GAPDH glyceraldehyde 3-phosphate dehydrogenase
AltitudeomicsDB
Protein Official symbol |
GAPDH |
Aliases |
GAPDH GAPD CDABP0047 OK/SW-cl.12 |
Chromosomal Location |
12 |
Length |
335 |
Uniprot ID |
P04406 |
EC number |
1.2.1.12; 2.6.99.- |
Protein family Information(Pfam) |
PF02800;PF00044; |
PDB id |
1U8F;1ZNQ;2FEH;3GPD;4WNC;4WNI;6ADE;6IQ6; |
InterPro ID |
IPR020831;IPR020830;IPR020829;IPR020828;IPR006424;IPR036291; |
dbSNP |
rs45541435 rs1062429 |
AltitudeomicsDB
Protein 1 |
Protein 2 |
Combine Score |
PGK1 |
TPI1 |
0.999 |
TKT |
TALDO1 |
0.999 |
GPI |
TPI1 |
0.999 |
TPI1 |
GAPDH |
0.999 |
PGK1 |
GAPDH |
0.998 |
RPL13A |
EPRS |
0.997 |
ENO1 |
TPI1 |
0.996 |
ALDOA |
GAPDH |
0.995 |
ENO1 |
GAPDH |
0.995 |
TALDO1 |
TKTL2 |
0.994 |
APOA1BP |
CARKD |
0.994 |
GPI |
G6PD |
0.994 |
AKT1 |
TP53 |
0.994 |
PGK2 |
TPI1 |
0.994 |
PGAM1 |
ENO1 |
0.993 |
PKM |
ENO1 |
0.993 |
AKT1 |
ESR1 |
0.991 |
PGK1 |
ENO1 |
0.991 |
GPI |
TALDO1 |
0.991 |
H6PD |
GPI |
0.991 |
ALDOA |
TPI1 |
0.99 |
RPL13A |
GAPDH |
0.99 |
GPI |
ENO1 |
0.99 |
PGK1 |
PGAM1 |
0.99 |
GPI |
TKT |
0.99 |
TKTL1 |
TALDO1 |
0.989 |
GPI |
PKM |
0.987 |
SYNCRIP |
EPRS |
0.986 |
GPI |
GAPDH |
0.986 |
ENO2 |
PGAM1 |
0.984 |
TKT |
TPI1 |
0.984 |
TPI1 |
ALDOC |
0.983 |
PGK2 |
GAPDH |
0.983 |
ALDOA |
ALDOC |
0.981 |
ENO2 |
PKM |
0.981 |
ALDOB |
TPI1 |
0.981 |
TALDO1 |
TPI1 |
0.979 |
ALDOA |
PKM |
0.979 |
PGAM1 |
PGK2 |
0.978 |
BPGM |
PGK2 |
0.977 |
ALDOA |
TALDO1 |
0.975 |
BPGM |
PGK1 |
0.973 |
TKT |
ALDOA |
0.973 |
ENO2 |
GPI |
0.972 |
GAPDH |
ALDOC |
0.972 |
G6PD |
TPI1 |
0.971 |
TKT |
GAPDH |
0.97 |
RPL13A |
SYNCRIP |
0.97 |
ALDOB |
GAPDH |
0.97 |
GPI |
ALDOA |
0.969 |
PGAM1 |
TPI1 |
0.969 |
PKM |
GAPDH |
0.969 |
EPRS |
GAPDH |
0.969 |
BPGM |
GAPDH |
0.968 |
BPGM |
ENO1 |
0.967 |
TKT |
PKM |
0.967 |
ESR1 |
GAPDH |
0.966 |
H6PD |
TPI1 |
0.966 |
APP |
GAPDH |
0.966 |
PKM |
TPI1 |
0.964 |
ENO2 |
ENO1 |
0.963 |
GPI |
PGAM1 |
0.962 |
ALDOA |
ENO1 |
0.962 |
G6PD |
GAPDH |
0.962 |
GPI |
TKTL1 |
0.961 |
GPI |
TKTL2 |
0.959 |
H6PD |
TALDO1 |
0.959 |
G6PD |
PKM |
0.959 |
H6PD |
PKM |
0.957 |
GPI |
PGK1 |
0.957 |
H6PD |
GAPDH |
0.957 |
TALDO1 |
ENO1 |
0.956 |
ENO2 |
BPGM |
0.955 |
ENO2 |
TPI1 |
0.955 |
ALDOA |
TKTL2 |
0.954 |
ACTB |
GAPDH |
0.953 |
ALDOB |
TALDO1 |
0.952 |
TKT |
ALDOC |
0.952 |
AKT1 |
GAPDH |
0.95 |
TALDO1 |
GAPDH |
0.95 |
TALDO1 |
ALDOC |
0.95 |
PKM |
ALDOC |
0.95 |
TKT |
ALDOB |
0.949 |
G6PD |
TALDO1 |
0.949 |
ESR1 |
TP53 |
0.948 |
