Mitochondrially encoded cytochrome c oxidase III

AltitudeomicsDB
Protein Official symbol MT-CO3
Aliases MT-CO3 COIII COXIII MTCO3
Chromosomal Location MT(non-nuclear)NC
Length 261
Uniprot ID P00414
EC number 7.1.1.9
Protein family Information(Pfam) PF00510;
PDB id 5Z62;
InterPro ID IPR024791;IPR033945;IPR000298;IPR035973;IPR013833;
dbSNP rs267606611 rs2853825 rs200613617 rs200809063

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
COX4I1 MT-CO2 0.9990000000000001
MT-CO2 COX5A 0.9990000000000001
MT-ND1 MT-CYB 0.9990000000000001
MT-CYB MT-CO1 0.9990000000000001
COX4I1 COX5A 0.9990000000000001
COX5A COX5B 0.9990000000000001
MT-CO3 MT-CYB 0.9990000000000001
MT-ND4 MT-ND1 0.9990000000000001
MT-CO2 MT-CO1 0.9990000000000001
MT-CO3 MT-CO2 0.9990000000000001
MT-CO3 MT-CO1 0.9990000000000001
MT-ATP6 MT-CYB 0.9990000000000001
MT-CO2 COX5B 0.9990000000000001
MT-ND1 MT-ATP6 0.9990000000000001
CYCS COX5B 0.9990000000000001
MT-ND4 MT-CYB 0.9990000000000001
MT-ND4 MT-ATP6 0.9990000000000001
MT-CO2 MT-CYB 0.9990000000000001
MT-CO3 MT-ATP6 0.9990000000000001
COX4I1 COX5B 0.9990000000000001
MT-CO1 CYCS 0.9990000000000001
MT-CO3 MT-ND4 0.998
MT-CO2 MT-ATP6 0.998
COX4I1 CYCS 0.998
MT-CYB CYCS 0.998
MT-ND4 MT-CO2 0.997
MT-CO2 CYCS 0.997
MT-CO3 COX5A 0.997
MT-ND4 MT-CO1 0.997
MT-ND1 MT-CO1 0.997
COX5A CYCS 0.997
MT-ATP6 MT-CO1 0.996
MT-CO3 MT-ND1 0.996
MT-CO1 COX5A 0.996
MT-CO2 MT-ND1 0.9940000000000001
MT-CO1 COX5B 0.9940000000000001
MT-CO3 CYCS 0.993
MT-CO3 COX5B 0.992
COX4I1 MT-CO1 0.992
COX4I1 MT-CO3 0.9890000000000001
MT-CYB COX5B 0.9490000000000001
COX4I1 MT-CYB 0.946
MT-CYB COX5A 0.929
MT-ATP6 CYCS 0.836
MT-ND4 COX5A 0.777
MT-ND1 CYCS 0.762
MT-ND1 COX5A 0.7559999999999999
MT-ND4 CYCS 0.679
COX4I1 MT-ND4 0.527
COX4I1 MT-ATP6 0.511
COX4I1 MT-ND1 0.505
MT-ATP6 COX5A 0.467
MT-ND1 COX5B 0.408
Gene Ontology Semantic Similarity
Download Tab separated file
# 4706 (NDUFAB1) 4712 (NDUFB6) 4700 (NDUFA6) 4716 (NDUFB10) 4702 (NDUFA8) 4701 (NDUFA7) 4708 (NDUFB2) 4729 (NDUFV2) 4704 (NDUFA9) 4720 (NDUFS2) 4694 (NDUFA1) 4715 (NDUFB9) 4725 (NDUFS5) 4728 (NDUFS8) 4698 (NDUFA5) 4722 (NDUFS3) 55967 (NDUFA12) 4719 (NDUFS1) 51079 (NDUFA13) 4714 (NDUFB8) 4723 (NDUFV1) 54539 (NDUFB11) 4707 (NDUFB1) 4695 (NDUFA2) 4726 (NDUFS6) 4711 (NDUFB5) 4724 (NDUFS4) 4731 (NDUFV3) 4717 (NDUFC1) 4718 (NDUFC2) 4705 (NDUFA10) 374291 (NDUFS7) 4709 (NDUFB3) 4713 (NDUFB7) 51300 (TIMMDC1) 51103 (NDUFAF1) 4710 (NDUFB4)
4706 (NDUFAB1) 1.00 1.00 1.00 0.65 0.53 0.37 1.00 0.42 0.66 0.63 1.00 0.65 1.00 0.38 0.65 0.63 1.00 0.62 0.63 1.00 1.00 1.00 1.00 1.00 0.42 1.00 1.00 0.44 1.00 1.00 1.00 0.66 1.00 1.00 1.00 0.54 1.00
4712 (NDUFB6) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4700 (NDUFA6) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4716 (NDUFB10) 0.65 1.00 1.00 1.00 0.86 0.63 1.00 0.67 0.90 0.81 1.00 1.00 1.00 0.72 1.00 0.84 1.00 0.87 0.81 1.00 1.00 1.00 1.00 1.00 0.67 1.00 1.00 0.68 1.00 1.00 1.00 0.90 1.00 1.00 1.00 0.74 1.00
4702 (NDUFA8) 0.53 1.00 1.00 0.86 1.00 0.59 1.00 0.62 0.90 0.68 1.00 0.86 1.00 0.71 0.86 0.73 1.00 0.73 0.71 1.00 1.00 0.71 1.00 1.00 0.62 1.00 1.00 0.63 1.00 1.00 1.00 0.80 1.00 1.00 0.71 0.53 1.00
4701 (NDUFA7) 0.37 1.00 1.00 0.63 0.59 1.00 1.00 0.67 0.57 0.54 1.00 0.63 1.00 0.72 0.63 0.61 1.00 0.59 0.55 1.00 1.00 0.26 1.00 1.00 0.67 1.00 1.00 0.58 1.00 1.00 1.00 0.65 1.00 1.00 0.26 0.22 1.00
