Heat shock protein 71 kDa

AltitudeomicsDB
Protein Official symbol HSPA4
Aliases HSPA4 APG2
Chromosomal Location
Length 840
Uniprot ID P34932
EC number None
Protein family Information(Pfam) PF00012;
PDB id None
InterPro ID IPR043129;IPR018181;IPR029048;IPR029047;IPR013126;IPR042052;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
Gene Ontology Semantic Similarity
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Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HSPA4 Rat Brain - 5000 m 4 Week No change 0.12 ± 0.15 RT-PCR Naqu, China SD rats 0.12 ± 0.1 SD male rats 30688112
HSPA4 Rat Brain - 3568 m 4 Week upregulated 0.14 ± 0.12 RT-PCR Lasa, China SD rats 0.12 ± 0.1 SD male rats 30688112
HSPA4 Rat Brain - 4500 m 4 Week upregulated 0.12 ± 0.14 RT-PCR Naqu, China SD rats 0.12 ± 0.1 SD male rats 30688112
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
BRCA1 672 HSPA4 3308 proximal_filtered 22955619 TRANSFAC
TAF1 6872 HSPA4 3308 proximal_filtered 22955619 TRANSFAC
TCF4 6925 HSPA4 3308 proximal_filtered 22955619 TRANSFAC
ZBTB33 10009 HSPA4 3308 proximal_filtered 22955619 TRANSFAC
CEBPA 1050 HSPA4 3308 Unknown 16973241 TRUSST
CREG1 8804 HSPA4 3308 Unknown 22580340 TRUSST
MYC 4609 HSPA4 3308 Unknown 15890065 TRUSST
SIRT1 23411 HSPA4 3308 Activation 16551619 TRUSST
STAT3 6774 HSPA4 3308 Repression 22459801 TRUSST
HSF1 3297 HSPA4 3308 Unknown 22580340 TRUSST
HSF2 3298 HSPA4 3308 Unknown 15890065 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT003977 hsa-miR-1-3p Homo sapiens HSPA4 3308 Homo sapiens Luciferase reporter assay Functional MTI 17715156
MIRT007050 hsa-miR-30c-5p Homo sapiens HSPA4 3308 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 22842562
MIRT030164 hsa-miR-26b-5p Homo sapiens HSPA4 3308 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT036559 hsa-miR-942-5p Homo sapiens HSPA4 3308 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT039721 hsa-miR-615-3p Homo sapiens HSPA4 3308 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044647 hsa-miR-320a Homo sapiens HSPA4 3308 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT047525 hsa-miR-10a-5p Homo sapiens HSPA4 3308 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048037 hsa-miR-148a-3p Homo sapiens HSPA4 3308 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048125 hsa-miR-197-3p Homo sapiens HSPA4 3308 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT459525 hsa-miR-552-3p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459519 hsa-miR-493-3p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459518 hsa-miR-4710 Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459520 hsa-miR-6806-3p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459521 hsa-miR-3928-5p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459523 hsa-miR-125a-3p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459527 hsa-miR-4517 Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459522 hsa-miR-3185 Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459517 hsa-miR-6804-5p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459524 hsa-miR-6854-5p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT459526 hsa-miR-6768-5p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT564011 hsa-miR-7856-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT564012 hsa-miR-3658 Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT564011 hsa-miR-7856-5p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT564015 hsa-miR-4282 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT564012 hsa-miR-3658 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT564013 hsa-miR-3653-3p Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT564014 hsa-miR-5680 Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT564013 hsa-miR-3653-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT564015 hsa-miR-4282 Homo sapiens HSPA4 3308 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT611481 hsa-miR-3613-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT611480 hsa-miR-4286 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT611480 hsa-miR-4286 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT611479 hsa-miR-2355-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT611480 hsa-miR-4286 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT611479 hsa-miR-2355-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT611479 hsa-miR-2355-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT611481 hsa-miR-3613-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT611483 hsa-miR-329-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT611484 hsa-miR-8485 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT611483 hsa-miR-329-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT611484 hsa-miR-8485 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT611482 