ALDOB |
TKTL2 |
0.948 |
GPI |
ALDOB |
0.947 |
TKTL2 |
ALDOC |
0.947 |
TKTL1 |
ALDOC |
0.947 |
ENO2 |
PGK1 |
0.945 |
PGK1 |
PKM |
0.944 |
GPI |
ALDOC |
0.944 |
ALDOA |
TKTL1 |
0.942 |
SYNCRIP |
GAPDH |
0.942 |
H6PD |
G6PD |
0.942 |
ALDOB |
TKTL1 |
0.941 |
G6PD |
TP53 |
0.941 |
G6PD |
PGAM1 |
0.94 |
HTT |
GAPDH |
0.938 |
GPI |
PGK2 |
0.938 |
ALDOB |
PKM |
0.936 |
TKT |
G6PD |
0.936 |
PGK2 |
ENO1 |
0.935 |
TKTL2 |
TPI1 |
0.934 |
PGAM1 |
TALDO1 |
0.933 |
TKTL1 |
TPI1 |
0.932 |
TALDO1 |
PKM |
0.932 |
H6PD |
ENO1 |
0.93 |
TPPP |
GAPDH |
0.93 |
TP53 |
GAPDH |
0.927 |
PKM |
TKTL2 |
0.927 |
H6PD |
TKT |
0.925 |
ALDOA |
PGAM1 |
0.923 |
GPI |
BPGM |
0.922 |
TKTL1 |
PKM |
0.922 |
TKT |
ENO1 |
0.92 |
H6PD |
BPGM |
0.918 |
PGAM1 |
ALDOC |
0.914 |
ENO2 |
GAPDH |
0.914 |
ESR1 |
ALDOA |
0.913 |
TKTL1 |
GAPDH |
0.913 |
ALDOA |
G6PD |
0.912 |
ALDOA |
APP |
0.91 |
ALDOA |
PGK1 |
0.909 |
G6PD |
ENO1 |
0.908 |
CARKD |
GAPDH |
0.907 |
H6PD |
ALDOB |
0.907 |
G6PD |
BPGM |
0.906 |
BPGM |
PGAM1 |
0.905 |
TKTL2 |
GAPDH |
0.904 |
PGAM1 |
GAPDH |
0.903 |
H6PD |
ALDOC |
0.903 |
APOA1BP |
GAPDH |
0.902 |
H6PD |
ALDOA |
0.9 |
Gene Ontology Semantic Similarity
Download Tab separated file
# |
5230 (PGK1) |
7086 (TKT) |
2821 (GPI) |
7167 (TPI1) |
23521 (RPL13A) |
2023 (ENO1) |
226 (ALDOA) |
6888 (TALDO1) |
5232 (PGK2) |
207 (AKT1) |
128240 (APOA1BP) |
5223 (PGAM1) |
5315 (PKM) |
10492 (SYNCRIP) |
2026 (ENO2) |
229 (ALDOB) |
669 (BPGM) |
2597 (GAPDH) |
2539 (G6PD) |
2058 (EPRS) |
2099 (ESR1) |
351 (APP) |
60 (ACTB) |
3064 (HTT) |
11076 (TPPP) |
7157 (TP53) |
55739 (CARKD) |
230 (ALDOC) |
5230 (PGK1)
|
1.00
|
0.54
|
0.31
|
0.47
|
0.26
|
0.48
|
0.56
|
0.51
|
0.72
|
0.66
|
0.43
|
0.43
|
0.55
|
0.48
|
0.45
|
0.51
|
0.15
|
0.47
|
0.54
|
0.43
|
0.45
|
0.56
|
0.45
|
0.67
|
0.52
|
0.54
|
0.47
|
0.50
|
7086 (TKT)
|
0.54
|
1.00
|
0.40
|
0.61
|
0.30
|
0.63
|
0.63
|
0.77
|
0.21
|
0.54
|
0.57
|
0.56
|
0.62
|
0.62
|
0.61
|
0.61
|
0.18
|
0.58
|
0.67
|
0.54
|
0.49
|
0.65
|
0.53
|
0.74
|
0.65
|
0.52
|
0.61
|
0.64
|
2821 (GPI)
|
0.31
|
0.40
|
1.00
|
0.81
|
0.18
|
0.36
|
0.38
|
0.42
|
0.14
|
0.32
|
0.48
|
0.45
|
0.36
|
0.39
|
0.40
|
0.40
|
0.27
|
0.33
|
0.35
|
0.36
|
0.31
|
0.43
|
0.32
|
0.46
|
0.41
|
0.37
|
0.39
|
0.42
|
7167 (TPI1)
|
0.47
|
0.61
|
0.81
|
1.00
|
0.28
|
0.55
|
0.62
|
0.61
|
0.15
|
0.47
|
0.63
|
0.60
|
0.57
|
0.63
|
0.60
|
0.59
|
0.24
|
0.51
|
0.56
|
0.52
|
0.49
|
0.65
|
0.51
|
0.74
|
0.66
|
0.54
|
0.59
|
0.64
|
23521 (RPL13A)
