Docking protein 7

AltitudeomicsDB
Protein Official symbol DOK7
Aliases DOK7 C4orf25
Chromosomal Location  4
Length 504
Uniprot ID Q18PE1
EC number None
Protein family Information(Pfam) PF02174;
PDB id None
InterPro ID IPR037746;IPR037747;IPR037748;IPR002404;IPR011993;IPR001849;
dbSNP rs763233743 rs62272670 rs940346413 rs138010842 rs1429428597 rs571769859 rs770987150 rs6811423 rs758131044 rs781227659 rs1286619522 rs768892432 rs118203994 rs16844422 rs16844460 rs115614731 rs6811423 rs150728781 rs6831659 rs560463670 rs370039804 rs16844464 rs2020433 rs753026831 rs16844470 rs9684786 rs147185207 rs184556570

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
MUSK RAPSN 0.995
MUSK DOK7 0.95
DOK7 RAPSN 0.901
Gene Ontology Semantic Similarity
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# 4593 (MUSK) 285489 (DOK7)
4593 (MUSK) 1.00 0.60
285489 (DOK7) 0.60 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
DOK7 Bird Lungs - 4000 m Native upregulated 2.9 Sequencing Central Asia L. dichrous (Bird) 1 L. dichrous vs. Po. Palustris 31127049
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
MAX 4149 DOK7 285489 distal 22955619 TRANSFAC
RAD21 5885 DOK7 285489 distal 22955619 TRANSFAC
TBP 6908 DOK7 285489 distal 22955619 TRANSFAC
YY1 7528 DOK7 285489 distal 22955619 TRANSFAC
CTBP2 1488 DOK7 285489 distal 22955619 TRANSFAC
EP300 2033 DOK7 285489 distal 22955619 TRANSFAC
TAF1 6872 DOK7 285489 distal 22955619 TRANSFAC
SP1 6667 DOK7 285489 distal 22955619 TRANSFAC
TCF12 6938 DOK7 285489 distal 22955619 TRANSFAC
USF1 7391 DOK7 285489 distal 22955619 TRANSFAC
NANOG 79923 DOK7 285489 distal 22955619 TRANSFAC
POU5F1 5460 DOK7 285489 distal 22955619 TRANSFAC
RFX5 5993 DOK7 285489 distal 22955619 TRANSFAC
CTCF 10664 DOK7 285489 distal 22955619 TRANSFAC
ESR1 2099 DOK7 285489 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT019810 hsa-miR-375 Homo sapiens DOK7 285489 Homo sapiens Microarray Functional MTI (Weak) 20215506
MIRT022616 hsa-miR-124-3p Homo sapiens DOK7 285489 Homo sapiens Microarray Functional MTI (Weak) 18668037
Gene Ontology
ID GO ID GO Term GO Type
285489 GO:0061098 positive regulation of protein tyrosine kinase activity GOTERM_BP_DIRECT
285489 GO:0030054 cell junction GOTERM_CC_DIRECT
285489 GO:0005158 type I interferon receptor binding GOTERM_MF_DIRECT
285489 GO:0008289 lipid binding GOTERM_MF_DIRECT
285489 GO:0019901 protein kinase binding GOTERM_MF_DIRECT
285489 GO:0045202 synapse GOTERM_CC_DIRECT
285489 GO:0005886 plasma membrane GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
DOK7 285489 Pena-Shokeir syndrome type I C1276035 Disease or Syndrome 0.61 0.607 0.552 disease
DOK7 285489 Congenital myasthenic syndrome ib C1850792 Disease or Syndrome 0.81 0.607 0.552 disease
DOK7 285489 Arthrogryposis C0003886 Disease or Syndrome 0.4 0.607 0.552 disease
DOK7 285489 Myasthenic Syndromes, Congenital C0751882 Disease or Syndrome 0.5 0.607 0.552 disease
DOK7 285489 Congenital Myasthenic Syndromes, Postsynaptic C0751883 Disease or Syndrome 0.3 0.607 0.552 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types