Serum Amyloid P

AltitudeomicsDB
Protein Official symbol APP
Aliases APP A4 AD1
Chromosomal Location  21
Length 770
Uniprot ID P05067
EC number None
Protein family Information(Pfam) PF10515;PF12924;PF12925;PF02177;PF03494;PF00014;
PDB id 1AAP;1AMB;1AMC;1AML;1BA4;1BA6;1BJB;1BJC;1BRC;1CA0;1HZ3;1IYT;1MWP;1OWT;1QCM;1QWP;1QXC;1QYT;1TAW;1TKN;1UO7;1UO8;1UOA;1UOI;1X11;1Z0Q;1ZE7;1ZE9;1ZJD;2BEG;2BOM;2BP4;2FJZ;2FK1;2FK2;2FK3;2FKL;2FMA;2G47;2IPU;2LFM;2LLM;2LMN;2LMO;2LMP;2LMQ;2LNQ;2LOH;2LP1;2LZ3;2LZ4;2M4J;2M9R;2M9S;2MGT;2MJ1;2MPZ;2MVX;2MXU;2NAO;2OTK;2R0W;2WK3;2Y29;2Y2A;2Y3J;2Y3K;2Y3L;3AYU;3BAE;3BKJ;3DXC;3DXD;3DXE;3GCI;3IFL;3IFN;3IFO;3IFP;3JQ5;3JQL;3JTI;3KTM;3L33;3L81;3MOQ;3MXC;3MXY;3NYJ;3NYL;3OVJ;3OW9;3PZZ;3Q2X;3SV1;3U0T;3UMH;3UMI;3UMK;4HIX;4JFN;4M1C;4MDR;4MVI;4MVK;4MVL;4NGE;4OJF;4ONF;4ONG;4PQD;4PWQ;4XXD;5AEF;5AM8;5AMB;5BUO;5C67;5CSZ;5HOW;5HOX;5HOY;5KK3;5LFY;5LV0;5MY4;5MYO;5MYX;5ONP;5ONQ;5OQV;5TXD;5VOS;5VZY;5W3P;6CO3;6GFI;6ITU;6IYC;6NB9;6O4J;6OC9;6OIZ;6RHY;6SHS;
InterPro ID IPR036669;IPR008155;IPR013803;IPR037071;IPR011178;IPR024329;IPR008154;IPR015849;IPR036454;IPR019745;IPR028866;IPR019543;IPR019744;IPR036176;IPR002223;IPR036880;IPR011993;IPR020901;
dbSNP rs45588932 rs63750363 rs281865161 rs63750064 rs63750671 rs63751039 rs63750579 rs63750579 rs63749810 rs63750921 rs63750066 rs1800557 rs63750643 rs63750973 rs63750734 rs63750399 rs63750264 rs63749964 rs63750264 rs63750264 rs63751122

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PSEN1 APP 0.997
BACE1 APP 0.995
INS IGF1 0.994
VEGFA EGF 0.993
VEGFA IGF1 0.993
APP APOE 0.993
IGF1 EGF 0.992
APBB1 APP 0.991
INS EGF 0.991
APP SORL1 0.991
FN1 ALB 0.989
VEGFA FN1 0.988
FN1 EGF 0.988
VEGFA ALB 0.986
APP ADAM10 0.986
IL6 ALB 0.983
IL6 MAPK1 0.982
FN1 CDH2 0.981
IGF1 MAPK3 0.981
ALB CP 0.98
CLU APP 0.98
ITM2B APP 0.98
ALB EGF 0.98
IL6 RELA 0.979
CST3 ALB 0.978
MAPK8 APP 0.978
GGA3 BACE1 0.977
GGA1 BACE1 0.976
IL6 MAPK3 0.976
A2M ALB 0.974
IL6 KNG1 0.974
IGF1 ALB 0.974
VEGFA KNG1 0.973
CDH2 ADAM10 0.972
ALB C3 0.972
ALB KNG1 0.971
IL6 FN1 0.971
FN1 MAPK3 0.97
EGF KNG1 0.97
AGER S100B 0.969
APP NGFR 0.969
IL6 APOE 0.969
PSEN2 APP 0.968
FN1 IGF1 0.968
APLP2 ADAM10 0.968
S100B APP 0.968
ALB APOE 0.968
SNCA APP 0.967
INS APP 0.965
ALB APP 0.965
APP CDH2 0.965
FN1 MAPK1 0.965
CLU IGF1 0.964
MAPK10 APP 0.964
CP C3 0.963
IGF1 MAPK1 0.962
CLU EGF 0.961
F2 KNG1 0.961
C3 TTR 0.96
CST3 APOE 0.959
APOE C3 0.959
F2 ALB 0.959
FOXO3 MAPK8 0.959
VEGFA IL6 0.959
MAPK9 APP 0.959
CLU ALB 0.958
A2M KNG1 0.958
FOXO3 MAPK1 0.958
IL6 C3 0.958
INS ALB 0.957
FN1 A2M 0.957
IL6 APP 0.957
EGF ADAM10 0.957
ALB CDH2 0.956
IL6 CST3 0.956
FN1 C3 0.956
CST3 APP 0.956
A2M CLU 0.955
KNG1 C3 0.954
AGER APP 0.954
MAPK8 NGFR 0.954
CLU APOE 0.953
APP MAPK3 0.953
APP TTR 0.953
FN1 APOE 0.952
RELA MAPK8 0.952
RELA MAPK1 0.952
NPY KNG1 0.952
CAPN1 SNCA 0.951
APP IAPP 0.951
A2M IGF1 0.951
IGF1 APP 0.95
A2M APP 0.95
RELA MAPK3 0.95
ADAM10 APOE 0.95
NUCB1 APP 0.95
FN1 KNG1 0.95
GGA3 APP 0.95
IL6 CP 0.949
APP EGF 0.949
APP APLP2 0.948
CP APOE 0.948
NPY PNOC 0.948
APP MAPK1 0.948
APP GAPDH 0.948
APP CP 0.948
IL6 INS 0.947
FN1 APP 0.946
GRM5 APP 0.946
FN1 CLU 0.945
AGER MAPK3 0.945
IL6 CDH2 0.945
CAPN2 APP 0.944
FN1 ADAM10 0.943
VEGFA APP 0.943
GGA1 APP 0.943
CAPN1 APP 0.943
APP CASP6 0.943
KNG1 CP 0.942
PNOC APP 0.942
INS IAPP 0.941
VEGFA CLU 0.941
KNG1 APOE 0.941
IL6 ADAM10 0.941
FOXO3 APP 0.94
APP KNG1 0.94
GSN APP 0.94
F2 MAPK3 0.94
APLP2 APOE 0.94
CAPN2 MAPK3 0.939
FN1 CP 0.939
FOXO3 MAPK3 0.939
S100B MAPK3 0.938
RELA APP 0.938
NPY APP 0.938
F2 APP 0.938
CX3CR1 APP 0.937
NAE1 APP 0.937
F2 IGF1 0.937
CST3 C3 0.937
APP C3 0.937
CLU KNG1 0.936
PSEN1 BACE1 0.935
CST3 FN1 0.934
CAPN2 MAPK1 0.933
ALB ADAM10 0.933
S100B MAPK1 0.933
AGER MAPK1 0.932
IGF1 KNG1 0.93
A2M EGF 0.93
F2 MAPK1 0.93
CX3CR1 C3 0.929
PSEN1 NGFR 0.927
CST3 CP 0.926
APBB1 MAPK8 0.926
VEGFA A2M 0.926
MAPK9 NGFR 0.925
ALB TTR 0.925
NUCB1 ALB 0.923
CASP6 NGFR 0.923
CST3 APLP2 0.922
C3 MAPK1 0.921
FN1 APLP2 0.92
PSEN2 NGFR 0.92
ALB APLP2 0.92
KNG1 APLP2 0.919
VEGFA INS 0.919
MAPK8 MAPK3 0.919
MAPK8 MAPK1 0.918
PNOC KNG1 0.918
MAPK10 NGFR 0.917
ADAM10 C3 0.917
RELA S100B 0.917
TTR MAPK1 0.915
CDH2 APOE 0.915
NUCB1 IL6 0.915
NPY C3 0.913
CDH2 APLP2 0.913
GRM5 KNG1 0.913
RELA AGER 0.913
CST3 ADAM10 0.912
CP APLP2 0.911
CST3 KNG1 0.911
KNG1 ADAM10 0.91
CX3CR1 KNG1 0.91
NUCB1 FN1 0.909
RELA NGFR 0.908
CST3 CDH2 0.908
CDH2 KNG1 0.907
NUCB1 CST3 0.907
APLP2 C3 0.907
NPY CX3CR1 0.906
CDH2 C3 0.905
CX3CR1 PNOC 0.905
CDH2 CP 0.905
MAPK9 MAPK8 0.905
MAPK9 MAPK10 0.904
CAPN1 CAPN2 0.904
CP ADAM10 0.904
MAPK8 MAPK10 0.903
NUCB1 APLP2 0.902
NUCB1 C3 0.902
MAPK3 MAPK1 0.902
NUCB1 APOE 0.902
PNOC C3 0.902
NUCB1 ADAM10 0.902
IL6 APLP2 0.902
NUCB1 CDH2 0.902
NUCB1 CP 0.901
NUCB1 KNG1 0.9
F2 GRM5 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 322 (APBB1) 177 (AGER) 841 (CASP8) 5664 (PSEN2) 5663 (PSEN1) 23621 (BACE1) 351 (APP) 3630 (INS) 3479 (IGF1) 348 (APOE) 213 (ALB) 9445 (ITM2B) 5595 (MAPK3) 1191 (CLU) 26088 (GGA1) 6622 (SNCA) 5599 (MAPK8) 3569 (IL6) 23163 (GGA3) 3339 (HSPG2) 323 (APBB2) 1471 (CST3) 2 (A2M) 334 (APLP2) 1000 (CDH2) 27242 (TNFRSF21) 1950 (EGF) 8883 (NAE1) 321 (APBA2) 6285 (S100B) 5601 (MAPK9) 5602 (MAPK10) 7042 (TGFB2) 2934 (GSN) 1356 (CP) 3827 (KNG1) 102 (ADAM10) 4924 (NUCB1) 4137 (MAPT) 2915 (GRM5) 7040 (TGFB1) 839 (CASP6) 2817 (GPC1) 7276 (TTR) 6653 (SORL1) 320 (APBA1) 335 (APOA1) 5594 (MAPK1) 4804 (NGFR) 2597 (GAPDH) 3375 (IAPP)
322 (APBB1) 1.00 0.67 0.54 0.69 0.61 0.68 0.69 0.73 0.71 0.59 0.61 0.87 0.59 0.76 0.70 0.58 0.58 0.72 0.73 0.77 0.90 0.72 0.67 0.72 0.78 0.68 0.54 0.68 1.00 0.70 0.74 0.62 0.72 0.71 0.56 0.63 0.59 1.00 0.67 0.12 0.69 0.56 0.53 0.74 0.74 1.00 0.64 0.57 0.56 0.58 0.64
177 (AGER) 0.67 1.00 0.52 0.60 0.55 0.52 0.67 0.71 0.65 0.53 0.60 0.64 0.53 0.70 0.67 0.55 0.52 0.66 0.66 0.70 0.66 0.60 0.63 0.70 0.72 0.82 0.62 0.61 1.00 0.72 0.63 0.56 0.62 0.65 0.49 0.56 0.55 1.00 0.66 0.51 0.65 0.52 0.49 0.71 0.75 1.00 0.57 0.55 0.80 0.55 0.66
841 (CASP8) 0.54 0.52 1.00 0.76 0.71 0.73 0.55 0.57 0.51 0.49 0.52 0.48 0.48 0.59 0.54 0.54 0.49 0.51 0.49 0.51 0.50 0.49 0.54 0.53 0.55 0.47 0.45 0.56 1.00 0.57 0.49 0.45 0.53 0.53 0.41 0.46 0.73 1.00 0.58 0.12 0.55 0.92 0.37 0.53 0.46 1.00 0.52 0.51 0.53 0.50 0.46
5664 (PSEN2) 0.69 0.60 0.76 1.00 0.78 0.76 0.64 0.70 0.66 0.49 0.56 0.64 0.49 0.73 0.67 0.53 0.50 0.68 0.67 0.74 0.68 0.54 0.63 0.67 0.77 0.57 0.46 0.62 1.00 0.66 0.62 0.49 0.60 0.66 0.51 0.53 0.80 1.00 0.63 0.13 0.65 0.81 0.51 0.69 0.52 1.00 0.53 0.49 0.50 0.50 0.64
5663 (PSEN1) 0.61 0.55 0.71 0.78 1.00 0.72 0.59 0.61 0.58 0.49 0.54 0.55 0.49 0.62 0.59 0.53 0.49 0.59 0.57 0.60 0.58 0.52 0.59 0.57 0.67 0.52 0.47 0.56 1.00 0.60 0.55 0.48 0.56 0.60 0.45 0.51 0.74 1.00 0.60 0.10 0.60 0.72 0.43 0.58 0.50 1.00 0.53 0.49 0.50 0.49 0.50
23621 (BACE1) 0.68 0.52 0.73 0.76 0.72 1.00 0.59 0.61 0.56 0.53 0.52 0.66 0.50 0.61 0.59 0.53 0.53 0.56 0.54 0.56 0.68 0.60 0.60 0.54 0.61 0.48 0.45 0.55 1.00 0.59 0.52 0.45 0.62 0.56 0.44 0.48 0.72 1.00 0.61 0.11 0.61 0.70 0.40 0.55 0.59 1.00 0.59 0.51 0.49 0.49 0.48
351 (APP) 0.69 0.67 0.55 0.64 0.59 0.59 1.00 0.78 0.72 0.58 0.70 0.67 0.58 0.73 0.68 0.64 0.62 0.73 0.70 0.72 0.68 0.81 0.80 0.84 0.73 0.64 0.56 0.65 1.00 0.71 0.65 0.59 0.69 0.69 0.53 0.74 0.62 1.00 0.76 0.12 0.73 0.56 0.50 0.73 0.60 1.00 0.64 0.59 0.56 0.59 0.71
3630 (INS) 0.73 0.71 0.57 0.70 0.61 0.61 0.78 1.00 0.93 0.57 0.64 0.73 0.60 0.77 0.71 0.59 0.60 0.74 0.75 0.78 0.74 0.72 0.74 0.78 0.79 0.70 0.56 0.69 1.00 0.74 0.71 0.63 0.69 0.72 0.57 0.68 0.66 1.00 0.71 0.12 0.71 0.59 0.55 0.79 0.63 1.00 0.62 0.61 0.57 0.63 0.82
3479 (IGF1) 0.71 0.65 0.51 0.66 0.58 0.56 0.72 0.93 1.00 0.52 0.59 0.69 0.56 0.74 0.68 0.56 0.55 0.72 0.71 0.75 0.71 0.60 0.69 0.70 0.76 0.65 0.53 0.65 1.00 0.69 0.67 0.58 0.67 0.69 0.54 0.66 0.69 1.00 0.66 0.11 0.68 0.52 0.53 0.72 0.59 1.00 0.57 0.54 0.54 0.57 0.78
348 (APOE) 0.59 0.53 0.49 0.49 0.49 0.53 0.58 0.57 0.52 1.00 0.63 0.56 0.47 0.54 0.56 0.65 0.50 0.52 0.50 0.52 0.58 0.59 0.59 0.54 0.55 0.48 0.48 0.50 1.00 0.66 0.50 0.47 0.61 0.56 0.40 0.61 0.53 1.00 0.59 0.11 0.55 0.48 0.42 0.54 0.53 1.00 0.81 0.49 0.50 0.49 0.50
213 (ALB) 0.61 0.60 0.52 0.56 0.54 0.52 0.70 0.64 0.59 0.63 1.00 0.57 0.52 0.64 0.61 0.70 0.52 0.60 0.58 0.60 0.59 0.57 0.60 0.72 0.63 0.55 0.50 0.57 1.00 0.69 0.57 0.52 0.58 0.63 0.50 0.61 0.54 1.00 0.68 0.13 0.60 0.52 0.54 0.62 0.53 1.00 0.60 0.53 0.53 0.54 0.54
9445 (ITM2B) 0.87 0.64 0.48 0.64 0.55 0.66 0.67 0.73 0.69 0.56 0.57 1.00 0.50 0.77 0.69 0.53 0.51 0.72 0.74 0.81 0.96 0.72 0.65 0.72 0.81 0.64 0.48 0.64 1.00 0.68 0.67 0.53 0.72 0.70 0.53 0.57 0.54 1.00 0.65 0.13 0.68 0.47 0.54 0.74 0.72 1.00 0.62 0.50 0.51 0.51 0.69
5595 (MAPK3) 0.59 0.53 0.48 0.49 0.49 0.50 0.58 0.60 0.56 0.47 0.52 0.50 1.00 0.60 0.57 0.52 0.86 0.56 0.52 0.56 0.54 0.48 0.59 0.54 0.62 0.47 0.63 0.53 1.00 0.59 0.79 0.78 0.72 0.56 0.42 0.47 0.49 1.00 0.61 0.13 0.59 0.44 0.40 0.55 0.47 1.00 0.51 0.98 0.49 0.52 0.48
1191 (CLU) 0.76 0.70 0.59 0.73 0.62 0.61 0.73 0.77 0.74 0.54 0.64 0.77 0.60 1.00 0.74 0.56 0.59 0.77 0.80 0.84 0.78 0.64 0.69 0.77 0.83 0.73 0.54 0.81 1.00 0.72 0.74 0.64 0.66 0.74 0.69 0.64 0.60 1.00 0.68 0.13 0.72 0.56 0.57 0.79 0.63 1.00 0.59 0.57 0.62 0.59 0.71
26088 (GGA1) 0.70 0.67 0.54 0.67 0.59 0.59 0.68 0.71 0.68 0.56 0.61 0.69 0.57 0.74 1.00 0.55 0.59 0.70 0.86 0.75 0.70 0.60 0.67 0.70 0.77 0.66 0.54 0.74 1.00 0.68 0.67 0.59 0.67 0.69 0.55 0.60 0.59 1.00 0.65 0.17 0.68 0.54 0.52 0.71 0.69 1.00 0.60 0.56 0.62 0.56 0.64
6622 (SNCA) 0.58 0.55 0.54 0.53 0.53 0.53 0.64 0.59 0.56 0.65 0.70 0.53 0.52 0.56 0.55 1.00 0.53 0.55 0.54 0.55 0.54 0.61 0.60 0.59 0.57 0.52 0.50 0.54 1.00 0.76 0.53 0.51 0.55 0.67 0.46 0.71 0.54 1.00 0.62 0.10 0.56 0.53 0.57 0.56 0.51 1.00 0.60 0.54 0.50 0.55 0.48
5599 (MAPK8) 0.58 0.52 0.49 0.50 0.49 0.53 0.62 0.60 0.55 0.50 0.52 0.51 0.86 0.59 0.59 0.53 1.00 0.55 0.53 0.55 0.54 0.55 0.65 0.53 0.60 0.48 0.64 0.54 1.00 0.58 0.77 0.75 0.68 0.55 0.42 0.51 0.50 1.00 0.61 0.12 0.61 0.45 0.40 0.54 0.48 1.00 0.56 0.86 0.50 0.52 0.46
3569 (IL6) 0.72 0.66 0.51 0.68 0.59 0.56 0.73 0.74 0.72 0.52 0.60 0.72 0.56 0.77 0.70 0.55 0.55 1.00 0.74 0.79 0.73 0.61 0.69 0.73 0.79 0.67 0.58 0.67 1.00 0.70 0.69 0.59 0.71 0.71 0.56 0.66 0.61 1.00 0.66 0.12 0.76 0.52 0.54 0.74 0.60 1.00 0.57 0.54 0.55 0.56 0.80
23163 (GGA3) 0.73 0.66 0.49 0.67 0.57 0.54 0.70 0.75 0.71 0.50 0.58 0.74 0.52 0.80 0.86 0.54 0.53 0.74 1.00 0.84 0.75 0.59 0.67 0.74 0.83 0.67 0.49 0.67 1.00 0.70 0.69 0.56 0.63 0.71 0.55 0.59 0.55 1.00 0.66 0.13 0.70 0.48 0.56 0.77 0.70 1.00 0.56 0.51 0.55 0.52 0.72
3339 (HSPG2) 0.77 0.70 0.51 0.74 0.60 0.56 0.72 0.78 0.75 0.52 0.60 0.81 0.56 0.84 0.75 0.55 0.55 0.79 0.84 1.00 0.81 0.62 0.68 0.80 0.88 0.74 0.51 0.71 1.00 0.72 0.75 0.61 0.65 0.75 0.61 0.63 0.58 1.00 0.67 0.14 0.71 0.52 0.60 0.82 0.61 1.00 0.57 0.54 0.55 0.56 0.78
323 (APBB2) 0.90 0.66 0.50 0.68 0.58 0.68 0.68 0.74 0.71 0.58 0.59 0.96 0.54 0.78 0.70 0.54 0.54 0.73 0.75 0.81 1.00 0.73 0.66 0.73 0.81 0.67 0.50 0.67 1.00 0.69 0.75 0.58 0.73 0.71 0.56 0.60 0.56 1.00 0.66 0.13 0.69 0.51 0.55 0.75 0.73 1.00 0.63 0.53 0.54 0.54 0.69
1471 (CST3) 0.72 0.60 0.49 0.54 0.52 0.60 0.81 0.72 0.60 0.59 0.57 0.72 0.48 0.64 0.60 0.61 0.55 0.61 0.59 0.62 0.73 1.00 0.78 0.64 0.66 0.54 0.49 0.56 1.00 0.65 0.57 0.49 0.66 0.60 0.44 0.75 0.52 1.00 0.64 0.11 0.62 0.49 0.44 0.65 0.62 1.00 0.64 0.51 0.50 0.52 0.59
2 (A2M) 0.67 0.63 0.54 0.63 0.59 0.60 0.80 0.74 0.69 0.59 0.60 0.65 0.59 0.69 0.67 0.60 0.65 0.69 0.67 0.68 0.66 0.78 1.00 0.66 0.70 0.63 0.59 0.64 1.00 0.69 0.64 0.59 0.66 0.66 0.51 0.72 0.61 1.00 0.67 0.11 0.71 0.55 0.53 0.67 0.60 1.00 0.65 0.57 0.59 0.57 0.61
334 (APLP2) 0.72 0.70 0.53 0.67 0.57 0.54 0.84 0.78 0.70 0.54 0.72 0.72 0.54 0.77 0.70 0.59 0.53 0.73 0.74 0.80 0.73 0.64 0.66 1.00 0.80 0.66 0.50 0.66 1.00 0.73 0.68 0.57 0.64 0.71 0.55 0.59 0.57 1.00 0.75 0.13 0.68 0.54 0.55 0.81 0.58 1.00 0.58 0.56 0.53 0.58 0.79
1000 (CDH2) 0.78 0.72 0.55 0.77 0.67 0.61 0.73 0.79 0.76 0.55 0.63 0.81 0.62 0.83 0.77 0.57 0.60 0.79 0.83 0.88 0.81 0.66 0.70 0.80 1.00 0.76 0.56 0.74 1.00 0.73 0.77 0.67 0.68 0.77 0.63 0.67 0.62 1.00 0.69 0.13 0.73 0.58 0.60 0.82 0.66 1.00 0.60 0.59 0.58 0.61 0.74
27242 (TNFRSF21) 0.68 0.82 0.47 0.57 0.52 0.48 0.64 0.70 0.65 0.48 0.55 0.64 0.47 0.73 0.66 0.52 0.48 0.67 0.67 0.74 0.67 0.54 0.63 0.66 0.76 1.00 0.56 0.60 1.00 0.66 0.61 0.49 0.60 0.66 0.47 0.53 0.51 1.00 0.63 0.57 0.65 0.43 0.51 0.69 0.71 1.00 0.53 0.47 0.73 0.47 0.64
1950 (EGF) 0.54 0.62 0.45 0.46 0.47 0.45 0.56 0.56 0.53 0.48 0.50 0.48 0.63 0.54 0.54 0.50 0.64 0.58 0.49 0.51 0.50 0.49 0.59 0.50 0.56 0.56 1.00 0.49 1.00 0.55 0.57 0.57 0.61 0.52 0.38 0.49 0.48 1.00 0.58 0.30 0.55 0.42 0.37 0.51 0.56 1.00 0.52 0.65 0.61 0.47 0.48
8883 (NAE1) 0.68 0.61 0.56 0.62 0.56 0.55 0.65 0.69 0.65 0.50 0.57 0.64 0.53 0.81 0.74 0.54 0.54 0.67 0.67 0.71 0.67 0.56 0.64 0.66 0.74 0.60 0.49 1.00 1.00 0.66 0.63 0.53 0.65 0.66 0.51 0.56 0.55 1.00 0.64 0.12 0.66 0.49 0.50 0.68 0.55 1.00 0.55 0.52 0.57 0.53 0.60
321 (APBA2) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82 1.00 1.00 1.00 1.00 0.14 1.00 1.00 0.71 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82
6285 (S100B) 0.70 0.72 0.57 0.66 0.60 0.59 0.71 0.74 0.69 0.66 0.69 0.68 0.59 0.72 0.68 0.76 0.58 0.70 0.70 0.72 0.69 0.65 0.69 0.73 0.73 0.66 0.55 0.66 1.00 1.00 0.67 0.61 0.69 0.80 0.54 0.75 0.65 1.00 0.71 0.11 0.68 0.60 0.62 0.74 0.61 1.00 0.61 0.60 0.57 0.62 0.70
5601 (MAPK9) 0.74 0.63 0.49 0.62 0.55 0.52 0.65 0.71 0.67 0.50 0.57 0.67 0.79 0.74 0.67 0.53 0.77 0.69 0.69 0.75 0.75 0.57 0.64 0.68 0.77 0.61 0.57 0.63 1.00 0.67 1.00 0.90 0.72 0.67 0.51 0.56 0.54 1.00 0.64 0.14 0.66 0.47 0.52 0.70 0.56 1.00 0.55 0.77 0.53 0.53 0.64
5602 (MAPK10) 0.62 0.56 0.45 0.49 0.48 0.45 0.59 0.63 0.58 0.47 0.52 0.53 0.78 0.64 0.59 0.51 0.75 0.59 0.56 0.61 0.58 0.49 0.59 0.57 0.67 0.49 0.57 0.53 1.00 0.61 0.90 1.00 0.71 0.59 0.41 0.48 0.48 1.00 0.61 0.17 0.61 0.40 0.44 0.59 0.48 1.00 0.51 0.76 0.51 0.47 0.53
7042 (TGFB2) 0.72 0.62 0.53 0.60 0.56 0.62 0.69 0.69 0.67 0.61 0.58 0.72 0.72 0.66 0.67 0.55 0.68 0.71 0.63 0.65 0.73 0.66 0.66 0.64 0.68 0.60 0.61 0.65 1.00 0.69 0.72 0.71 1.00 0.63 0.49 0.63 0.65 1.00 0.66 0.12 0.82 0.53 0.46 0.65 0.65 1.00 0.63 0.73 0.56 0.57 0.69
2934 (GSN) 0.71 0.65 0.53 0.66 0.60 0.56 0.69 0.72 0.69 0.56 0.63 0.70 0.56 0.74 0.69 0.67 0.55 0.71 0.71 0.75 0.71 0.60 0.66 0.71 0.77 0.66 0.52 0.66 1.00 0.80 0.67 0.59 0.63 1.00 0.54 0.66 0.57 1.00 0.69 0.12 0.68 0.53 0.61 0.72 0.59 1.00 0.57 0.54 0.55 0.56 0.63
1356 (CP) 0.56 0.49 0.41 0.51 0.45 0.44 0.53 0.57 0.54 0.40 0.50 0.53 0.42 0.69 0.55 0.46 0.42 0.56 0.55 0.61 0.56 0.44 0.51 0.55 0.63 0.47 0.38 0.51 0.82 0.54 0.51 0.41 0.49 0.54 1.00 0.44 0.44 0.82 0.52 0.11 0.53 0.39 0.42 0.57 0.42 0.82 0.44 0.42 0.41 0.44 0.53
3827 (KNG1) 0.63 0.56 0.46 0.53 0.51 0.48 0.74 0.68 0.66 0.61 0.61 0.57 0.47 0.64 0.60 0.71 0.51 0.66 0.59 0.63 0.60 0.75 0.72 0.59 0.67 0.53 0.49 0.56 1.00 0.75 0.56 0.48 0.63 0.66 0.44 1.00 0.54 1.00 0.62 0.11 0.66 0.45 0.57 0.61 0.50 1.00 0.58 0.47 0.49 0.47 0.61
102 (ADAM10) 0.59 0.55 0.73 0.80 0.74 0.72 0.62 0.66 0.69 0.53 0.54 0.54 0.49 0.60 0.59 0.54 0.50 0.61 0.55 0.58 0.56 0.52 0.61 0.57 0.62 0.51 0.48 0.55 1.00 0.65 0.54 0.48 0.65 0.57 0.44 0.54 1.00 1.00 0.64 0.10 0.63 0.75 0.42 0.58 0.49 1.00 0.55 0.50 0.49 0.51 0.58
4924 (NUCB1) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82 1.00 1.00 1.00 1.00 0.14 1.00 1.00 0.71 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82
4137 (MAPT) 0.67 0.66 0.58 0.63 0.60 0.61 0.76 0.71 0.66 0.59 0.68 0.65 0.61 0.68 0.65 0.62 0.61 0.66 0.66 0.67 0.66 0.64 0.67 0.75 0.69 0.63 0.58 0.64 1.00 0.71 0.64 0.61 0.66 0.69 0.52 0.62 0.64 1.00 1.00 0.12 0.67 0.59 0.48 0.69 0.66 1.00 0.63 0.62 0.59 0.67 0.61
2915 (GRM5) 0.12 0.51 0.12 0.13 0.10 0.11 0.12 0.12 0.11 0.11 0.13 0.13 0.13 0.13 0.17 0.10 0.12 0.12 0.13 0.14 0.13 0.11 0.11 0.13 0.13 0.57 0.30 0.12 0.14 0.11 0.14 0.17 0.12 0.12 0.11 0.11 0.10 0.14 0.12 1.00 0.11 0.10 0.10 0.13 0.44 0.14 0.11 0.12 0.43 0.10 0.12
7040 (TGFB1) 0.69 0.65 0.55 0.65 0.60 0.61 0.73 0.71 0.68 0.55 0.60 0.68 0.59 0.72 0.68 0.56 0.61 0.76 0.70 0.71 0.69 0.62 0.71 0.68 0.73 0.65 0.55 0.66 1.00 0.68 0.66 0.61 0.82 0.68 0.53 0.66 0.63 1.00 0.67 0.11 1.00 0.56 0.50 0.69 0.61 1.00 0.60 0.58 0.58 0.58 0.70
839 (CASP6) 0.56 0.52 0.92 0.81 0.72 0.70 0.56 0.59 0.52 0.48 0.52 0.47 0.44 0.56 0.54 0.53 0.45 0.52 0.48 0.52 0.51 0.49 0.55 0.54 0.58 0.43 0.42 0.49 1.00 0.60 0.47 0.40 0.53 0.53 0.39 0.45 0.75 1.00 0.59 0.10 0.56 1.00 0.38 0.56 0.44 1.00 0.51 0.47 0.46 0.47 0.51
2817 (GPC1) 0.53 0.49 0.37 0.51 0.43 0.40 0.50 0.55 0.53 0.42 0.54 0.54 0.40 0.57 0.52 0.57 0.40 0.54 0.56 0.60 0.55 0.44 0.53 0.55 0.60 0.51 0.37 0.50 0.71 0.62 0.52 0.44 0.46 0.61 0.42 0.57 0.42 0.71 0.48 0.10 0.50 0.38 1.00 0.56 0.43 0.71 0.42 0.39 0.42 0.40 0.51
7276 (TTR) 0.74 0.71 0.53 0.69 0.58 0.55 0.73 0.79 0.72 0.54 0.62 0.74 0.55 0.79 0.71 0.56 0.54 0.74 0.77 0.82 0.75 0.65 0.67 0.81 0.82 0.69 0.51 0.68 1.00 0.74 0.70 0.59 0.65 0.72 0.57 0.61 0.58 1.00 0.69 0.13 0.69 0.56 0.56 1.00 0.59 1.00 0.59 0.57 0.54 0.59 0.80
6653 (SORL1) 0.74 0.75 0.46 0.52 0.50 0.59 0.60 0.63 0.59 0.53 0.53 0.72 0.47 0.63 0.69 0.51 0.48 0.60 0.70 0.61 0.73 0.62 0.60 0.58 0.66 0.71 0.56 0.55 1.00 0.61 0.56 0.48 0.65 0.59 0.42 0.50 0.49 1.00 0.66 0.44 0.61 0.44 0.43 0.59 1.00 1.00 0.59 0.47 0.71 0.46 0.52
320 (APBA1) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82 1.00 1.00 1.00 1.00 0.14 1.00 1.00 0.71 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.82
335 (APOA1) 0.64 0.57 0.52 0.53 0.53 0.59 0.64 0.62 0.57 0.81 0.60 0.62 0.51 0.59 0.60 0.60 0.56 0.57 0.56 0.57 0.63 0.64 0.65 0.58 0.60 0.53 0.52 0.55 1.00 0.61 0.55 0.51 0.63 0.57 0.44 0.58 0.55 1.00 0.63 0.11 0.60 0.51 0.42 0.59 0.59 1.00 1.00 0.53 0.53 0.52 0.56
5594 (MAPK1) 0.57 0.55 0.51 0.49 0.49 0.51 0.59 0.61 0.54 0.49 0.53 0.50 0.98 0.57 0.56 0.54 0.86 0.54 0.51 0.54 0.53 0.51 0.57 0.56 0.59 0.47 0.65 0.52 1.00 0.60 0.77 0.76 0.73 0.54 0.42 0.47 0.50 1.00 0.62 0.12 0.58 0.47 0.39 0.57 0.47 1.00 0.53 1.00 0.49 0.55 0.51
4804 (NGFR) 0.56 0.80 0.53 0.50 0.50 0.49 0.56 0.57 0.54 0.50 0.53 0.51 0.49 0.62 0.62 0.50 0.50 0.55 0.55 0.55 0.54 0.50 0.59 0.53 0.58 0.73 0.61 0.57 1.00 0.57 0.53 0.51 0.56 0.55 0.41 0.49 0.49 1.00 0.59 0.43 0.58 0.46 0.42 0.54 0.71 1.00 0.53 0.49 1.00 0.47 0.45
2597 (GAPDH) 0.58 0.55 0.50 0.50 0.49 0.49 0.59 0.63 0.57 0.49 0.54 0.51 0.52 0.59 0.56 0.55 0.52 0.56 0.52 0.56 0.54 0.52 0.57 0.58 0.61 0.47 0.47 0.53 1.00 0.62 0.53 0.47 0.57 0.56 0.44 0.47 0.51 1.00 0.67 0.10 0.58 0.47 0.40 0.59 0.46 1.00 0.52 0.55 0.47 1.00 0.54
3375 (IAPP) 0.64 0.66 0.46 0.64 0.50 0.48 0.71 0.82 0.78 0.50 0.54 0.69 0.48 0.71 0.64 0.48 0.46 0.80 0.72 0.78 0.69 0.59 0.61 0.79 0.74 0.64 0.48 0.60 0.82 0.70 0.64 0.53 0.69 0.63 0.53 0.61 0.58 0.82 0.61 0.12 0.70 0.51 0.51 0.80 0.52 0.82 0.56 0.51 0.45 0.54 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
APP Human Plasma - 3760 m 1-3 day upregulated 2 2-DE Southeast Asia Han-Chinese 1 Lowland Han-Chinese individuals from Xining, China (2,260 m above sea level) 24940404
APP Human Plasma - 3500-4000m Native downregulated -1.54 2-DE Northern indo-australian plate Ladakhi 1 Sea level healthy individuals 23844025
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
CHD2 1106 APP 351 distal 22955619 TRANSFAC
NFKB1 4790 APP 351 distal 22955619 TRANSFAC
EP300 2033 APP 351 distal 22955619 TRANSFAC
IRF4 3662 APP 351 distal 22955619 TRANSFAC
MEF2C 4208 APP 351 distal 22955619 TRANSFAC
SPI1 6688 APP 351 distal 22955619 TRANSFAC
BATF 10538 APP 351 distal 22955619 TRANSFAC
JUND 3727 APP 351 distal 22955619 TRANSFAC
STAT3 6774 APP 351 distal 22955619 TRANSFAC
SRF 6722 APP 351 distal 22955619 TRANSFAC
MEF2A 4205 APP 351 distal 22955619 TRANSFAC
BCL3 602 APP 351 distal 22955619 TRANSFAC
TBP 6908 APP 351 distal 22955619 TRANSFAC
RAD21 5885 APP 351 distal 22955619 TRANSFAC
RXRA 6256 APP 351 distal 22955619 TRANSFAC
TCF12 6938 APP 351 distal 22955619 TRANSFAC
BCL11A 53335 APP 351 distal 22955619 TRANSFAC
EBF1 1879 APP 351 distal 22955619 TRANSFAC
PAX5 5079 APP 351 distal 22955619 TRANSFAC
POU2F2 5452 APP 351 distal 22955619 TRANSFAC
SP1 6667 APP 351 distal 22955619 TRANSFAC
CTCF 10664 APP 351 proximal_filtered 22955619 TRANSFAC
HDAC9 9734 APP 351 Unknown 15469392 TRUSST
STAT1 6772 APP 351 Unknown 19067706 TRUSST
NFIL3 4783 APP 351 Activation 20331626 TRUSST
ETS2 2114 APP 351 Activation 15184887 TRUSST
TFAP2A 7020 APP 351 Unknown 7961760 TRUSST
JUN 3725 APP 351 Unknown 19131553 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT000373 hsa-miR-106b-5p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 19110058
MIRT000430 hsa-miR-101-3p Homo sapiens APP 351 Homo sapiens qRT-PCR//Luciferase reporter assay//Western blot Functional MTI 20395292
MIRT000430 hsa-miR-101-3p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 21172309
MIRT000430 hsa-miR-101-3p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT001934 hsa-miR-520c-3p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay//Western blot//qRT-PCR Functional MTI 18684319
MIRT001935 hsa-miR-106a-5p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay Non-Functional MTI 19110058
