Cytochrome P450 26B1

AltitudeomicsDB
Protein Official symbol CYP26B1
Aliases CYP26B1 CYP26A2 P450RAI2
Chromosomal Location  2
Length 512
Uniprot ID Q9NR63
EC number 1.14.13.-
Protein family Information(Pfam) PF00067;
PDB id None
InterPro ID IPR001128;IPR017972;IPR002403;IPR036396;
dbSNP rs281875232 rs142999899 rs765423228 rs76025186 rs143738797 rs2241057 rs281875231 rs2286965 rs7568553 rs61751056 rs148075682

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ALDH1A2 CYP26B1 0.977
ALDH1A1 CYP26B1 0.957
CYP3A7 CYP3A4 0.957
CRABP1 CYP26B1 0.956
AOX1 CYP2A6 0.954
CYP1A2 CYP3A4 0.952
AOX1 CYP2B6 0.95
CYP1A1 CYP3A4 0.95
CYP3A4 CYP2A6 0.949
AOX1 CYP3A4 0.948
CYP3A4 CYP2B6 0.948
CYP1A1 CYP3A5 0.946
CYP3A7 CYP1A1 0.945
CYP1A2 CYP3A5 0.945
CYP2B6 CYP3A5 0.944
CYP4A11 CYP2A6 0.944
CYP2B6 CYP4A11 0.943
CYP2A6 CYP3A5 0.942
CYP1A1 CYP4A11 0.942
CYP3A7 CYP2A6 0.941
CYP3A7 CYP2B6 0.94
CYP3A7 CYP1A2 0.939
CYP1A2 CYP4A11 0.939
CYP3A4 CYP4A11 0.939
CYP4A11 CYP3A5 0.933
CYP3A7 CYP4A11 0.933
CYP1A2 CYP2A6 0.932
CYP1A2 CYP2B6 0.93
CYP2S1 CYP26B1 0.93
CYP1A1 ALDH1A1 0.929
CYP1A1 CYP26B1 0.929
CYP3A4 CYP2S1 0.929
CYP2B6 CYP26B1 0.929
AOX1 CYP1A2 0.929
CYP1A1 CYP2B6 0.928
CYP2B6 ALDH1A2 0.928
CYP2B6 ALDH1A1 0.928
CYP3A4 ALDH1A1 0.926
CYP2S1 CYP3A5 0.925
CYP3A4 CYP26B1 0.925
CYP4A11 CYP26B1 0.925
CYP4A11 CYP2S1 0.924
CYP1A1 CYP2A6 0.924
CYP2A6 CYP26B1 0.922
CYP3A7 CYP26B1 0.922
CYP3A7 CYP2S1 0.922
CYP1A2 CYP26B1 0.921
CYP1A1 AOX1 0.921
ALDH1A1 CYP3A5 0.921
CYP3A5 CYP26B1 0.92
CYP1A1 CYP2S1 0.92
CYP1A2 CYP2S1 0.919
CYP2A6 ALDH1A1 0.916
CYP3A4 CYP3A5 0.916
CYP1A2 ALDH1A1 0.916
CYP3A7 ALDH1A2 0.913
CYP2S1 ALDH1A2 0.912
AOX1 CYP3A5 0.912
CYP2B6 CYP2A6 0.911
CYP3A7 ALDH1A1 0.909
CYP1A1 ALDH1A2 0.909
AOX1 CYP26B1 0.908
CYP3A4 ALDH1A2 0.908
AOX1 CYP4A11 0.907
CYP3A7 AOX1 0.906
AOX1 CYP2S1 0.906
ALDH1A2 CYP3A5 0.905
NANOS2 CYP26B1 0.905
CYP2A6 ALDH1A2 0.905
CYP2S1 ALDH1A1 0.904
CYP3A7 CYP3A5 0.903
CYP4A11 ALDH1A1 0.903
CYP4A11 ALDH1A2 0.903
CYP1A2 ALDH1A2 0.902
Gene Ontology Semantic Similarity
Download Tab separated file
# 8854 (ALDH1A2) 216 (ALDH1A1) 1551 (CYP3A7) 1381 (CRABP1) 316 (AOX1) 1544 (CYP1A2) 1543 (CYP1A1) 1576 (CYP3A4) 1555 (CYP2B6) 1579 (CYP4A11) 1548 (CYP2A6) 29785 (CYP2S1) 1577 (CYP3A5) 339345 (NANOS2)
8854 (ALDH1A2) 1.00 0.66 0.37 0.37 0.32 0.40 0.43 0.40 0.38 0.37 0.33 0.34 0.44 0.31
216 (ALDH1A1) 0.66 1.00 0.34 0.25 0.42 0.41 0.40 0.43 0.38 0.32 0.35 0.35 0.39 0.35
1551 (CYP3A7) 0.37 0.34 1.00 0.33 0.37 0.59 0.89 0.79 0.68 0.63 0.63 0.66 0.96 0.59
1381 (CRABP1) 0.37 0.25 0.33 1.00 0.42 0.37 0.46 0.35 0.24 0.17 0.37 0.43 0.34 1.00
316 (AOX1) 0.32 0.42 0.37 0.42 1.00 0.48 0.48 0.51 0.38 0.26 0.43 0.47 0.41 0.82
1544 (CYP1A2) 0.40 0.41 0.59 0.37 0.48 1.00 0.68 0.72 0.76 0.59 0.78 0.76 0.63 0.82
1543 (CYP1A1) 0.43 0.40 0.89 0.46 0.48 0.68 1.00 0.85 0.62 0.59 0.63 0.67 0.94 1.00
1576 (CYP3A4) 0.40 0.43 0.79 0.35 0.51 0.72 0.85 1.00 0.62 0.55 0.65 0.63 0.81 0.82
1555 (CYP2B6) 0.38 0.38 0.68 0.24 0.38 0.76 0.62 0.62 1.00 0.79 0.90 0.91 0.65 0.37
1579 (CYP4A11) 0.37 0.32 0.63 0.17 0.26 0.59 0.59 0.55 0.79 1.00 0.68 0.69 0.63 0.21
1548 (CYP2A6) 0.33 0.35 0.63 0.37 0.43 0.78 0.63 0.65 0.90 0.68 1.00 0.93 0.59 0.82