hsa-miR-362-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT611483 hsa-miR-329-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT611481 hsa-miR-3613-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT611482 hsa-miR-362-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT611482 hsa-miR-362-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT611484 hsa-miR-8485 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT672260 hsa-miR-6734-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT672260 hsa-miR-6734-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT672260 hsa-miR-6734-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT714493 hsa-miR-6715b-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714489 hsa-miR-302d-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714496 hsa-miR-216b-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714491 hsa-miR-4692 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714497 hsa-miR-200a-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714498 hsa-miR-141-3p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714487 hsa-miR-302c-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714492 hsa-miR-4514 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714494 hsa-miR-4269 Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714495 hsa-miR-4742-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714488 hsa-miR-593-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT714490 hsa-miR-302b-5p Homo sapiens HSPA4 3308 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT731408 hsa-let-7c-5p Homo sapiens HSPA4 3308 Homo sapiens Luciferase reporter assay Functional MTI 26923191
Gene Ontology
ID GO ID GO Term GO Type
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HSPA4 3308 Muscular Dystrophy, Facioscapulohumeral C0238288 Disease or Syndrome 0.3 0.441 0.793 disease
HSPA4 3308 Alcoholic Intoxication C0001969 Mental or Behavioral Dysfunction 0.3 0.441 0.793 disease
HSPA4 3308 Manic C0338831 Mental or Behavioral Dysfunction 0.31 0.441 0.793 disease
HSPA4 3308 Manic mood C0564408 Finding 0.3 0.441 0.793 phenotype
HSPA4 3308 Unipolar Depression C0041696 Mental or Behavioral Dysfunction 0.02 0.441 0.793 disease
HSPA4 3308 Major Depressive Disorder C1269683 Mental or Behavioral Dysfunction 0.02 0.441 0.793 disease
HSPA4 3308 Mood Disorders C0525045 Mental or Behavioral Dysfunction 0.31 0.441 0.793 group
HSPA4 3308 cocaine use C3496069 Mental or Behavioral Dysfunction 0.31 0.441 0.793 disease
HSPA4 3308 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.33 0.441 0.793 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
HSPA4 3308 ANTINEOPLASTIC None None None
HSPA4 3308 ARSENIC TRIOXIDE ARSENIC TRIOXIDE CHEMBL1200978 None
HSPA4 3308 BORTEZOMIB BORTEZOMIB CHEMBL325041 None
HSPA4 3308 CELECOXIB CELECOXIB CHEMBL118 None
HSPA4 3308 CHLORPROMAZINE CHLORPROMAZINE CHEMBL71 None
HSPA4 3308 CISPLATIN None None None
HSPA4 3308 CHELATORS None None None
HSPA4 3308 CYTARABINE CYTARABINE CHEMBL803 None
HSPA4 3308 DDC ZALCITABINE CHEMBL853 None
HSPA4 3308 DEFEROXAMINE DEFEROXAMINE CHEMBL556 None
HSPA4 3308 DON 6-DIAZO-5-OXO-L-NORLEUCINE CHEMBL97485 None
HSPA4 3308 ENALAPRIL ENALAPRIL CHEMBL578 None
HSPA4 3308 EPO EPOETIN ALFA CHEMBL1201565 None
HSPA4 3308 FLUTICASONE PROPIONATE FLUTICASONE PROPIONATE CHEMBL1473 None
HSPA4 3308 GDNF None None None
HSPA4 3308 GOSSYPOL GOSSYPOL CHEMBL51483 None
HSPA4 3308 HALOPERIDOL HALOPERIDOL CHEMBL54 None
HSPA4 3308 HEPARIN HEPARIN CHEMBL1909300 None
HSPA4 3308 HYDRALAZINE HYDRALAZINE CHEMBL276832 None
HSPA4 3308 IFOSFAMIDE IFOSFAMIDE CHEMBL1024 None
HSPA4 3308 ISOPROTERENOL ISOPROTERENOL CHEMBL434 None
HSPA4 3308 KETANSERIN KETANSERIN CHEMBL51 None
HSPA4 3308 KINASE INHIBITOR None None None
HSPA4 3308 LITHIUM LITHIUM CHEMBL2146126 None
HSPA4 3308 NDGA None None None
HSPA4 3308 NIMESULIDE NIMESULIDE CHEMBL56367 None
HSPA4 3308 NIFEDIPINE NIFEDIPINE CHEMBL193 None
HSPA4 3308 PHENYLEPHRINE PHENYLEPHRINE CHEMBL1215 None
HSPA4 3308 PHOSPHODIESTERASE INHIBITOR None None None
HSPA4 3308 PHOTOFRIN PHOTOFRIN CHEMBL594426 None
HSPA4 3308 PHOTOSENSITIZERS None None None
HSPA4 3308 PIOGLITAZONE PIOGLITAZONE CHEMBL595 None
HSPA4 3308 PKC412 MIDOSTAURIN CHEMBL608533 None
HSPA4 3308 POH PERILLYL ALCOHOL CHEMBL236687 None
HSPA4 3308 PROTEIN SYNTHESIS INHIBITOR None None None
HSPA4 3308 PUROMYCIN PUROMYCIN CHEMBL469912 None
HSPA4 3308 RANITIDINE RANITIDINE CHEMBL1790041 None
HSPA4 3308 SALINE SODIUM CHLORIDE CHEMBL1200574 None
HSPA4 3308 SODIUM SALICYLATE SODIUM SALICYLATE CHEMBL447868 None
HSPA4 3308 THIABENDAZOLE THIABENDAZOLE CHEMBL625 None
HSPA4 3308 TRAIL None None None
HSPA4 3308 UREA UREA CHEMBL985 None
HSPA4 3308 VITAMIN C ASCORBATE CHEMBL196 None
HSPA4 3308 VERAPAMIL VERAPAMIL CHEMBL6966 None
HSPA4 3308 WORTMANNIN WORTMANNIN CHEMBL428496 None