ALTITUDEOMICSDB

Synaptophysin

AltitudeomicsDB

Protein Official symbol	SYP
Aliases	SYP
Chromosomal Location	X
Length	313
Uniprot ID	P08247
EC number	None
Protein family Information(Pfam)	PF01284;
PDB id	None
InterPro ID	IPR008253;IPR001285;IPR028714;
dbSNP	rs200470034 rs137852561 rs782086106 rs139475570

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
VAMP2	SNAP25	0.9990000000000001
SNAP25	STX1A	0.9990000000000001
SYT1	STX1A	0.9990000000000001
SYT1	SNAP25	0.9990000000000001
VAMP2	STX1A	0.998
GRIN2B	DLG4	0.997
DLG4	GRIN2A	0.995
GAD2	SLC32A1	0.9940000000000001
VAMP2	SYT1	0.9940000000000001
DLG4	GRIN1	0.993
GRIA1	DLG4	0.993
DLG4	GRIA2	0.991
GRIN2B	GRIN1	0.991
SNAP25	RAB3A	0.991
GRIN2A	GRIN1	0.99
SLC17A7	SLC32A1	0.988
SLC17A6	SLC32A1	0.987
SYN1	SNAP25	0.986
SYN1	SYT1	0.9840000000000001
GRIN2B	BDNF	0.982
SYN1	RAB3A	0.981
SYT1	RAB3A	0.981
NCAM1	GDNF	0.978
SYT1	SLC17A7	0.976
SYT1	SLC32A1	0.976
VAMP2	RAB3A	0.9740000000000001
SNAP25	SLC32A1	0.973
SNAP25	SLC17A7	0.972
VAMP2	SYN1	0.972
STX1A	RAB3A	0.9690000000000001
GRIA1	GRIA2	0.9670000000000001
GAD2	SNAP25	0.9670000000000001
VAMP2	SLC17A7	0.9670000000000001
GRIN1	GRIA2	0.9640000000000001
SYN1	STX1A	0.9620000000000001
GRIA1	GRIN2A	0.9590000000000001
BDNF	GDNF	0.958
RAB3A	SLC17A7	0.9570000000000001
GAD2	SYT1	0.9570000000000001
GRIA1	GRIN1	0.9570000000000001
GRIN2B	GRIA2	0.956
GRIN2B	GRIA1	0.955
VAMP2	SLC32A1	0.9540000000000001
GRIN2A	GRIA2	0.951
RAB3A	SLC32A1	0.95
GAD2	VAMP2	0.9470000000000001
SYP	CHGA	0.945
GAD2	STX1A	0.943
STX1A	SLC17A7	0.943
STX1A	SLC32A1	0.9390000000000001
KRT7	KRT20	0.9390000000000001
GFAP	RBFOX3	0.938
GRIN2B	GRIN2A	0.937
GAD2	RAB3A	0.9329999999999999
VAMP2	SYP	0.929
SST	APP	0.9279999999999999
ENO2	SYP	0.927
ENO2	CHGA	0.925
BDNF	NGF	0.92
SYP	SNAP25	0.91
DLG4	SYN1	0.905
GDNF	NGF	0.903
DLG4	SYP	0.893
SST	CHGA	0.892
SV2A	SYT1	0.89
SYN1	SYP	0.88
DLG4	SLC17A7	0.879
NCAM1	SYP	0.878
SRCIN1	SNAP25	0.866
SYT1	CHGA	0.866
GAD2	SLC17A6	0.86
STX1A	CHGA	0.858
GFAP	SYP	0.857
CALB2	SST	0.857
SYP	SLC17A7	0.856
GAD2	SLC17A7	0.856
GRIA1	SYP	0.84
DLG4	APP	0.84
ENO2	CEACAM5	0.8390000000000001
SLC17A6	SLC17A7	0.838
GRIA1	BDNF	0.838
KRT7	CEACAM5	0.836
SYP	SYT1	0.836
NKX2-1	KRT7	0.836
GFAP	MAP2	0.835
MAP2	SYP	0.83
SYN1	SLC17A7	0.83
BDNF	APP	0.828
SV2A	SNAP25	0.8270000000000001
CEACAM5	KRT20	0.8270000000000001
BDNF	SYN1	0.825
NGF	APP	0.818
BDNF	GRIN2A	0.8170000000000001
