.69 0.80 0.62 0.60 0.48 0.60 0.70 1.00 0.60 0.50 0.62 0.66 0.47 0.55 0.60 0.46 0.42 0.53 0.46 0.60 0.61 0.56 0.46 0.64
29765 (TMOD4) 1.00 0.70 0.70 1.00 0.18 0.70 0.69 0.40 0.69 0.70 0.70 0.60 0.70 0.84 0.84 0.70 1.00 0.60 1.00 1.00 0.69 0.69 0.69 0.70 0.70 0.56 0.60 0.69 1.00 1.00 0.70 0.84 0.69 0.69
29766 (TMOD3) 0.62 0.46 0.56 0.62 0.18 0.55 0.69 0.20 0.50 0.56 0.66 0.43 0.49 0.54 0.52 0.56 0.76 0.50 1.00 1.00 0.52 0.54 0.49 0.52 0.53 0.32 0.28 0.47 0.60 1.00 0.55 0.60 0.49 0.51
4606 (MYBPC2) 0.63 0.76 0.74 0.62 1.00 0.78 1.00 0.27 0.75 0.71 0.71 0.68 0.82 0.84 0.72 0.72 0.59 0.62 0.69 0.52 1.00 0.79 0.78 0.77 0.84 0.51 0.56 0.82 0.57 0.69 0.97 0.76 0.70 0.93
7170 (TPM3) 0.67 0.67 0.80 0.66 0.48 0.71 1.00 0.33 0.65 0.76 0.77 0.55 0.73 0.76 0.68 0.76 0.63 0.66 0.69 0.54 0.79 1.00 0.68 0.69 0.71 0.58 0.50 0.74 0.62 0.69 0.77 0.74 0.70 0.83
89 (ACTN3) 0.63 0.68 0.66 0.62 1.00 0.81 1.00 0.30 0.75 0.66 0.70 0.60 0.80 0.82 0.83 0.73 0.51 0.47 0.69 0.49 0.78 0.68 1.00 0.76 0.72 0.44 0.47 0.81 0.60 0.69 0.77 0.76 0.73 0.81
1756 (DMD) 0.66 0.69 0.70 0.65 1.00 0.77 1.00 0.32 0.80 0.69 0.72 0.69 0.77 0.86 0.74 0.66 0.61 0.55 0.70 0.52 0.77 0.69 0.76 1.00 0.77 0.46 0.55 0.75 0.60 0.70 0.77 0.84 0.76 0.79
4607 (MYBPC3) 0.62 0.74 0.69 0.61 1.00 0.76 1.00 0.30 0.76 0.69 0.66 0.65 0.78 0.82 0.77 0.69 0.57 0.60 0.70 0.53 0.84 0.71 0.72 0.77 1.00 0.50 0.58 0.78 0.58 0.70 0.88 0.76 0.69 0.79
4621 (MYH3) 0.62 0.51 0.57 0.62 0.21 0.48 0.82 0.79 0.42 0.55 0.50 0.34 0.52 0.54 0.49 0.55 0.40 0.46 0.56 0.32 0.51 0.58 0.44 0.46 0.50 1.00 0.76 0.52 0.60 0.56 0.52 0.46 0.48 0.53
4626 (MYH8) 0.52 0.48 0.45 0.52 1.00 0.48 0.60 0.67 0.50 0.46 0.40 0.49 0.54 0.57 0.48 0.45 0.35 0.42 0.60 0.28 0.56 0.50 0.47 0.55 0.58 0.76 1.00 0.51 0.48 0.60 0.56 0.44 0.42 0.57
7171 (TPM4) 0.72 0.78 0.83 0.71 1.00 0.75 1.00 0.30 0.83 0.70 0.69 0.58 0.91 0.91 0.77 0.85 0.52 0.53 0.69 0.47 0.82 0.74 0.81 0.75 0.78 0.52 0.51 1.00 0.70 0.69 0.81 0.76 0.72 0.85
7138 (TNNT1) 0.89 0.63 0.76 0.90 0.26 0.65 1.00 0.52 0.70 0.68 0.73 0.43 0.57 0.63 0.64 0.79 0.63 0.46 1.00 0.60 0.57 0.62 0.60 0.60 0.58 0.60 0.48 0.70 1.00 1.00 0.59 0.67 0.64 0.58
29767 (TMOD2) 1.00 0.70 0.70 1.00 0.18 0.70 0.69 0.40 0.69 0.70 0.70 0.60 0.70 0.84 0.84 0.70 1.00 0.60 1.00 1.00 0.69 0.69 0.69 0.70 0.70 0.56 0.60 0.69 1.00 1.00 0.70 0.84 0.69 0.69
4604 (MYBPC1) 0.64 0.76 0.74 0.63 1.00 0.82 1.00 0.28 0.74 0.72 0.71 0.67 0.81 0.84 0.76 0.72 0.61 0.61 0.70 0.55 0.97 0.77 0.77 0.77 0.88 0.52 0.56 0.81 0.59 0.70 1.00 0.77 0.70 0.90
1674 (DES) 0.71 0.70 0.73 0.71 0.59 0.79 1.00 0.31 0.74 0.73 0.80 0.61 0.77 0.88 0.76 0.74 0.66 0.56 0.84 0.60 0.76 0.74 0.76 0.84 0.76 0.46 0.44 0.76 0.67 0.84 0.77 1.00 0.85 0.78
