Prostaglandin reductase 1

AltitudeomicsDB
Protein Official symbol PTGR1
Aliases PTGR1 LTB4DH
Chromosomal Location 9
Length 329
Uniprot ID Q14914
EC number 1.3.1.-; 1.3.1.48; 1.3.1.74
Protein family Information(Pfam) PF16884;PF00107;
PDB id 1ZSV;2Y05;
InterPro ID IPR013149;IPR041694;IPR011032;IPR036291;IPR020843;IPR014190;
dbSNP rs1053959

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SRXN1 PRDX6 0.84
PTGR1 PRDX6 0.691
PTGR1 ADH5 0.642
PTGR1 SRXN1 0.637
Gene Ontology Semantic Similarity
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# 140809 (SRXN1) 9588 (PRDX6)
140809 (SRXN1) 1.00 0.63
9588 (PRDX6) 0.63 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PTGR1 Toad Heart - 3464 m 33 day upregulated 2.22931201 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
PTGR1 Toad Brain - 3464 m 33 day upregulated 2.655267877 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 PTGR1 22949 distal 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT735044 hsa-miR-522-3p Homo sapiens PTGR1 22949 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 28088550
Gene Ontology
ID GO ID GO Term GO Type
22949 GO:0047522 protein N-terminus binding GOTERM_MF_DIRECT
22949 GO:0032440 MutSalpha complex binding GOTERM_MF_DIRECT
22949 GO:0036132 long-chain fatty acyl-CoA binding GOTERM_MF_DIRECT
22949 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
22949 GO:0005737 cytoplasm GOTERM_CC_DIRECT
22949 GO:0006691 leukotriene metabolic process GOTERM_BP_DIRECT
22949 GO:0016491 oxidoreductase activity GOTERM_MF_DIRECT
22949 GO:0006693 prostaglandin metabolic process GOTERM_BP_DIRECT
22949 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
22949 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types