NCAM1	CHGA	0.8170000000000001
SYN1	SLC32A1	0.813
RBFOX3	SYP	0.812
SV2A	SYP	0.799
KRT7	SYP	0.797
BSN	SYN1	0.787
SYP	RAB3A	0.7859999999999999
KIT	SYP	0.7859999999999999
GAP43	MAP2	0.785
NGF	SYP	0.7829999999999999
SYP	SLC32A1	0.7829999999999999
GRIN1	SLC32A1	0.779
DLG4	BSN	0.777
DLG4	MAP2	0.7759999999999999
DLG4	SNAP25	0.774
SYP	SLC17A6	0.774
GAP43	SYP	0.773
GFAP	BDNF	0.77
BSN	SYP	0.769
GDNF	CHL1	0.769
BSN	SLC17A7	0.768
RBFOX3	MAP2	0.7659999999999999
APP	SYP	0.7659999999999999
GAD2	CALB2	0.7659999999999999
GRIN1	SYP	0.763
GFAP	SLC17A7	0.7609999999999999
RBFOX3	CALB2	0.759
NGF	KIT	0.758
GRIA1	SLC17A7	0.758
GFAP	ENO2	0.757
GRIN2B	SYP	0.7559999999999999
BSN	RAB3A	0.7559999999999999
GRIA2	SYP	0.753
NCAM1	ENO2	0.752
BDNF	DLG4	0.752
MAP2	APP	0.7509999999999999
SYN1	SLC17A6	0.75
GRIA2	SLC17A7	0.7490000000000001
MAP2	SYN1	0.7490000000000001
GAD2	SST	0.748
BDNF	SYP	0.748
GRIA1	SYN1	0.748
GRIA2	SNAP25	0.745
BDNF	SLC17A7	0.745
DLG4	SLC32A1	0.7440000000000001
RBFOX3	BDNF	0.7440000000000001
NCAM1	KIT	0.742
GRIN1	SLC17A7	0.741
RBFOX3	SLC17A7	0.74
SST	SYP	0.74
NKX2-1	KRT20	0.7390000000000001
ENO2	CD99	0.7390000000000001
NCAM1	GFAP	0.736
KRT7	CALB2	0.735
BSN	SNAP25	0.7340000000000001
SV2A	SYN1	0.7340000000000001
SYP	KRT20	0.733
GFAP	GAP43	0.732
DLG4	SLC17A6	0.731
NKX2-1	SYP	0.73
SYNGR1	SYP	0.7290000000000001
GFAP	SYN1	0.722
GAP43	SYN1	0.722
SRCIN1	SYP	0.721
RBFOX3	SLC17A6	0.7190000000000001
GRIN2A	SYP	0.7190000000000001
NCAM1	BDNF	0.718
SYP	CHL1	0.716
GAD2	SYP	0.7140000000000001
RBFOX3	SYN1	0.713
BDNF	KIT	0.7120000000000001
GFAP	GAD2	0.7120000000000001
GAP43	SNAP25	0.7120000000000001
GRIA2	SLC17A6	0.7120000000000001
SYP	STX1A	0.711
ENO2	KRT7	0.71
CD99	SYP	0.71
CEACAM5	CHGA	0.7090000000000001
KRT7	CHGA	0.7090000000000001
NCAM1	KRT7	0.7090000000000001
CALB2	SYP	0.7090000000000001
GAD2	GRIA2	0.7090000000000001
GFAP	APP	0.708
BSN	SLC32A1	0.708
GDNF	SYP	0.703
BDNF	MAP2	0.703
CALB2	SLC17A7	0.703
MLANA	SYP	0.703
GAP43	NGF	0.7020000000000001
NKX2-1	CALB2	0.7020000000000001
BDNF	GAP43	0.701
SYP	CEACAM5	0.7
GFAP	DLG4	0.7
KRT7	KIT	0.7

Gene Ontology Semantic Similarity

