Vitamin D –binding protein

AltitudeomicsDB
Protein Official symbol GC
Aliases GC
Chromosomal Location 4
Length 474
Uniprot ID P02774
EC number None
Protein family Information(Pfam) PF00273;PF09164;
PDB id 1J78;1J7E;1KW2;1KXP;1LOT;1MA9;
InterPro ID IPR000264;IPR020858;IPR020857;IPR014760;IPR000213;IPR015247;
dbSNP rs7041 rs4588 rs9016

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
CUBN LRP2 0.996
GC LRP2 0.972
GC CUBN 0.966
LGMN CUBN 0.914
GC LGMN 0.904
VDR GC 0.904
GC AHSG 0.903
Gene Ontology Semantic Similarity
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# 8029 (CUBN) 2638 (GC) 5641 (LGMN) 7421 (VDR) 4036 (LRP2) 197 (AHSG)
8029 (CUBN) 1.00 0.39 0.21 0.49 0.70 0.16
2638 (GC) 0.39 1.00 0.11 0.47 0.35 0.09
5641 (LGMN) 0.21 0.11 1.00 0.14 0.17 0.11
7421 (VDR) 0.49 0.47 0.14 1.00 0.41 0.11
4036 (LRP2) 0.70 0.35 0.17 0.41 1.00 0.13
197 (AHSG) 0.16 0.09 0.11 0.11 0.13 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
GC Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
GC Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
GC Human Plasma - 3500-4000m Native upregulated 1.78 2-DE Northern indo-australian plate Ladakhi 1 Sea level healthy individuals 23844025
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
TP53 7157 GC 2638 Activation 12556536 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT016788 hsa-miR-335-5p Homo sapiens GC 2638 Homo sapiens Microarray Functional MTI (Weak) 18185580
Gene Ontology
ID GO ID GO Term GO Type
2638 GO:0042359 vitamin D metabolic process GOTERM_BP_DIRECT
2638 GO:1902118 acyl-L-homoserine-lactone lactonohydrolase activity GOTERM_MF_DIRECT
2638 GO:0051180 vitamin transport GOTERM_BP_DIRECT
2638 GO:0043202 lysosomal lumen GOTERM_CC_DIRECT
2638 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2638 GO:0051183 ATPase binding GOTERM_MF_DIRECT
2638 GO:0005829 cytosol GOTERM_CC_DIRECT
2638 GO:0003779 microtubule motor activity GOTERM_MF_DIRECT
2638 GO:0005499 sodium:potassium-exchanging ATPase activity GOTERM_MF_DIRECT
2638 GO:0005576 extracellular region GOTERM_CC_DIRECT
2638 GO:0005615 extracellular space GOTERM_CC_DIRECT
2638 GO:0072562 blood microparticle GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
GC 2638 Liver Cirrhosis C0023890 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Graves Disease C0018213 Disease or Syndrome 0.32 0.525 0.793 disease
GC 2638 Injury wounds C0043250 Injury or Poisoning 0.3 0.525 0.793 group
GC 2638 Wounds and Injuries C0043251 Injury or Poisoning 0.3 0.525 0.793 group
GC 2638 Hepatic Coma C0019147 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Adverse reaction to drug C0041755 Pathologic Function 0.3 0.525 0.793 group
GC 2638 Multiple Sclerosis C0026769 Disease or Syndrome 0.32 0.525 0.793 disease
GC 2638 Hepatic Stupor C0751198 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Drug toxicity C0013221 Injury or Poisoning 0.3 0.525 0.793 group
GC 2638 Endotoxic shock C0036981 Pathologic Function 0.3 0.525 0.793 phenotype
GC 2638 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.525 0.793 disease
GC 2638 Kidney Failure, Acute C0022660 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.31 0.525 0.793 disease
GC 2638 Septic Shock C0036983 Pathologic Function 0.3 0.525 0.793 phenotype
GC 2638 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Osteopenia C0029453 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Multiple Sclerosis, Acute Fulminating C0751324 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Hepatic Encephalopathy C0019151 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Rheumatoid Arthritis C0003873 Disease or Syndrome 0.32 0.525 0.793 disease
GC 2638 Metabolic Bone Disorder C0005944 Disease or Syndrome 0.3 0.525 0.793 group
GC 2638 Fibrosis, Liver C0239946 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Toxic Shock Syndrome C0600327 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.525 0.793 disease
GC 2638 Liver Failure, Acute C0162557 Disease or Syndrome 0.32 0.525 0.793 disease
GC 2638 Fulminant Hepatic Failure with Cerebral Edema C0751197 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Lung Neoplasms C0024121 Neoplastic Process 0.3 0.525 0.793 group
GC 2638 Malignant neoplasm of lung C0242379 Neoplastic Process 0.31 0.525 0.793 disease
GC 2638 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Acute kidney injury C2609414 Injury or Poisoning 0.3 0.525 0.793 disease
GC 2638 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Traumatic injury C3263723 Injury or Poisoning 0.3 0.525 0.793 group
GC 2638 Acute Kidney Insufficiency C1565662 Disease or Syndrome 0.3 0.525 0.793 disease
GC 2638 Research-Related Injuries C4046002 Injury or Poisoning 0.3 0.525 0.793 group
GC 2638 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.525 0.793 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
GC 2638 AFEGOSTAT TARTRATE AFEGOSTAT TARTRATE CHEMBL2105671 None
GC 2638 ANISINDIONE ANISINDIONE CHEMBL712 inhibitor
GC 2638 ASA ASPIRIN CHEMBL25 None
GC 2638 VITAMIN D None None None