4708 (NDUFB2) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4729 (NDUFV2) 0.42 1.00 1.00 0.67 0.62 0.67 1.00 1.00 0.60 0.75 1.00 0.67 1.00 0.73 0.67 0.84 1.00 0.87 0.58 1.00 1.00 0.34 1.00 1.00 1.00 1.00 1.00 0.60 1.00 1.00 1.00 0.68 1.00 1.00 0.34 0.27 1.00
4704 (NDUFA9) 0.66 1.00 1.00 0.90 0.90 0.57 1.00 0.60 1.00 0.85 1.00 0.90 1.00 0.72 0.90 0.88 1.00 0.82 0.86 1.00 1.00 1.00 1.00 1.00 0.60 1.00 1.00 0.62 1.00 1.00 1.00 0.93 1.00 1.00 1.00 0.64 1.00
4720 (NDUFS2) 0.63 1.00 1.00 0.81 0.68 0.54 1.00 0.75 0.85 1.00 1.00 0.81 1.00 0.65 0.81 0.96 1.00 0.91 0.79 1.00 1.00 1.00 1.00 1.00 0.75 1.00 1.00 0.55 1.00 1.00 1.00 0.85 1.00 1.00 1.00 0.58 1.00
4694 (NDUFA1) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4715 (NDUFB9) 0.65 1.00 1.00 1.00 0.86 0.63 1.00 0.67 0.90 0.81 1.00 1.00 1.00 0.72 1.00 0.84 1.00 0.87 0.81 1.00 1.00 1.00 1.00 1.00 0.67 1.00 1.00 0.68 1.00 1.00 1.00 0.90 1.00 1.00 1.00 0.74 1.00
4725 (NDUFS5) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4728 (NDUFS8) 0.38 1.00 1.00 0.72 0.71 0.72 1.00 0.73 0.72 0.65 1.00 0.72 1.00 1.00 0.72 0.74 1.00 0.62 0.71 1.00 1.00 0.18 1.00 1.00 0.73 1.00 1.00 0.70 1.00 1.00 1.00 0.81 1.00 1.00 0.18 0.16 1.00
4698 (NDUFA5) 0.65 1.00 1.00 1.00 0.86 0.63 1.00 0.67 0.90 0.81 1.00 1.00 1.00 0.72 1.00 0.84 1.00 0.87 0.81 1.00 1.00 1.00 1.00 1.00 0.67 1.00 1.00 0.68 1.00 1.00 1.00 0.90 1.00 1.00 1.00 0.74 1.00
4722 (NDUFS3) 0.63 1.00 1.00 0.84 0.73 0.61 1.00 0.84 0.88 0.96 1.00 0.84 1.00 0.74 0.84 1.00 1.00 0.96 0.81 1.00 1.00 1.00 1.00 1.00 0.84 1.00 1.00 0.61 1.00 1.00 1.00 0.88 1.00 1.00 1.00 0.58 1.00
55967 (NDUFA12) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4719 (NDUFS1) 0.62 1.00 1.00 0.87 0.73 0.59 1.00 0.87 0.82 0.91 1.00 0.87 1.00 0.62 0.87 0.96 1.00 1.00 0.74 1.00 1.00 1.00 1.00 1.00 0.87 1.00 1.00 0.59 1.00 1.00 1.00 0.82 1.00 1.00 1.00 0.66 1.00
51079 (NDUFA13) 0.63 1.00 1.00 0.81 0.71 0.55 1.00 0.58 0.86 0.79 1.00 0.81 1.00 0.71 0.81 0.81 1.00 0.74 1.00 1.00 1.00 1.00 1.00 1.00 0.58 1.00 1.00 0.61 1.00 1.00 1.00 0.86 1.00 1.00 1.00 0.55 1.00
4714 (NDUFB8) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4723 (NDUFV1) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
54539 (NDUFB11) 1.00 0.13 0.13 1.00 0.71 0.26 0.13 0.34 1.00 1.00 0.13 1.00 0.13 0.18 1.00 1.00 0.13 1.00 1.00 0.13 0.13 1.00 0.13 0.13 0.34 0.13 0.13 0.37 0.13 0.13 0.13 1.00 0.13 0.13 1.00 1.00 0.13
4707 (NDUFB1) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4695 (NDUFA2) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4726 (NDUFS6) 0.42 1.00 1.00 0.67 0.62 0.67 1.00 1.00 0.60 0.75 1.00 0.67 1.00 0.73 0.67 0.84 1.00 0.87 0.58 1.00 1.00 0.34 1.00 1.00 1.00 1.00 1.00 0.60 1.00 1.00 1.00 0.68 1.00 1.00 0.34 0.27 1.00
4711 (NDUFB5) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4724 (NDUFS4) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4731 (NDUFV3) 0.44 1.00 1.00 0.68 0.63 0.58 1.00 0.60 0.62 0.55 1.00 0.68 1.00 0.70 0.68 0.61 1.00 0.59 0.61 1.00 1.00 0.37 1.00 1.00 0.60 1.00 1.00 1.00 1.00 1.00 1.00 0.69 1.00 1.00 0.37 0.29 1.00
4717 (NDUFC1) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4718 (NDUFC2) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4705 (NDUFA10) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
374291 (NDUFS7) 0.66 1.00 1.00 0.90 0.80 0.65 1.00 0.68 0.93 0.85 1.00 0.90 1.00 0.81 0.90 0.88 1.00 0.82 0.86 1.00 1.00 1.00 1.00 1.00 0.68 1.00 1.00 0.69 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.55 1.00
4709 (NDUFB3) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