|
0.26
|
0.30
|
0.18
|
0.28
|
1.00
|
0.44
|
0.43
|
0.30
|
0.19
|
0.24
|
0.28
|
0.26
|
0.50
|
0.68
|
0.29
|
0.27
|
0.13
|
0.23
|
0.29
|
0.45
|
0.28
|
0.40
|
0.34
|
0.29
|
0.29
|
0.34
|
0.36
|
0.29
|
2023 (ENO1)
|
0.48
|
0.63
|
0.36
|
0.55
|
0.44
|
1.00
|
0.73
|
0.55
|
0.15
|
0.49
|
0.52
|
0.52
|
0.70
|
0.70
|
0.72
|
0.60
|
0.13
|
0.51
|
0.61
|
0.64
|
0.57
|
0.67
|
0.53
|
0.69
|
0.59
|
0.62
|
0.65
|
0.60
|
226 (ALDOA)
|
0.56
|
0.63
|
0.38
|
0.62
|
0.43
|
0.73
|
1.00
|
0.63
|
0.16
|
0.54
|
0.60
|
0.59
|
0.74
|
0.75
|
0.65
|
0.89
|
0.14
|
0.60
|
0.69
|
0.65
|
0.55
|
0.71
|
0.60
|
0.76
|
0.72
|
0.60
|
0.63
|
0.83
|
6888 (TALDO1)
|
0.51
|
0.77
|
0.42
|
0.61
|
0.30
|
0.55
|
0.63
|
1.00
|
0.25
|
0.52
|
0.56
|
0.55
|
0.63
|
0.64
|
0.62
|
0.60
|
0.21
|
0.56
|
0.57
|
0.52
|
0.48
|
0.64
|
0.50
|
0.75
|
0.68
|
0.51
|
0.61
|
0.66
|
5232 (PGK2)
|
0.72
|
0.21
|
0.14
|
0.15
|
0.19
|
0.15
|
0.16
|
0.25
|
1.00
|
0.44
|
0.19
|
0.15
|
0.25
|
0.19
|
0.16
|
0.15
|
0.14
|
0.17
|
0.21
|
0.17
|
0.12
|
0.15
|
0.12
|
0.12
|
0.13
|
0.17
|
0.19
|
0.16
|
207 (AKT1)
|
0.66
|
0.54
|
0.32
|
0.47
|
0.24
|
0.49
|
0.54
|
0.52
|
0.44
|
1.00
|
0.45
|
0.45
|
0.60
|
0.46
|
0.45
|
0.52
|
0.14
|
0.51
|
0.51
|
0.45
|
0.53
|
0.57
|
0.47
|
0.61
|
0.48
|
0.56
|
0.48
|
0.48
|
128240 (APOA1BP)
|
0.43
|
0.57
|
0.48
|
0.63
|
0.28
|
0.52
|
0.60
|
0.56
|
0.19
|
0.45
|
1.00
|
0.59
|
0.54
|
0.55
|
0.54
|
0.56
|
0.34
|
0.48
|
0.53
|
0.48
|
0.46
|
0.60
|
0.48
|
0.71
|
0.59
|
0.50
|
0.56
|
0.59
|
5223 (PGAM1)
|
0.43
|
0.56
|
0.45
|
0.60
|
0.26
|
0.52
|
0.59
|
0.55
|
0.15
|
0.45
|
0.59
|
1.00
|
0.53
|
0.55
|
0.53
|
0.55
|
0.64
|
0.48
|
0.52
|
0.48
|
0.50
|
0.60
|
0.48
|
0.73
|
0.59
|
0.53
|
0.55
|
0.57
|
5315 (PKM)
|
0.55
|
0.62
|
0.36
|
0.57
|
0.50
|
0.70
|
0.74
|
0.63
|
0.25
|
0.60
|
0.54
|
0.53
|
1.00
|
0.77
|
0.57
|
0.57
|
0.15
|
0.54
|
0.56
|
0.62
|
0.51
|
0.68
|
0.53
|
0.71
|
0.62
|
0.57
|
0.57
|
0.60
|
10492 (SYNCRIP)
|
0.48
|
0.62
|
0.39
|
0.63
|
0.68
|
0.70
|
0.75
|
0.64
|
0.19
|
0.46
|
0.55
|
0.55
|
0.77
|
1.00
|
0.63
|
0.60
|
0.14
|
0.50
|
0.59
|
0.68
|
0.52
|
0.75
|
0.55
|
0.76
|
0.71
|
0.58
|
0.60
|
0.67
|
2026 (ENO2)
|
0.45
|
0.61
|
0.40
|
0.60
|
0.29
|
0.72
|
0.65
|
0.62
|
0.16
|
0.45
|
0.54
|
0.53
|
0.57
|
0.63
|
1.00
|
0.63
|
0.18
|
0.50
|
0.56
|
0.51
|
0.47
|
0.64
|
0.50
|
0.75
|
0.67
|
0.51
|
0.79
|
0.70
|
229 (ALDOB)
|
0.51
|
0.61
|
0.40
|
0.59
|
0.27
|
0.60
|
0.89
|
0.60
|
0.15
|
0.52
|
0.56
|
0.55
|
0.57
|
0.60
|
0.63
