Heme oxygenase 1

AltitudeomicsDB
Protein Official symbol HMOX1
Aliases HMOX1 HO HO1
Chromosomal Location  22
Length 288
Uniprot ID P09601
EC number 1.14.14.18
Protein family Information(Pfam) PF01126;
PDB id 1N3U;1N45;1NI6;1OYK;1OYL;1OZE;1OZL;1OZR;1OZW;1S13;1S8C;1T5P;1TWN;1TWR;1XJZ;1XK0;1XK1;1XK2;1XK3;3CZY;3HOK;3K4F;3TGM;4WD4;5BTQ;6EHA;
InterPro ID IPR002051;IPR016053;IPR016084;IPR018207;
dbSNP rs2071747 rs9282702

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
JUN FOS 0.999
NFE2L2 KEAP1 0.996
NFE2L2 HMOX1 0.996
JUN MAPK14 0.991
CREB1 FOS 0.99
CREB1 JUN 0.987
FECH FXN 0.986
HMOX2 BLVRA 0.983
CREB1 MAPK14 0.978
JUN HMOX1 0.977
BLVRA HMOX1 0.973
MAPK14 HMOX1 0.972
FOS MAPK14 0.972
IL13 IL4 0.971
FECH HMOX1 0.969
HMOX2 BLVRB 0.968
IL4 MAPK14 0.962
HMOX2 FECH 0.961
NFE2L2 JUN 0.956
BLVRB HMOX1 0.954
JUN IL4 0.954
HEPH FECH 0.952
NQO1 HMOX1 0.952
HCCS COX10 0.95
FECH COX10 0.95
CP HMOX1 0.949
FXN HMOX1 0.948
BLVRA BLVRB 0.948
HEPH HMOX1 0.947
CREB1 HMOX1 0.946
FOS HMOX1 0.946
IL4 HMOX1 0.945
HMOX2 NFE2L2 0.945
NFE2L2 NQO1 0.941
HMOX2 FXN 0.941
FECH CP 0.941
NFE2L2 FOS 0.94
IL13 HMOX1 0.939
CREB1 NFE2L2 0.937
HMOX2 CP 0.931
HMOX2 HEPH 0.928
HMOX2 CREB1 0.921
HMOX2 HCCS 0.921
HMOX2 JUN 0.92
FXN CP 0.92
HMOX2 FOS 0.92
FECH HCCS 0.917
HMOX1 KEAP1 0.917
HEPH FXN 0.917
HMOX2 HMOX1 0.909
COX10 HMOX1 0.906
HCCS HMOX1 0.905
HMOX2 COX10 0.905
NQO1 KEAP1 0.901
NFE2L2 FXYD2 0.9
CREB1 FXYD2 0.9
FXYD2 HMOX1 0.9
FOS FXYD2 0.9
HMOX2 FXYD2 0.9
JUN FXYD2 0.9
Gene Ontology Semantic Similarity
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# 3725 (JUN) 4780 (NFE2L2) 1385 (CREB1) 2235 (FECH) 3163 (HMOX2) 644 (BLVRA) 1432 (MAPK14) 2353 (FOS) 3596 (IL13) 3565 (IL4) 645 (BLVRB) 9843 (HEPH) 1728 (NQO1) 3052 (HCCS) 1356 (CP) 2395 (FXN) 3162 (HMOX1) 1352 (COX10) 486 (FXYD2) 9817 (KEAP1)
3725 (JUN) 1.00 0.82 0.89 0.44 0.48 0.44 0.48 0.85 1.00 0.47 0.11 0.19 0.55 0.18 0.36 0.43 0.54 0.11 0.22 0.49
4780 (NFE2L2) 0.82 1.00 0.84 0.47 0.53 0.48 0.48 0.89 1.00 0.54 0.12 0.21 0.54 0.18 0.38 0.44 0.56 0.12 0.23 0.56
1385 (CREB1) 0.89 0.84 1.00 0.40 0.42 0.41 0.45 0.85 1.00 0.45 0.11 0.19 0.47 0.18 0.32 0.39 0.48 0.11 0.22 0.46
2235 (FECH) 0.44 0.47 0.40 1.00 0.55 0.57 0.52 0.49 1.00 0.62 0.22 0.58 0.53 0.56 0.49 0.72 0.59 0.21 0.24 0.66
3163 (HMOX2) 0.48 0.53 0.42 0.55 1.00 0.63 0.52 0.51 1.00 0.63 0.29 0.38 0.64 0.27 0.57 0.50 0.93 0.20 0.24 0.67
644 (BLVRA) 0.44 0.48 0.41 0.57 0.63 1.00 0.52 0.50 1.00 0.68 0.62 0.37 0.60 0.24 0.59 0.50 0.66 0.20 0.23 0.74
1432 (MAPK14) 0.48 0.48 0.45 0.52 0.52 0.52 1.00 0.50 1.00 0.56 0.13 0.23 0.50 0.19 0.43 0.46 0.59 0.17 0.21 0.60
2353 (FOS) 0.85 0.89 0.85 0.49 0.51 0.50 0.50 1.00 1.00 0.54 0.11 0.20 0.52 0.18 0.39 0.45 0.54 0.11 0.22 0.59
3596 (IL13) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.16 0.32 1.00 0.18 0.82 1.00 1.00 0.16 0.34 1.00
3565 (IL4) 0.47 0.54 0.45 0.62 0.63 0.68 0.56 0.54 1.00 1.00 0.13 0.24 0.53 0.18 0.50 0.52 0.65 0.13 0.23 0.81
645 (BLVRB) 0.11 0.12 0.11 0.22 0.29 0.62 0.13 0.11 0.16 0.13 1.00 0.32 0.34 0.24 0.38 0.19 0.24 0.22 0.16 0.15
9843 (HEPH) 0.19 0.21 0.19 0.58 0.38 0.37 0.23 0.20 0.32 0.24 0.32 1.00 0.44 0.33 0.68 0.74 0.34 0.22 0.20 0.26
1728 (NQO1) 0.55 0.54 0.47 0.53 0.64 0.60 0.50 0.52 1.00 0.53 0.34 0.44 1.00 0.41 0.61 0.52 0.67 0.25 0.29 0.55
3052 (HCCS) 0.18 0.18 0.18 0.56 0.27 0.24 0.19 0.18 0.18 0.18 0.24 0.33 0.41 1.00 0.33 0.24 0.27 0.24 0.23 0.18
1356 (CP) 0.36 0.38 0.32 0.49 0.57 0.59 0.43 0.39 0.82 0.50 0.38 0.68 0.61 0.33 1.00 0.60 0.57 0.25 0.22 0.53
2395 (FXN) 0.43 0.44 0.39 0.72 0.50 0.50 0.46 0.45 1.00 0.52 0.19 0.74 0.52 0.24 0.60 1.00 0.53 0.15 0.22 0.53
3162 (HMOX1) 0.54 0.56 0.48 0.59 0.93 0.66 0.59 0.54 1.00 0.65 0.24 0.34 0.67 0.27 0.57 0.53 1.00 0.18 0.24 0.68
1352 (COX10) 0.11 0.12 0.11 0.21 0.20 0.20 0.17 0.11 0.16 0.13 0.22 0.22 0.25 0.24 0.25 0.15 0.18 1.00 0.24 0.14
486 (FXYD2) 0.22 0.23 0.22 0.24 0.24 0.23 0.21 0.22 0.34 0.23 0.16 0.20 0.29 0.23 0.22 0.22 0.24 0.24 1.00 0.25
9817 (KEAP1) 0.49 0.56 0.46 0.66 0.67 0.74 0.60 0.59 1.00 0.81 0.15 0.26 0.55 0.18 0.53 0.53 0.68 0.14 0.25 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
HMOX1 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 7.5 RT-qPCR Western US C57BL/6 mice 1.8 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
HMOX1 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 3.8 RT-qPCR Western US C57BL/6 mice 1.8 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
CEBPB 1051 HMOX1 3162 proximal_filtered 22955619 TRANSFAC
MAFF 23764 HMOX1 3162 proximal_filtered 22955619 TRANSFAC
SPI1 6688 HMOX1 3162 proximal_filtered 22955619 TRANSFAC
MAFK 7975 HMOX1 3162 proximal_filtered 22955619 TRANSFAC
PPARA 5465 HMOX1 3162 Unknown 15828872 TRUSST
STAT1 6772 HMOX1 3162 Unknown 21824252 TRUSST
TFAP2A 7020 HMOX1 3162 Unknown 14612449 TRUSST
PPARG 5468 HMOX1 3162 Unknown 15828872 TRUSST
AR 367 HMOX1 3162 Activation 19479054 TRUSST
BACH1 100379661571 HMOX1 3162 Repression 16199874 TRUSST
USF1 7391 HMOX1 3162 Unknown 14612449 TRUSST
ETS1 2113 HMOX1 3162 Repression 14990861 TRUSST
NFE2L2 4780 HMOX1 3162 Unknown 22162832 TRUSST
NFKB1 4790 HMOX1 3162 Unknown 8642300 TRUSST
STAT3 6774 HMOX1 3162 Repression 22908259 TRUSST
ERG 2078 HMOX1 3162 Repression 15983365 TRUSST
SMAD7 4092 HMOX1 3162 Repression 17426099 TRUSST
USF2 7392 HMOX1 3162 Activation 8866550 TRUSST
RELA 5970 HMOX1 3162 Unknown 21824252 TRUSST
CREB1 1385 HMOX1 3162 Repression 16199874 TRUSST
FLI1 2313 HMOX1 3162 Unknown 9272862 TRUSST
SREBF1 6720 HMOX1 3162 Unknown 21824252 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT001455 hsa-miR-16-5p Homo sapiens HMOX1 3162 Homo sapiens pSILAC//Proteomics;Other Functional MTI (Weak) 18668040
MIRT004719 hsa-miR-196a-5p Homo sapiens HMOX1 3162 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 20127796
MIRT017714 hsa-miR-335-5p Homo sapiens HMOX1 3162 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT019368 hsa-miR-148b-3p Homo sapiens HMOX1 3162 Homo sapiens Microarray Functional MTI (Weak) 17612493
MIRT021967 hsa-miR-128-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT021967 hsa-miR-128-3p Homo sapiens HMOX1 3162 Homo sapiens Microarray Functional MTI (Weak) 17612493
MIRT022531 hsa-miR-124-3p Homo sapiens HMOX1 3162 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT023272 hsa-miR-122-5p Homo sapiens HMOX1 3162 Homo sapiens Western blot;qRT-PCR Functional MTI 20633528
MIRT023272 hsa-miR-122-5p Homo sapiens HMOX1 3162 Homo sapiens Microarray Functional MTI (Weak) 17612493
MIRT023697 hsa-miR-1-3p Homo sapiens HMOX1 3162 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT029307 hsa-miR-26b-5p Homo sapiens HMOX1 3162 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT054754 hsa-miR-24-3p Homo sapiens HMOX1 3162 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 24854275
