Lipid droplet-associated hydrolase

AltitudeomicsDB
Protein Official symbol C2orf43
Aliases LDAH C2orf43
Chromosomal Location 2
Length 325
Uniprot ID Q9H6V9
EC number 3.1.1.-
Protein family Information(Pfam) PF10230;
PDB id None
InterPro ID IPR029058;IPR019363;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PPP1R12B PPP1R12A 0.952
PPP1R12A PPP1R12C 0.91
PPP1R12B PPP1R12C 0.825
HS1BP3 C2orf43 0.812
EPHX1 C2orf43 0.747
PPP1R12A C2orf43 0.723
PPP1R12B C2orf43 0.723
PPP1R12C C2orf43 0.723
Gene Ontology Semantic Similarity
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# 4660 (PPP1R12B) 4659 (PPP1R12A) 64342 (HS1BP3) 2052 (EPHX1)
4660 (PPP1R12B) 1.00 0.90 1.00 0.14
4659 (PPP1R12A) 0.90 1.00 1.00 0.13
64342 (HS1BP3) 1.00 1.00 1.00 0.16
2052 (EPHX1) 0.14 0.13 0.16 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
LDAH Bird Liver - 4000 m Native downregulated -4.21 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT003883 hsa-miR-15a-5p Homo sapiens C2orf43 60526 Homo sapiens Microarray Functional MTI (Weak) 18362358
MIRT004377 hsa-miR-16-5p Homo sapiens C2orf43 60526 Homo sapiens Microarray Functional MTI (Weak) 18362358
MIRT030683 hsa-miR-21-5p Homo sapiens C2orf43 60526 Homo sapiens Microarray Functional MTI (Weak) 18591254
Gene Ontology
ID GO ID GO Term GO Type
60526 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
60526 GO:0005811 lipid particle GOTERM_CC_DIRECT
60526 GO:0019915 lipid storage GOTERM_BP_DIRECT
60526 GO:0016042 lipid catabolic process GOTERM_BP_DIRECT
60526 GO:0016298 linoleoyl-CoA desaturase activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
LDAH 60526 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.32 0.857 0.103 disease
LDAH 60526 Prostatic Neoplasms C0033578 Neoplastic Process 0.3 0.857 0.103 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types