K-transporting ATPase α chain 1
AltitudeomicsDB
| Protein Official symbol |
ATP4A |
| Aliases |
ATP4A |
| Chromosomal Location |
19 |
| Length |
1035 |
| Uniprot ID |
P20648 |
| EC number |
7.2.2.19 |
| Protein family Information(Pfam) |
PF00689;PF00690;PF09040; |
| PDB id |
None |
| InterPro ID |
IPR006068;IPR004014;IPR023299;IPR015127;IPR018303;IPR023298;IPR008250;IPR036412;IPR023214;IPR005775;IPR001757; |
| dbSNP |
rs2733743 |
AltitudeomicsDB
| Protein 1 |
Protein 2 |
Combine Score |
| ATP4B |
ATP4A |
0.988 |
| PPA1 |
ATP4A |
0.9640000000000001 |
| LHPP |
ATP4B |
0.9279999999999999 |
| LHPP |
ATP4A |
0.922 |
| PPA2 |
ATP4B |
0.919 |
| PPA2 |
ATP4A |
0.9159999999999999 |
| PPA1 |
ATP4B |
0.915 |
| PPA1 |
LHPP |
0.903 |
Gene Ontology Semantic Similarity
Download Tab separated file
| # |
496 (ATP4B) |
5464 (PPA1) |
64077 (LHPP) |
27068 (PPA2) |
|
496 (ATP4B)
|
1.00
|
0.25
|
0.34
|
0.25
|
|
5464 (PPA1)
|
0.25
|
1.00
|
1.00
|
1.00
|
|
64077 (LHPP)
|
0.34
|
1.00
|
1.00
|
1.00
|
|
27068 (PPA2)
|
0.25
|
1.00
|
1.00
|
1.00
|
Association with High Altitude
| Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
| ATP4A |
Rat |
Left brain cortices |
300hPa |
9144 m |
1 hour |
downregulated |
0.57±0.1 |
TMT labeled LTQ orbitrap |
Southwestern europe |
Male wistar rats |
1 |
Adult male Wistar rats weighing 350 g |
28697276 |
Association with TF
| TF |
TF Entrez |
Gene |
Gene Entrez |
Type |
PMID |
Database |
Association with miRNA
| miRTarBase ID |
miRNA |
Species (miRNA) |
Protein Official Symbol |
Human Entrez ID |
Species (Target Gene) |
Experiments |
Support Type |
References (PMID) |
| MIRT054640 |
hsa-miR-1289 |
Homo sapiens |
ATP4A |
495 |
Homo sapiens |
Luciferase reporter assay//qRT-PCR//Western blot |
Functional MTI |
24503769 |
Gene Ontology
| ID |
GO ID |
GO Term |
GO Type |
| 495 |
GO:0010248 |
establishment or maintenance of transmembrane electrochemical gradient |
GOTERM_BP_DIRECT |
| 495 |
GO:0034220 |
ion transmembrane transport |
GOTERM_BP_DIRECT |
| 495 |
GO:0000287 |
nucleotide binding |
GOTERM_MF_DIRECT |
| 495 |
GO:0005886 |
plasma membrane |
GOTERM_CC_DIRECT |
| 495 |
GO:0030007 |
cellular potassium ion homeostasis |
GOTERM_BP_DIRECT |
| 495 |
GO:0036376 |
sodium ion export from cell |
GOTERM_BP_DIRECT |
| 495 |
GO:0000166 |
microfilament motor activity |
GOTERM_MF_DIRECT |
| 495 |
GO:0005615 |
extracellular space |
GOTERM_CC_DIRECT |
| 495 |
GO:0006810 |
transport |
GOTERM_BP_DIRECT |
| 495 |
GO:0005887 |
integral component of plasma membrane |
GOTERM_CC_DIRECT |
| 495 |
GO:0005391 |
glucose transmembrane transporter activity |
GOTERM_MF_DIRECT |
| 495 |
GO:0016021 |
integral component of membrane |
GOTERM_CC_DIRECT |
| 495 |
GO:0010107 |
potassium ion import |
GOTERM_BP_DIRECT |
| 495 |
GO:0005524 |
ATP binding |
GOTERM_MF_DIRECT |
| 495 |
GO:0008900 |
cholate 7-alpha-dehydrogenase activity |
GOTERM_MF_DIRECT |
| 495 |
GO:0043231 |
intracellular membrane-bounded organelle |
GOTERM_CC_DIRECT |
| 495 |
GO:0006883 |
cellular sodium ion homeostasis |
GOTERM_BP_DIRECT |
| 495 |
GO:0015991 |
ATP hydrolysis coupled proton transport |
GOTERM_BP_DIRECT |
| 495 |
GO:0046872 |
metal ion binding |
GOTERM_MF_DIRECT |
Pathways
| Human Entrez ID |
KEGG ID |
KEGG Term |
| 495 |
hsa00190 |
Oxidative phosphorylation |
| 495 |
hsa04971 |
Gastric acid secretion |
| 495 |
hsa04966 |
Collecting duct acid secretion |
Association with Disease
| Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |