Aspartate--tRNA ligase, cytoplasmic

AltitudeomicsDB
Protein Official symbol DARS
Aliases DARS1 DARS PIG40
Chromosomal Location :2
Length 501
Uniprot ID P14868
EC number 6.1.1.12
Protein family Information(Pfam) PF00152;PF01336;
PDB id 4J15;5Y6L;6IY6;
InterPro ID IPR004364;IPR006195;IPR004523;IPR002312;IPR012340;IPR004365;
dbSNP rs886037635 rs369152939 rs370064817 rs1803165 rs587776985 rs148806569 rs587776984 rs147077598 rs147077598

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
LARS EPRS 0.999
IARS MARS 0.999
EPRS DARS 0.999
IARS EPRS 0.999
IARS QARS 0.999
KARS AIMP2 0.999
AIMP1 EPRS 0.999
LARS QARS 0.999
EPRS MARS 0.999
MARS RARS 0.999
EEF1E1 AIMP2 0.999
EPRS AIMP2 0.999
AIMP1 QARS 0.999
EEF1E1 EPRS 0.999
AIMP1 EEF1E1 0.999
AIMP1 RARS 0.999
AIMP1 AIMP2 0.999
AIMP1 MARS 0.999
EPRS RARS 0.999
QARS RARS 0.999
IARS KARS 0.999
KARS RARS 0.999
LARS IARS 0.999
QARS MARS 0.999
EPRS KARS 0.999
LARS MARS 0.999
EEF1E1 MARS 0.999
KARS QARS 0.999
IARS RARS 0.998
RARS AIMP2 0.998
LARS KARS 0.998
GARS IARS 0.998
LARS DARS 0.998
IARS DARS 0.998
AIMP1 LARS 0.998
AIMP1 KARS 0.998
MARS AIMP2 0.998
KARS MARS 0.998
EPRS QARS 0.998
YARS EPRS 0.998
LARS RARS 0.998
AIMP1 IARS 0.998
EEF1E1 RARS 0.997
GARS EPRS 0.997
QARS AIMP2 0.997
YARS QARS 0.997
QARS DARS 0.997
DARS MARS 0.997
AIMP1 DARS 0.996
DARS RARS 0.996
LARS AIMP2 0.996
IARS AIMP2 0.994
GARS AARS 0.994
DARS AIMP2 0.994
KARS DARS 0.994
EEF1E1 KARS 0.994
YARS MARS 0.993
EEF1E1 IARS 0.993
LARS EEF1E1 0.993
EEF1E1 QARS 0.993
EEF1E1 DARS 0.992
YARS AARS 0.99
IARS AARS 0.99
LARS AARS 0.989
QARS GATB 0.989
EPRS AARS 0.988
IARS YARS 0.988
LARS YARS 0.986
YARS KARS 0.985
GARS MARS 0.984
QARS AARS 0.983
MARS AARS 0.975
YARS RARS 0.975
EPRS AARS2 0.975
GARS QARS 0.974
GARS YARS 0.971
DARS AARS 0.97
KARS AARS 0.964
GARS KARS 0.961
GARS DARS 0.958
YARS DARS 0.953
LARS GARS 0.943
GARS RARS 0.936
YARS AARS2 0.927
DARS AARS2 0.924
MARS AARS2 0.911
GARS AARS2 0.905
VBP1 DARS 0.903
DARS GATB 0.903
Gene Ontology Semantic Similarity
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# 51520 (LARS) 3376 (IARS) 2058 (EPRS) 3735 (KARS) 9255 (AIMP1) 4141 (MARS) 9521 (EEF1E1) 5859 (QARS) 5917 (RARS) 2617 (GARS) 8565 (YARS) 1615 (DARS) 7411 (VBP1) 7965 (AIMP2) 16 (AARS) 5188 (GATB) 57505 (AARS2)
51520 (LARS) 1.00 0.73 0.66 0.63 0.53 0.75 1.00 0.74 0.73 0.68 0.62 0.62 0.52 1.00 0.38 0.27 0.43
3376 (IARS) 0.73 1.00 0.76 0.68 0.72 0.75 1.00 0.70 0.81 0.74 0.67 0.68 0.70 1.00 0.35 0.29 0.40
2058 (EPRS) 0.66 0.76 1.00 0.78 0.74 0.75 1.00 0.64 0.70 0.71 0.74 0.72 0.57 1.00 0.42 0.36 0.46
3735 (KARS) 0.63 0.68 0.78 1.00 0.77 0.75 1.00 0.61 0.68 0.70 0.76 0.70 0.59 1.00 0.44 0.38 0.50
9255 (AIMP1) 0.53 0.72 0.74 0.77 1.00 0.14 1.00 0.58 0.64 0.63 0.75 0.67 0.72 1.00 0.36 0.38 0.40
4141 (MARS) 0.75 0.75 0.75 0.75 0.14 1.00 0.14 0.75 0.75 0.75 0.75 0.75 0.14 0.14 0.75 0.29 0.75
9521 (EEF1E1) 1.00 1.00 1.00 1.00 1.00 0.14 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.33 0.33 0.33
5859 (QARS) 0.74 0.70 0.64 0.61 0.58 0.75 1.00 1.00 0.70 0.66 0.60 0.60 0.59 1.00 0.32 0.25 0.36
5917 (RARS) 0.73 0.81 0.70 0.68 0.64 0.75 1.00 0.70 1.00 0.74 0.67 0.68 0.70 1.00 0.35 0.29 0.40
2617 (GARS) 0.68 0.74 0.71 0.70 0.63 0.75 1.00 0.66 0.74 1.00 0.64 0.66 0.65 1.00 0.35 0.27 0.36
8565 (YARS) 0.62 0.67 0.74 0.76 0.75 0.75 1.00 0.60 0.67 0.64 1.00 0.78 0.57 1.00 0.52 0.51 0.60
1615 (DARS) 0.62 0.68 0.72 0.70 0.67 0.75 1.00 0.60 0.68 0.66 0.78 1.00 0.56 1.00 0.51 0.48 0.54
7411 (VBP1) 0.52 0.70 0.57 0.59 0.72 0.14 1.00 0.59 0.70 0.65 0.57 0.56 1.00 1.00 0.22 0.26 0.24
7965 (AIMP2) 1.00 1.00 1.00 1.00 1.00 0.14 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.33 0.33 0.33
16 (AARS) 0.38 0.35 0.42 0.44 0.36 0.75 0.33 0.32 0.35 0.35 0.52 0.51 0.22 0.33 1.00 0.36 0.83
5188 (GATB) 0.27 0.29 0.36 0.38 0.38 0.29 0.33 0.25 0.29 0.27 0.51 0.48 0.26 0.33 0.36 1.00 0.42
57505 (AARS2) 0.43 0.40 0.46 0.50 0.40 0.75 0.33 0.36 0.40 0.36 0.60 0.54 0.24 0.33 0.83 0.42 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