MIRT001935 hsa-miR-106a-5p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay//Western blot//qRT-PCR Functional MTI 18684319
MIRT003382 hsa-miR-20a-5p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 19110058
MIRT003382 hsa-miR-20a-5p Homo sapiens APP 351 Homo sapiens GFP reporter assay//qRT-PCR//Western blot Functional MTI 20458444
MIRT003900 hsa-miR-130a-3p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay Non-Functional MTI 19110058
MIRT003902 hsa-let-7a-5p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay Non-Functional MTI 19110058
MIRT003898 hsa-miR-17-5p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 19110058
MIRT003899 hsa-miR-15a-5p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay Non-Functional MTI 19110058
MIRT003901 hsa-let-7d-5p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay Non-Functional MTI 19110058
MIRT003899 hsa-miR-15a-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT003898 hsa-miR-17-5p Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT031838 hsa-miR-16-5p Homo sapiens APP 351 Homo sapiens ELISA//Immunoprecipitaion//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 26440600
MIRT031838 hsa-miR-16-5p Homo sapiens APP 351 Homo sapiens Proteomics Functional MTI (Weak) 18668040
MIRT031838 hsa-miR-16-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT037918 hsa-miR-532-3p Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT038001 hsa-miR-500a-5p Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042260 hsa-miR-484 Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT042631 hsa-miR-423-3p Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT043760 hsa-miR-328-3p Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046755 hsa-miR-222-3p Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT048186 hsa-miR-196a-5p Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052777 hsa-miR-1260b Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT052863 hsa-miR-3620-3p Homo sapiens APP 351 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT084793 hsa-let-7g-3p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT084789 hsa-let-7a-2-3p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT407081 hsa-miR-6504-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT543071 hsa-miR-298 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543081 hsa-miR-144-3p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543077 hsa-miR-6838-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543075 hsa-miR-3662 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543079 hsa-miR-424-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543073 hsa-miR-545-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543076 hsa-miR-15b-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543080 hsa-miR-195-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543074 hsa-miR-3688-3p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543070 hsa-miR-455-3p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543081 hsa-miR-144-3p Homo sapiens APP 351 Homo sapiens Luciferase reporter assay//qRT-PCR Functional MTI 27329039
MIRT543072 hsa-miR-490-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT543078 hsa-miR-497-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT549360 hsa-miR-4495 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT549363 hsa-miR-4311 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT549358 hsa-miR-4786-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT549361 hsa-miR-583 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT549359 hsa-miR-4698 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT549358 hsa-miR-4786-5p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT549362 hsa-miR-1276 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT559572 hsa-miR-190a-3p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT559573 hsa-miR-5011-5p Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT559574 hsa-miR-567 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT559570 hsa-miR-297 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT559571 hsa-miR-3924 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT559575 hsa-miR-944 Homo sapiens APP 351 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT660580 hsa-miR-7111-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660588 hsa-miR-548f-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660591 hsa-miR-548ar-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660579 hsa-miR-6881-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660590 hsa-miR-548az-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660592 hsa-miR-548a-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660584 hsa-miR-5696 Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660577 hsa-miR-1238-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660578 hsa-miR-670-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660581 hsa-miR-6780a-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660583 hsa-miR-579-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660587 hsa-miR-5582-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660589 hsa-miR-548e-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660585 hsa-miR-302d-5p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660586 hsa-miR-302b-5p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT660582 hsa-miR-664b-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT705588 hsa-miR-224-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705583 hsa-miR-6073 Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705581 hsa-miR-1229-5p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705584 hsa-miR-3132 Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705585 hsa-miR-197-5p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705587 hsa-miR-522-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705582 hsa-miR-3606-5p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT705586 hsa-miR-3908 Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 23313552