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#	6844 (VAMP2)	6616 (SNAP25)	6857 (SYT1)	2904 (GRIN2B)	1742 (DLG4)	2572 (GAD2)	2890 (GRIA1)	2903 (GRIN2A)	57030 (SLC17A7)	57084 (SLC17A6)	6853 (SYN1)	4684 (NCAM1)	6804 (STX1A)	2902 (GRIN1)	627 (BDNF)	5864 (RAB3A)	6855 (SYP)	3855 (KRT7)	2670 (GFAP)	6750 (SST)	2026 (ENO2)	2668 (GDNF)	9900 (SV2A)	80725 (SRCIN1)	794 (CALB2)	7080 (NKX2-1)	4133 (MAP2)	1048 (CEACAM5)	4803 (NGF)	146713 (RBFOX3)	3815 (KIT)	2596 (GAP43)	351 (APP)	2891 (GRIA2)	9145 (SYNGR1)	2315 (MLANA)	140679 (SLC32A1)	54474 (KRT20)
6844 (VAMP2)	1.00	0.90	0.84	0.63	0.64	0.72	0.62	0.69	0.09	0.08	0.69	0.21	0.80	0.62	0.53	0.71	0.65	1.00	0.74	0.69	0.72	0.72	0.60	0.76	0.38	0.56	0.71	0.67	0.69	0.30	0.61	1.00	0.71	0.61	1.00	1.00	0.08	0.73
6616 (SNAP25)	0.90	1.00	0.70	0.57	0.63	0.73	0.58	0.68	0.09	0.08	0.67	0.21	0.79	0.53	0.56	0.71	0.62	1.00	0.76	0.69	0.73	0.73	0.60	0.81	0.36	0.51	0.71	0.62	0.68	0.30	0.56	1.00	0.71	0.56	1.00	1.00	0.09	0.75
6857 (SYT1)	0.84	0.70	1.00	0.56	0.58	0.57	0.51	0.60	0.08	0.08	0.56	0.21	0.65	0.58	0.44	0.57	0.48	1.00	0.60	0.69	0.57	0.61	0.60	0.61	1.00	0.48	0.58	0.61	0.56	0.30	0.50	1.00	0.62	0.49	1.00	1.00	0.07	0.58
2904 (GRIN2B)	0.63	0.57	0.56	1.00	0.67	0.43	0.66	0.81	0.14	0.19	0.47	1.00	0.57	0.84	0.35	0.45	0.38	1.00	0.50	0.69	0.43	0.68	0.60	0.50	0.63	0.39	0.49	0.42	0.47	0.30	0.58	1.00	0.55	0.70	1.00	1.00	0.14	0.45
1742 (DLG4)	0.64	0.63	0.58	0.67	1.00	0.59	0.69	0.66	0.12	0.27	0.60	1.00	0.65	0.66	0.48	0.58	0.48	1.00	0.60	0.70	0.59	0.72	0.86	0.63	0.36	0.52	0.61	0.49	0.59	0.30	0.66	1.00	0.66	0.68	1.00	1.00	0.11	0.59
2572 (GAD2)	0.72	0.73	0.57	0.43	0.59	1.00	0.45	0.54	0.09	0.08	0.55	0.21	0.66	0.44	0.49	0.58	0.51	1.00	0.65	0.69	0.67	0.63	0.60	0.69	0.36	0.42	0.61	0.53	0.57	0.30	0.47	1.00	0.64	0.40	1.00	1.00	0.09	0.61
2890 (GRIA1)	0.62	0.58	0.51	0.66	0.69	0.45	1.00	0.44	0.18	0.23	0.49	0.21	0.56	0.62	0.36	0.47	0.39	1.00	0.51	0.69	0.45	0.51	0.60	0.51	0.36	0.39	0.51	0.41	0.47	0.30	0.51	1.00	0.55	0.91	1.00	1.00	0.19	0.47
2903 (GRIN2A)	0.69	0.68	0.60	0.81	0.66	0.54	0.44	1.00	0.09	0.08	0.53	1.00	0.65	0.62	0.45	0.54	0.47	1.00	0.60	0.69	0.54	0.82	0.60	0.63	0.63	0.42	0.58	0.49	0.55	0.30	0.61	1.00	0.63	0.40	1.00	1.00	0.08	0.56
57030 (SLC17A7)	0.09	0.09	0.08	0.14	0.12	0.09	0.18	0.09	1.00	1.00	0.19	0.09	0.09	0.17	0.06	0.08	0.07	0.12	0.10	0.07	0.09	0.09	0.06	0.09	0.06	0.07	0.10	0.07	0.08	0.05	0.08	0.12	0.08	0.22	0.12	0.12	0.59	0.10
57084 (SLC17A6)	0.08	0.08	0.08	0.19	0.27	0.08	0.23	0.08	1.00	1.00	0.23	0.07	0.08	0.23	0.06	0.08	0.07	0.08	0.08	0.06	0.08	0.08	0.05	0.08	0.05	0.08	0.10	0.07	0.08	0.04	0.08	0.08	0.08	0.23	0.08	0.08	0.76	0.08