MIRT462665 hsa-miR-650 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462670 hsa-miR-6875-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462656 hsa-miR-520a-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462683 hsa-miR-6758-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462650 hsa-miR-3180-5p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462655 hsa-miR-525-5p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462656 hsa-miR-520a-5p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462663 hsa-miR-6775-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462667 hsa-miR-3135b Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462654 hsa-miR-4691-5p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462661 hsa-miR-4430 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462674 hsa-miR-6734-3p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462676 hsa-miR-5193 Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462658 hsa-miR-5001-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462660 hsa-miR-4492 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462654 hsa-miR-4691-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462659 hsa-miR-4498 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462682 hsa-miR-6856-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462657 hsa-miR-762 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462671 hsa-miR-3126-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462672 hsa-miR-5008-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462652 hsa-miR-6749-3p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462673 hsa-miR-3667-3p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462676 hsa-miR-5193 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462678 hsa-miR-216a-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462681 hsa-miR-6873-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462651 hsa-miR-4443 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462668 hsa-miR-7976 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462662 hsa-miR-3652 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462666 hsa-miR-3612 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462669 hsa-miR-4721 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462679 hsa-miR-4446-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462655 hsa-miR-525-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462653 hsa-miR-6792-3p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462680 hsa-miR-7845-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462664 hsa-miR-1291 Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462674 hsa-miR-6734-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462675 hsa-miR-660-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462650 hsa-miR-3180-5p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462677 hsa-miR-3681-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462675 hsa-miR-660-3p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT462652 hsa-miR-6749-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462653 hsa-miR-6792-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT462673 hsa-miR-3667-3p Homo sapiens HMOX1 3162 Homo sapiens PAR-CLIP Functional MTI (Weak) 23592263
MIRT650815 hsa-miR-5590-5p Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT650816 hsa-miR-4448 Homo sapiens HMOX1 3162 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT732641 hsa-miR-218-5p Homo sapiens HMOX1 3162 Homo sapiens Luciferase reporter assay Functional MTI 26876575
Gene Ontology
ID GO ID GO Term GO Type