MIRT710394 hsa-miR-3646 Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT710391 hsa-miR-5093 Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT710389 hsa-miR-4709-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT710392 hsa-miR-5584-5p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT710393 hsa-miR-6502-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723035 hsa-miR-548ad-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723031 hsa-miR-3120-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723034 hsa-miR-424-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723032 hsa-miR-551b-5p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT723033 hsa-miR-4484 Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT785112 hsa-miR-3672 Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT785939 hsa-miR-4461 Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT789117 hsa-miR-6864-3p Homo sapiens APP 351 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
Gene Ontology
ID GO ID GO Term GO Type
351 GO:0007409 axonogenesis GOTERM_BP_DIRECT
351 GO:0002576 platelet degranulation GOTERM_BP_DIRECT
351 GO:0001878 response to yeast GOTERM_BP_DIRECT
351 GO:0007219 Notch signaling pathway GOTERM_BP_DIRECT
351 GO:0007399 nervous system development GOTERM_BP_DIRECT
351 GO:0006878 cellular copper ion homeostasis GOTERM_BP_DIRECT
351 GO:0008344 adult locomotory behavior GOTERM_BP_DIRECT
351 GO:0010951 negative regulation of endopeptidase activity GOTERM_BP_DIRECT
351 GO:0008088 axo-dendritic transport GOTERM_BP_DIRECT
351 GO:0001967 suckling behavior GOTERM_BP_DIRECT
351 GO:0007626 locomotory behavior GOTERM_BP_DIRECT
351 GO:0010952 positive regulation of peptidase activity GOTERM_BP_DIRECT
351 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GOTERM_BP_DIRECT
351 GO:0006417 regulation of translation GOTERM_BP_DIRECT
351 GO:0016199 axon midline choice point recognition GOTERM_BP_DIRECT
351 GO:0006468 protein phosphorylation GOTERM_BP_DIRECT
351 GO:0006897 endocytosis GOTERM_BP_DIRECT
351 GO:0006378 mRNA polyadenylation GOTERM_BP_DIRECT
351 GO:0007617 mating behavior GOTERM_BP_DIRECT
351 GO:0006979 response to oxidative stress GOTERM_BP_DIRECT
351 GO:0007155 cell adhesion GOTERM_BP_DIRECT
351 GO:0007176 regulation of epidermal growth factor-activated receptor activity GOTERM_BP_DIRECT
351 GO:0008203 cholesterol metabolic process GOTERM_BP_DIRECT
351 GO:0008542 visual learning GOTERM_BP_DIRECT
351 GO:0009987 cellular process GOTERM_BP_DIRECT
351 GO:0010288 response to lead ion GOTERM_BP_DIRECT
351 GO:0045087 innate immune response GOTERM_BP_DIRECT
351 GO:0004867 endopeptidase inhibitor activity GOTERM_MF_DIRECT
351 GO:0019899 enzyme binding GOTERM_MF_DIRECT
351 GO:0070851 leucine binding GOTERM_MF_DIRECT
351 GO:0005737 cytoplasm GOTERM_CC_DIRECT
351 GO:0005905 clathrin-coated pit GOTERM_CC_DIRECT
351 GO:0016322 neuron remodeling GOTERM_BP_DIRECT
351 GO:0040014 regulation of multicellular organism growth GOTERM_BP_DIRECT
351 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
351 GO:0043195 terminal bouton GOTERM_CC_DIRECT
351 GO:0031175 neuron projection development GOTERM_BP_DIRECT
351 GO:0051124 synaptic growth at neuromuscular junction GOTERM_BP_DIRECT
351 GO:0005886 plasma membrane GOTERM_CC_DIRECT
351 GO:0035253 ciliary rootlet GOTERM_CC_DIRECT
351 GO:0033130 GTPase activating protein binding GOTERM_MF_DIRECT
351 GO:0031093 platelet alpha granule lumen GOTERM_CC_DIRECT
351 GO:0050829 defense response to Gram-negative bacterium GOTERM_BP_DIRECT
351 GO:0008233 heparin binding GOTERM_MF_DIRECT
351 GO:0005641 nuclear envelope lumen GOTERM_CC_DIRECT
351 GO:0005794 Golgi apparatus GOTERM_CC_DIRECT
351 GO:0048669 collateral sprouting in absence of injury GOTERM_BP_DIRECT
351 GO:0050803 regulation of synapse structure or activity GOTERM_BP_DIRECT
351 GO:0051402 neuron apoptotic process GOTERM_BP_DIRECT
351 GO:0005102 receptor binding GOTERM_MF_DIRECT
351 GO:0051425 NAD binding GOTERM_MF_DIRECT
351 GO:0005829 cytosol GOTERM_CC_DIRECT
351 GO:0043197 dendritic spine GOTERM_CC_DIRECT
351 GO:0019732 antifungal humoral response GOTERM_BP_DIRECT
351 GO:0071320 cellular response to cAMP GOTERM_BP_DIRECT
351 GO:0030134 ER to Golgi transport vesicle GOTERM_CC_DIRECT
351 GO:0031594 neuromuscular junction GOTERM_CC_DIRECT
351 GO:0032588 trans-Golgi network membrane GOTERM_CC_DIRECT
351 GO:0030900 forebrain development GOTERM_BP_DIRECT
351 GO:0008201 ferrous iron binding GOTERM_MF_DIRECT
351 GO:0030198 extracellular matrix organization GOTERM_BP_DIRECT
