Ganglioside-induced differentiation-associated protein 1

AltitudeomicsDB
Protein Official symbol GDAP1
Aliases GDAP1
Chromosomal Location 8
Length 358
Uniprot ID Q8TB36
EC number None
Protein family Information(Pfam) PF13417;
PDB id None
InterPro ID IPR034336;IPR010987;IPR036282;IPR040079;IPR004045;IPR036249;
dbSNP rs1174933176 rs104894078 rs397515442 rs879254005 rs397515441 rs104894076 rs121908113 rs267606842 rs1476856429 rs28937906 rs375431837 rs1323153568 rs538389475

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PMP2 GDAP1 0.907
MFN2 GDAP1 0.85
Gene Ontology Semantic Similarity
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# 5375 (PMP2) 9927 (MFN2)
5375 (PMP2) 1.00 0.55
9927 (MFN2) 0.55 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
GDAP1 Toad Heart - 3464 m 33 day downregulated -2.022036506 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
REST 5978 GDAP1 54332 proximal_filtered 22955619 TRANSFAC
YY1 7528 GDAP1 54332 Activation 20851106 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT005747 hsa-miR-203a-3p Homo sapiens GDAP1 54332 Homo sapiens Immunofluorescence//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR Functional MTI 20827281
MIRT005751 hsa-miR-26a-5p Homo sapiens GDAP1 54332 Homo sapiens Immunofluorescence//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR//Western blot Functional MTI 20827281
MIRT005752 hsa-miR-200a-3p Homo sapiens GDAP1 54332 Homo sapiens Immunofluorescence//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR//Western blot Functional MTI 20827281
MIRT020027 hsa-miR-375 Homo sapiens GDAP1 54332 Homo sapiens Microarray Functional MTI (Weak) 20215506
MIRT030243 hsa-miR-26b-5p Homo sapiens GDAP1 54332 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT050800 hsa-miR-17-5p Homo sapiens GDAP1 54332 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
54332 GO:0031307 integral component of mitochondrial outer membrane GOTERM_CC_DIRECT
54332 GO:0005739 mitochondrion GOTERM_CC_DIRECT
54332 GO:0016020 membrane GOTERM_CC_DIRECT
54332 GO:0006749 glutathione metabolic process GOTERM_BP_DIRECT
54332 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
54332 GO:0008053 mitochondrial fusion GOTERM_BP_DIRECT
54332 GO:0032526 response to retinoic acid GOTERM_BP_DIRECT
54332 GO:0000266 mitochondrial fission GOTERM_BP_DIRECT
54332 GO:0006626 protein targeting to mitochondrion GOTERM_BP_DIRECT
54332 GO:0005634 nucleus GOTERM_CC_DIRECT
54332 GO:0004364 glutathione transferase activity GOTERM_MF_DIRECT
54332 GO:0005737 cytoplasm GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
GDAP1 54332 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2K C1842983 Disease or Syndrome 0.91 0.645 0.31 disease
GDAP1 54332 Charcot-Marie-Tooth Disease, Recessive Intermediate A C1842197 Disease or Syndrome 0.7 0.645 0.31 disease
GDAP1 54332 CHARCOT-MARIE-TOOTH DISEASE, TYPE 4A (disorder) C1859198 Disease or Syndrome 0.78 0.645 0.31 disease
GDAP1 54332 Charcot-Marie-Tooth disease, Type 4A, axonal form C1843183 Disease or Syndrome 0.6 0.645 0.31 disease
GDAP1 54332 Arthrogryposis C0003886 Disease or Syndrome 0.3 0.645 0.31 disease
GDAP1 54332 Mitochondrial Diseases C0751651 Disease or Syndrome 0.31 0.645 0.31 group
GDAP1 54332 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.645 0.31 group
GDAP1 54332 Charcot-Marie-Tooth Disease C0007959 Disease or Syndrome 0.7 0.645 0.31 disease
GDAP1 54332 Charcot-Marie-Tooth disease, Type 2H C1843173 Disease or Syndrome 0.3 0.645 0.31 disease
GDAP1 54332 Charcot-Marie-Tooth Disease, Autosomal Dominant, Type 2k C1842984 Disease or Syndrome 0.7 0.645 0.31 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types