29785 (CYP2S1) 0.34 0.35 0.66 0.43 0.47 0.76 0.67 0.63 0.91 0.69 0.93 1.00 0.61 1.00
1577 (CYP3A5) 0.44 0.39 0.96 0.34 0.41 0.63 0.94 0.81 0.65 0.63 0.59 0.61 1.00 0.59
339345 (NANOS2) 0.31 0.35 0.59 1.00 0.82 0.82 1.00 0.82 0.37 0.21 0.82 1.00 0.59 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CYP26B1 Toad Brain - 3464 m 33 day upregulated 2.250185492 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
CYP26B1 Toad Heart - 3464 m 33 day upregulated 3.446391022 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT027171 hsa-miR-103a-3p Homo sapiens CYP26B1 56603 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT031931 hsa-miR-16-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT031931 hsa-miR-16-5p Homo sapiens CYP26B1 56603 Homo sapiens Sequencing//PAR-CLIP Functional MTI (Weak) 20371350
MIRT558511 hsa-miR-15a-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558495 hsa-miR-3912-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558496 hsa-miR-3671 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558501 hsa-miR-5697 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558503 hsa-miR-4703-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558494 hsa-miR-607 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558497 hsa-miR-4524b-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558498 hsa-miR-4524a-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558507 hsa-miR-424-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558508 hsa-miR-195-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558505 hsa-miR-562 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558512 hsa-miR-497-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558500 hsa-miR-6826-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558506 hsa-miR-503-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558507 hsa-miR-424-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558512 hsa-miR-497-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558496 hsa-miR-3671 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558510 hsa-miR-15b-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558502 hsa-miR-646 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558504 hsa-miR-3942-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558508 hsa-miR-195-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558510 hsa-miR-15b-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558501 hsa-miR-5697 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558505 hsa-miR-562 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558494 hsa-miR-607 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558497 hsa-miR-4524b-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558504 hsa-miR-3942-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558509 hsa-miR-6838-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558502 hsa-miR-646 Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558503 hsa-miR-4703-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558498 hsa-miR-4524a-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558499 hsa-miR-589-3p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558500 hsa-miR-6826-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558506 hsa-miR-503-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT558509 hsa-miR-6838-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