|
1.00
|
0.15
|
0.57
|
0.67
|
0.54
|
0.53
|
0.66
|
0.55
|
0.74
|
0.65
|
0.54
|
0.62
|
0.86
|
669 (BPGM)
|
0.15
|
0.18
|
0.27
|
0.24
|
0.13
|
0.13
|
0.14
|
0.21
|
0.14
|
0.14
|
0.34
|
0.64
|
0.15
|
0.14
|
0.18
|
0.15
|
1.00
|
0.15
|
0.14
|
0.15
|
0.11
|
0.12
|
0.10
|
0.12
|
0.13
|
0.10
|
0.24
|
0.17
|
2597 (GAPDH)
|
0.47
|
0.58
|
0.33
|
0.51
|
0.23
|
0.51
|
0.60
|
0.56
|
0.17
|
0.51
|
0.48
|
0.48
|
0.54
|
0.50
|
0.50
|
0.57
|
0.15
|
1.00
|
0.56
|
0.46
|
0.47
|
0.59
|
0.49
|
0.69
|
0.65
|
0.56
|
0.51
|
0.54
|
2539 (G6PD)
|
0.54
|
0.67
|
0.35
|
0.56
|
0.29
|
0.61
|
0.69
|
0.57
|
0.21
|
0.51
|
0.53
|
0.52
|
0.56
|
0.59
|
0.56
|
0.67
|
0.14
|
0.56
|
1.00
|
0.52
|
0.50
|
0.65
|
0.54
|
0.72
|
0.60
|
0.54
|
0.56
|
0.59
|
2058 (EPRS)
|
0.43
|
0.54
|
0.36
|
0.52
|
0.45
|
0.64
|
0.65
|
0.52
|
0.17
|
0.45
|
0.48
|
0.48
|
0.62
|
0.68
|
0.51
|
0.54
|
0.15
|
0.46
|
0.52
|
1.00
|
0.49
|
0.64
|
0.49
|
0.68
|
0.56
|
0.55
|
0.52
|
0.54
|
2099 (ESR1)
|
0.45
|
0.49
|
0.31
|
0.49
|
0.28
|
0.57
|
0.55
|
0.48
|
0.12
|
0.53
|
0.46
|
0.50
|
0.51
|
0.52
|
0.47
|
0.53
|
0.11
|
0.47
|
0.50
|
0.49
|
1.00
|
0.62
|
0.59
|
0.62
|
0.50
|
0.74
|
0.51
|
0.49
|
351 (APP)
|
0.56
|
0.65
|
0.43
|
0.65
|
0.40
|
0.67
|
0.71
|
0.64
|
0.15
|
0.57
|
0.60
|
0.60
|
0.68
|
0.75
|
0.64
|
0.66
|
0.12
|
0.59
|
0.65
|
0.64
|
0.62
|
1.00
|
0.64
|
0.76
|
0.68
|
0.66
|
0.63
|
0.66
|
60 (ACTB)
|
0.45
|
0.53
|
0.32
|
0.51
|
0.34
|
0.53
|
0.60
|
0.50
|
0.12
|
0.47
|
0.48
|
0.48
|
0.53
|
0.55
|
0.50
|
0.55
|
0.10
|
0.49
|
0.54
|
0.49
|
0.59
|
0.64
|
1.00
|
0.67
|
0.55
|
0.60
|
0.51
|
0.54
|
3064 (HTT)
|
0.67
|
0.74
|
0.46
|
0.74
|
0.29
|
0.69
|
0.76
|
0.75
|
0.12
|
0.61
|
0.71
|
0.73
|
0.71
|
0.76
|
0.75
|
0.74
|
0.12
|
0.69
|
0.72
|
0.68
|
0.62
|
0.76
|
0.67
|
1.00
|
0.81
|
0.62
|
0.73
|
0.77
|
11076 (TPPP)
|
0.52
|
0.65
|
0.41
|
0.66
|
0.29
|
0.59
|
0.72
|
0.68
|
0.13
|
0.48
|
0.59
|
0.59
|
0.62
|
0.71
|
0.67
|
0.65
|
0.13
|
0.65
|
0.60
|
0.56
|
0.50
|
0.68
|
0.55
|
0.81
|
1.00
|
0.53
|
0.64
|
0.74
|
7157 (TP53)
|
0.54
|
0.52
|
0.37
|
0.54
|
0.34
|
0.62
|
0.60
|
0.51
|
0.17
|
0.56
|
0.50
|
0.53
|
0.57
|
0.58
|
0.51
|
0.54
|
0.10
|
0.56
|
0.54
|
0.55
|
0.74
|
0.66
|
0.60
|
0.62
|
0.53
|
1.00
|
0.53
|
0.52
|
55739 (CARKD)
|
0.47
|
0.61
|
0.39
|
0.59
|
0.36
|
0.65
|
0.63
|
0.61
|
0.19
|
0.48
|
0.56
|
0.55
|
0.57
|
0.60
|
0.79
|
0.62
|
0.24
|
0.51
|
0.56
|
0.52
|
0.51
|
0.63
|
0.51
|
0.73
|
0.64
|
0.53
|
1.00
|
0.66
|
230 (ALDOC)
|
0.50
|
0.64