6853 (SYN1)	0.69	0.67	0.56	0.47	0.60	0.55	0.49	0.53	0.19	0.23	1.00	0.28	0.67	0.48	0.44	0.55	0.48	1.00	0.61	0.69	0.55	0.60	1.00	0.75	0.36	0.45	0.60	0.50	0.54	0.30	0.47	1.00	0.63	0.47	1.00	1.00	0.17	0.57
4684 (NCAM1)	0.21	0.21	0.21	1.00	1.00	0.21	0.21	1.00	0.09	0.07	0.28	1.00	0.27	1.00	0.15	0.21	0.17	0.21	0.21	0.15	0.21	1.00	0.13	0.21	0.13	0.21	0.28	0.17	0.21	0.11	1.00	0.21	0.22	0.21	0.21	0.21	0.09	0.21
6804 (STX1A)	0.80	0.79	0.65	0.57	0.65	0.66	0.56	0.65	0.09	0.08	0.67	0.27	1.00	0.53	0.50	0.70	0.56	1.00	0.69	0.69	0.66	0.70	0.86	0.77	0.36	0.52	0.67	0.56	0.64	0.30	0.56	1.00	0.69	0.54	1.00	1.00	0.08	0.68
2902 (GRIN1)	0.62	0.53	0.58	0.84	0.66	0.44	0.62	0.62	0.17	0.23	0.48	1.00	0.53	1.00	0.34	0.45	0.37	1.00	0.48	0.69	0.44	0.61	0.60	0.48	1.00	0.40	0.48	0.41	0.46	0.30	0.54	1.00	0.53	0.65	1.00	1.00	0.16	0.45
627 (BDNF)	0.53	0.56	0.44	0.35	0.48	0.49	0.36	0.45	0.06	0.06	0.44	0.15	0.50	0.34	1.00	0.47	0.42	0.69	0.52	0.70	0.49	0.59	0.40	0.57	0.24	0.32	0.48	0.42	0.65	0.20	0.36	0.69	0.54	0.34	0.69	0.69	0.06	0.51
5864 (RAB3A)	0.71	0.71	0.57	0.45	0.58	0.58	0.47	0.54	0.08	0.08	0.55	0.21	0.70	0.45	0.47	1.00	0.50	1.00	0.64	0.69	0.58	0.62	0.60	0.67	0.36	0.43	0.61	0.51	0.57	0.30	0.47	1.00	0.64	0.42	1.00	1.00	0.08	0.60
6855 (SYP)	0.65	0.62	0.48	0.38	0.48	0.51	0.39	0.47	0.07	0.07	0.48	0.17	0.56	0.37	0.42	0.50	1.00	0.82	0.56	0.56	0.51	0.54	0.48	0.60	0.28	0.36	0.52	0.46	0.48	0.24	0.39	0.82	0.54	0.35	0.82	0.82	0.07	0.53
3855 (KRT7)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.12	0.08	1.00	0.21	1.00	1.00	0.69	1.00	0.82	1.00	1.00	0.69	1.00	1.00	0.60	1.00	0.36	1.00	1.00	0.82	1.00	0.30	1.00	1.00	1.00	1.00	1.00	1.00	0.11	1.00
2670 (GFAP)	0.74	0.76	0.60	0.50	0.60	0.65	0.51	0.60	0.10	0.08	0.61	0.21	0.69	0.48	0.52	0.64	0.56	1.00	1.00	0.69	0.65	0.69	0.60	0.74	0.36	0.46	0.78	0.67	0.62	0.30	0.52	1.00	0.71	0.47	1.00	1.00	0.10	0.96
6750 (SST)	0.69	0.69	0.69	0.69	0.70	0.69	0.69	0.69	0.07	0.06	0.69	0.15	0.69	0.69	0.70	0.69	0.56	0.69	0.69	1.00	0.69	0.84	0.40	0.69	0.24	0.69	0.69	0.56	0.70	0.20	0.69	0.69	0.84	0.69	0.69	0.69	0.07	0.69
2026 (ENO2)	0.72	0.73	0.57	0.43	0.59	0.67	0.45	0.54	0.09	0.08	0.55	0.21	0.66	0.44	0.49	0.58	0.51	1.00	0.65	0.69	1.00	0.63	0.60	0.69	0.36	0.42	0.61	0.53	0.57	0.30	0.47	1.00	0.64	0.40	1.00	1.00	0.09	0.61
2668 (GDNF)	0.72	0.73	0.61	0.68	0.72	0.63	0.51	0.82	0.09	0.08	0.60	1.00	0.70	0.61	0.59	0.62	0.54	1.00	0.69	0.84	0.63	1.00	0.60	0.71	0.36	0.47	0.65	0.68	0.65	0.30	0.72	1.00	0.72	0.48	1.00	1.00	0.09	0.65
