Glutathione S-transferase mu 2

AltitudeomicsDB
Protein Official symbol GSTM2
Aliases GSTM2 GST4
Chromosomal Location 1
Length 218
Uniprot ID P28161
EC number 2.5.1.18
Protein family Information(Pfam) PF00043;PF02798;
PDB id 1HNA;1HNB;1HNC;1XW5;1YKC;2AB6;2C4J;2GTU;3GTU;3GUR;5HWL;
InterPro ID IPR010987;IPR036282;IPR040079;IPR004045;IPR004046;IPR003081;IPR036249;
dbSNP rs2229050

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
GSTM3 GSTM2 0.99
GSTM4 GSTM2 0.985
GSTM1 GSTM2 0.96
GSTM4 GSTM5 0.959
GSTM5 GSTM2 0.959
GSTM4 GSTM3 0.952
GSTM3 GSTM5 0.939
GSTM1 GGH 0.905
GSTM4 GGH 0.905
GGH GSTM5 0.902
GGH GSTM2 0.902
GGH GSTM3 0.902
Gene Ontology Semantic Similarity
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# 2946 (GSTM2) 2949 (GSTM5) 2947 (GSTM3) 8836 (GGH) 2948 (GSTM4) 2944 (GSTM1)
2946 (GSTM2) 1.00 0.77 0.91 0.17 0.92 0.88
2949 (GSTM5) 0.77 1.00 0.87 0.19 0.83 0.77
2947 (GSTM3) 0.91 0.87 1.00 0.16 0.98 0.96
8836 (GGH) 0.17 0.19 0.16 1.00 0.17 0.17
2948 (GSTM4) 0.92 0.83 0.98 0.17 1.00 0.98
2944 (GSTM1) 0.88 0.77 0.96 0.17 0.98 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
GSTM2 Human Skeletal muscle - 4559 m 9 day downregulated -1.51 2-DIGE Southern Europe Italians 1 Fasting control subjects at laboratory in Copenhagen with no caffeine intake 18937252
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT025057 hsa-miR-181a-5p Homo sapiens GSTM2 2946 Homo sapiens Microarray Functional MTI (Weak) 17612493
Gene Ontology
ID GO ID GO Term GO Type
2946 GO:0018916 nitrobenzene metabolic process GOTERM_BP_DIRECT
2946 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
2946 GO:0016529 sarcoplasmic reticulum GOTERM_CC_DIRECT
2946 GO:0098869 cellular oxidant detoxification GOTERM_BP_DIRECT
2946 GO:0070458 cellular detoxification of nitrogen compound GOTERM_BP_DIRECT
2946 GO:1901687 glutathione derivative biosynthetic process GOTERM_BP_DIRECT
2946 GO:0004364 glutathione transferase activity GOTERM_MF_DIRECT
2946 GO:0005737 cytoplasm GOTERM_CC_DIRECT
2946 GO:0043651 linoleic acid metabolic process GOTERM_BP_DIRECT
2946 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GOTERM_BP_DIRECT
2946 GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GOTERM_BP_DIRECT
2946 GO:0055119 relaxation of cardiac muscle GOTERM_BP_DIRECT
2946 GO:0005102 receptor binding GOTERM_MF_DIRECT
2946 GO:0043295 laminin binding GOTERM_MF_DIRECT
2946 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity GOTERM_BP_DIRECT
2946 GO:0006749 glutathione metabolic process GOTERM_BP_DIRECT
2946 GO:0008152 metabolic process GOTERM_BP_DIRECT
2946 GO:0004602 peroxidase activity GOTERM_MF_DIRECT
2946 GO:0005515 protein binding GOTERM_MF_DIRECT
2946 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2946 GO:0019899 enzyme binding GOTERM_MF_DIRECT
2946 GO:0005829 cytosol GOTERM_CC_DIRECT
2946 GO:0042178 xenobiotic catabolic process GOTERM_BP_DIRECT
2946 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity GOTERM_BP_DIRECT
2946 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion GOTERM_BP_DIRECT
2946 GO:0071313 cellular response to caffeine GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
2946 hsa00480 Glutathione metabolism
2946 hsa00980 Metabolism of xenobiotics by cytochrome P450
2946 hsa00982 Drug metabolism - cytochrome P450
2946 hsa05204 Chemical carcinogenesis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
GSTM2 2946 Kidney Failure, Acute C0022660 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Acute kidney injury C2609414 Injury or Poisoning 0.3 0.517 0.793 disease
GSTM2 2946 Myocardial Ischemia C0151744 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Degenerative Diseases, Spinal Cord C0751733 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Down Syndrome C0013080 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Degenerative Diseases, Central Nervous System C0270715 Disease or Syndrome 0.3 0.517 0.793 group
GSTM2 2946 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.32 0.517 0.793 disease
GSTM2 2946 Non-Small Cell Lung Carcinoma C0007131 Neoplastic Process 0.31 0.517 0.793 disease
GSTM2 2946 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.517 0.793 disease
GSTM2 2946 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Acute Kidney Insufficiency C1565662 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Neurodegenerative Disorders C0524851 Disease or Syndrome 0.3 0.517 0.793 group
GSTM2 2946 Trisomy 21, Mitotic Nondisjunction C0751081 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Down Syndrome, Partial Trisomy 21 C0432416 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Trisomy 21, Meiotic Nondisjunction C0432417 Disease or Syndrome 0.3 0.517 0.793 disease
GSTM2 2946 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.33 0.517 0.793 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types