4713 (NDUFB7) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
51300 (TIMMDC1) 1.00 0.13 0.13 1.00 0.71 0.26 0.13 0.34 1.00 1.00 0.13 1.00 0.13 0.18 1.00 1.00 0.13 1.00 1.00 0.13 0.13 1.00 0.13 0.13 0.34 0.13 0.13 0.37 0.13 0.13 0.13 1.00 0.13 0.13 1.00 1.00 0.13
51103 (NDUFAF1) 0.54 0.13 0.13 0.74 0.53 0.22 0.13 0.27 0.64 0.58 0.13 0.74 0.13 0.16 0.74 0.58 0.13 0.66 0.55 0.13 0.13 1.00 0.13 0.13 0.27 0.13 0.13 0.29 0.13 0.13 0.13 0.55 0.13 0.13 1.00 1.00 0.13
4710 (NDUFB4) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 0.13 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
MT-CO3 Human Blood - 3250 m 4 day upregulated –2.0502 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT036178 hsa-miR-320c Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT037543 hsa-miR-744-5p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT038405 hsa-miR-296-3p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT038946 hsa-miR-28-3p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042090 hsa-miR-484 Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042659 hsa-miR-196b-5p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044848 hsa-miR-320a Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT045024 hsa-miR-186-5p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048192 hsa-miR-196a-5p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050111 hsa-miR-26a-5p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT051535 hsa-let-7e-5p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT051745 hsa-let-7c-5p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT051976 hsa-let-7b-5p Homo sapiens MT-CO3 4514 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
4514 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
4514 GO:0008535 respiratory chain complex IV assembly GOTERM_BP_DIRECT
4514 GO:0019646 aerobic electron transport chain GOTERM_BP_DIRECT
4514 GO:0004129 creatine kinase activity GOTERM_MF_DIRECT
4514 GO:0045277 respiratory chain complex IV GOTERM_CC_DIRECT
4514 GO:0005743 mitochondrial inner membrane GOTERM_CC_DIRECT
4514 GO:0022904 respiratory electron transport chain GOTERM_BP_DIRECT
4514 GO:0006123 mitochondrial electron transport GOTERM_BP_DIRECT
4514 GO:0015002 FMN binding GOTERM_MF_DIRECT
4514 GO:0005739 mitochondrion GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
4514 hsa00190 Oxidative phosphorylation
4514 hsa01100 Metabolic pathways
4514 hsa04260 Cardiac muscle contraction
4514 hsa04932 Non-alcoholic fatty liver disease
4514 hsa05010 Alzheimer's disease
4514 hsa05012 Parkinson's disease
4514 hsa05016 Huntington's disease
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
COX3 4514 Epilepsy, Temporal Lobe C0014556 Disease or Syndrome 0.3 0.592 0.517 disease
COX3 4514 Uncinate Epilepsy C0014558 Disease or Syndrome 0.3 0.592 0.517 disease
COX3 4514 Epilepsy, Benign Psychomotor, Childhood C0393672 Disease or Syndrome 0.3 0.592 0.517 disease
COX3 4514 Epilepsy, Lateral Temporal C0393682 Disease or Syndrome 0.3 0.592 0.517 disease
COX3 4514 MELAS Syndrome C0162671 Disease or Syndrome 0.51 0.592 0.517 disease
COX3 4514 Optic Atrophy, Hereditary, Leber C0917796 Disease or Syndrome 0.71 0.592 0.517 disease
COX3 4514 Cytochrome-c Oxidase Deficiency C0268237 Congenital Abnormality; Disease or Syndrome 0.3 0.592 0.517 disease
COX3 4514 Genetic recurrent myoglobinuria C4274324 Finding 0.3 0.592 0.517 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types