DARS Rat Blood - 9144 m 1 hour upregulated - 2D- gel Electrophoresis, MALDI India SD rats - Susceptible(<27min )Vs Tolerant(8 min) at 9300 m 25758574
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
POU2F2 5452 DARS 1615 distal 22955619 TRANSFAC
EP300 2033 DARS 1615 distal 22955619 TRANSFAC
IRF4 3662 DARS 1615 distal 22955619 TRANSFAC
BCLAF1 9774 DARS 1615 distal 22955619 TRANSFAC
TCF12 6938 DARS 1615 distal 22955619 TRANSFAC
CHD2 1106 DARS 1615 distal 22955619 TRANSFAC
STAT3 6774 DARS 1615 distal 22955619 TRANSFAC
EGR1 1958 DARS 1615 distal 22955619 TRANSFAC
BCL11A 53335 DARS 1615 distal 22955619 TRANSFAC
E2F6 1876 DARS 1615 distal 22955619 TRANSFAC
EBF1 1879 DARS 1615 distal 22955619 TRANSFAC
PBX3 5090 DARS 1615 distal 22955619 TRANSFAC
RXRA 6256 DARS 1615 distal 22955619 TRANSFAC
PAX5 5079 DARS 1615 distal 22955619 TRANSFAC
MEF2C 4208 DARS 1615 distal 22955619 TRANSFAC
SRF 6722 DARS 1615 distal 22955619 TRANSFAC
TBP 6908 DARS 1615 distal 22955619 TRANSFAC
NR2C2 7182 DARS 1615 distal 22955619 TRANSFAC
SMC3 9126 DARS 1615 distal 22955619 TRANSFAC
BCL3 602 DARS 1615 distal 22955619 TRANSFAC
MEF2A 4205 DARS 1615 distal 22955619 TRANSFAC
RAD21 5885 DARS 1615 distal 22955619 TRANSFAC
SPI1 6688 DARS 1615 distal 22955619 TRANSFAC
SP1 6667 DARS 1615 distal 22955619 TRANSFAC
ZEB1 6935 DARS 1615 distal 22955619 TRANSFAC
BATF 10538 DARS 1615 distal 22955619 TRANSFAC
ZNF263 10127 DARS 1615 proximal_filtered 22955619 TRANSFAC
ZBTB33 10009 DARS 1615 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT628911 hsa-miR-7977 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT628915 hsa-miR-1228-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT628917 hsa-miR-4695-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT628910 hsa-miR-651-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT628911 hsa-miR-7977 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT628914 hsa-miR-383-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT628914 hsa-miR-383-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT628916 hsa-miR-4779 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT628912 hsa-miR-4266 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT628913 hsa-miR-342-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT659186 hsa-miR-1264 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT659184 hsa-miR-5584-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT659179 hsa-miR-1305 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT659183 hsa-miR-3691-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT659185 hsa-miR-6873-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT659180 hsa-miR-607 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT659181 hsa-miR-3671 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT659182 hsa-miR-627-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673810 hsa-miR-6728-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673819 hsa-miR-4673 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673822 hsa-miR-6715b-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673827 hsa-miR-6895-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673807 hsa-miR-3122 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673811 hsa-miR-769-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673808 hsa-miR-450a-1-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673814 hsa-miR-4640-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673806 hsa-miR-3913-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673806 hsa-miR-3913-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673817 hsa-miR-4284 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673805 hsa-miR-887-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673809 hsa-miR-5089-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673820 hsa-miR-4645-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673826 hsa-miR-128-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673811 