MIRT558511 hsa-miR-15a-5p Homo sapiens CYP26B1 56603 Homo sapiens PAR-CLIP Functional MTI (Weak) 20371350
Gene Ontology
ID GO ID GO Term GO Type
56603 GO:0016709 oxidoreductase activity GOTERM_MF_DIRECT
56603 GO:0009954 proximal/distal pattern formation GOTERM_BP_DIRECT
56603 GO:0005506 iron ion binding GOTERM_MF_DIRECT
56603 GO:0001768 establishment of T cell polarity GOTERM_BP_DIRECT
56603 GO:0006766 vitamin metabolic process GOTERM_BP_DIRECT
56603 GO:0006954 inflammatory response GOTERM_BP_DIRECT
56603 GO:0001972 fibronectin binding GOTERM_MF_DIRECT
56603 GO:0031090 organelle membrane GOTERM_CC_DIRECT
56603 GO:0045580 regulation of T cell differentiation GOTERM_BP_DIRECT
56603 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
56603 GO:0061436 establishment of skin barrier GOTERM_BP_DIRECT
56603 GO:0070268 cornification GOTERM_BP_DIRECT
56603 GO:0007283 spermatogenesis GOTERM_BP_DIRECT
56603 GO:0004497 malate synthase activity GOTERM_MF_DIRECT
56603 GO:0005789 endoplasmic reticulum membrane GOTERM_CC_DIRECT
56603 GO:0006805 xenobiotic metabolic process GOTERM_BP_DIRECT
56603 GO:0010628 positive regulation of gene expression GOTERM_BP_DIRECT
56603 GO:0030326 embryonic limb morphogenesis GOTERM_BP_DIRECT
56603 GO:0034653 retinoic acid catabolic process GOTERM_BP_DIRECT
56603 GO:0005737 cytoplasm GOTERM_CC_DIRECT
56603 GO:0048387 negative regulation of retinoic acid receptor signaling pathway GOTERM_BP_DIRECT
56603 GO:0060349 bone morphogenesis GOTERM_BP_DIRECT
56603 GO:0008401 arachidonic acid epoxygenase activity GOTERM_MF_DIRECT
56603 GO:0016705 oxidoreductase activity GOTERM_MF_DIRECT
56603 GO:0001709 cell fate determination GOTERM_BP_DIRECT
56603 GO:0007140 male meiosis GOTERM_BP_DIRECT
56603 GO:0048384 retinoic acid receptor signaling pathway GOTERM_BP_DIRECT
56603 GO:0071300 cellular response to retinoic acid GOTERM_BP_DIRECT
56603 GO:2001037 positive regulation of tongue muscle cell differentiation GOTERM_BP_DIRECT
56603 GO:0043587 tongue morphogenesis GOTERM_BP_DIRECT
56603 GO:0020037 heme binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
56603 hsa00830 Retinol metabolism
56603 hsa01100 Metabolic pathways
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CYP26B1 56603 Obesity C0028754 Disease or Syndrome 0.3 0.701 0.379 disease
CYP26B1 56603 Mouth Diseases C0026636 Disease or Syndrome 0.3 0.701 0.379 group
CYP26B1 56603 Squamous cell carcinoma of esophagus C0279626 Neoplastic Process 0.3 0.701 0.379 disease
CYP26B1 56603 Craniosynostosis C0010278 Disease or Syndrome 0.41 0.701 0.379 disease
CYP26B1 56603 Osteogenesis Imperfecta C0029434 Congenital Abnormality; Disease or Syndrome 0.3 0.701 0.379 disease
CYP26B1 56603 RADIOHUMERAL FUSIONS WITH OTHER SKELETAL AND CRANIOFACIAL ANOMALIES C3280729 Disease or Syndrome 0.6 0.701 0.379 disease
CYP26B1 56603 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.11 0.701 0.379 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
CYP26B1 56603 TALAROZOLE TALAROZOLE CHEMBL459505 None