3162 GO:0010656 negative regulation of muscle cell apoptotic process GOTERM_BP_DIRECT
3162 GO:0016239 positive regulation of macroautophagy GOTERM_BP_DIRECT
3162 GO:0046872 metal ion binding GOTERM_MF_DIRECT
3162 GO:0008219 cell death GOTERM_BP_DIRECT
3162 GO:0042542 response to hydrogen peroxide GOTERM_BP_DIRECT
3162 GO:0045909 positive regulation of vasodilation GOTERM_BP_DIRECT
3162 GO:0071456 cellular response to hypoxia GOTERM_BP_DIRECT
3162 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GOTERM_BP_DIRECT
3162 GO:0004392 helicase activity GOTERM_MF_DIRECT
3162 GO:0005789 endoplasmic reticulum membrane GOTERM_CC_DIRECT
3162 GO:0002246 wound healing involved in inflammatory response GOTERM_BP_DIRECT
3162 GO:0014806 smooth muscle hyperplasia GOTERM_BP_DIRECT
3162 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GOTERM_BP_DIRECT
3162 GO:0005634 nucleus GOTERM_CC_DIRECT
3162 GO:0001525 angiogenesis GOTERM_BP_DIRECT
3162 GO:0006979 response to oxidative stress GOTERM_BP_DIRECT
3162 GO:0008217 regulation of blood pressure GOTERM_BP_DIRECT
3162 GO:0031670 cellular response to nutrient GOTERM_BP_DIRECT
3162 GO:0034101 erythrocyte homeostasis GOTERM_BP_DIRECT
3162 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron GOTERM_BP_DIRECT
3162 GO:0043627 response to estrogen GOTERM_BP_DIRECT
3162 GO:0051260 protein homooligomerization GOTERM_BP_DIRECT
3162 GO:1904036 negative regulation of epithelial cell apoptotic process GOTERM_BP_DIRECT
3162 GO:0019899 enzyme binding GOTERM_MF_DIRECT
3162 GO:0020037 heme binding GOTERM_MF_DIRECT
3162 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GOTERM_BP_DIRECT
3162 GO:0034605 cellular response to heat GOTERM_BP_DIRECT
3162 GO:0045765 regulation of angiogenesis GOTERM_BP_DIRECT
3162 GO:0048661 positive regulation of smooth muscle cell proliferation GOTERM_BP_DIRECT
3162 GO:0071276 cellular response to cadmium ion GOTERM_BP_DIRECT
3162 GO:0072719 cellular response to cisplatin GOTERM_BP_DIRECT
3162 GO:0005783 endoplasmic reticulum GOTERM_CC_DIRECT
3162 GO:0006879 cellular iron ion homeostasis GOTERM_BP_DIRECT
3162 GO:0034383 low-density lipoprotein particle clearance GOTERM_BP_DIRECT
3162 GO:0005730 nucleolus GOTERM_CC_DIRECT
3162 GO:0043305 negative regulation of mast cell degranulation GOTERM_BP_DIRECT
3162 GO:0048471 perinuclear region of cytoplasm GOTERM_CC_DIRECT
3162 GO:0005901 caveola GOTERM_CC_DIRECT
3162 GO:0002686 negative regulation of leukocyte migration GOTERM_BP_DIRECT
3162 GO:0035556 intracellular signal transduction GOTERM_BP_DIRECT
3162 GO:0045080 positive regulation of chemokine biosynthetic process GOTERM_BP_DIRECT
3162 GO:0055072 iron ion homeostasis GOTERM_BP_DIRECT
3162 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
3162 GO:0006788 heme oxidation GOTERM_BP_DIRECT
3162 GO:0032764 negative regulation of mast cell cytokine production GOTERM_BP_DIRECT
3162 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
3162 GO:0045766 positive regulation of angiogenesis GOTERM_BP_DIRECT
3162 GO:0001666 response to hypoxia GOTERM_BP_DIRECT
3162 GO:0007588 excretion GOTERM_BP_DIRECT
3162 GO:0042167 heme catabolic process GOTERM_BP_DIRECT
3162 GO:0048662 negative regulation of smooth muscle cell proliferation GOTERM_BP_DIRECT
3162 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
3162 GO:0007264 small GTPase mediated signal transduction GOTERM_BP_DIRECT
3162 GO:0043392 negative regulation of DNA binding GOTERM_BP_DIRECT