9900 (SV2A)	0.60	0.60	0.60	0.60	0.86	0.60	0.60	0.60	0.06	0.05	1.00	0.13	0.86	0.60	0.40	0.60	0.48	0.60	0.60	0.40	0.60	0.60	1.00	1.00	0.20	0.73	0.60	0.48	0.60	0.17	0.60	0.60	0.73	0.60	0.60	0.60	0.06	0.60
80725 (SRCIN1)	0.76	0.81	0.61	0.50	0.63	0.69	0.51	0.63	0.09	0.08	0.75	0.21	0.77	0.48	0.57	0.67	0.60	1.00	0.74	0.69	0.69	0.71	1.00	1.00	0.36	0.47	0.68	0.60	0.64	0.30	0.51	1.00	0.71	0.47	1.00	1.00	0.09	0.72
794 (CALB2)	0.38	0.36	1.00	0.63	0.36	0.36	0.36	0.63	0.06	0.05	0.36	0.13	0.36	1.00	0.24	0.36	0.28	0.36	0.36	0.24	0.36	0.36	0.20	0.36	1.00	0.36	0.36	0.28	0.36	0.17	0.36	0.36	0.36	0.36	0.36	0.36	0.06	0.36
7080 (NKX2-1)	0.56	0.51	0.48	0.39	0.52	0.42	0.39	0.42	0.07	0.08	0.45	0.21	0.52	0.40	0.32	0.43	0.36	1.00	0.46	0.69	0.42	0.47	0.73	0.47	0.36	1.00	0.46	0.37	0.44	0.59	0.41	1.00	0.74	0.37	1.00	1.00	0.07	0.43
4133 (MAP2)	0.71	0.71	0.58	0.49	0.61	0.61	0.51	0.58	0.10	0.10	0.60	0.28	0.67	0.48	0.48	0.61	0.52	1.00	0.78	0.69	0.61	0.65	0.60	0.68	0.36	0.46	1.00	0.53	0.59	0.30	0.51	1.00	0.65	0.47	1.00	1.00	0.10	0.78
1048 (CEACAM5)	0.67	0.62	0.61	0.42	0.49	0.53	0.41	0.49	0.07	0.07	0.50	0.17	0.56	0.41	0.42	0.51	0.46	0.82	0.67	0.56	0.53	0.68	0.48	0.60	0.28	0.37	0.53	1.00	0.50	0.24	0.50	0.82	0.61	0.39	0.82	0.82	0.07	0.54
4803 (NGF)	0.69	0.68	0.56	0.47	0.59	0.57	0.47	0.55	0.08	0.08	0.54	0.21	0.64	0.46	0.65	0.57	0.48	1.00	0.62	0.70	0.57	0.65	0.60	0.64	0.36	0.44	0.59	0.50	1.00	0.30	0.48	1.00	0.76	0.43	1.00	1.00	0.07	0.58
146713 (RBFOX3)	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.30	0.05	0.04	0.30	0.11	0.30	0.30	0.20	0.30	0.24	0.30	0.30	0.20	0.30	0.30	0.17	0.30	0.17	0.59	0.30	0.24	0.30	1.00	0.30	0.30	0.59	0.30	0.30	0.30	0.05	0.30
3815 (KIT)	0.61	0.56	0.50	0.58	0.66	0.47	0.51	0.61	0.08	0.08	0.47	1.00	0.56	0.54	0.36	0.47	0.39	1.00	0.52	0.69	0.47	0.72	0.60	0.51	0.36	0.41	0.51	0.50	0.48	0.30	1.00	1.00	0.56	0.46	1.00	1.00	0.07	0.47
2596 (GAP43)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.12	0.08	1.00	0.21	1.00	1.00	0.69	1.00	0.82	1.00	1.00	0.69	1.00	1.00	0.60	1.00	0.36	1.00	1.00	0.82	1.00	0.30	1.00	1.00	1.00	1.00	1.00	1.00	0.11	1.00
351 (APP)	0.71	0.71	0.62	0.55	0.66	0.64	0.55	0.63	0.08	0.08	0.63	0.22	0.69	0.53	0.54	0.64	0.54	1.00	0.71	0.84	0.64	0.72	0.73	0.71	0.36	0.74	0.65	0.61	0.76	0.59	0.56	1.00	1.00	0.53	1.00	1.00	0.08	0.65
