RAS guanyl releasing protein 2
AltitudeomicsDB
| Protein Official symbol |
RASGRP2 |
| Aliases |
RASGRP2 CDC25L MCG7 |
| Chromosomal Location |
11 |
| Length |
609 |
| Uniprot ID |
Q7LDG7 |
| EC number |
None |
| Protein family Information(Pfam) |
PF00130;PF13499;PF00617;PF00618; |
| PDB id |
2MA2;6AXF; |
| InterPro ID |
IPR011992;IPR018247;IPR002048;IPR002219;IPR008937;IPR000651;IPR023578;IPR001895;IPR036964; |
| dbSNP |
rs587777529 rs767965347 rs2301562 |
AltitudeomicsDB
| Protein 1 |
Protein 2 |
Combine Score |
| NRAS |
KRAS |
0.996 |
| RAP1A |
RASGRP2 |
0.983 |
| RASGRP2 |
RAP1B |
0.972 |
| RASGRP1 |
RAP1B |
0.963 |
| RASGRP1 |
KRAS |
0.961 |
| RASGRP2 |
KRAS |
0.9590000000000001 |
| NRAS |
RASGRP1 |
0.9570000000000001 |
| RAP1A |
RASGRP1 |
0.956 |
| NRAS |
RASGRP2 |
0.9540000000000001 |
| RASGRP1 |
RRAS |
0.9520000000000001 |
| RASGRP2 |
RRAS |
0.9470000000000001 |
| ITPR3 |
ITPR1 |
0.938 |
| RASGRP1 |
ITPR1 |
0.9229999999999999 |
| ITPR3 |
RASGRP1 |
0.9209999999999999 |
| RAP1A |
NRAS |
0.9209999999999999 |
| KRAS |
RAP1B |
0.92 |
| NRAS |
RAP1B |
0.92 |
| RAP1A |
KRAS |
0.92 |
| RAP1A |
RAP1B |
0.9159999999999999 |
| RASGRP2 |
ITPR1 |
0.909 |
| ITPR3 |
RASGRP2 |
0.909 |
| RASGRP2 |
RASGRP1 |
0.9079999999999999 |
| ITPR2 |
RASGRP1 |
0.9059999999999999 |
| ITPR2 |
RASGRP2 |
0.9059999999999999 |
| ITPR2 |
ITPR1 |
0.905 |
| ITPR2 |
ITPR3 |
0.903 |
Gene Ontology Semantic Similarity
Download Tab separated file
| # |
4893 (NRAS) |
5906 (RAP1A) |
10235 (RASGRP2) |
10125 (RASGRP1) |
3710 (ITPR3) |
3845 (KRAS) |
3709 (ITPR2) |
5908 (RAP1B) |
6237 (RRAS) |
3708 (ITPR1) |
|
4893 (NRAS)
|
1.00
|
1.00
|
0.42
|
0.44
|
0.71
|
1.00
|
0.25
|
1.00
|
1.00
|
0.71
|
|
5906 (RAP1A)
|
1.00
|
1.00
|
0.50
|
0.50
|
0.43
|
0.73
|
0.27
|
0.54
|
0.59
|
0.44
|
|
10235 (RASGRP2)
|
0.42
|
0.50
|
1.00
|
0.81
|
0.46
|
0.45
|
0.42
|
0.35
|
0.38
|
0.47
|
|
10125 (RASGRP1)
|
0.44
|
0.50
|
0.81
|
1.00
|
0.52
|
0.40
|
0.38
|
0.38
|
0.38
|
0.49
|
|
3710 (ITPR3)
|
0.71
|
0.43
|
0.46
|
0.52
|
1.00
|
0.46
|
0.68
|
0.42
|
0.43
|
0.75
|
|
3845 (KRAS)
|
1.00
|
0.73
|
0.45
|
0.40
|
0.46
|
1.00
|
0.23
|
0.64
|
0.72
|
0.42
|
|
3709 (ITPR2)
|
0.25
|
0.27
|
0.42
|
0.38
|
0.68
|
0.23
|
1.00
|
0.19
|
0.20
|
0.77
|
|
5908 (RAP1B)
|
1.00
|
0.54
|
0.35
|
0.38
|
0.42
|
0.64
|
0.19
|
1.00
|
0.99
|
0.37
|
|
6237 (RRAS)
|
1.00
|
0.59
|
0.38
|
0.38
|
0.43
|
0.72
|
0.20
|
0.99
|
1.00
|
0.38
|
|
3708 (ITPR1)
|
0.71
|
0.44
|
0.47
|
0.49
|
0.75
|
0.42
|
0.77
