| Protein Official symbol | |
| Aliases | IGHM |
| Chromosomal Location | |
| Length | 453 |
| Uniprot ID | P01871 |
| EC number | None |
| Protein family Information(Pfam) | PF07654; |
| PDB id | 1HEZ;2AGJ;2RCJ;6KXS; |
| InterPro ID | IPR007110;IPR036179;IPR013783;IPR003006;IPR003597; |
| dbSNP | rs12365 |
| Protein 1 | Protein 2 | Combine Score |
|---|
| # | 333 (APLP1) | 334 (APLP2) | 351 (APP) | 973 (CD79A) | 1357 (CPA1) | 2217 (FCGRT) | 2566 (GABRG2) | 4225 (MEP1B) | 6710 (SPTB) | 7311 (UBA52) | 9851 (KIAA0753) | 10136 (CELA3A) | 57731 (SPTBN4) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 333 (APLP1) | 1.00 | 0.75 | 0.73 | 0.74 | 0.65 | 0.59 | 0.39 | 0.72 | 0.65 | 0.67 | 1.00 | 0.12 | 0.64 |
| 334 (APLP2) | 0.75 | 1.00 | 0.84 | 0.79 | 0.66 | 0.63 | 0.35 | 0.75 | 0.66 | 0.69 | 1.00 | 0.12 | 0.64 |
| 351 (APP) | 0.73 | 0.84 | 1.00 | 0.71 | 0.64 | 0.57 | 0.42 | 0.69 | 0.65 | 0.67 | 1.00 | 0.12 | 0.65 |
| 973 (CD79A) | 0.74 | 0.79 | 0.71 | 1.00 | 0.68 | 0.67 | 0.33 | 0.74 | 0.67 | 0.71 | 1.00 | 0.12 | 0.65 |
| 1357 (CPA1) | 0.65 | 0.66 | 0.64 | 0.68 | 1.00 | 0.57 | 0.28 | 0.77 | 0.60 | 0.62 | 1.00 | 0.37 | 0.59 |
| 2217 (FCGRT) | 0.59 | 0.63 | 0.57 | 0.67 | 0.57 | 1.00 | 0.27 | 0.59 | 0.58 | 0.59 | 0.82 | 0.10 | 0.53 |
| 2566 (GABRG2) | 0.39 | 0.35 | 0.42 | 0.33 | 0.28 | 0.27 | 1.00 | 0.33 | 0.37 | 0.34 | 1.00 | 0.12 | 0.39 |
| 4225 (MEP1B) | 0.72 | 0.75 | 0.69 | 0.74 | 0.77 | 0.59 | 0.33 | 1.00 | 0.63 | 0.65 | 1.00 | 0.59 | 0.62 |
| 6710 (SPTB) | 0.65 | 0.66 | 0.65 | 0.67 | 0.60 | 0.58 | 0.37 | 0.63 | 1.00 | 0.64 | 1.00 | 0.12 | 0.87 |
| 7311 (UBA52) | 0.67 | 0.69 | 0.67 | 0.71 | 0.62 | 0.59 | 0.34 | 0.65 | 0.64 | 1.00 | 1.00 | 0.15 | 0.63 |
| 9851 (KIAA0753) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.82 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.12 | 1.00 |
| 10136 (CELA3A) | 0.12 | 0.12 | 0.12 | 0.12 | 0.37 | 0.10 | 0.12 | 0.59 | 0.12 | 0.15 | 0.12 | 1.00 | 0.12 |
| 57731 (SPTBN4) | 0.64 | 0.64 | 0.65 | 0.65 | 0.59 | 0.53 | 0.39 | 0.62 | 0.87 | 0.63 | 1.00 | 0.12 | 1.00 |
| Protein Official symbol | Source Organism | Tissue of Expression | Level of hypoxia | Altitude | Duration of experiment | Level of expression | Fold change | Experiment details | geographical location | ethnicity of the patients | Control group | Control (Fold change) | Reference (PMID) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IGHM | Human | Peripheral venous blood | - | 4875 m | 9 hours | upregulated | 2.2 | LTQ-XL Mass Spectrometry | Western US | Americans | 1 | Men and women living near Denver, Colorado (1,609 m) | 24265281 |