2891 (GRIA2)	0.61	0.56	0.49	0.70	0.68	0.40	0.91	0.40	0.22	0.23	0.47	0.21	0.54	0.65	0.34	0.42	0.35	1.00	0.47	0.69	0.40	0.48	0.60	0.47	0.36	0.37	0.47	0.39	0.43	0.30	0.46	1.00	0.53	1.00	1.00	1.00	0.24	0.42
9145 (SYNGR1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.12	0.08	1.00	0.21	1.00	1.00	0.69	1.00	0.82	1.00	1.00	0.69	1.00	1.00	0.60	1.00	0.36	1.00	1.00	0.82	1.00	0.30	1.00	1.00	1.00	1.00	1.00	1.00	0.11	1.00
2315 (MLANA)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.12	0.08	1.00	0.21	1.00	1.00	0.69	1.00	0.82	1.00	1.00	0.69	1.00	1.00	0.60	1.00	0.36	1.00	1.00	0.82	1.00	0.30	1.00	1.00	1.00	1.00	1.00	1.00	0.11	1.00
140679 (SLC32A1)	0.08	0.09	0.07	0.14	0.11	0.09	0.19	0.08	0.59	0.76	0.17	0.09	0.08	0.16	0.06	0.08	0.07	0.11	0.10	0.07	0.09	0.09	0.06	0.09	0.06	0.07	0.10	0.07	0.07	0.05	0.07	0.11	0.08	0.24	0.11	0.11	1.00	0.10
54474 (KRT20)	0.73	0.75	0.58	0.45	0.59	0.61	0.47	0.56	0.10	0.08	0.57	0.21	0.68	0.45	0.51	0.60	0.53	1.00	0.96	0.69	0.61	0.65	0.60	0.72	0.36	0.43	0.78	0.54	0.58	0.30	0.47	1.00	0.65	0.42	1.00	1.00	0.10	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
SYP	Rat	Left brain cortices	300hPa	9144 m	1 hour	downregulated	0.61±0.0	TMT labeled LTQ orbitrap	Southwestern europe	Male wistar rats	1	Adult male Wistar rats weighing 350 g	28697276

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
EP300	2033	SYP	6855	proximal_filtered	22955619	TRANSFAC
REST	5978	SYP	6855	proximal_filtered	22955619	TRANSFAC
PKNOX1	5316	SYP	6855	Unknown	12057991	TRUSST
SP1	6667	SYP	6855	Activation	11274170	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT017945	hsa-miR-335-5p	Homo sapiens	SYP	6855	Homo sapiens	Microarray	Functional MTI (Weak)	18185580
MIRT520836	hsa-miR-3120-3p	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520831	hsa-miR-545-3p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520832	hsa-miR-5011-5p	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520828	hsa-miR-6083	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520835	hsa-miR-369-3p	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520839	hsa-miR-374b-5p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520839	hsa-miR-374b-5p	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520840	hsa-miR-374a-5p	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520838	hsa-miR-410-3p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520833	