7431 (VIM) 0.65 0.66 0.68 0.64 0.59 0.74 1.00 0.33 0.68 0.69 0.71 0.48 0.68 0.79 0.73 0.68 0.51 0.46 0.69 0.49 0.70 0.70 0.73 0.76 0.69 0.48 0.42 0.72 0.64 0.69 0.70 0.85 1.00 0.72
4703 (NEB) 0.64 0.72 0.77 0.62 1.00 0.80 1.00 0.27 0.78 0.73 0.73 0.72 0.85 0.85 0.73 0.74 0.60 0.64 0.69 0.51 0.93 0.83 0.81 0.79 0.79 0.53 0.57 0.85 0.58 0.69 0.90 0.78 0.72 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
TNNC1 Toad Heart - 3464 m 33 day downregulated -3.339412431 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 TNNC1 7134 distal 22955619 TRANSFAC
TCF12 6938 TNNC1 7134 distal 22955619 TRANSFAC
EP300 2033 TNNC1 7134 distal 22955619 TRANSFAC
TCF12 6938 TNNC1 7134 distal 22955619 TRANSFAC
EP300 2033 TNNC1 7134 distal 22955619 TRANSFAC
TCF12 6938 TNNC1 7134 distal 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT017278 hsa-miR-335-5p Homo sapiens TNNC1 7134 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT627380 hsa-miR-4652-3p Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT627381 hsa-miR-4743-3p Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT627382 hsa-miR-3686 Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT627383 hsa-miR-4732-5p Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT627384 hsa-miR-6832-5p Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT627385 hsa-miR-20b-3p Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT627386 hsa-miR-3137 Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT627387 hsa-miR-513c-3p Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT627388 hsa-miR-513a-3p Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT627389 hsa-miR-3606-3p Homo sapiens TNNC1 7134 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
Gene Ontology
ID GO ID GO Term GO Type
7134 GO:0002086 diaphragm contraction GOTERM_BP_DIRECT
7134 GO:0003009 skeletal muscle contraction GOTERM_BP_DIRECT
7134 GO:0005509 calcium ion binding GOTERM_MF_DIRECT
7134 GO:0005515 protein binding GOTERM_MF_DIRECT
7134 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
7134 GO:0005739 mitochondrion GOTERM_CC_DIRECT
7134 GO:0005829 cytosol GOTERM_CC_DIRECT
7134 GO:0005861 troponin complex GOTERM_CC_DIRECT
7134 GO:0006937 regulation of muscle contraction GOTERM_BP_DIRECT
7134 GO:0010038 response to metal ion GOTERM_BP_DIRECT
7134 GO:0014883 transition between fast and slow fiber GOTERM_BP_DIRECT
7134 GO:0015629 actin cytoskeleton GOTERM_CC_DIRECT
7134 GO:0030049 muscle filament sliding GOTERM_BP_DIRECT
7134 GO:0031013 troponin I binding GOTERM_MF_DIRECT
7134 GO:0031014 troponin T binding GOTERM_MF_DIRECT
7134 GO:0032972 regulation of muscle filament sliding speed GOTERM_BP_DIRECT
7134 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
7134 GO:0043292 contractile fiber GOTERM_CC_DIRECT