3162 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GOTERM_BP_DIRECT
3162 GO:0043524 negative regulation of neuron apoptotic process GOTERM_BP_DIRECT
3162 GO:0004630 phospholipase A2 activity GOTERM_MF_DIRECT
3162 GO:0005829 cytosol GOTERM_CC_DIRECT
3162 GO:0035094 response to nicotine GOTERM_BP_DIRECT
3162 GO:0097421 liver regeneration GOTERM_BP_DIRECT
3162 GO:0001935 endothelial cell proliferation GOTERM_BP_DIRECT
3162 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GOTERM_BP_DIRECT
3162 GO:1904706 negative regulation of vascular smooth muscle cell proliferation GOTERM_BP_DIRECT
3162 GO:0005515 protein binding GOTERM_MF_DIRECT
3162 GO:0005615 extracellular space GOTERM_CC_DIRECT
3162 GO:0016020 membrane GOTERM_CC_DIRECT
3162 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GOTERM_BP_DIRECT
3162 GO:0071243 cellular response to arsenic-containing substance GOTERM_BP_DIRECT
3162 GO:0005886 plasma membrane GOTERM_CC_DIRECT
3162 GO:0004871 signal transducer activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
3162 hsa00860 Porphyrin and chlorophyll metabolism
3162 hsa04066 HIF-1 signaling pathway
3162 hsa04978 Mineral absorption
3162 hsa05206 MicroRNAs in cancer
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
HMOX1 3162 Contact Dermatitis C0011616 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Diabetes Mellitus, Experimental C0011853 Experimental Model of Disease 0.3 0.403 0.862 disease
HMOX1 3162 Hyperplasia C0020507 Pathologic Function 0.31 0.403 0.862 phenotype
HMOX1 3162 Thrombosis C0040053 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Extravascular Hemolysis C0312854 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Non-Convulsive Status Epilepticus C0751523 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Experimental Lung Inflammation C0887898 Experimental Model of Disease 0.3 0.403 0.862 disease
HMOX1 3162 Hepatitis, Drug-Induced C1262760 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Cardiac Hypertrophy C1383860 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Cirrhosis C1623038 Disease or Syndrome 0.31 0.403 0.862 disease
HMOX1 3162 Heart Decompensation C1961112 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Chronic Lung Injury C2350344 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Focal Emphysema C2350878 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Acute kidney injury C2609414 Injury or Poisoning 0.3 0.403 0.862 disease
HMOX1 3162 Drug-Induced Acute Liver Injury C3658290 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Presenile dementia C0011265 Mental or Behavioral Dysfunction 0.3 0.403 0.862 disease
HMOX1 3162 Growth Disorders C0018273 Pathologic Function 0.3 0.403 0.862 group
HMOX1 3162 Hyperinsulinism C0020459 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Learning Disorders C0023186 Mental or Behavioral Dysfunction 0.3 0.403 0.862 group
HMOX1 3162 Lung Neoplasms C0024121 Neoplastic Process 0.3 0.403 0.862 group
HMOX1 3162 Alloxan Diabetes C0002152 Experimental Model of Disease 0.3 0.403 0.862 disease
HMOX1 3162 Anemia, Hemolytic C0002878 Disease or Syndrome 0.4 0.403 0.862 disease
HMOX1 3162 Liver diseases C0023895 Disease or Syndrome 0.33 0.403 0.862 group
HMOX1 3162 Research-Related Injuries C4046002 Injury or Poisoning 0.3 0.403 0.862 group
