Nuclear receptor subfamily 4 group A member 1

AltitudeomicsDB
Protein Official symbol NR4A1
Aliases NR4A1 GFRP1 HMR NAK1
Chromosomal Location  12
Length 598
Uniprot ID P22736
EC number None
Protein family Information(Pfam) PF00104;PF00105;
PDB id 2QW4;3V3E;3V3Q;4JGV;4KZI;4KZJ;4KZM;4RE8;4REE;4REF;4RZE;4RZF;4RZG;4WHF;4WHG;6LC1;
InterPro ID IPR035500;IPR003071;IPR003070;IPR000536;IPR001723;IPR001628;IPR013088;
dbSNP rs1882118

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
RXRA MED1 0.989
MEF2D EP300 0.988
AKT1 NR4A1 0.984
AKT1 AKT2 0.983
MAPK7 MEF2D 0.977
AKT1 EP300 0.976
RXRA EP300 0.975
RXRG MED1 0.968
NR4A1 MEF2D 0.968
RXRA RXRG 0.967
RXRB MED1 0.967
AKT1 MEF2D 0.961
NR4A1 BCL2 0.958
NR4A1 EP300 0.955
MED1 EP300 0.955
NR4A1 MAPK1 0.951
NR4A1 RXRA 0.95
NR4A1 NFATC1 0.949
BCL2 MAPK1 0.945
NR4A1 RXRG 0.942
AKT1 BCL2 0.941
RXRA MAPK1 0.941
NR4A1 MED1 0.94
AKT1 AKT3 0.931
AKT1 RXRA 0.93
NFATC1 MEF2D 0.929
NR4A1 MAPK7 0.927
NR4A1 RXRB 0.921
AKT1 RXRB 0.912
AKT2 AKT3 0.909
AKT1 RXRG 0.908
RXRB MAPK1 0.907
BCL2 EP300 0.907
NR4A1 AKT2 0.906
MAPK7 MAPK1 0.906
RXRA RXRB 0.905
AKT1 MAPK1 0.905
RXRG MAPK1 0.904
BCL2 RXRB 0.904
NR4A1 AKT3 0.903
RXRB RXRG 0.903
RXRA BCL2 0.902
BCL2 RXRG 0.902
Gene Ontology Semantic Similarity
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# 6256 (RXRA) 4209 (MEF2D) 207 (AKT1) 5598 (MAPK7) 6258 (RXRG) 3164 (NR4A1) 6257 (RXRB) 5469 (MED1) 596 (BCL2) 4772 (NFATC1) 208 (AKT2) 2033 (EP300) 5594 (MAPK1) 10000 (AKT3)
6256 (RXRA) 1.00 0.70 0.44 0.43 0.55 0.77 0.77 0.78 0.60 0.67 0.42 0.57 0.43 0.41
4209 (MEF2D) 0.70 1.00 0.42 0.41 0.71 0.84 0.82 0.63 0.53 0.84 0.40 0.50 0.41 0.38
207 (AKT1) 0.44 0.42 1.00 0.69 0.45 0.42 0.37 0.45 0.57 0.43 0.76 0.47 0.77 0.79
5598 (MAPK7) 0.43 0.41 0.69 1.00 0.50 0.41 0.35 0.46 0.53 0.47 0.77 0.43 0.88 0.79
6258 (RXRG) 0.55 0.71 0.45 0.50 1.00 0.63 0.72 0.54 0.57 0.67 0.50 0.41 0.47 0.44
3164 (NR4A1) 0.77 0.84 0.42 0.41 0.63 1.00 0.76 0.64 0.65 0.75 0.41 0.56 0.41 0.39
6257 (RXRB) 0.77 0.82 0.37 0.35 0.72 0.76 1.00 0.74 0.48 0.76 0.33 0.47 0.37 0.31
5469 (MED1) 0.78 0.63 0.45 0.46 0.54 0.64 0.74 1.00 0.53 0.66 0.45 0.64 0.46 0.44
596 (BCL2) 0.60 0.53 0.57 0.53 0.57 0.65 0.48 0.53 1.00 0.52 0.54 0.50 0.54 0.51
4772 (NFATC1) 0.67 0.84 0.43 0.47 0.67 0.75 0.76 0.66 0.52 1.00 0.42 0.53 0.42 0.40
208 (AKT2) 0.42 0.40 0.76 0.77 0.50 0.41 0.33 0.45 0.54 0.42 1.00 0.43 0.80 0.98
2033 (EP300) 0.57 0.50 0.47 0.43 0.41 0.56 0.47 0.64 0.50 0.53 0.43 1.00 0.48 0.43
5594 (MAPK1) 0.43 0.41 0.77 0.88 0.47 0.41 0.37 0.46 0.54 0.42 0.80 0.48 1.00 0.81
10000 (AKT3) 0.41 0.38 0.79 0.79 0.44 0.39 0.31 0.44 0.51 0.40 0.98 0.43 0.81 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
NR4A1 Toad Liver - 3464 m 33 day upregulated 2.841386699 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
NR4A1 Toad Heart - 3464 m 33 day downregulated -2.621215305 RNA-seq Tibetan Plateau Asiatic toad 1 Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) - 28673260
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
