Malate dehydrogenase, cytoplasmic

AltitudeomicsDB
Protein Official symbol MDH1
Aliases MDH1 MDHA
Chromosomal Location 2
Length 334
Uniprot ID P40925
EC number 1.1.1.37; 1.1.1.96
Protein family Information(Pfam) PF02866;PF00056;
PDB id None
InterPro ID IPR001557;IPR022383;IPR001236;IPR015955;IPR001252;IPR011274;IPR010945;IPR036291;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
FH MDH2 0.997
CS MDH2 0.997
CS ACLY 0.995
GLUD2 GLUD1 0.9940000000000001
MDH1 MDH2 0.9940000000000001
FH CS 0.9940000000000001
MDH2 GOT2 0.993
PC CS 0.991
MDH1 GOT1 0.99
PC MDH2 0.99
PC PCK2 0.986
MDH1 CS 0.986
GLUD1 GOT2 0.986
MDH1 FH 0.983
PC ACLY 0.98
PC ME1 0.9790000000000001
GOT1 GLUD1 0.9790000000000001
MDH1 GOT2 0.9790000000000001
PC PCK1 0.9790000000000001
ME1 MDH2 0.978
ME3 MDH2 0.978
GOT1 GLUD2 0.978
MDH2 ME2 0.977
MDH1 ME1 0.975
GLUD2 GOT2 0.973
ME3 PC 0.972
MDH1 PC 0.971
ME3 MDH1 0.971
MDH1 ME2 0.9690000000000001
ME1 FH 0.9670000000000001
PC ME2 0.965
GOT1 MDH2 0.9640000000000001
FH ME2 0.9620000000000001
PC GOT1 0.96
ACLY PCK2 0.96
CS PCK2 0.96
MDH2 ACLY 0.9590000000000001
MDH1 PCK2 0.9590000000000001
MDH1 ACLY 0.9570000000000001
ME3 FH 0.9570000000000001
MDH2 PCK2 0.9540000000000001
MDH1 PCK1 0.9540000000000001
PCK1 ACLY 0.951
MDH2 GLUD1 0.946
PC GOT2 0.943
CS PCK1 0.9420000000000001
CS GOT2 0.94
MDH2 PCK1 0.9390000000000001
GLUD2 MDH2 0.937
MDH1 PGM1 0.934
MDH1 GLUD1 0.9309999999999999
GOT1 GOT2 0.9309999999999999
MDH1 SOD1 0.929
GOT1 FH 0.929
CS GLUD1 0.9279999999999999
MDH1 UQCRFS1 0.9279999999999999
MDH2 UQCRFS1 0.927
ME1 CS 0.9229999999999999
PC GLUD1 0.92
ME3 CS 0.9179999999999999
GLUD1 ACLY 0.914
CS GLUD2 0.912
FH GOT2 0.9109999999999999
MDH1 GLUD2 0.902
CS ME2 0.9009999999999999
Gene Ontology Semantic Similarity
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# 55124 (PIWIL2) 122402 (TDRD9) 143689 (PIWIL4) 91646 (TDRD12) 84944 (MAEL) 54514 (DDX4) 136991 (ASZ1) 3320 (HSP90AA1) 54456 (MOV10L1) 113802 (HENMT1) 8468 (FKBP6) 9271 (PIWIL1)
55124 (PIWIL2) 1.00 0.12 1.00 0.26 0.57 0.12 0.19 0.28 0.40 0.23 0.30 0.83
122402 (TDRD9) 0.12 1.00 0.04 0.13 0.04 1.00 0.10 0.56 1.00 0.09 0.11 0.12
143689 (PIWIL4) 1.00 0.04 1.00 0.26 0.57 0.04 0.19 0.88 0.88 0.33 0.45 1.00
91646 (TDRD12) 0.26 0.13 0.26 1.00 0.26 0.13 0.64 0.48 0.28 0.48 0.48 0.48
84944 (MAEL) 0.57 0.04 0.57 0.26 1.00 0.04 0.19 0.66 0.66 0.33 0.45 0.57
54514 (DDX4) 0.12 1.00 0.04 0.13 0.04 1.00 0.10 0.56 1.00 0.09 0.11 0.12
136991 (ASZ1) 0.19 0.10 0.19 0.64 0.19 0.10 1.00 0.34 0.21 0.34 0.34 0.34
3320 (HSP90AA1) 0.28 0.56 0.88 0.48 0.66 0.56 0.34 1.00 0.42 0.49 0.56 0.56
54456 (MOV10L1) 0.40 1.00 0.88 0.28 0.66 1.00 0.21 0.42 1.00 0.22 0.31 0.47
113802 (HENMT1) 0.23 0.09 0.33 0.48 0.33 0.09 0.34 0.49 0.22 1.00 0.57 0.44
8468 (FKBP6) 0.30 0.11 0.45 0.48 0.45 0.11 0.34 0.56 0.31 0.57 1.00 0.58
9271 (PIWIL1) 0.83 0.12 1.00 0.48 0.57 0.12 0.34 0.56 0.47 0.44 0.58 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MDH1 Human Skeletal muscle - 4559 m 9 day downregulated -1.28 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 MDH1 4190 distal 22955619 TRANSFAC
