3-Hydroxyanthranilate 3,4-dioxygenase

AltitudeomicsDB
Protein Official symbol HAAO
Aliases HAAO
Chromosomal Location 2
Length 286
Uniprot ID P46952
EC number 1.13.11.6
Protein family Information(Pfam) PF06052;
PDB id 2QNK;5TK5;5TKQ;
InterPro ID IPR010329;IPR016700;IPR014710;IPR011051;
dbSNP rs3816183 rs3816182

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
KMO KYNU 0.999
HAAO KYNU 0.998
ACMSD HAAO 0.991
KMO HAAO 0.985
ACMSD KYNU 0.919
HAAO CAT 0.919
KMO ACMSD 0.915
KYNU CAT 0.914
Gene Ontology Semantic Similarity
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# 8942 (KYNU) 23498 (HAAO) 847 (CAT) 130013 (ACMSD) 8564 (KMO)
8942 (KYNU) 1.00 0.28 0.43 0.30 0.15
23498 (HAAO) 0.28 1.00 0.52 0.58 0.25
847 (CAT) 0.43 0.52 1.00 0.49 0.40
130013 (ACMSD) 0.30 0.58 0.49 1.00 0.21
8564 (KMO) 0.15 0.25 0.40 0.21 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HAAO Rat Lungs - 7600 m 12 hours upregulated 1.4 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
HAAO Rat Lungs - 7600 m 24 hours upregulated 10.2 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
HAAO Rat Lungs - 7600 m 6 hours upregulated 1.3 2-DE Northern indo-australian plate Sprague-Dawley 1 Male SD rats weighing 220g 26022216
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
HNF4A 3172 HAAO 23498 proximal_filtered 22955619 TRANSFAC
TAF1 6872 HAAO 23498 proximal_filtered 22955619 TRANSFAC
HNF4G 3174 HAAO 23498 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT460077 hsa-miR-185-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460082 hsa-miR-7153-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460078 hsa-miR-6088 Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460081 hsa-miR-6770-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460088 hsa-miR-3919 Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460080 hsa-miR-143-3p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460074 hsa-miR-4644 Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460075 hsa-miR-5192 Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460089 hsa-miR-4773 Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460079 hsa-miR-4770 Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460083 hsa-miR-146b-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460085 hsa-miR-589-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460084 hsa-miR-146a-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460076 hsa-miR-4306 Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460086 hsa-miR-4795-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT460087 hsa-miR-1252-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490264 hsa-miR-744-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490257 hsa-miR-3132 Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490265 hsa-miR-4722-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490268 hsa-miR-6502-3p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490262 hsa-miR-6781-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490261 hsa-miR-128-1-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490259 hsa-miR-6835-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490258 hsa-miR-197-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490267 hsa-miR-4781-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490263 hsa-miR-6721-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490260 hsa-miR-128-2-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490256 hsa-miR-3529-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490255 hsa-miR-379-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT490266 hsa-miR-4787-5p Homo sapiens HAAO 23498 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
Gene Ontology
ID GO ID GO Term GO Type
23498 GO:0006569 tryptophan catabolic process GOTERM_BP_DIRECT
23498 GO:0070050 neuron cellular homeostasis GOTERM_BP_DIRECT
23498 GO:0000334 magnesium ion binding GOTERM_MF_DIRECT
23498 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
23498 GO:0005829 cytosol GOTERM_CC_DIRECT
23498 GO:0010043 response to zinc ion GOTERM_BP_DIRECT
23498 GO:0005506 fatty acid binding GOTERM_MF_DIRECT
23498 GO:0019805 quinolinate biosynthetic process GOTERM_BP_DIRECT
23498 GO:0034354 'de novo' NAD biosynthetic process from tryptophan GOTERM_BP_DIRECT
23498 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
23498 GO:0008198 phosphatidate phosphatase activity GOTERM_MF_DIRECT
23498 GO:0005515 protein binding GOTERM_MF_DIRECT
23498 GO:0046686 response to cadmium ion GOTERM_BP_DIRECT
23498 GO:0043420 anthranilate metabolic process GOTERM_BP_DIRECT
23498 GO:0046874 quinolinate metabolic process GOTERM_BP_DIRECT
23498 GO:0009055 hydroxypyruvate isomerase activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
23498 hsa00380 Tryptophan metabolism
23498 hsa01100 Metabolic pathways
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HAAO 23498 Cakut C1968949 Disease or Syndrome 0.3 0.762 0.172 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types