SMARCA4 6597 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
TFAP2A 7020 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
KAT2A 2648 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
E2F1 1869 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
SMARCB1 6598 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
ELK4 2005 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
SRF 6722 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
TCF4 6925 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
TFAP2C 7022 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
NR3C1 2908 NR4A1 3164 proximal_filtered 22955619 TRANSFAC
NR4A1 3164 FASLG 356 Unknown 17011549 TRUSST
NR4A1 3164 CCNA2 890 Unknown 21742769 TRUSST
NR4A1 3164 CDKN1B 1027 Repression 22120723 TRUSST
NR4A1 3164 CYP11A1 1583 Unknown 18524846 TRUSST
NR4A1 3164 CYP17A1 1586 Unknown 17660446 TRUSST
NR4A1 3164 E2F1 1869 Unknown 11485307 TRUSST
HIF1A 3091 NR4A1 3164 Unknown 9729303 TRUSST
NR4A1 3164 HSD3B2 3284 Activation 19081374 TRUSST
HDAC7 51564 NR4A1 3164 Activation 9677331 TRUSST
PML 5371 NR4A1 3164 Activation 20414733 TRUSST
MEF2C 4208 NR4A1 3164 Unknown 9729303 TRUSST
SP1 6667 NR4A1 3164 Unknown 19540848 TRUSST
NR4A1 3164 MDM2 4193 Activation 15963597 TRUSST
NR4A1 3164 MMP2 4313 Activation 17490615 TRUSST
NR4A1 3164 SERPINE1 5054 Activation 12654640 TRUSST
NR4A1 3164 STAR 6770 Unknown 18694960 TRUSST
NR4A1 3164 TNF 7124 Unknown 20169197 TRUSST
NR4A1 3164 TIMP2 7077 Unknown 15118068 TRUSST
NR4A1 3164 BRE 9577 Activation 19895734 TRUSST
NR4A1 3164 RNF7 9616 Activation 10634504 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT018925 hsa-miR-335-5p Homo sapiens NR4A1 3164 Homo sapiens Microarray Functional MTI (Weak) 18185580
MIRT023110 hsa-miR-124-3p Homo sapiens NR4A1 3164 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT026031 hsa-miR-196a-5p Homo sapiens NR4A1 3164 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT032110 hsa-let-7d-5p Homo sapiens NR4A1 3164 Homo sapiens Sequencing Functional MTI (Weak) 20371350
MIRT048853 hsa-miR-93-5p Homo sapiens NR4A1 3164 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT734544 hsa-miR-124-5p Homo sapiens NR4A1 3164 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26840408
Gene Ontology
ID GO ID GO Term GO Type
3164 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GOTERM_BP_DIRECT
3164 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
3164 GO:0005654 nucleoplasm GOTERM_CC_DIRECT
3164 GO:0007165 signal transduction GOTERM_BP_DIRECT
3164 GO:0043401 steroid hormone mediated signaling pathway GOTERM_BP_DIRECT
3164 GO:0045444 fat cell differentiation GOTERM_BP_DIRECT
3164 GO:0003677 DNA binding GOTERM_MF_DIRECT
3164 GO:0005634 nucleus GOTERM_CC_DIRECT
3164 GO:0003707 transcription factor activity GOTERM_MF_DIRECT
3164 GO:0005737 cytoplasm GOTERM_CC_DIRECT
3164 GO:0001938 positive regulation of endothelial cell proliferation GOTERM_BP_DIRECT
3164 GO:0035767 endothelial cell chemotaxis GOTERM_BP_DIRECT