|
0.37
|
0.38
|
1.00
|
Association with High Altitude
| Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
| RASGRP2 |
Human |
Blood |
- |
3250 m |
4 day |
upregulated |
1.6064 |
Microarray |
Himalayas |
Indians |
1 |
Sea level healthy individuals |
24465776 |
Association with TF
| TF |
TF Entrez |
Gene |
Gene Entrez |
Type |
PMID |
Database |
| ZBTB7A |
51341 |
RASGRP2 |
10235 |
proximal_filtered |
22955619 |
TRANSFAC |
Association with miRNA
| miRTarBase ID |
miRNA |
Species (miRNA) |
Protein Official Symbol |
Human Entrez ID |
Species (Target Gene) |
Experiments |
Support Type |
References (PMID) |
Gene Ontology
| ID |
GO ID |
GO Term |
GO Type |
| 10235 |
GO:0071277 |
cellular response to calcium ion |
GOTERM_BP_DIRECT |
| 10235 |
GO:0005085 |
protein kinase C binding |
GOTERM_MF_DIRECT |
| 10235 |
GO:0007265 |
Ras protein signal transduction |
GOTERM_BP_DIRECT |
| 10235 |
GO:0045202 |
synapse |
GOTERM_CC_DIRECT |
| 10235 |
GO:0030054 |
cell junction |
GOTERM_CC_DIRECT |
| 10235 |
GO:0032587 |
ruffle membrane |
GOTERM_CC_DIRECT |
| 10235 |
GO:0007165 |
signal transduction |
GOTERM_BP_DIRECT |
| 10235 |
GO:0008289 |
lipid binding |
GOTERM_MF_DIRECT |
| 10235 |
GO:0005886 |
plasma membrane |
GOTERM_CC_DIRECT |
| 10235 |
GO:0001558 |
regulation of cell growth |
GOTERM_BP_DIRECT |
| 10235 |
GO:0043547 |
positive regulation of GTPase activity |
GOTERM_BP_DIRECT |
| 10235 |
GO:0005829 |
cytosol |
GOTERM_CC_DIRECT |
| 10235 |
GO:0005509 |
calcium ion binding |
GOTERM_MF_DIRECT |
| 10235 |
GO:0019992 |
cytokine binding |
GOTERM_MF_DIRECT |
| 10235 |
GO:0005622 |
intracellular |
GOTERM_CC_DIRECT |
| 10235 |
GO:0043005 |
neuron projection |
GOTERM_CC_DIRECT |
| 10235 |
GO:0007264 |
small GTPase mediated signal transduction |
GOTERM_BP_DIRECT |
Pathways
| Human Entrez ID |
KEGG ID |
KEGG Term |
| 10235 |
hsa04014 |
Ras signaling pathway |
| 10235 |
hsa04010 |
MAPK signaling pathway |
| 10235 |
hsa04015 |
Rap1 signaling pathway |
| 10235 |
hsa04062 |
Chemokine signaling pathway |
| 10235 |
hsa04611 |
Platelet activation |
| 10235 |
hsa05200 |
Pathways in cancer |
Association with Disease
| Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
| RASGRP2 |
10235 |
BLEEDING DISORDER, PLATELET-TYPE, 18 |
C4014584 |
Disease or Syndrome |
0.7 |
0.886 |
0.034 |
disease |
Association with Drug
| Protein Official Symbol |
Human Entrez ID |
drug_claim_primary_name |
drug_name |
drug_chembl_id |
interaction_types |