Dipeptidyl aminopeptidase-like p6

AltitudeomicsDB
Protein Official symbol DPP6
Aliases DPP6
Chromosomal Location 7
Length 865
Uniprot ID P42658
EC number None
Protein family Information(Pfam) PF00930;PF00326;
PDB id 1XFD;
InterPro ID IPR029058;IPR001375;IPR002469;IPR038554;
dbSNP rs786205143 rs3734960

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
KCNIP2 KCND3 0.998
KCNIP1 KCND3 0.998
KCNIP2 KCND2 0.997
KCNIP1 KCND2 0.997
LGI1 CNTNAP2 0.927
KCNIP1 KCNC1 0.9009999999999999
KCNIP2 KCNC1 0.885
KCNIP2 KCNIP1 0.8759999999999999
DPP6 KCND2 0.8740000000000001
DPP6 KCNC1 0.872
ZIC4 DNER 0.8420000000000001
DPP6 KCND3 0.836
KCNIP2 DPP6 0.818
KCNIP2 KCNA4 0.8009999999999999
DPP6 IGLON5 0.7909999999999999
DPP6 KCNA4 0.787
SCN5A KCND3 0.7829999999999999
KCNIP1 KCNA4 0.778
DPP6 DNER 0.7709999999999999
DPP6 LGI1 0.741
KCNIP1 DPP6 0.737
KCNIP2 SCN5A 0.727
LGI1 IGLON5 0.7240000000000001
SCN5A DPP6 0.716
DPP6 CNTNAP2 0.7120000000000001
ZIC4 DPP6 0.7020000000000001
SCN5A KCNA4 0.7020000000000001
Gene Ontology Semantic Similarity
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# 30819 (KCNIP2) 30820 (KCNIP1) 9211 (LGI1) 1804 (DPP6) 84107 (ZIC4) 6331 (SCN5A) 3752 (KCND3) 3751 (KCND2) 26047 (CNTNAP2) 3746 (KCNC1) 92737 (DNER) 3739 (KCNA4)
30819 (KCNIP2) 1.00 0.74 0.55 1.00 0.37 0.72 0.82 0.77 0.55 0.40 0.61 0.74
30820 (KCNIP1) 0.74 1.00 0.68 1.00 0.37 0.54 0.45 0.45 0.68 0.06 0.74 0.53
9211 (LGI1) 0.55 0.68 1.00 0.21 0.37 0.54 0.55 0.59 0.91 0.06 0.69 0.72
1804 (DPP6) 1.00 1.00 0.21 1.00 0.13 0.66 0.21 0.21 0.21 0.05 0.21 0.21
84107 (ZIC4) 0.37 0.37 0.37 0.13 1.00 0.37 0.37 0.37 0.37 0.04 0.37 0.37
6331 (SCN5A) 0.72 0.54 0.54 0.66 0.37 1.00 0.73 0.73 0.58 0.32 0.51 0.73
3752 (KCND3) 0.82 0.45 0.55 0.21 0.37 0.73 1.00 0.95 0.55 0.68 0.48 0.93
3751 (KCND2) 0.77 0.45 0.59 0.21 0.37 0.73 0.95 1.00 0.59 0.78 0.49 0.98
26047 (CNTNAP2) 0.55 0.68 0.91 0.21 0.37 0.58 0.55 0.59 1.00 0.06 0.69 0.72
3746 (KCNC1) 0.40 0.06 0.06 0.05 0.04 0.32 0.68 0.78 0.06 1.00 0.05 0.75
92737 (DNER) 0.61 0.74 0.69 0.21 0.37 0.51 0.48 0.49 0.69 0.05 1.00 0.57
3739 (KCNA4) 0.74 0.53 0.72 0.21 0.37 0.73 0.93 0.98 0.72 0.75 0.57 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
DPP6 Rat Left brain cortices 300hPa 9144 m 1 hour downregulated 1.33±0.2 TMT labeled LTQ orbitrap Southwestern europe Male wistar rats 1 Adult male Wistar rats weighing 350 g 28697276
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT449361 hsa-miR-3153 Homo sapiens DPP6 1804 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT449362 hsa-miR-513b-3p Homo sapiens DPP6 1804 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT449360 hsa-miR-4668-5p Homo sapiens DPP6 1804 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT449358 hsa-miR-6739-5p Homo sapiens DPP6 1804 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT449359 hsa-miR-6733-5p Homo sapiens DPP6 1804 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT449363 hsa-miR-1276 Homo sapiens DPP6 1804 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT449362 hsa-miR-513b-3p Homo sapiens DPP6 1804 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT496681 hsa-miR-497-3p Homo sapiens DPP6 1804 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT496681 hsa-miR-497-3p Homo sapiens DPP6 1804 Homo sapiens PAR-CLIP Functional MTI (Weak) 22291592
MIRT496681 hsa-miR-497-3p Homo sapiens DPP6 1804 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT786307 hsa-miR-4652-3p Homo sapiens DPP6 1804 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT786588 hsa-miR-4743-3p Homo sapiens DPP6 1804 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787123 hsa-miR-511-5p Homo sapiens DPP6 1804 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT788981 hsa-miR-6830-3p Homo sapiens DPP6 1804 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
Gene Ontology
ID GO ID GO Term GO Type
1804 GO:0008236 cysteine-type peptidase activity GOTERM_MF_DIRECT
1804 GO:0008239 metallopeptidase activity GOTERM_MF_DIRECT
1804 GO:0006508 proteolysis GOTERM_BP_DIRECT
1804 GO:0015459 antiporter activity GOTERM_MF_DIRECT
1804 GO:0008076 voltage-gated potassium channel complex GOTERM_CC_DIRECT
1804 GO:1901379 regulation of potassium ion transmembrane transport GOTERM_BP_DIRECT
1804 GO:0005886 plasma membrane GOTERM_CC_DIRECT
1804 GO:0072659 protein localization to plasma membrane GOTERM_BP_DIRECT
1804 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
1804 GO:0004177 endopeptidase activity GOTERM_MF_DIRECT
1804 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
DPP6 1804 Amyotrophic Lateral Sclerosis, Guam Form C0543859 Disease or Syndrome 0.3 0.652 0.552 disease
DPP6 1804 Amyotrophic Lateral Sclerosis With Dementia C0393554 Disease or Syndrome 0.3 0.652 0.552 disease
DPP6 1804 Autism Spectrum Disorders C1510586 Mental or Behavioral Dysfunction 0.35 0.652 0.552 disease
DPP6 1804 Amyotrophic Lateral Sclerosis C0002736 Disease or Syndrome 0.47 0.652 0.552 disease
DPP6 1804 Paroxysmal familial ventricular fibrillation C0340493 Disease or Syndrome 0.53 0.652 0.552 disease
DPP6 1804 MENTAL RETARDATION, AUTOSOMAL DOMINANT 33 C4225375 Mental or Behavioral Dysfunction 0.6 0.652 0.552 disease
DPP6 1804 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.41 0.652 0.552 group
DPP6 1804 Primary microcephaly C0431350 Congenital Abnormality 0.3 0.652 0.552 disease
DPP6 1804 VENTRICULAR FIBRILLATION DURING MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO C4017668 Finding 0.3 0.652 0.552 phenotype
DPP6 1804 Microcephaly autosomal dominant C0220693 Disease or Syndrome 0.31 0.652 0.552 disease
DPP6 1804 Ventricular Fibrillation, Paroxysmal Familial, 1 C2751898 Disease or Syndrome 0.3 0.652 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types