|
0.42
|
0.64
|
0.29
|
0.60
|
0.83
|
0.66
|
0.16
|
0.48
|
0.59
|
0.57
|
0.60
|
0.67
|
0.70
|
0.86
|
0.17
|
0.54
|
0.59
|
0.54
|
0.49
|
0.66
|
0.54
|
0.77
|
0.74
|
0.52
|
0.66
|
1.00
|
Association with High Altitude
Protein Official symbol |
Source Organism |
Tissue of Expression |
Level of hypoxia |
Altitude |
Duration of experiment |
Level of expression |
Fold change |
Experiment details |
geographical location |
ethnicity of the patients |
Control group |
Control (Fold change) |
Reference (PMID) |
GAPDH |
Human |
Serum |
- |
2400 m |
0.5 hours |
downregulated |
0.019 |
2-DE |
Western Europe |
Germans |
0.027 |
Healthy adults never had ear surgery or problems with pressure equalization |
28858246 |
GAPDH |
Rat |
Lung Tissue |
- |
4500 m |
30 day |
downregulated |
22.3 ± 2.4 |
RT-PCR |
Central Asia |
Male wistar rats |
22.7 ± 1.7 |
Low altitute 458 m wistar rats |
27596558 |
GAPDH |
Rat |
Brain cortex |
316 hPa |
8810 m |
1 hour |
downregulated |
9.69-13.23 |
2-DE |
Southwestern europe |
Male albino wistar Rat |
24.08-52.23 |
Adult male albino Wistar rats weighing 350 g kept at standard conditions |
22961459 |
GAPDH |
Rat |
Brain cortex |
300hPa |
9144 m |
1 hour |
upregulated |
14.53 ± 1.15 |
2-DE |
Southwestern europe |
Male wistar rats |
37.17 ± 1.92 |
adult male wistar rats weighing 350 g |
25064252 |
GAPDH |
Human |
Blood |
- |
3600 m |
Native |
upregulated |
- |
TMT-based proteomic analysis/LC-MS |
Central Asia |
Tibetans |
- |
High altitude native vs. low Lander |
30908922 |
GAPDH |
Rat |
Left brain cortices |
300hPa |
9144 m |
1 hour |
upregulated |
1.40±0.2 |
TMT labeled LTQ orbitrap |
Southwestern europe |
Male wistar rats |
1 |
Adult male Wistar rats weighing 350 g |
28697276 |
GAPDH |
Rat |
Lung tissue |
- |
2260 m |
30 day |
downregulated |
21.9 ± 1.9 |
RT-PCR |
Central Asia |
Male wistar rats |
22.7 ± 1.6 |
Low altitute 458 m wistar rats |
27596558 |
GAPDH |
Human |
Muscle biopsies |
- |
3500-4500 m |
30 day |
downregulated |
- |
2-DE |
Himalayas |
Tibetan and nepali |
- |
Nepali controls residing at 1300m |
14734630 |
Gene Ontology
ID |
GO ID |
GO Term |
GO Type |
2597 |
GO:0006096 |
glycolytic process |
GOTERM_BP_DIRECT |
2597 |
GO:0043231 |
intracellular membrane-bounded organelle |
GOTERM_CC_DIRECT |
2597 |
GO:0097452 |
GAIT complex |
GOTERM_CC_DIRECT |
2597 |
GO:0031965 |
nuclear membrane |
GOTERM_CC_DIRECT |
2597 |
GO:0048471 |
perinuclear region of cytoplasm |