HMOX1 3162 Hemolysis (disorder) C0019054 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Left-Sided Heart Failure C0023212 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Neoplasm Invasiveness C0027626 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Obesity C0028754 Disease or Syndrome 0.34 0.403 0.862 disease
HMOX1 3162 Anemia, Microangiopathic C0002889 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Anemia, Hemolytic, Acquired C0002879 Disease or Syndrome 0.3 0.403 0.862 group
HMOX1 3162 Alzheimer's Disease C0002395 Disease or Syndrome 0.4 0.403 0.862 disease
HMOX1 3162 Fibrosis C0016059 Pathologic Function 0.31 0.403 0.862 phenotype
HMOX1 3162 Hepatitis, Toxic C0019193 Injury or Poisoning 0.3 0.403 0.862 disease
HMOX1 3162 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.403 0.862 disease
HMOX1 3162 Pulmonary Emphysema C0034067 Disease or Syndrome 0.33 0.403 0.862 disease
HMOX1 3162 Carotid Atherosclerosis C0577631 Disease or Syndrome 0.31 0.403 0.862 disease
HMOX1 3162 Breast Carcinoma C0678222 Neoplastic Process 0.39 0.403 0.862 disease
HMOX1 3162 Arterial Diseases, Common Carotid C0750987 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Exogenous Hyperinsulinism C1257964 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Mammary Neoplasms, Experimental C0024668 Experimental Model of Disease; Neoplastic Process 0.3 0.403 0.862 group
HMOX1 3162 Asthma C0004096 Disease or Syndrome 0.34 0.403 0.862 disease
HMOX1 3162 Malignant neoplasm of breast C0006142 Neoplastic Process 0.38 0.403 0.862 disease
HMOX1 3162 Hypertensive disease C0020538 Disease or Syndrome 0.6 0.403 0.862 group
HMOX1 3162 Kidney Failure, Acute C0022660 Disease or Syndrome 0.53 0.403 0.862 disease
HMOX1 3162 Liver neoplasms C0023903 Neoplastic Process 0.37 0.403 0.862 group
HMOX1 3162 Microangiopathy, Diabetic C0025945 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Indolent Systemic Mastocytosis C0272203 Neoplastic Process 0.3 0.403 0.862 disease
HMOX1 3162 Grand Mal Status Epilepticus C0311335 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Malignant neoplasm of liver C0345904 Neoplastic Process 0.3 0.403 0.862 disease
HMOX1 3162 Neurodegenerative Disorders C0524851 Disease or Syndrome 0.35 0.403 0.862 group
HMOX1 3162 Learning Disabilities C0751265 Mental or Behavioral Dysfunction 0.3 0.403 0.862 disease
HMOX1 3162 Mammary Neoplasms C1458155 Neoplastic Process 0.32 0.403 0.862 group
HMOX1 3162 Carotid Artery Diseases C0007273 Disease or Syndrome 0.31 0.403 0.862 group
HMOX1 3162 Congestive heart failure C0018802 Disease or Syndrome 0.53 0.403 0.862 disease
HMOX1 3162 Insulin Resistance C0021655 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Ischemia C0022116 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Chronic Obstructive Airway Disease C0024117 Disease or Syndrome 0.6 0.403 0.862 disease
HMOX1 3162 Retinal Diseases C0035309 Disease or Syndrome 0.3 0.403 0.862 group
HMOX1 3162 Vascular System Injuries C0178324 Injury or Poisoning 0.3 0.403 0.862 group
HMOX1 3162 Mastocytosis, Systemic C0221013 Neoplastic Process 0.3 0.403 0.862 disease
HMOX1 3162 Degenerative Diseases, Spinal Cord C0751733 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Cardiomegaly C0018800 Finding 0.3 0.403 0.862 phenotype
HMOX1 3162 Inflammation C0021368 Pathologic Function 0.35 0.403 0.862 phenotype
HMOX1 3162 Pancreatic Diseases C0030286 Disease or Syndrome 0.3 0.403 0.862 group
HMOX1 3162 Reperfusion Injury C0035126 Injury or Poisoning 0.31 0.403 0.862 disease
HMOX1 3162 Stomach Neoplasms C0038356 Neoplastic Process 0.32 0.403 0.862 group
