Complexin-2

AltitudeomicsDB
Protein Official symbol CPLX2
Aliases CPLX2
Chromosomal Location 5
Length 134
Uniprot ID Q6PUV4
EC number None
Protein family Information(Pfam) PF05835;
PDB id None
InterPro ID IPR008849;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CPLX2 SNAP25 0.956
CPLX2 CPLX4 0.927
Gene Ontology Semantic Similarity
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# 6616 (SNAP25) 339302 (CPLX4) 10814 (CPLX2)
6616 (SNAP25) 1.00 0.84 0.83
339302 (CPLX4) 0.84 1.00 1.00
10814 (CPLX2) 0.83 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CPLX2 Rat Left brain cortices 300hPa 9144 m 1 hour upregulated 1.15±0.4 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
REST 5978 CPLX2 10814 proximal_filtered 22955619 TRANSFAC
NR3C1 2908 CPLX2 10814 proximal_filtered 22955619 TRANSFAC
TCF4 6925 CPLX2 10814 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT713796 hsa-miR-3622b-3p Homo sapiens CPLX2 10814 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT713797 hsa-miR-3622a-3p Homo sapiens CPLX2 10814 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT713798 hsa-miR-1306-5p Homo sapiens CPLX2 10814 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT713799 hsa-miR-574-3p Homo sapiens CPLX2 10814 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT713795 hsa-miR-6765-3p Homo sapiens CPLX2 10814 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
Gene Ontology
ID GO ID GO Term GO Type
10814 GO:0007399 nervous system development GOTERM_BP_DIRECT
10814 GO:0043025 neuronal cell body GOTERM_CC_DIRECT
10814 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex GOTERM_CC_DIRECT
10814 GO:0006836 neurotransmitter transport GOTERM_BP_DIRECT
10814 GO:0031915 positive regulation of synaptic plasticity GOTERM_BP_DIRECT
10814 GO:0043303 mast cell degranulation GOTERM_BP_DIRECT
10814 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex GOTERM_CC_DIRECT
10814 GO:0030154 cell differentiation GOTERM_BP_DIRECT
10814 GO:0005829 cytosol GOTERM_CC_DIRECT
10814 GO:0006904 vesicle docking involved in exocytosis GOTERM_BP_DIRECT
10814 GO:0017157 regulation of exocytosis GOTERM_BP_DIRECT
10814 GO:0048306 calcium-dependent protein binding GOTERM_MF_DIRECT
10814 GO:0042629 mast cell granule GOTERM_CC_DIRECT
10814 GO:0030425 dendrite GOTERM_CC_DIRECT
10814 GO:0043195 terminal bouton GOTERM_CC_DIRECT
10814 GO:0016079 synaptic vesicle exocytosis GOTERM_BP_DIRECT
10814 GO:0017075 Rho GTPase binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
10814 hsa04721 Synaptic vesicle cycle
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CPLX2 10814 Psychotic Disorders C0033975 Mental or Behavioral Dysfunction 0.3 0.713 0.172 group
CPLX2 10814 Schizoaffective Disorder C0036337 Mental or Behavioral Dysfunction 0.3 0.713 0.172 disease
CPLX2 10814 Depression, Bipolar C0005587 Mental or Behavioral Dysfunction 0.3 0.713 0.172 disease
CPLX2 10814 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.3 0.713 0.172 disease
CPLX2 10814 Psychosis, Brief Reactive C0033958 Mental or Behavioral Dysfunction 0.3 0.713 0.172 disease
CPLX2 10814 Manic Disorder C0024713 Mental or Behavioral Dysfunction 0.3 0.713 0.172 disease
CPLX2 10814 Manic C0338831 Mental or Behavioral Dysfunction 0.3 0.713 0.172 disease
CPLX2 10814 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.38 0.713 0.172 disease
CPLX2 10814 Schizophreniform Disorders C0036358 Mental or Behavioral Dysfunction 0.3 0.713 0.172 group
CPLX2 10814 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.31 0.713 0.172 disease
CPLX2 10814 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.31 0.713 0.172 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types