NSE gamma-enolase

AltitudeomicsDB
Protein Official symbol ENO2
Aliases ENO2
Chromosomal Location 12
Length 434
Uniprot ID P09104
EC number 4.2.1.11
Protein family Information(Pfam) PF00113;PF03952;
PDB id 1TE6;2AKM;2AKZ;3UCC;3UCD;3UJE;3UJF;3UJR;3UJS;4ZA0;4ZCW;5EU9;5IDZ;5TD9;5TIJ;
InterPro ID IPR000941;IPR036849;IPR029017;IPR020810;IPR020809;IPR020811;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
PGK1 TPI1 0.9990000000000001
GPI TPI1 0.9990000000000001
TPI1 GAPDH 0.9990000000000001
PGK1 GAPDH 0.998
ENO1 TPI1 0.996
ENO1 GAPDH 0.995
PGAM1 ENO3 0.9940000000000001
PKM ENO1 0.993
PGAM1 ENO1 0.993
PGK1 ENO1 0.991
PGK1 PGAM1 0.99
GPI ENO1 0.99
ENO3 PKM 0.9890000000000001
GPI PKM 0.987
GPI GAPDH 0.986
PKLR ENO3 0.985
ENO2 PGAM1 0.9840000000000001
PKLR ENO1 0.9840000000000001
GPI ENO3 0.983
ENO3 PGAM2 0.983
GPI PKLR 0.983
PGK1 PGAM2 0.983
ENO2 PKM 0.981
ENO2 PKLR 0.98
PGAM2 ENO1 0.978
BPGM PGK1 0.973
ENO2 GPI 0.972
PKM GAPDH 0.9690000000000001
PGAM1 TPI1 0.9690000000000001
BPGM GAPDH 0.968
BPGM ENO1 0.9670000000000001
PKLR PCK1 0.966
PKM TPI1 0.9640000000000001
ENO2 PGAM2 0.9640000000000001
ENO2 ENO1 0.963
BPGM ENO3 0.963
GPI PGAM1 0.9620000000000001
ENO2 ENO3 0.9620000000000001
ENO3 ENO1 0.9620000000000001
ENO3 TPI1 0.961
PKLR PCK2 0.96
GPI PGK1 0.9570000000000001
PKM PCK2 0.955
ENO2 TPI1 0.955
ENO2 BPGM 0.955
BPGM PGAM2 0.9540000000000001
BPGM MINPP1 0.9520000000000001
PKM PCK1 0.95
GPI PGAM2 0.95
PCK1 ENO1 0.946
ENO2 PGK1 0.945
SYP CHGA 0.945
ENO1 PCK2 0.9440000000000001
PGK1 PKM 0.9440000000000001
PKLR TPI1 0.941
ENO3 PCK1 0.94
ENO3 PCK2 0.94
ENO2 PCK1 0.9390000000000001
PGK1 ENO3 0.938
PGAM1 PGAM2 0.935
ENO2 PCK2 0.935
ENO2 SYP 0.927
ENO2 CHGA 0.925
GPI BPGM 0.922
PGAM2 TPI1 0.915
ENO2 GAPDH 0.914
MINPP1 PGAM1 0.9059999999999999
BPGM PGAM1 0.905
MINPP1 PGAM2 0.904
PGAM1 GAPDH 0.903
MINPP1 ENO1 0.9
ENO2 MINPP1 0.9
MINPP1 ENO3 0.9
Gene Ontology Semantic Similarity
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# 5230 (PGK1) 2821 (GPI) 7167 (TPI1) 2023 (ENO1) 5223 (PGAM1) 5315 (PKM) 2027 (ENO3) 5313 (PKLR) 2026 (ENO2) 5224 (PGAM2) 669 (BPGM) 5105 (PCK1) 6855 (SYP) 9562 (MINPP1) 2597 (GAPDH) 5106 (PCK2)
5230 (PGK1) 1.00 0.31 0.47 0.48 0.43 0.55 0.18 0.46 0.45 0.15 0.15 0.38 0.39 0.14 0.47 0.41
2821 (GPI) 0.31 1.00 0.81 0.36 0.45 0.36 0.20 0.20 0.40 0.27 0.27 0.17 0.31 0.15 0.33 0.36
7167 (TPI1) 0.47 0.81 1.00 0.55 0.60 0.57 0.20 0.20 0.60 0.24 0.24 0.26 0.50 0.15 0.51 0.53
2023 (ENO1) 0.48 0.36 0.55 1.00 0.52 0.70 1.00 0.20 0.72 0.13 0.13 0.27 0.45 0.13 0.51 0.55
5223 (PGAM1) 0.43 0.45 0.60 0.52 1.00 0.53 0.20 0.20 0.53 0.71 0.64 0.24 0.44 0.15 0.48 0.48
5315 (PKM) 0.55 0.36 0.57 0.70 0.53 1.00 0.20 1.00 0.57 0.15 0.15 0.26 0.48 0.14 0.54 0.52
2027 (ENO3) 0.18 0.20 0.20 1.00 0.20 0.20 1.00 0.20 1.00 0.20 0.20 0.29 0.13 0.17 0.24 0.34
5313 (PKLR) 0.46 0.20 0.20 0.20 0.20 1.00 0.20 1.00 0.20 0.20 0.20 0.17 0.13 0.17 0.40 0.20
2026 (ENO2) 0.45 0.40 0.60 0.72 0.53 0.57 1.00 0.20 1.00 0.18 0.18 0.30 0.51 0.16 0.50 0.59
5224 (PGAM2) 0.15 0.27 0.24 0.13 0.71 0.15 0.20 0.20 0.18 1.00 0.90 0.11 0.11 0.16 0.15 0.18
669 (BPGM) 0.15 0.27 0.24 0.13 0.64 0.15 0.20 0.20 0.18 0.90 1.00 0.11 0.11 0.16 0.15 0.18
5105 (PCK1) 0.38 0.17 0.26 0.27 0.24 0.26 0.29 0.17 0.30 0.11 0.11 1.00 0.24 0.11 0.23 0.55
6855 (SYP) 0.39 0.31 0.50 0.45 0.44 0.48 0.13 0.13 0.51 0.11 0.11 0.24 1.00 0.10 0.41 0.43
9562 (MINPP1) 0.14 0.15 0.15 0.13 0.15 0.14 0.17 0.17 0.16 0.16 0.16 0.11 0.10 1.00 0.15 0.16
2597 (GAPDH) 0.47 0.33 0.51 0.51 0.48 0.54 0.24 0.40 0.50 0.15 0.15 0.23 0.41 0.15 1.00 0.46
5106 (PCK2) 0.41 0.36 0.53 0.55 0.48 0.52 0.34 0.20 0.59 0.18 0.18 0.55 0.43 0.16 0.46 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
ENO2 Rat Brain cortex 316 hPa 8810 m 1 hour downregulated 13.96 ± 0.12 2-DE Southwestern europe Male albino wistar Rat 7.04 ±0.03 Adult male albino Wistar rats weighing 350 g kept at standard conditions 22961459
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT038722 hsa-miR-93-3p Homo sapiens ENO2 2026 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT044208 hsa-miR-99b-5p Homo sapiens ENO2 2026 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT440723 hsa-miR-382-3p Homo sapiens ENO2 2026 Homo sapiens HITS-CLIP Functional MTI (Weak) 24374217
Gene Ontology
ID GO ID GO Term GO Type
2026 GO:0006094 gluconeogenesis GOTERM_BP_DIRECT
2026 GO:0000287 magnesium ion binding GOTERM_MF_DIRECT
2026 GO:0005515 protein binding GOTERM_MF_DIRECT
2026 GO:0005829 cytosol GOTERM_CC_DIRECT
2026 GO:0000015 phosphopyruvate hydratase complex GOTERM_CC_DIRECT
2026 GO:0043204 perikaryon GOTERM_CC_DIRECT
2026 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2026 GO:0005886 plasma membrane GOTERM_CC_DIRECT
2026 GO:0043209 myelin sheath GOTERM_CC_DIRECT
2026 GO:0005615 extracellular space GOTERM_CC_DIRECT
2026 GO:0004634 phospholipase D activity GOTERM_MF_DIRECT
2026 GO:0001917 photoreceptor inner segment GOTERM_CC_DIRECT
2026 GO:0006096 glycolytic process GOTERM_BP_DIRECT
2026 GO:0061621 canonical glycolysis GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
2026 hsa00010 Glycolysis / Gluconeogenesis
2026 hsa01100 Metabolic pathways
2026 hsa01200 Carbon metabolism
2026 hsa01130 Biosynthesis of antibiotics
2026 hsa03018 RNA degradation
2026 hsa01230 Biosynthesis of amino acids
2026 hsa04066 HIF-1 signaling pathway
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
ENO2 2026 Malignant neoplasm of urinary bladder C0005684 Neoplastic Process 0.3 0.559 0.724 disease
ENO2 2026 Hepatoma, Morris C0019207 Experimental Model of Disease; Neoplastic Process 0.3 0.559 0.724 disease
ENO2 2026 Bladder Neoplasm C0005695 Neoplastic Process 0.3 0.559 0.724 group
ENO2 2026 Non-Small Cell Lung Carcinoma C0007131 Neoplastic Process 0.38 0.559 0.724 disease
ENO2 2026 Neoplastic Cell Transformation C0007621 Neoplastic Process 0.3 0.559 0.724 phenotype
ENO2 2026 Hepatoma, Novikoff C0019208 Experimental Model of Disease; Neoplastic Process 0.3 0.559 0.724 disease
ENO2 2026 Liver Neoplasms, Experimental C0023904 Experimental Model of Disease; Neoplastic Process 0.3 0.559 0.724 group
ENO2 2026 Experimental Hepatoma C0086404 Experimental Model of Disease; Neoplastic Process 0.3 0.559 0.724 disease
ENO2 2026 Neoplasms, Experimental C0027659 Experimental Model of Disease; Neoplastic Process 0.3 0.559 0.724 group
ENO2 2026 Leukemia, Myelocytic, Acute C0023467 Neoplastic Process 0.3 0.559 0.724 disease
ENO2 2026 Acute Myeloid Leukemia (AML-M2) C1879321 Neoplastic Process 0.3 0.559 0.724 disease
ENO2 2026 Acute Myeloid Leukemia, M1 C0026998 Neoplastic Process 0.3 0.559 0.724 disease
ENO2 2026 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.31 0.559 0.724 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
ENO2 2026 FLOXURIDINE FLOXURIDINE CHEMBL917 None
ENO2 2026 FENRETINIDE FENRETINIDE CHEMBL7301 None
ENO2 2026 GABAPENTIN GABAPENTIN CHEMBL940 None
ENO2 2026 INDOMETHACIN INDOMETHACIN CHEMBL6 None
ENO2 2026 INSULIN None None None
ENO2 2026 NERVE GROWTH FACTOR None None None
ENO2 2026 PROPOFOL PROPOFOL CHEMBL526 None
ENO2 2026 SODIUM BUTYRATE SODIUM BUTYRATE CHEMBL62381 None
ENO2 2026 STREPTOZOTOCIN STREPTOZOTOCIN CHEMBL1651906 None
ENO2 2026 TRIIODOTHYRONINE LIOTHYRONINE SODIUM CHEMBL1201119 None