HMOX1 3162 Contact hypersensitivity C0162351 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Lung Injury C0273115 Injury or Poisoning 0.3 0.403 0.862 disease
HMOX1 3162 Drug-Induced Liver Disease C0860207 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Insulin Sensitivity C0920563 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Coronary Arteriosclerosis C0010054 Disease or Syndrome 0.4 0.403 0.862 disease
HMOX1 3162 Heart failure C0018801 Disease or Syndrome 0.54 0.403 0.862 disease
HMOX1 3162 Lobar Pneumonia C0032300 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Streptozotocin Diabetes C0038433 Experimental Model of Disease 0.3 0.403 0.862 disease
HMOX1 3162 Wounds and Injuries C0043251 Injury or Poisoning 0.3 0.403 0.862 group
HMOX1 3162 Internal Carotid Artery Diseases C0750986 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Simple Partial Status Epilepticus C0751524 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Chronic Airflow Obstruction C1527303 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Acute Kidney Insufficiency C1565662 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Pneumonitis C3714636 Disease or Syndrome 0.32 0.403 0.862 disease
HMOX1 3162 Colitis C0009319 Disease or Syndrome 0.53 0.403 0.862 disease
HMOX1 3162 Diabetes Mellitus, Non-Insulin-Dependent C0011860 Disease or Syndrome 0.6 0.403 0.862 disease
HMOX1 3162 Hepatorenal Syndrome C0019212 Disease or Syndrome 0.31 0.403 0.862 disease
HMOX1 3162 Kidney Failure, Chronic C0022661 Disease or Syndrome 0.32 0.403 0.862 disease
HMOX1 3162 Leishmaniasis, Visceral C0023290 Disease or Syndrome 0.31 0.403 0.862 disease
HMOX1 3162 Parkinson Disease C0030567 Disease or Syndrome 0.4 0.403 0.862 disease
HMOX1 3162 Pulmonary Fibrosis C0034069 Disease or Syndrome 0.31 0.403 0.862 disease
HMOX1 3162 Status Epilepticus C0038220 Disease or Syndrome 0.5 0.403 0.862 disease
HMOX1 3162 Petit mal status C0270823 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Alzheimer Disease, Early Onset C0750901 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Developmental Academic Disorder C1330966 Finding 0.3 0.403 0.862 phenotype
HMOX1 3162 Adrenomyeloneuropathy C1527231 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Cerebral Hemorrhage C2937358 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Pre-Eclampsia C0032914 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Injury wounds C0043250 Injury or Poisoning 0.3 0.403 0.862 group
HMOX1 3162 Adrenoleukodystrophy C0162309 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 External Carotid Artery Diseases C0600178 Disease or Syndrome 0.3 0.403 0.862 group
HMOX1 3162 Alzheimer's Disease, Focal Onset C0750900 Mental or Behavioral Dysfunction 0.3 0.403 0.862 disease
HMOX1 3162 Learning Disturbance C0751263 Mental or Behavioral Dysfunction 0.3 0.403 0.862 disease
HMOX1 3162 Degenerative Diseases, Central Nervous System C0270715 Disease or Syndrome 0.3 0.403 0.862 group
HMOX1 3162 Endogenous Hyperinsulinism C1257963 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.403 0.862 disease
HMOX1 3162 SPINOCEREBELLAR ATAXIA 17 C1846707 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Coronary Artery Disease C1956346 Disease or Syndrome 0.4 0.403 0.862 disease
HMOX1 3162 Chemically-Induced Liver Toxicity C4279912 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Hepatitis C0019158 Disease or Syndrome 0.32 0.403 0.862 disease