GOTERM_CC_DIRECT |
2597 |
GO:0006006 |
glucose metabolic process |
GOTERM_BP_DIRECT |
2597 |
GO:0050661 |
NADP binding |
GOTERM_MF_DIRECT |
2597 |
GO:0000226 |
microtubule cytoskeleton organization |
GOTERM_BP_DIRECT |
2597 |
GO:0008017 |
microtubule binding |
GOTERM_MF_DIRECT |
2597 |
GO:0015630 |
microtubule cytoskeleton |
GOTERM_CC_DIRECT |
2597 |
GO:0016020 |
membrane |
GOTERM_CC_DIRECT |
2597 |
GO:0030529 |
intracellular ribonucleoprotein complex |
GOTERM_CC_DIRECT |
2597 |
GO:0070062 |
extracellular exosome |
GOTERM_CC_DIRECT |
2597 |
GO:0005515 |
protein binding |
GOTERM_MF_DIRECT |
2597 |
GO:0035605 |
zymogen binding |
GOTERM_MF_DIRECT |
2597 |
GO:0005829 |
cytosol |
GOTERM_CC_DIRECT |
2597 |
GO:0061621 |
canonical glycolysis |
GOTERM_BP_DIRECT |
2597 |
GO:0016620 |
oxidoreductase activity |
GOTERM_MF_DIRECT |
2597 |
GO:0017148 |
negative regulation of translation |
GOTERM_BP_DIRECT |
2597 |
GO:0004365 |
glutathione transferase activity |
GOTERM_MF_DIRECT |
2597 |
GO:0005811 |
lipid particle |
GOTERM_CC_DIRECT |
2597 |
GO:0016241 |
regulation of macroautophagy |
GOTERM_BP_DIRECT |
2597 |
GO:0035606 |
peptidyl-cysteine S-trans-nitrosylation |
GOTERM_BP_DIRECT |
2597 |
GO:0005634 |
nucleus |
GOTERM_CC_DIRECT |
2597 |
GO:0071346 |
cellular response to interferon-gamma |
GOTERM_BP_DIRECT |
2597 |
GO:0042802 |
identical protein binding |
GOTERM_MF_DIRECT |
2597 |
GO:0005737 |
cytoplasm |
GOTERM_CC_DIRECT |
2597 |
GO:0051402 |
neuron apoptotic process |
GOTERM_BP_DIRECT |
2597 |
GO:0031982 |
vesicle |
GOTERM_CC_DIRECT |
2597 |
GO:0006094 |
gluconeogenesis |
GOTERM_BP_DIRECT |
2597 |
GO:0051287 |
phosphoprotein binding |
GOTERM_MF_DIRECT |
2597 |
GO:0031012 |
extracellular matrix |
GOTERM_CC_DIRECT |
2597 |
GO:0050821 |
protein stabilization |
GOTERM_BP_DIRECT |
2597 |
GO:0005886 |
plasma membrane |
GOTERM_CC_DIRECT |
Pathways
Human Entrez ID |
KEGG ID |
KEGG Term |
2597 |
hsa00010 |
Glycolysis / Gluconeogenesis |
2597 |
hsa01100 |
Metabolic pathways |
2597 |
hsa01200 |
Carbon metabolism |
2597 |
hsa01130 |
Biosynthesis of antibiotics |
2597 |
hsa01230 |
Biosynthesis of amino acids |
2597 |
hsa04066 |
HIF-1 signaling pathway |
2597 |
hsa05010 |
Alzheimer's disease |
Association with Disease
Protein Official Symbol |
Human Entrez ID |
Disease Name |
Disease Id |
Disease Semantic Type |
Semantic score |
DSI |
DPI |
Disease Type |
GAPDH |
2597 |
Osteoporosis |
C0029456 |
Disease or Syndrome |
