WD repeat domain phosphoinositide-interacting protein 2

AltitudeomicsDB
Protein Official symbol WIPI2
Aliases WIPI2 CGI-50
Chromosomal Location  7
Length 454
Uniprot ID Q9Y4P8
EC number None
Protein family Information(Pfam) None
PDB id None
InterPro ID IPR015943;IPR001680;IPR036322;IPR032911;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ATG12 ATG7 0.999
ATG7 ATG3 0.999
BECN1 PIK3C3 0.998
ATG16L1 ATG5 0.998
ATG12 ATG5 0.998
PIK3R4 PIK3C3 0.997
ATG5 BECN1 0.997
ATG5 ATG7 0.996
ATG3 GABARAPL1 0.996
BECN1 PIK3R4 0.996
ATG12 ATG3 0.995
ATG12 BECN1 0.995
ATG3 GABARAPL2 0.995
ATG7 GABARAPL1 0.995
BECN1 ATG3 0.994
ATG7 GABARAPL2 0.994
ATG5 ATG3 0.994
ATG12 GABARAPL1 0.994
ATG12 GABARAPL2 0.993
ATG5 PIK3C3 0.993
ATG5 GABARAPL1 0.993
ATG12 ATG16L1 0.993
BECN1 MAP1LC3B 0.992
MAP1LC3A BECN1 0.991
ATG5 GABARAPL2 0.991
BECN1 GABARAPL1 0.991
ATG12 PIK3C3 0.991
ATG16L1 ATG7 0.99
BECN1 GABARAPL2 0.99
ATG5 MAP1LC3B 0.99
ATG3 PIK3C3 0.989
ATG16L1 BECN1 0.989
MAP1LC3A ATG7 0.989
MAP1LC3A ATG5 0.989
ATG16L1 ATG3 0.989
ATG5 PIK3R4 0.988
ATG12 PIK3R4 0.988
MAP1LC3A ATG3 0.988
ATG7 MAP1LC3B 0.987
ATG12 MAP1LC3A 0.987
GABARAP ATG3 0.987
PIK3R4 ATG3 0.987
ATG16L1 WIPI2 0.986
GABARAPL1 PIK3C3 0.986
ATG7 GABARAP 0.986
WIPI2 PIK3C3 0.985
PIK3C3 GABARAPL2 0.985
BECN1 WIPI2 0.985
ATG5 GABARAP 0.985
ATG12 GABARAP 0.985
ATG16L1 GABARAPL1 0.984
ATG12 MAP1LC3B 0.984
BECN1 GABARAP 0.984
ATG16L1 PIK3C3 0.983
ATG5 WIPI2 0.983
ATG12 WIPI2 0.982
ATG7 WIPI2 0.982
ATG3 MAP1LC3B 0.982
ATG16L1 GABARAPL2 0.982
PIK3R4 GABARAPL1 0.981
PIK3R4 WIPI2 0.981
BECN1 ATG7 0.981
PIK3R4 GABARAPL2 0.981
WIPI2 GABARAPL1 0.98
ATG16L1 PIK3R4 0.98
MAP1LC3A WIPI2 0.98
ATG16L1 GABARAP 0.98
GABARAP WIPI2 0.979
WIPI2 ATG3 0.979
ATG16L1 MAP1LC3A 0.979
WIPI2 GABARAPL2 0.979
MAP1LC3A PIK3C3 0.978
GABARAP PIK3C3 0.978
MAP1LC3C ATG3 0.976
ATG16L1 MAP1LC3B 0.975
MAP1LC3B PIK3C3 0.975
PIK3R4 GABARAP 0.973
ATG5 MAP1LC3C 0.972
MAP1LC3C ATG7 0.969
ATG12 MAP1LC3C 0.969
BECN1 MAP1LC3C 0.967
MAP1LC3C WIPI2 0.964
MAP1LC3C PIK3C3 0.963
WIPI2 MAP1LC3B 0.961
ATG16L1 MAP1LC3C 0.96
MAP1LC3A PIK3R4 0.96
MAP1LC3C PIK3R4 0.959
PIK3R4 MAP1LC3B 0.958
ATG2A WIPI2 0.953
ATG2B WIPI2 0.939
ATG7 PIK3C3 0.928
MAP1LC3A GABARAPL1 0.919
MAP1LC3B GABARAPL1 0.919
MAP1LC3B GABARAPL2 0.918
MAP1LC3A GABARAP 0.917
GABARAP MAP1LC3B 0.915
MAP1LC3A MAP1LC3B 0.912
MAP1LC3A GABARAPL2 0.911
GABARAP GABARAPL2 0.909
MAP1LC3C GABARAPL1 0.909
MAP1LC3C GABARAP 0.908
MAP1LC3C GABARAPL2 0.908
GABARAPL1 GABARAPL2 0.905
MAP1LC3A MAP1LC3C 0.905
MAP1LC3C MAP1LC3B 0.904
GABARAP GABARAPL1 0.903
Gene Ontology Semantic Similarity
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# 9140 (ATG12) 10533 (ATG7) 8678 (BECN1) 55054 (ATG16L1) 30849 (PIK3R4) 9474 (ATG5) 64422 (ATG3) 84557 (MAP1LC3A) 11337 (GABARAP) 23710 (GABARAPL1) 26100 (WIPI2) 5289 (PIK3C3) 440738 (MAP1LC3C) 81631 (MAP1LC3B) 23130 (ATG2A)
9140 (ATG12) 1.00 0.57 0.70 0.80 0.60 1.00 0.86 0.58 0.69 0.69 0.55 0.69 0.67 0.67 1.00
10533 (ATG7) 0.57 1.00 0.60 0.62 0.45 0.57 0.54 0.52 0.58 0.61 0.49 0.50 0.56 0.56 1.00
8678 (BECN1) 0.70 0.60 1.00 0.78 0.57 0.70 0.66 0.73 0.82 0.81 0.66 0.63 0.83 0.83 1.00
55054 (ATG16L1) 0.80 0.62 0.78 1.00 0.64 0.80 0.89 0.62 0.70 0.70 0.61 0.71 0.69 0.69 1.00
30849 (PIK3R4) 0.60 0.45 0.57 0.64 1.00 0.60 0.58 0.47 0.54 0.55 0.42 0.89 0.50 0.50 1.00
9474 (ATG5) 1.00 0.57 0.70 0.80 0.60 1.00 0.86 0.58 0.69 0.69 0.55 0.69 0.67 0.67 1.00
64422 (ATG3) 0.86 0.54 0.66 0.89 0.58 0.86 1.00 0.54 0.61 0.61 0.50 0.66 0.58 0.58 1.00
84557 (MAP1LC3A) 0.58 0.52 0.73 0.62 0.47 0.58 0.54 1.00 0.74 0.73 0.73 0.52 0.84 0.84 1.00
11337 (GABARAP) 0.69 0.58 0.82 0.70 0.54 0.69 0.61 0.74 1.00 0.97 0.64 0.60 0.85 0.85 1.00
23710 (GABARAPL1) 0.69 0.61 0.81 0.70 0.55 0.69 0.61 0.73 0.97 1.00 0.64 0.61 0.83 0.83 1.00
26100 (WIPI2) 0.55 0.49 0.66 0.61 0.42 0.55 0.50 0.73 0.64 0.64 1.00 0.47 0.61 0.61 1.00
5289 (PIK3C3) 0.69 0.50 0.63 0.71 0.89 0.69 0.66 0.52 0.60 0.61 0.47 1.00 0.57 0.57 1.00
440738 (MAP1LC3C) 0.67 0.56 0.83 0.69 0.50 0.67 0.58 0.84 0.85 0.83 0.61 0.57 1.00 1.00 1.00
81631 (MAP1LC3B) 0.67 0.56 0.83 0.69 0.50 0.67 0.58 0.84 0.85 0.83 0.61 0.57 1.00 1.00 1.00