HMOX1 3162 Prostatic Neoplasms C0033578 Neoplastic Process 0.3 0.403 0.862 group
HMOX1 3162 Adverse reaction to drug C0041755 Pathologic Function 0.3 0.403 0.862 group
HMOX1 3162 Liver Dysfunction C0086565 Finding 0.3 0.403 0.862 phenotype
HMOX1 3162 Thrombus C0087086 Pathologic Function 0.3 0.403 0.862 phenotype
HMOX1 3162 Gastroparesis C0152020 Disease or Syndrome 0.31 0.403 0.862 disease
HMOX1 3162 Centriacinar Emphysema C0221227 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Intravascular hemolysis C0235574 Disease or Syndrome 0.32 0.403 0.862 disease
HMOX1 3162 Alzheimer Disease, Late Onset C0494463 Mental or Behavioral Dysfunction 0.3 0.403 0.862 disease
HMOX1 3162 Adult Learning Disorders C0751262 Mental or Behavioral Dysfunction 0.3 0.403 0.862 group
HMOX1 3162 Aggressive Systemic Mastocytosis C1112486 Neoplastic Process 0.3 0.403 0.862 disease
HMOX1 3162 Heme Oxygenase 1 Deficiency C1841651 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Blood Coagulation Disorders C0005779 Disease or Syndrome 0.3 0.403 0.862 group
HMOX1 3162 Drug toxicity C0013221 Injury or Poisoning 0.3 0.403 0.862 group
HMOX1 3162 Myocardial Ischemia C0151744 Disease or Syndrome 0.32 0.403 0.862 disease
HMOX1 3162 Heart Failure, Right-Sided C0235527 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Myocardial Failure C1959583 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Traumatic injury C3263723 Injury or Poisoning 0.3 0.403 0.862 group
HMOX1 3162 Chemical and Drug Induced Liver Injury C4277682 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Malignant neoplasm of lung C0242379 Neoplastic Process 0.37 0.403 0.862 disease
HMOX1 3162 Familial Alzheimer Disease (FAD) C0276496 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Complex Partial Status Epilepticus C0393734 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Status Epilepticus, Subclinical C0751522 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.36 0.403 0.862 disease
HMOX1 3162 Pneumonia C0032285 Disease or Syndrome 0.33 0.403 0.862 disease
HMOX1 3162 Hamman-Rich syndrome C0085786 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Microangiopathic hemolytic anemia C0221021 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Panacinar Emphysema C0264393 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Mammary Neoplasms, Human C1257931 Neoplastic Process 0.3 0.403 0.862 group
HMOX1 3162 Compensatory Hyperinsulinemia C1257965 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Diabetic Angiopathies C0011875 Disease or Syndrome 0.3 0.403 0.862 disease
HMOX1 3162 Iron Metabolism Disorders C0012715 Disease or Syndrome 0.3 0.403 0.862 group
HMOX1 3162 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.4 0.403 0.862 disease
HMOX1 3162 Acute Confusional Senile Dementia C0546126 Mental or Behavioral Dysfunction 0.3 0.403 0.862 disease
HMOX1 3162 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.32 0.403 0.862 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
HMOX1 3162 ASPIRIN ASPIRIN CHEMBL25 None
HMOX1 3162 COMPOUND 1 [PMID: 16821802] None None inhibitor
HMOX1 3162 HORMONES None None None
HMOX1 3162 NEUROTROPHIC FACTOR None None None
HMOX1 3162 SELENIUM None None None
HMOX1 3162 SORAFENIB SORAFENIB CHEMBL1336 None
HMOX1 3162 STANNSOPORFIN None None inhibitor
HMOX1 3162 STANNSOPORFIN None None None
HMOX1 3162 SUNITINIB SUNITINIB CHEMBL535 None
HMOX1 3162 VITAMIN D None None None
HMOX1 3162 ZNCL2 ZINC CHLORIDE CHEMBL1200679 None