Cystatin S

AltitudeomicsDB
Protein Official symbol CST1
Aliases CST1
Chromosomal Location 20
Length 141
Uniprot ID P01037
EC number None
Protein family Information(Pfam) PF00031;
PDB id None
InterPro ID IPR000010;IPR018073;
dbSNP rs6076122 rs2070856 rs3188319 rs3188320 rs3188322

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CST1 CST4 0.883
CPPED1 CST1 0.879
CTSL CST1 0.79
CTSL CST4 0.7759999999999999
CPPED1 CST4 0.7559999999999999
Gene Ontology Semantic Similarity
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# 1469 (CST1) 1514 (CTSL) 1472 (CST4)
1469 (CST1) 1.00 1.00 0.12
1514 (CTSL) 1.00 1.00 0.12
1472 (CST4) 0.12 0.12 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CST1 Human Saliva - 4175 m 7 day downregulated 6.75 2-DE Himalayas Indians 3.29 Individuals residing at sea level 30219637
CST1 Human Saliva - 4175 m 7 day upregulated 1.38 2-DE Himalayas Indians 0.6 Individuals residing at sea level 30219637
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT018277 hsa-miR-335-5p Homo sapiens CST1 1469 Homo sapiens Microarray Functional MTI (Weak) 18185580
Gene Ontology
ID GO ID GO Term GO Type
1469 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GOTERM_BP_DIRECT
1469 GO:2000117 negative regulation of cysteine-type endopeptidase activity GOTERM_BP_DIRECT
1469 GO:0002020 protease binding GOTERM_MF_DIRECT
1469 GO:0005615 extracellular space GOTERM_CC_DIRECT
1469 GO:0004869 serine-type endopeptidase inhibitor activity GOTERM_MF_DIRECT
1469 GO:0005515 protein binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
1469 hsa04970 Salivary secretion
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CST1 1469 Hay fever C0018621 Disease or Syndrome 0.31 0.707 0.345 disease
CST1 1469 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.707 0.345 disease
CST1 1469 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.32 0.707 0.345 disease
CST1 1469 Stomach Neoplasms C0038356 Neoplastic Process 0.3 0.707 0.345 group
CST1 1469 Prostatic Neoplasms C0033578 Neoplastic Process 0.3 0.707 0.345 group
CST1 1469 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.3 0.707 0.345 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types