Corticotropin-releasing factor-binding protein

AltitudeomicsDB
Protein Official symbol CRHBP
Aliases CRHBP CRFBP
Chromosomal Location  5
Length 322
Uniprot ID P24387
EC number None
Protein family Information(Pfam) PF05428;
PDB id None
InterPro ID IPR008435;IPR035914;
dbSNP None

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CRHR1 CRH 0.997
CRH CRHBP 0.996
CRHR2 CRH 0.995
UCN CRH 0.993
CRHR1 UCN 0.991
CRHR2 UCN 0.99
UCN3 CRHR2 0.935
CRHR1 CRHR2 0.906
CRHR2 CRHBP 0.895
CRHR1 CRHBP 0.855
CRHR1 UCN3 0.837
UCN3 UCN 0.836
UCN3 CRH 0.834
UCN CRHBP 0.728
UCN3 CRHBP 0.702
Gene Ontology Semantic Similarity
Download Tab separated file
# 1392 (CRH) 1393 (CRHBP) 7349 (UCN) 1395 (CRHR2) 114131 (UCN3) 1394 (CRHR1)
1392 (CRH) 1.00 0.69 0.96 0.60 0.69 0.57
1393 (CRHBP) 0.69 1.00 0.67 0.69 0.48 0.74
7349 (UCN) 0.96 0.67 1.00 0.55 0.61 0.53
1395 (CRHR2) 0.60 0.69 0.55 1.00 0.38 0.99
114131 (UCN3) 0.69 0.48 0.61 0.38 1.00 0.36
1394 (CRHR1) 0.57 0.74 0.53 0.99 0.36 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CRHBP Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
ESR1 2099 CRHBP 1393 Unknown 11409902 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT002477 hsa-miR-16-5p Homo sapiens CRHBP 1393 Homo sapiens proteomics analysis Functional MTI (Weak) 18362358
Gene Ontology
ID GO ID GO Term GO Type
1393 GO:0042277 peptide binding GOTERM_MF_DIRECT
1393 GO:0005622 intracellular GOTERM_CC_DIRECT
1393 GO:0030141 secretory granule GOTERM_CC_DIRECT
1393 GO:0035690 cellular response to drug GOTERM_BP_DIRECT
1393 GO:0035865 cellular response to potassium ion GOTERM_BP_DIRECT
1393 GO:0042445 hormone metabolic process GOTERM_BP_DIRECT
1393 GO:0048149 behavioral response to ethanol GOTERM_BP_DIRECT
1393 GO:0005634 nucleus GOTERM_CC_DIRECT
1393 GO:0043196 varicosity GOTERM_CC_DIRECT
1393 GO:0051424 NAD binding GOTERM_MF_DIRECT
1393 GO:0005615 extracellular space GOTERM_CC_DIRECT
1393 GO:0005767 secondary lysosome GOTERM_CC_DIRECT
1393 GO:0033554 cellular response to stress GOTERM_BP_DIRECT
1393 GO:1900011 negative regulation of corticotropin-releasing hormone receptor activity GOTERM_BP_DIRECT
1393 GO:0005874 microtubule GOTERM_CC_DIRECT
1393 GO:0031045 dense core granule GOTERM_CC_DIRECT
1393 GO:0007611 learning or memory GOTERM_BP_DIRECT
1393 GO:0071356 cellular response to tumor necrosis factor GOTERM_BP_DIRECT
1393 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity GOTERM_BP_DIRECT
1393 GO:0043204 perikaryon GOTERM_CC_DIRECT
1393 GO:0043679 axon terminus GOTERM_CC_DIRECT
1393 GO:0005771 multivesicular body GOTERM_CC_DIRECT
1393 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
1393 GO:0001963 synaptic transmission GOTERM_BP_DIRECT
1393 GO:0045055 regulated exocytosis GOTERM_BP_DIRECT
1393 GO:0071314 cellular response to cocaine GOTERM_BP_DIRECT
1393 GO:0030425 dendrite GOTERM_CC_DIRECT
1393 GO:0002125 maternal aggressive behavior GOTERM_BP_DIRECT
1393 GO:0007565 female pregnancy GOTERM_BP_DIRECT
1393 GO:0071320 cellular response to cAMP GOTERM_BP_DIRECT
1393 GO:0005794 Golgi apparatus GOTERM_CC_DIRECT
1393 GO:0007165 signal transduction GOTERM_BP_DIRECT
1393 GO:0051460 negative regulation of corticotropin secretion GOTERM_BP_DIRECT
1393 GO:0071277 cellular response to calcium ion GOTERM_BP_DIRECT
1393 GO:0071392 cellular response to estradiol stimulus GOTERM_BP_DIRECT
1393 GO:0006954 inflammatory response GOTERM_BP_DIRECT
1393 GO:0009755 hormone-mediated signaling pathway GOTERM_BP_DIRECT
1393 GO:0071391 cellular response to estrogen stimulus GOTERM_BP_DIRECT
1393 GO:0097211 cellular response to gonadotropin-releasing hormone GOTERM_BP_DIRECT
1393 GO:0005515 protein binding GOTERM_MF_DIRECT
1393 GO:0051459 regulation of corticotropin secretion GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CRHBP 1393 Cocaine Abuse C0009171 Mental or Behavioral Dysfunction 0.3 0.701 0.345 disease
CRHBP 1393 Cocaine-Related Disorders C0236736 Mental or Behavioral Dysfunction 0.3 0.701 0.345 group
CRHBP 1393 Cocaine Dependence C0600427 Mental or Behavioral Dysfunction 0.3 0.701 0.345 disease
CRHBP 1393 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.01 0.701 0.345 disease
CRHBP 1393 Alcoholic Intoxication, Chronic C0001973 Mental or Behavioral Dysfunction 0.32 0.701 0.345 disease
CRHBP 1393 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.52 0.701 0.345 disease
CRHBP 1393 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.32 0.701 0.345 disease
CRHBP 1393 Unipolar Depression C0041696 Mental or Behavioral Dysfunction 0.31 0.701 0.345 disease
CRHBP 1393 Major Depressive Disorder C1269683 Mental or Behavioral Dysfunction 0.32 0.701 0.345 disease
CRHBP 1393 Mood Disorders C0525045 Mental or Behavioral Dysfunction 0.32 0.701 0.345 group
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types