CEBPB 1051 MDH1 4190 proximal_filtered 22955619 TRANSFAC
SIX5 147912 MDH1 4190 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT028752 hsa-miR-26b-5p Homo sapiens MDH1 4190 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT045287 hsa-miR-186-5p Homo sapiens MDH1 4190 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046497 hsa-miR-15b-5p Homo sapiens MDH1 4190 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
4190 GO:0006734 NADH metabolic process GOTERM_BP_DIRECT
4190 GO:0005813 centrosome GOTERM_CC_DIRECT
4190 GO:0006099 tricarboxylic acid cycle GOTERM_BP_DIRECT
4190 GO:0016616 oxidoreductase activity GOTERM_MF_DIRECT
4190 GO:0006108 malate metabolic process GOTERM_BP_DIRECT
4190 GO:0051287 NAD binding GOTERM_MF_DIRECT
4190 GO:0016615 glutamate binding GOTERM_MF_DIRECT
4190 GO:0047860 arachidonate-CoA ligase activity GOTERM_MF_DIRECT
4190 GO:0005739 mitochondrion GOTERM_CC_DIRECT
4190 GO:0005737 cytoplasm GOTERM_CC_DIRECT
4190 GO:0006094 gluconeogenesis GOTERM_BP_DIRECT
4190 GO:0006107 oxaloacetate metabolic process GOTERM_BP_DIRECT
4190 GO:0005515 protein binding GOTERM_MF_DIRECT
4190 GO:0005829 cytosol GOTERM_CC_DIRECT
4190 GO:0005975 carbohydrate metabolic process GOTERM_BP_DIRECT
4190 GO:0005615 extracellular space GOTERM_CC_DIRECT
4190 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
4190 GO:0004470 lactose synthase activity GOTERM_MF_DIRECT
4190 GO:0030060 MHC class II protein complex binding GOTERM_MF_DIRECT
4190 GO:0043209 myelin sheath GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
4190 hsa00020 Citrate cycle
4190 hsa00270 Cysteine and methionine metabolism
4190 hsa00620 Pyruvate metabolism
4190 hsa00630 Glyoxylate and dicarboxylate metabolism
4190 hsa01100 Metabolic pathways
4190 hsa01130 Biosynthesis of antibiotics
4190 hsa01200 Carbon metabolism
4190 hsa04964 Proximal tubule bicarbonate reclamation
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
MDH1 4190 Hypertensive disease C0020538 Disease or Syndrome 0.3 0.735 0.276 group
MDH1 4190 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.735 0.276 disease
MDH1 4190 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.3 0.735 0.276 disease
MDH1 4190 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.735 0.276 disease
MDH1 4190 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.735 0.276 disease
MDH1 4190 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.735 0.276 disease
MDH1 4190 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.735 0.276 disease
MDH1 4190 Respiratory Distress Syndrome, Adult C0035222 Disease or Syndrome 0.3 0.735 0.276 disease
MDH1 4190 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.735 0.276 disease
MDH1 4190 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.32 0.735 0.276 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types