3164 GO:0046982 protein heterodimerization activity GOTERM_MF_DIRECT
3164 GO:0001077 transcriptional activator activity GOTERM_MF_DIRECT
3164 GO:0004879 receptor activity GOTERM_MF_DIRECT
3164 GO:0006915 apoptotic process GOTERM_BP_DIRECT
3164 GO:0044344 cellular response to fibroblast growth factor stimulus GOTERM_BP_DIRECT
3164 GO:0005515 protein binding GOTERM_MF_DIRECT
3164 GO:0043565 sequence-specific DNA binding GOTERM_MF_DIRECT
3164 GO:0031965 nuclear membrane GOTERM_CC_DIRECT
3164 GO:0043065 positive regulation of apoptotic process GOTERM_BP_DIRECT
3164 GO:0002042 cell migration involved in sprouting angiogenesis GOTERM_BP_DIRECT
3164 GO:0006351 transcription GOTERM_BP_DIRECT
3164 GO:0005667 transcription factor complex GOTERM_CC_DIRECT
3164 GO:0035924 cellular response to vascular endothelial growth factor stimulus GOTERM_BP_DIRECT
3164 GO:0008270 zinc ion binding GOTERM_MF_DIRECT
3164 GO:0035914 skeletal muscle cell differentiation GOTERM_BP_DIRECT
3164 GO:0045786 negative regulation of cell cycle GOTERM_BP_DIRECT
3164 GO:0006367 transcription initiation from RNA polymerase II promoter GOTERM_BP_DIRECT
3164 GO:0030522 intracellular receptor signaling pathway GOTERM_BP_DIRECT
3164 GO:0061469 regulation of type B pancreatic cell proliferation GOTERM_BP_DIRECT
3164 GO:0071376 cellular response to corticotropin-releasing hormone stimulus GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
3164 hsa04010 MAPK signaling pathway
3164 hsa04151 PI3K-Akt signaling pathway
3164 hsa04925 Aldosterone synthesis and secretion
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
NR4A1 3164 Endometrioma C0269102 Neoplastic Process 0.3 0.558 0.621 disease
NR4A1 3164 Myocardial Ischemia C0151744 Disease or Syndrome 0.3 0.558 0.621 disease
NR4A1 3164 Insulin Resistance C0021655 Pathologic Function 0.3 0.558 0.621 phenotype
NR4A1 3164 Proteinuria C0033687 Finding 0.3 0.558 0.621 phenotype
NR4A1 3164 Kidney Diseases C0022658 Disease or Syndrome 0.3 0.558 0.621 group
NR4A1 3164 Malignant neoplasm of pancreas C0346647 Neoplastic Process 0.35 0.558 0.621 disease
NR4A1 3164 Endometriosis C0014175 Disease or Syndrome 0.3 0.558 0.621 disease
NR4A1 3164 Insulin Sensitivity C0920563 Pathologic Function 0.3 0.558 0.621 phenotype
NR4A1 3164 Pancreatic Neoplasm C0030297 Neoplastic Process 0.32 0.558 0.621 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
NR4A1 3164 CYCLOSPORIN A CYCLOSPORINE CHEMBL160 None
NR4A1 3164 HALOPERIDOL HALOPERIDOL CHEMBL54 None
NR4A1 3164 HISTONE DEACETYLASE INHIBITOR CHEMBL1213492 CHEMBL1213492 None
NR4A1 3164 IL-1 None None None
NR4A1 3164 IONOMYCIN IONOMYCIN CHEMBL501617 None
NR4A1 3164 KINASE INHIBITOR None None None
NR4A1 3164 L-DOPA LEVODOPA CHEMBL1009 None
NR4A1 3164 LIF None None None
NR4A1 3164 MORPHINE MORPHINE CHEMBL70 None
NR4A1 3164 NAC ACETYLCYSTEINE CHEMBL600 None
NR4A1 3164 NICOTINE NICOTINE CHEMBL3 None
NR4A1 3164 PD-98059 CHEMBL35482 CHEMBL35482 None
NR4A1 3164 RETINOIC ACID TRETINOIN CHEMBL38 None
NR4A1 3164 VP-16 ETOPOSIDE CHEMBL44657 None