351 GO:0045665 negative regulation of neuron differentiation GOTERM_BP_DIRECT
351 GO:0050885 neuromuscular process controlling balance GOTERM_BP_DIRECT
351 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis GOTERM_BP_DIRECT
351 GO:0003677 DNA binding GOTERM_MF_DIRECT
351 GO:0005576 extracellular region GOTERM_CC_DIRECT
351 GO:0046914 metal ion binding GOTERM_MF_DIRECT
351 GO:0005615 extracellular space GOTERM_CC_DIRECT
351 GO:0031904 endosome lumen GOTERM_CC_DIRECT
351 GO:0043393 regulation of protein binding GOTERM_BP_DIRECT
351 GO:0050830 defense response to Gram-positive bacterium GOTERM_BP_DIRECT
351 GO:0005515 protein binding GOTERM_MF_DIRECT
351 GO:0016504 oxidoreductase activity GOTERM_MF_DIRECT
351 GO:0009986 cell surface GOTERM_CC_DIRECT
351 GO:0044267 cellular protein metabolic process GOTERM_BP_DIRECT
351 GO:0016358 dendrite development GOTERM_BP_DIRECT
351 GO:0045931 positive regulation of mitotic cell cycle GOTERM_BP_DIRECT
351 GO:1990090 cellular response to nerve growth factor stimulus GOTERM_BP_DIRECT
351 GO:0019731 antibacterial humoral response GOTERM_BP_DIRECT
351 GO:0035235 ionotropic glutamate receptor signaling pathway GOTERM_BP_DIRECT
351 GO:0071874 cellular response to norepinephrine stimulus GOTERM_BP_DIRECT
351 GO:0005768 endosome GOTERM_CC_DIRECT
351 GO:0005887 integral component of plasma membrane GOTERM_CC_DIRECT
351 GO:0030424 axon GOTERM_CC_DIRECT
351 GO:1990000 amyloid fibril formation GOTERM_BP_DIRECT
351 GO:0042802 identical protein binding GOTERM_MF_DIRECT
351 GO:0005790 smooth endoplasmic reticulum GOTERM_CC_DIRECT
351 GO:0005791 rough endoplasmic reticulum GOTERM_CC_DIRECT
351 GO:0005911 cell-cell junction GOTERM_CC_DIRECT
351 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
351 GO:0043198 dendritic shaft GOTERM_CC_DIRECT
351 GO:0045121 membrane raft GOTERM_CC_DIRECT
351 GO:0097449 astrocyte projection GOTERM_CC_DIRECT
351 GO:0048471 perinuclear region of cytoplasm GOTERM_CC_DIRECT
351 GO:1990812 growth cone filopodium GOTERM_CC_DIRECT
351 GO:0044304 main axon GOTERM_CC_DIRECT
351 GO:0045177 apical part of cell GOTERM_CC_DIRECT
351 GO:0051233 spindle midzone GOTERM_CC_DIRECT
351 GO:1990761 growth cone lamellipodium GOTERM_CC_DIRECT
351 GO:0043231 intracellular membrane-bounded organelle GOTERM_CC_DIRECT
351 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
351 GO:0043235 receptor complex GOTERM_CC_DIRECT
351 GO:0045202 synapse GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
351 hsa04726 Serotonergic synapse
351 hsa05010 Alzheimer's disease
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
APP 351 Sporadic Cerebral Amyloid Angiopathy C0338582 Disease or Syndrome 0.31 0.43 0.862 disease
APP 351 Fragile X Syndrome C0016667 Disease or Syndrome 0.32 0.43 0.862 disease
APP 351 Weight Gain C0043094 Finding 0.3 0.43 0.862 phenotype
APP 351 Hysterical amnesia C0233750 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Acute Confusional Senile Dementia C0546126 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Tactile Amnesia C0750906 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.43 0.862 disease
APP 351 Necrosis C0027540 Organ or Tissue Function 0.3 0.43 0.862 phenotype
APP 351 Nerve Degeneration C0027746 Cell or Molecular Dysfunction 0.3 0.43 0.862 phenotype
APP 351 Dissociative Amnesia C0236795 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Alzheimer's Disease, Focal Onset C0750900 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 FRAXE Syndrome C0751157 Disease or Syndrome 0.3 0.43 0.862 disease
APP 351 Memory Disorder, Spatial C0751294 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Senile Plaques C0333463 Acquired Abnormality 0.4 0.43 0.862 phenotype
APP 351 Senile Paranoid Dementia C0338630 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Learning Disorders C0023186 Mental or Behavioral Dysfunction 0.3 0.43 0.862 group
APP 351 Degenerative Diseases, Central Nervous System C0270715 Disease or Syndrome 0.3 0.43 0.862 group
APP 351 Alzheimer Disease, Late Onset C0494463 Mental or Behavioral Dysfunction 0.4 0.43 0.862 disease
APP 351 Amnestic State C0750907 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Cognition Disorders C0009241 Mental or Behavioral Dysfunction 0.4 0.43 0.862 group
APP 351 Memory Disorders C0025261 Mental or Behavioral Dysfunction 0.31 0.43 0.862 disease
APP 351 Dementia C0497327 Mental or Behavioral Dysfunction 0.5 0.43 0.862 disease
APP 351 Memory impairment C0233794 Mental or Behavioral Dysfunction 0.5 0.43 0.862 phenotype
APP 351 Neurogenic Inflammation C0600467 Injury or Poisoning 0.3 0.43 0.862 disease
APP 351 FRAXA Syndrome C0751156 Disease or Syndrome 0.3 0.43 0.862 disease
APP 351 Amnesia C0002622 Mental or Behavioral Dysfunction 0.39 0.43 0.862 disease
APP 351 Anxiety Disorders C0003469 Mental or Behavioral Dysfunction 0.4 0.43 0.862 group
APP 351 Encephalopathies C0085584 Disease or Syndrome 0.3 0.43 0.862 group
APP 351 Premature aging syndrome C0231341 Disease or Syndrome 0.3 0.43 0.862 disease
APP 351 Neurodegenerative Disorders C0524851 Disease or Syndrome 0.4 0.43 0.862 group
APP 351 Learning Disabilities C0751265 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Age-Related Memory Disorders C0751292 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Amyloidosis C0002726 Disease or Syndrome 0.4 0.43 0.862 disease