hsa-miR-5692c	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520832	hsa-miR-5011-5p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520834	hsa-miR-5692b	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520835	hsa-miR-369-3p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520834	hsa-miR-5692b	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520836	hsa-miR-3120-3p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520840	hsa-miR-374a-5p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520829	hsa-miR-190a-3p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520830	hsa-miR-3145-3p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520830	hsa-miR-3145-3p	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520828	hsa-miR-6083	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520829	hsa-miR-190a-3p	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520837	hsa-miR-1277-5p	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520837	hsa-miR-1277-5p	Homo sapiens	SYP	6855	Homo sapiens	PAR-CLIP	Functional MTI (Weak)	23446348
MIRT520833	hsa-miR-5692c	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407
MIRT520838	hsa-miR-410-3p	Homo sapiens	SYP	6855	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	21572407

Gene Ontology

ID	GO ID	GO Term	GO Type
6855	GO:0048172	regulation of short-term neuronal synaptic plasticity	GOTERM_BP_DIRECT
6855	GO:0015485	cholesterol binding	GOTERM_MF_DIRECT
6855	GO:0042802	identical protein binding	GOTERM_MF_DIRECT
6855	GO:0008021	synaptic vesicle	GOTERM_CC_DIRECT
6855	GO:0042734	presynaptic membrane	GOTERM_CC_DIRECT
6855	GO:0030054	cell junction	GOTERM_CC_DIRECT
6855	GO:0043195	terminal bouton	GOTERM_CC_DIRECT
6855	GO:0048168	regulation of neuronal synaptic plasticity	GOTERM_BP_DIRECT
6855	GO:0048499	synaptic vesicle membrane organization	GOTERM_BP_DIRECT
6855	GO:0043621	protein self-association	GOTERM_MF_DIRECT
6855	GO:0043005	neuron projection	GOTERM_CC_DIRECT
6855	GO:0030285	integral component of synaptic vesicle membrane	GOTERM_CC_DIRECT
6855	GO:0006897	endocytosis	GOTERM_BP_DIRECT
6855	GO:0048169	regulation of long-term neuronal synaptic plasticity	GOTERM_BP_DIRECT
6855	GO:2000474	regulation of opioid receptor signaling pathway	GOTERM_BP_DIRECT
6855	GO:0005215	transporter activity	GOTERM_MF_DIRECT
6855	GO:0016021	integral component of membrane	GOTERM_CC_DIRECT
