Acyl-CoA-binding protein

AltitudeomicsDB
Protein Official symbol DBI
Aliases DBI
Chromosomal Location 2
Length 87
Uniprot ID P07108
EC number None
Protein family Information(Pfam) PF00887;
PDB id 2CB8;2FJ9;
InterPro ID IPR022408;IPR000582;IPR035984;IPR014352;
dbSNP rs8192504 rs8192506 rs8192507

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
FDXR FDX1 0.997
SCP2 FDX1 0.806
DBI SCP2 0.769
DBI FDX1 0.754
DBI FDXR 0.75
FDXR SCP2 0.743
PFDN5 DBI 0.721
DBI ACBD3 0.706
Gene Ontology Semantic Similarity
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# 2230 (FDX1) 6342 (SCP2) 2232 (FDXR) 1622 (DBI) 64746 (ACBD3) 5204 (PFDN5)
2230 (FDX1) 1.00 0.29 0.25 0.29 0.35 0.34
6342 (SCP2) 0.29 1.00 0.22 0.69 0.54 0.48
2232 (FDXR) 0.25 0.22 1.00 0.17 0.22 0.22
1622 (DBI) 0.29 0.69 0.17 1.00 0.63 0.55
64746 (ACBD3) 0.35 0.54 0.22 0.63 1.00 0.72
5204 (PFDN5) 0.34 0.48 0.22 0.55 0.72 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
DBI Rat Left brain cortices 300hPa 9144 m 1 hour upregulated 1.41±0.1 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 DBI 1622 distal 22955619 TRANSFAC
CEBPB 1051 DBI 1622 proximal_filtered 22955619 TRANSFAC
SREBF1 6720 DBI 1622 proximal_filtered 22955619 TRANSFAC
PPARG 5468 DBI 1622 Activation 14522018 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
1622 GO:0008289 lipid binding GOTERM_MF_DIRECT
1622 GO:0046983 protein heterodimerization activity GOTERM_MF_DIRECT
1622 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
1622 GO:0005794 Golgi apparatus GOTERM_CC_DIRECT
1622 GO:0036151 phosphatidylcholine acyl-chain remodeling GOTERM_BP_DIRECT
1622 GO:0006810 transport GOTERM_BP_DIRECT
1622 GO:0018345 protein palmitoylation GOTERM_BP_DIRECT
1622 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
1622 GO:0000062 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process GOTERM_MF_DIRECT
1622 GO:0030156 manganese ion binding GOTERM_MF_DIRECT
1622 GO:0036042 lysophosphatidic acid binding GOTERM_MF_DIRECT
1622 GO:0097038 perinuclear endoplasmic reticulum GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
1622 hsa03320 PPAR signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
DBI 1622 Carcinomatosis C0205699 Neoplastic Process 0.3 0.727 0.414 phenotype
DBI 1622 Animal Mammary Neoplasms C0024667 Neoplastic Process 0.3 0.727 0.414 group
DBI 1622 Carcinoma C0007097 Neoplastic Process 0.3 0.727 0.414 group
DBI 1622 Undifferentiated carcinoma C0205698 Neoplastic Process 0.3 0.727 0.414 phenotype
DBI 1622 Anaplastic carcinoma C0205696 Neoplastic Process 0.3 0.727 0.414 disease
DBI 1622 Mammary Neoplasms, Experimental C0024668 Experimental Model of Disease; Neoplastic Process 0.3 0.727 0.414 group
DBI 1622 Carcinoma, Spindle-Cell C0205697 Neoplastic Process 0.3 0.727 0.414 disease
DBI 1622 Mammary Carcinoma, Animal C1257925 Neoplastic Process 0.3 0.727 0.414 disease
DBI 1622 Psychotic Disorders C0033975 Mental or Behavioral Dysfunction 0.01 0.727 0.414 group
DBI 1622 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.02 0.727 0.414 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
DBI 1622 HORMONES None None None