hsa-miR-769-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673812 hsa-miR-450b-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673819 hsa-miR-4673 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673820 hsa-miR-4645-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673821 hsa-miR-5693 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673828 hsa-miR-5582-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673805 hsa-miR-887-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673818 hsa-miR-4755-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673824 hsa-miR-3681-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673803 hsa-miR-1972 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673815 hsa-miR-5187-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673823 hsa-miR-4269 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673804 hsa-miR-6513-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673810 hsa-miR-6728-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673812 hsa-miR-450b-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673804 hsa-miR-6513-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673807 hsa-miR-3122 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673808 hsa-miR-450a-1-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673813 hsa-miR-4726-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673825 hsa-miR-216a-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673815 hsa-miR-5187-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT673816 hsa-miR-24-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT673809 hsa-miR-5089-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT704363 hsa-miR-4514 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT704362 hsa-miR-4692 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT783092 hsa-miR-1182 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783130 hsa-miR-1207-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783471 hsa-miR-129-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783711 hsa-miR-1304-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783962 hsa-miR-1827 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT784233 hsa-miR-215-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786657 hsa-miR-4763-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788617 hsa-miR-6765-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788894 hsa-miR-6812-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789361 hsa-miR-6893-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788647 hsa-miR-6773-3p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788866 hsa-miR-6808-5p Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789662 hsa-miR-8055 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789994 hsa-miR-940 Homo sapiens DARS 1615 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
Gene Ontology
ID GO ID GO Term GO Type
1615 GO:0004046 aldo-keto reductase GOTERM_MF_DIRECT
1615 GO:0005829 cytosol GOTERM_CC_DIRECT
1615 GO:0006422 aspartyl-tRNA aminoacylation GOTERM_BP_DIRECT
1615 GO:0016020 membrane GOTERM_CC_DIRECT
1615 GO:0005737 cytoplasm GOTERM_CC_DIRECT
1615 GO:0005515 protein binding GOTERM_MF_DIRECT
1615 GO:0006412 translation GOTERM_BP_DIRECT
1615 GO:0006418 tRNA aminoacylation for protein translation GOTERM_BP_DIRECT
1615 GO:0003676 nucleic acid binding GOTERM_MF_DIRECT
1615 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
1615 GO:0006461 protein complex assembly GOTERM_BP_DIRECT
1615 GO:0004815 triglyceride lipase activity GOTERM_MF_DIRECT
1615 GO:0044822 poly GOTERM_MF_DIRECT
1615 GO:0005524 ATP binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
1615 hsa00970 Aminoacyl-tRNA biosynthesis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
DARS 1615 HYPOMYELINATION WITH BRAINSTEM AND SPINAL CORD INVOLVEMENT AND LEG SPASTICITY C3809008 Disease or Syndrome 0.71 0.834 0.207 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types