6855	GO:0016188	synaptic vesicle maturation	GOTERM_BP_DIRECT
6855	GO:0042169	thiamine phosphate phosphatase activity	GOTERM_MF_DIRECT
6855	GO:0060076	excitatory synapse	GOTERM_CC_DIRECT
6855	GO:0016020	membrane	GOTERM_CC_DIRECT
6855	GO:0071310	cellular response to organic substance	GOTERM_BP_DIRECT
6855	GO:0048786	presynaptic active zone	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
SYP	6855	MENTAL RETARDATION, X-LINKED 96	C3275408	Disease or Syndrome	0.7	0.55	0.69	disease
SYP	6855	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.36	0.55	0.69	disease
SYP	6855	Learning Disturbance	C0751263	Mental or Behavioral Dysfunction	0.3	0.55	0.69	disease
SYP	6855	Memory impairment	C0233794	Mental or Behavioral Dysfunction	0.3	0.55	0.69	phenotype
SYP	6855	Memory Disorder, Spatial	C0751294	Mental or Behavioral Dysfunction	0.3	0.55	0.69	disease
SYP	6855	Memory Loss	C0751295	Sign or Symptom	0.3	0.55	0.69	phenotype
SYP	6855	CEROID LIPOFUSCINOSIS, NEURONAL, 6	C1866282	Disease or Syndrome	0.3	0.55	0.69	disease
SYP	6855	Learning Disabilities	C0751265	Mental or Behavioral Dysfunction	0.3	0.55	0.69	disease
SYP	6855	Non-Small Cell Lung Carcinoma	C0007131	Neoplastic Process	0.31	0.55	0.69	disease
SYP	6855	Developmental Academic Disorder	C1330966	Finding	0.3	0.55	0.69	phenotype
SYP	6855	Learning Disorders	C0023186	Mental or Behavioral Dysfunction	0.3	0.55	0.69	group
SYP	6855	Memory Disorders	C0025261	Mental or Behavioral Dysfunction	0.3	0.55	0.69	disease
SYP	6855	Ceroid lipofuscinosis, neuronal 1, infantile	C2931673	Disease or Syndrome	0.3	0.55	0.69	disease
SYP	6855	Adult Learning Disorders	C0751262	Mental or Behavioral Dysfunction	0.3	0.55	0.69	group
SYP	6855	Memory Disorder, Semantic	C0751293	Mental or Behavioral Dysfunction	0.3	0.55	0.69	disease
SYP	6855	Age-Related Memory Disorders	C0751292	Mental or Behavioral Dysfunction	0.3	0.55	0.69	disease
SYP	6855	Mental Retardation, X-Linked	C1136249	Disease or Syndrome	0.3	0.55	0.69	disease
SYP	6855	Intellectual Disability	C3714756	Mental or Behavioral Dysfunction	0.4	0.55	0.69	group
SYP	6855	Mental Retardation, X-Linked 1	C2931498	Disease or Syndrome	0.3	0.55	0.69	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
SYP	6855	6-HYDROXYDOPAMINE	None	None	None
SYP	6855	DIMETHYL SULFOXIDE	DIMETHYL SULFOXIDE	CHEMBL504	None
SYP	6855	MORPHINE	MORPHINE	CHEMBL70	None