0.3 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Malignant neoplasm of esophagus |
C0546837 |
Neoplastic Process |
0.31 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Necrosis |
C0027540 |
Organ or Tissue Function |
0.3 |
0.484 |
0.793 |
phenotype |
GAPDH |
2597 |
Liver carcinoma |
C2239176 |
Neoplastic Process |
0.4 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Anoxia |
C0003130 |
Pathologic Function |
0.3 |
0.484 |
0.793 |
phenotype |
GAPDH |
2597 |
Squamous cell carcinoma |
C0007137 |
Neoplastic Process |
0.33 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Colorectal Carcinoma |
C0009402 |
Neoplastic Process |
0.31 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Esophageal Neoplasms |
C0014859 |
Neoplastic Process |
0.3 |
0.484 |
0.793 |
group |
GAPDH |
2597 |
Post-Traumatic Osteoporosis |
C0751406 |
Disease or Syndrome |
0.3 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Acute Coronary Syndrome |
C0948089 |
Disease or Syndrome |
0.3 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Hypoxia |
C0242184 |
Pathologic Function |
0.3 |
0.484 |
0.793 |
phenotype |
GAPDH |
2597 |
Anoxemia |
C0003129 |
Sign or Symptom |
0.3 |
0.484 |
0.793 |
phenotype |
GAPDH |
2597 |
Osteoporosis, Senile |
C0029459 |
Disease or Syndrome |
0.3 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Mouth Neoplasms |
C0026640 |
Neoplastic Process |
0.3 |
0.484 |
0.793 |
group |
GAPDH |
2597 |
Degenerative polyarthritis |
C0029408 |
Disease or Syndrome |
0.3 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Adenocarcinoma of lung (disorder) |
C0152013 |
Neoplastic Process |
0.3 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Hypoxemia |
C0700292 |
Finding |
0.3 |
0.484 |
0.793 |
phenotype |
GAPDH |
2597 |
Osteoporosis, Age-Related |
C0001787 |
Disease or Syndrome |
0.3 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Osteoarthrosis Deformans |
C0086743 |
Disease or Syndrome |
0.3 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Colorectal Cancer |
C1527249 |
Neoplastic Process |
0.31 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Colorectal Neoplasms |
C0009404 |
Neoplastic Process |
0.3 |
0.484 |
0.793 |
group |
GAPDH |
2597 |
Malignant neoplasm of mouth |
C0153381 |
Neoplastic Process |
0.3 |
0.484 |
0.793 |
disease |
GAPDH |
2597 |
Alcoholic Intoxication, Chronic |
C0001973 |
Mental or Behavioral Dysfunction |
0.31 |
0.484 |
0.793 |
disease |