| TF | TF Entrez | Gene | Gene Entrez | Type | PMID | Database |
|---|
| miRTarBase ID | miRNA | Species (miRNA) | Protein Official Symbol | Human Entrez ID | Species (Target Gene) | Experiments | Support Type | References (PMID) |
|---|
| ID | GO ID | GO Term | GO Type |
|---|---|---|---|
| 3507 | GO:0002250 | adaptive immune response | GOTERM_BP_DIRECT |
| 3507 | GO:0019731 | antibacterial humoral response | GOTERM_BP_DIRECT |
| 3507 | GO:0045087 | innate immune response | GOTERM_BP_DIRECT |
| 3507 | GO:0016021 | integral component of membrane | GOTERM_CC_DIRECT |
| 3507 | GO:0006911 | phagocytosis | GOTERM_BP_DIRECT |
| 3507 | GO:0009897 | external side of plasma membrane | GOTERM_CC_DIRECT |
| 3507 | GO:0071757 | hexameric IgM immunoglobulin complex | GOTERM_CC_DIRECT |
| 3507 | GO:0034987 | type I transforming growth factor beta receptor binding | GOTERM_MF_DIRECT |
| 3507 | GO:0005886 | plasma membrane | GOTERM_CC_DIRECT |
| 3507 | GO:0071756 | pentameric IgM immunoglobulin complex | GOTERM_CC_DIRECT |
| 3507 | GO:0006910 | phagocytosis | GOTERM_BP_DIRECT |
| 3507 | GO:0070062 | extracellular exosome | GOTERM_CC_DIRECT |
| 3507 | GO:0050829 | defense response to Gram-negative bacterium | GOTERM_BP_DIRECT |
| 3507 | GO:0003823 | antigen binding | GOTERM_MF_DIRECT |
| 3507 | GO:0031210 | POZ domain binding | GOTERM_MF_DIRECT |
| 3507 | GO:0042834 | histone deacetylase binding | GOTERM_MF_DIRECT |
| 3507 | GO:0009986 | cell surface | GOTERM_CC_DIRECT |
| 3507 | GO:0006958 | complement activation | GOTERM_BP_DIRECT |
| 3507 | GO:0003697 | single-stranded DNA binding | GOTERM_MF_DIRECT |
| 3507 | GO:0050853 | B cell receptor signaling pathway | GOTERM_BP_DIRECT |
| 3507 | GO:0005515 | protein binding | GOTERM_MF_DIRECT |
| 3507 | GO:0072562 | blood microparticle | GOTERM_CC_DIRECT |
| 3507 | GO:0005615 | extracellular space | GOTERM_CC_DIRECT |
| 3507 | GO:0050871 | positive regulation of B cell activation | GOTERM_BP_DIRECT |
| Human Entrez ID | KEGG ID | KEGG Term |
|---|
| Protein Official Symbol | Human Entrez ID | Disease Name | Disease Id | Disease Semantic Type | Semantic score | DSI | DPI | Disease Type |
|---|---|---|---|---|---|---|---|---|
| IGHM | 3507 | Hypogammaglobulinemia | C0086438 | Disease or Syndrome | 0.3 | 0.672 | 0.517 | disease |
| IGHM | 3507 | Agammaglobulinemia | C0001768 | Disease or Syndrome | 0.4 | 0.672 | 0.517 | disease |
| IGHM | 3507 | Agammaglobulinemia, non-Bruton type | C1832241 | Disease or Syndrome | 0.4 | 0.672 | 0.517 | disease |
| Protein Official Symbol | Human Entrez ID | drug_claim_primary_name | drug_name | drug_chembl_id | interaction_types |
|---|