7134 GO:0043462 regulation of ATPase activity GOTERM_BP_DIRECT
7134 GO:0048306 calcium-dependent protein binding GOTERM_MF_DIRECT
7134 GO:0051015 actin filament binding GOTERM_MF_DIRECT
7134 GO:0055010 ventricular cardiac muscle tissue morphogenesis GOTERM_BP_DIRECT
7134 GO:0060048 cardiac muscle contraction GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
7134 hsa04020 Calcium signaling pathway
7134 hsa04260 Cardiac muscle contraction
7134 hsa04261 Adrenergic signaling in cardiomyocytes
7134 hsa05410 Hypertrophic cardiomyopathy (HCM)
7134 hsa05414 Dilated cardiomyopathy
7134 hsa04020 Calcium signaling pathway
7134 hsa04260 Cardiac muscle contraction
7134 hsa04261 Adrenergic signaling in cardiomyocytes
7134 hsa05410 Hypertrophic cardiomyopathy (HCM)
7134 hsa05414 Dilated cardiomyopathy
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
TNNC1 7134 Cardiomyopathy, Familial Hypertrophic, 13 C2750472 Disease or Syndrome 0.7 0.701 0.276 disease
TNNC1 7134 Cardiomyopathy, Dilated, 1z C2678475 Disease or Syndrome 0.6 0.701 0.276 disease
TNNC1 7134 Cardiomyopathy, Dilated C0007193 Disease or Syndrome 0.5 0.701 0.276 group
TNNC1 7134 Hypertrophic Cardiomyopathy C0007194 Disease or Syndrome 0.5 0.701 0.276 disease
TNNC1 7134 Charcot-Marie-Tooth Disease C0007959 Disease or Syndrome 0.3 0.701 0.276 disease
TNNC1 7134 Conduction disorder of the heart C0264886 Disease or Syndrome 0.3 0.701 0.276 group
TNNC1 7134 Familial dilated cardiomyopathy C0340427 Disease or Syndrome 0.3 0.701 0.276 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
TNNC1 7134 BEPRIDIL BEPRIDIL CHEMBL1008 None
TNNC1 7134 BEPRIDIL BEPRIDIL CHEMBL1008 None
TNNC1 7134 DIHYDROXYALUMINIUM ALUMINIUM GLYCINATE CHEMBL3707233 stimulator
TNNC1 7134 LEVOSIMENDAN LEVOSIMENDAN CHEMBL2051955 None
TNNC1 7134 LEVOSIMENDAN LEVOSIMENDAN CHEMBL2051955 None
TNNC1 7134 LEVOSIMENDAN LEVOSIMENDAN CHEMBL2051955 stimulator
TNNC1 7134 TIRAMSETIV None None None
TNNC1 7134 BEPRIDIL BEPRIDIL CHEMBL1008 None
TNNC1 7134 BEPRIDIL BEPRIDIL CHEMBL1008 None
TNNC1 7134 DIHYDROXYALUMINIUM ALUMINIUM GLYCINATE CHEMBL3707233 stimulator
TNNC1 7134 LEVOSIMENDAN LEVOSIMENDAN CHEMBL2051955 None
TNNC1 7134 LEVOSIMENDAN LEVOSIMENDAN CHEMBL2051955 None
TNNC1 7134 LEVOSIMENDAN LEVOSIMENDAN CHEMBL2051955 stimulator
TNNC1 7134 TIRAMSETIV None None None
TNNC1 7134 BEPRIDIL BEPRIDIL CHEMBL1008 None
TNNC1 7134 BEPRIDIL BEPRIDIL CHEMBL1008 None
TNNC1 7134 DIHYDROXYALUMINIUM ALUMINIUM GLYCINATE CHEMBL3707233 stimulator
TNNC1 7134 LEVOSIMENDAN LEVOSIMENDAN CHEMBL2051955 None
TNNC1 7134 LEVOSIMENDAN LEVOSIMENDAN CHEMBL2051955 None
TNNC1 7134 LEVOSIMENDAN LEVOSIMENDAN CHEMBL2051955 stimulator
TNNC1 7134 TIRAMSETIV None None None