APP 351 Todd Paralysis C0234544 Sign or Symptom 0.3 0.43 0.862 phenotype
APP 351 Learning Disturbance C0751263 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Presenile dementia C0011265 Mental or Behavioral Dysfunction 0.4 0.43 0.862 disease
APP 351 Temporary Amnesia C0233796 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Global Amnesia C0262497 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Brain Diseases C0006111 Disease or Syndrome 0.3 0.43 0.862 group
APP 351 Alzheimer Disease, Early Onset C0750901 Disease or Syndrome 0.4 0.43 0.862 disease
APP 351 Cerebral Amyloid Angiopathy C0085220 Disease or Syndrome 0.5 0.43 0.862 disease
APP 351 Mental deterioration C0234985 Mental or Behavioral Dysfunction 0.3 0.43 0.862 phenotype
APP 351 Impaired cognition C0338656 Mental or Behavioral Dysfunction 0.4 0.43 0.862 disease
APP 351 Paralysed C0522224 Finding 0.3 0.43 0.862 phenotype
APP 351 Familial Dementia C0751071 Mental or Behavioral Dysfunction 0.32 0.43 0.862 disease
APP 351 Spinal Cord Diseases C0037928 Disease or Syndrome 0.3 0.43 0.862 group
APP 351 Splenomegaly C0038002 Finding 0.3 0.43 0.862 phenotype
APP 351 Anxiety States, Neurotic C0376280 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Adult Learning Disorders C0751262 Mental or Behavioral Dysfunction 0.3 0.43 0.862 group
APP 351 Memory Disorder, Semantic C0751293 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Mild cognitive disorder C1270972 Mental or Behavioral Dysfunction 0.37 0.43 0.862 disease
APP 351 Anxiety neurosis (finding) C1279420 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Plaque, Amyloid C2936349 Acquired Abnormality 0.4 0.43 0.862 phenotype
APP 351 Memory Loss C0751295 Sign or Symptom 0.49 0.43 0.862 phenotype
APP 351 Degenerative Diseases, Spinal Cord C0751733 Disease or Syndrome 0.3 0.43 0.862 disease
APP 351 Developmental Academic Disorder C1330966 Finding 0.3 0.43 0.862 phenotype
APP 351 Familial Alzheimer Disease (FAD) C0276496 Disease or Syndrome 0.6 0.43 0.862 disease
APP 351 Cerebral hemorrhage with amyloidosis, hereditary, Dutch type C2931672 Disease or Syndrome 0.6 0.43 0.862 disease
APP 351 CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ARCTIC VARIANT C2751494 Disease or Syndrome 0.5 0.43 0.862 disease
APP 351 CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, FLEMISH VARIANT C3888307 Disease or Syndrome 0.5 0.43 0.862 disease
APP 351 Alzheimer's Disease C0002395 Disease or Syndrome 0.9 0.43 0.862 disease
APP 351 CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ITALIAN VARIANT C3888308 Disease or Syndrome 0.5 0.43 0.862 disease
APP 351 CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, IOWA VARIANT C3888309 Disease or Syndrome 0.5 0.43 0.862 disease
APP 351 CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED C2751536 Disease or Syndrome 0.6 0.43 0.862 disease
APP 351 Periodic Fever Syndrome C3889979 Disease or Syndrome 0.3 0.43 0.862 disease
APP 351 Bipolar Disorder C0005586 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Endogenous depression C0011573 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Mental Depression C0011570 Mental or Behavioral Dysfunction 0.33 0.43 0.862 disease
APP 351 Depressive disorder C0011581 Mental or Behavioral Dysfunction 0.33 0.43 0.862 disease
APP 351 ALZHEIMER DISEASE, FAMILIAL, 1 C1863052 Disease or Syndrome 0.41 0.43 0.862 disease
APP 351 ALZHEIMER DISEASE, PROTECTION AGAINST C3549448 Disease or Syndrome 0.3 0.43 0.862 disease
APP 351 PRESENILE AND SENILE DEMENTIA C1541844 Mental or Behavioral Dysfunction 0.3 0.43 0.862 disease
APP 351 Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy C1863053 Disease or Syndrome 0.3 0.43 0.862 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
APP 351 ACC-001 VANUTIDE CRIDIFICAR CHEMBL2108058 None
APP 351 AD01 None None None
APP 351 ADUCANUMAB ADUCANUMAB CHEMBL3039540 None
APP 351 AMB PRIDINOL CHEMBL404215 None
APP 351 ANTI-ABETA None None antibody
APP 351 BAN2401 BAN2401 CHEMBL3833321 None
APP 351 BAPINEUZUMAB BAPINEUZUMAB CHEMBL2108576 None
APP 351 BAPINEUZUMAB BAPINEUZUMAB CHEMBL2108576 None
APP 351 BAF None None None
APP 351 BAN2401 BAN2401 CHEMBL3833321 inhibitor
APP 351 BIIB037 BIIB-037 CHEMBL2109299 None
APP 351 CAPROSPINOL CAPROSPINOL CHEMBL2386881 None
APP 351 CRENEZUMAB CRENEZUMAB CHEMBL1743004 None
APP 351 DAUNOMYCIN DAUNORUBICIN CHEMBL178 None
APP 351 EXEBRYL-1 None None None
APP 351 GANTENERUMAB GANTENERUMAB CHEMBL1743025 None
APP 351 GANTENERUMAB GANTENERUMAB CHEMBL1743025 None
APP 351 GSK-933776 GSK-933776 CHEMBL2109300 None
APP 351 HOMOTAURINE TRAMIPROSATE CHEMBL149082 None
APP 351 HYDROXYCHLOROQUINE HYDROXYCHLOROQUINE CHEMBL1535 None
APP 351 MABT5102A CRENEZUMAB CHEMBL1743004 None
APP 351 NRM8499 None None None
APP 351 PONEZUMAB PONEZUMAB CHEMBL1743058 None
APP 351 POSIPHEN None None None
APP 351 PONEZUMAB PONEZUMAB CHEMBL1743058 None
APP 351 PROPOFOL PROPOFOL CHEMBL526 None
APP 351 R1450 GANTENERUMAB CHEMBL1743025 antibody
APP 351 SCYLLO-INOSITOL CHEMBL468154 CHEMBL468154 None
APP 351 SOLANEZUMAB SOLANEZUMAB CHEMBL1743072 None
APP 351 SOLANEZUMAB SOLANEZUMAB CHEMBL1743072 None
APP 351 TAXANES None None None