COP9 signalosome complex subunit 5

AltitudeomicsDB
Protein Official symbol COPS5
Aliases COPS5 CSN5 JAB1
Chromosomal Location  8
Length 334
Uniprot ID Q92905
EC number 3.4.-.-
Protein family Information(Pfam) PF18323;PF01398;
PDB id 4D10;4D18;4F7O;4WSN;5JOG;5JOH;5M5Q;6R6H;6R7F;6R7H;6R7I;
InterPro ID IPR037740;IPR040961;IPR000555;IPR037518;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
COPS5 COPS4 0.996
COPS5 COPS6 0.995
GPS1 COPS2 0.994
COPS6 COPS4 0.994
COPS8 COPS4 0.994
COPS8 COPS6 0.993
CUL1 NEDD8 0.993
GPS1 COPS3 0.993
COPS2 COPS3 0.992
COPS5 COPS8 0.991
COPS5 COPS2 0.991
JUN COPS5 0.99
COPS5 NEDD8 0.99
COPS7A COPS4 0.99
COPS7A COPS6 0.99
COPS3 COPS4 0.989
GPS1 COPS5 0.989
COPS7A COPS8 0.988
COPS5 COPS3 0.988
COPS5 CUL1 0.987
COPS2 COPS4 0.987
COPS4 NEDD8 0.984
COPS7A COPS5 0.984
COPS7A GPS1 0.984
GPS1 COPS4 0.983
COPS8 COPS2 0.983
GPS1 COPS6 0.983
COPS7A COPS3 0.982
COPS6 NEDD8 0.982
COPS6 COPS2 0.981
CUL1 COPS4 0.979
GPS1 COPS8 0.978
CUL1 COPS6 0.976
COPS6 COPS3 0.975
COPS8 COPS3 0.971
COPS8 NEDD8 0.97
COPS7A COPS2 0.97
COPS8 CUL1 0.959
COPS2 NEDD8 0.959
COPS7A NEDD8 0.958
CUL1 COPS2 0.957
GPS1 NEDD8 0.953
COPS7A CUL1 0.953
CUL1 COPS3 0.943
GPS1 CUL1 0.936
COPS3 NEDD8 0.923
JUN CUL1 0.454
Gene Ontology Semantic Similarity
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# 10987 (COPS5) 2873 (GPS1) 10980 (COPS6) 10920 (COPS8) 8454 (CUL1) 9318 (COPS2) 3725 (JUN) 50813 (COPS7A) 8533 (COPS3) 51138 (COPS4)
10987 (COPS5) 1.00 0.38 1.00 1.00 0.41 0.51 0.52 1.00 1.00 0.71
2873 (GPS1) 0.38 1.00 1.00 1.00 0.51 0.58 0.48 1.00 1.00 0.57
10980 (COPS6) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
10920 (COPS8) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
8454 (CUL1) 0.41 0.51 1.00 1.00 1.00 0.52 0.47 1.00 1.00 0.52
9318 (COPS2) 0.51 0.58 1.00 1.00 0.52 1.00 0.49 1.00 1.00 0.58
3725 (JUN) 0.52 0.48 1.00 1.00 0.47 0.49 1.00 1.00 1.00 0.44
50813 (COPS7A) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
8533 (COPS3) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
51138 (COPS4) 0.71 0.57 1.00 1.00 0.52 0.58 0.44 1.00 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
COPS5 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 13.3 RT-qPCR Western US C57BL/6 mice 1.4 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
COPS5 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 24.5 RT-qPCR Western US C57BL/6 mice 1.4 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
COPS5 10987 CDKN1B 1027 Repression 11430829 TRUSST
COPS5 10987 VEGFA 7422 Activation 22824755 TRUSST
STAT3 6774 COPS5 10987 Repression 17533737 TRUSST
GATA1 2623 COPS5 10987 Activation 11960372 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT031695 hsa-miR-16-5p Homo sapiens COPS5 10987 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT047407 hsa-miR-10b-5p Homo sapiens COPS5 10987 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT731966 hsa-miR-24-3p Homo sapiens COPS5 10987 Homo sapiens Luciferase reporter assay Functional MTI 27157611
Gene Ontology
ID GO ID GO Term GO Type
10987 GO:0006412 translation GOTERM_BP_DIRECT
10987 GO:0010388 cullin deneddylation GOTERM_BP_DIRECT
10987 GO:0003743 structural constituent of ribosome GOTERM_MF_DIRECT
10987 GO:0005515 protein binding GOTERM_MF_DIRECT
10987 GO:0000338 protein deneddylation GOTERM_BP_DIRECT
10987 GO:0048471 perinuclear region of cytoplasm GOTERM_CC_DIRECT
10987 GO:0006283 transcription-coupled nucleotide-excision repair GOTERM_BP_DIRECT
10987 GO:0046328 regulation of JNK cascade GOTERM_BP_DIRECT
10987 GO:0000715 nucleotide-excision repair GOTERM_BP_DIRECT
10987 GO:0005737 cytoplasm GOTERM_CC_DIRECT
10987 GO:0004843 ubiquitin-protein transferase activity GOTERM_MF_DIRECT
10987 GO:0008180 COP9 signalosome GOTERM_CC_DIRECT
10987 GO:0046872 metal ion binding GOTERM_MF_DIRECT
10987 GO:0051726 regulation of cell cycle GOTERM_BP_DIRECT
10987 GO:0005634 nucleus GOTERM_CC_DIRECT
10987 GO:0005852 eukaryotic translation initiation factor 3 complex GOTERM_CC_DIRECT
10987 GO:0008021 synaptic vesicle GOTERM_CC_DIRECT
10987 GO:0006366 transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
10987 GO:0006413 translational initiation GOTERM_BP_DIRECT
10987 GO:1903894 regulation of IRE1-mediated unfolded protein response GOTERM_BP_DIRECT
10987 GO:0008237 serine-type peptidase activity GOTERM_MF_DIRECT
10987 GO:0016579 protein deubiquitination GOTERM_BP_DIRECT
10987 GO:0003713 transcription cofactor activity GOTERM_MF_DIRECT
10987 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
10987 GO:0030054 cell junction GOTERM_CC_DIRECT
10987 GO:1990182 exosomal secretion GOTERM_BP_DIRECT
10987 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
COPS5 10987 Mycoplasma-Induced Stevens-Johnson Syndrome C3658301 Disease or Syndrome 0.3 0.624 0.552 disease
COPS5 10987 Stevens-Johnson Syndrome C0038325 Disease or Syndrome 0.3 0.624 0.552 disease
COPS5 10987 Toxic Epidermal Necrolysis C0014518 Disease or Syndrome 0.3 0.624 0.552 disease
COPS5 10987 Drug-Induced Stevens Johnson Syndrome C1274933 Disease or Syndrome 0.3 0.624 0.552 disease
COPS5 10987 Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum C3658302 Disease or Syndrome 0.3 0.624 0.552 disease
COPS5 10987 Liver carcinoma C2239176 Neoplastic Process 0.4 0.624 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types