23130 (ATG2A) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
WIPI2 Bird Kidney - 4000 m Native upregulated 3.76 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
SPI1 6688 WIPI2 26100 proximal_filtered 22955619 TRANSFAC
NRF1 4899 WIPI2 26100 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT037966 hsa-miR-505-5p Homo sapiens WIPI2 26100 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT040290 hsa-miR-615-3p Homo sapiens WIPI2 26100 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052545 hsa-let-7a-5p Homo sapiens WIPI2 26100 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT258420 hsa-miR-4524b-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258424 hsa-miR-6852-3p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258419 hsa-miR-4524a-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258410 hsa-miR-15a-5p Homo sapiens WIPI2 26100 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT258411 hsa-miR-16-5p Homo sapiens WIPI2 26100 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT258414 hsa-miR-424-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258411 hsa-miR-16-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258417 hsa-miR-3908 Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258418 hsa-miR-3909 Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258413 hsa-miR-195-5p Homo sapiens WIPI2 26100 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT258410 hsa-miR-15a-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258412 hsa-miR-15b-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258421 hsa-miR-6507-3p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258422 hsa-miR-6780a-3p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258412 hsa-miR-15b-5p Homo sapiens WIPI2 26100 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT258415 hsa-miR-497-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258423 hsa-miR-6838-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT258413 hsa-miR-195-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT320955 hsa-miR-3611 Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT541021 hsa-miR-376a-3p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT541014 hsa-miR-7843-3p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT541019 hsa-miR-646 Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT541022 hsa-miR-503-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT541020 hsa-miR-376b-3p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT541015 hsa-miR-4786-3p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT541017 hsa-miR-4677-3p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT541016 hsa-miR-4679 Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT541018 hsa-miR-103b Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT542622 hsa-miR-575 Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT542623 hsa-miR-4676-5p Homo sapiens WIPI2 26100 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
Gene Ontology
ID GO ID GO Term GO Type
26100 GO:0016236 macroautophagy GOTERM_BP_DIRECT
26100 GO:0032266 clathrin light chain binding GOTERM_MF_DIRECT
26100 GO:0034045 pre-autophagosomal structure membrane GOTERM_CC_DIRECT
26100 GO:0006497 protein lipidation GOTERM_BP_DIRECT
26100 GO:0016020 membrane GOTERM_CC_DIRECT
26100 GO:0044804 nucleophagy GOTERM_BP_DIRECT
26100 GO:0005515 protein binding GOTERM_MF_DIRECT
26100 GO:0000045 autophagosome assembly GOTERM_BP_DIRECT
26100 GO:0005737 cytoplasm GOTERM_CC_DIRECT
26100 GO:0019898 extrinsic component of membrane GOTERM_CC_DIRECT
26100 GO:0010314 pseudouridine synthase activity GOTERM_MF_DIRECT
26100 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
26100 GO:0005776 autophagosome GOTERM_CC_DIRECT
26100 GO:0097352 autophagosome maturation GOTERM_BP_DIRECT
26100 GO:0000422 mitophagy GOTERM_BP_DIRECT
26100 GO:0034497 protein localization to pre-autophagosomal structure GOTERM_BP_DIRECT
26100 GO:0080025 modified amino acid binding GOTERM_MF_DIRECT
26100 GO:0043234 protein complex GOTERM_CC_DIRECT
26100 GO:0000407 pre-autophagosomal structure GOTERM_CC_DIRECT
26100 GO:0005829 cytosol GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types