Iron-sulfur cluster assembly 2 homolog, mitochondrial

AltitudeomicsDB
Protein Official symbol ISCA2
Aliases ISCA2 HBLD1
Chromosomal Location 14
Length 154
Uniprot ID Q86U28
EC number None
Protein family Information(Pfam) PF01521;
PDB id None
InterPro ID IPR000361;IPR016092;IPR017870;IPR035903;
dbSNP rs730882246

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ISCU HSCB 0.993
ISCA2 GLRX5 0.991
ISCA1 GLRX5 0.991
ISCA2 HSCB 0.99
ISCA1 HSCB 0.988
GLRX5 HSCB 0.986
NFU1 IBA57 0.962
NFU1 ISCA1 0.953
NFU1 ISCU 0.949
ISCA2 IBA57 0.947
ISCA2 ISCA1 0.942
ISCA2 NFU1 0.94
ISCA1 IBA57 0.937
ISCA1 ISCU 0.926
ISCA2 ISCU 0.925
ISCA2 LIAS 0.908
Gene Ontology Semantic Similarity
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# 23479 (ISCU) 122961 (ISCA2) 81689 (ISCA1) 51218 (GLRX5) 27247 (NFU1) 150274 (HSCB) 200205 (IBA57)
23479 (ISCU) 1.00 0.89 1.00 0.51 0.85 0.60 0.37
122961 (ISCA2) 0.89 1.00 1.00 0.55 0.96 0.66 0.37
81689 (ISCA1) 1.00 1.00 1.00 0.41 0.70 0.41 0.25
51218 (GLRX5) 0.51 0.55 0.41 1.00 0.57 0.73 0.37
27247 (NFU1) 0.85 0.96 0.70 0.57 1.00 0.69 0.37
150274 (HSCB) 0.60 0.66 0.41 0.73 0.69 1.00 0.37
200205 (IBA57) 0.37 0.37 0.25 0.37 0.37 0.37 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ISCA2 Bird Cardiac muscle - 4000 m Native downregulated -3.94 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
ISCA2 Bird Flight muscle - 4000 m Native downregulated -3.55 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
ISCA2 Bird Lungs - 4000 m Native downregulated -5.29 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
ISCA2 Bird Kidney - 4000 m Native downregulated -5.12 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
ISCA2 Bird Liver - 4000 m Native downregulated -3.02 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT522935 hsa-miR-1271-3p Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT522938 hsa-miR-214-5p Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT522936 hsa-miR-3622b-5p Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT522932 hsa-miR-6514-3p Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT522933 hsa-miR-550a-5p Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT522931 hsa-miR-2054 Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT522940 hsa-miR-4645-5p Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT522939 hsa-miR-4673 Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT522937 hsa-miR-6811-3p Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT522934 hsa-miR-550a-3-5p Homo sapiens ISCA2 122961 Homo sapiens PAR-CLIP Functional MTI (Weak) 23446348
MIRT669827 hsa-miR-3672 Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669836 hsa-miR-5007-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669835 hsa-miR-500b-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669830 hsa-miR-4524a-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669832 hsa-miR-4769-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669824 hsa-miR-8055 Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669826 hsa-miR-6864-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669825 hsa-miR-4715-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669828 hsa-miR-4727-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669831 hsa-miR-6817-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669837 hsa-miR-4797-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669829 hsa-miR-6794-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669833 hsa-miR-1304-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT669834 hsa-miR-4639-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT672733 hsa-miR-129-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT687839 hsa-miR-769-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687854 hsa-miR-186-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687855 hsa-miR-520h Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687861 hsa-miR-520b Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687865 hsa-miR-302e Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687869 hsa-miR-302a-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687859 hsa-miR-520d-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687866 hsa-miR-302d-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687873 hsa-miR-20b-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687876 hsa-miR-106b-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687864 hsa-miR-372-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687842 hsa-miR-513a-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687844 hsa-miR-4713-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687857 hsa-miR-512-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687868 hsa-miR-302b-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687871 hsa-miR-526b-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687848 hsa-miR-5589-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687843 hsa-miR-638 Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687875 hsa-miR-17-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687841 hsa-miR-6878-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687845 hsa-miR-6744-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687851 hsa-miR-6506-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687872 hsa-miR-519d-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687867 hsa-miR-302c-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687877 hsa-miR-106a-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687849 hsa-miR-4731-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687846 hsa-miR-4757-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687870 hsa-miR-93-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687840 hsa-miR-450b-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687850 hsa-miR-6778-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687852 hsa-miR-619-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687860 hsa-miR-520c-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687862 hsa-miR-520a-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687863 hsa-miR-373-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687847 hsa-miR-1251-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687856 hsa-miR-520g-3p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687858 hsa-miR-520e Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687874 hsa-miR-20a-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT687853 hsa-miR-150-5p Homo sapiens ISCA2 122961 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
Gene Ontology
ID GO ID GO Term GO Type
122961 GO:0005506 iron ion binding GOTERM_MF_DIRECT
122961 GO:0005198 structural molecule activity GOTERM_MF_DIRECT
122961 GO:0051537 iron-sulfur cluster binding GOTERM_MF_DIRECT
122961 GO:0016226 iron-sulfur cluster assembly GOTERM_BP_DIRECT
122961 GO:0005759 mitochondrial matrix GOTERM_CC_DIRECT
122961 GO:0097428 protein maturation by iron-sulfur cluster transfer GOTERM_BP_DIRECT
122961 GO:0051604 protein maturation GOTERM_BP_DIRECT
122961 GO:0008198 phosphatidate phosphatase activity GOTERM_MF_DIRECT
122961 GO:0005515 protein binding GOTERM_MF_DIRECT
122961 GO:0005739 mitochondrion GOTERM_CC_DIRECT
122961 GO:0006790 sulfur compound metabolic process GOTERM_BP_DIRECT
122961 GO:0051539 4 iron GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ISCA2 122961 Multiple Mitochondrial Dysfunctions Syndrome C3502075 Disease or Syndrome 0.4 0.834 0.172 disease
ISCA2 122961 Leukodystrophy C0023520 Disease or Syndrome 0.4 0.834 0.172 disease
ISCA2 122961 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.3 0.834 0.172 group
ISCA2 122961 Mitochondrial Diseases C0751651 Disease or Syndrome 0.31 0.834 0.172 group
ISCA2 122961 MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 4 C4225348 Disease or Syndrome 0.6 0.834 0.172 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types