Phosphoglycerate kinase 1

AltitudeomicsDB
Protein Official symbol PGK1
Aliases PGK1 PGKA MIG10 OK/SW-cl.110
Chromosomal Location  X
Length 417
Uniprot ID P00558
EC number 2.7.2.3
Protein family Information(Pfam) PF00162;
PDB id 2WZB;2WZC;2WZD;2X13;2X14;2X15;2XE6;2XE7;2XE8;2Y3I;2YBE;2ZGV;3C39;3C3A;3C3B;3C3C;3ZOZ;4AXX;4O33;5M1R;5M3U;5M6Z;5MXM;5NP8;5O7D;
InterPro ID IPR001576;IPR015911;IPR015824;IPR036043;
dbSNP rs137852531 rs137852532 rs137852538 rs137852529 rs431905501 rs137852528 rs137852535 rs137852533 rs137852530

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
GPI TPI1 0.998
TPI1 GAPDH 0.998
PGK1 TPI1 0.997
TPI1 GAPDHS 0.994
PKM ENO1 0.993
PGK1 GAPDH 0.991
PGAM1 ENO1 0.989
PGK1 PGAM1 0.988
GPI PKM 0.987
GPI GAPDH 0.986
GPI ENO1 0.985
PGAM4 PGK1 0.985
PGK1 GAPDHS 0.983
ENO1 TPI1 0.982
PGK1 PGAM2 0.978
ENO1 GAPDH 0.973
GPI GAPDHS 0.971
PGAM2 ENO1 0.971
BPGM PGK1 0.969
BPGM ENO1 0.966
PKM TPI1 0.964
GPI PGAM1 0.962
GPI PGK1 0.957
PGAM1 TPI1 0.954
PGAM4 GPI 0.952
PKM GAPDH 0.951
GPI PGAM2 0.95
BPGM GAPDHS 0.95
BPGM GAPDH 0.949
PGK1 ENO1 0.947
PGAM4 ENO1 0.925
GPI BPGM 0.922
PGK1 PKM 0.916
PGAM2 TPI1 0.915
PGAM4 TPI1 0.915
BPGM PGAM1 0.905
BPGM PGAM2 0.905
PGAM4 BPGM 0.904
Gene Ontology Semantic Similarity
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# 2821 (GPI) 7167 (TPI1) 5230 (PGK1) 5315 (PKM) 5223 (PGAM1) 441531 (PGAM4) 2023 (ENO1) 5224 (PGAM2) 669 (BPGM) 2597 (GAPDH) 26330 (GAPDHS)
2821 (GPI) 1.00 0.71 0.33 0.37 0.56 0.73 0.34 0.73 0.73 0.33 0.38
7167 (TPI1) 0.71 1.00 0.43 0.57 0.65 0.34 0.49 0.34 0.34 0.47 0.59
5230 (PGK1) 0.33 0.43 1.00 0.52 0.43 0.18 0.42 0.18 0.18 0.42 0.43
5315 (PKM) 0.37 0.57 0.52 1.00 0.57 0.20 0.64 0.20 0.20 0.50 0.56
5223 (PGAM1) 0.56 0.65 0.43 0.57 1.00 1.00 0.49 1.00 0.73 0.47 0.59
441531 (PGAM4) 0.73 0.34 0.18 0.20 1.00 1.00 0.20 1.00 0.73 0.24 0.17
2023 (ENO1) 0.34 0.49 0.42 0.64 0.49 0.20 1.00 0.20 0.20 0.44 0.47
5224 (PGAM2) 0.73 0.34 0.18 0.20 1.00 1.00 0.20 1.00 0.73 0.24 0.17
669 (BPGM) 0.73 0.34 0.18 0.20 0.73 0.73 0.20 0.73 1.00 0.24 0.17
2597 (GAPDH) 0.33 0.47 0.42 0.50 0.47 0.24 0.44 0.24 0.24 1.00 0.63
26330 (GAPDHS) 0.38 0.59 0.43 0.56 0.59 0.17 0.47 0.17 0.17 0.63 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
PGK1 Human Serum - 2400 m 0.5 hours upregulated 0.021 2-DE Western Europe Germans 0.017 Healthy adults never had ear surgery or problems with pressure equalization 28858246
PGK1 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 2.2 RT-qPCR Western US C57BL/6 mice 1.7 7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
PGK1 Mice Blood 8% Oxygen 7600 m 24 hours upregulated 2 RT-qPCR Western US C57BL/6 mice 1.7 7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen) 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
MEF2A 4205 PGK1 5230 distal 22955619 TRANSFAC
TCF12 6938 PGK1 5230 distal 22955619 TRANSFAC
EBF1 1879 PGK1 5230 distal 22955619 TRANSFAC
EGR1 1958 PGK1 5230 distal 22955619 TRANSFAC
NFKB1 4790 PGK1 5230 distal 22955619 TRANSFAC
RXRA 6256 PGK1 5230 distal 22955619 TRANSFAC
IRF4 3662 PGK1 5230 distal 22955619 TRANSFAC
MYC 4609 PGK1 5230 distal 22955619 TRANSFAC
EP300 2033 PGK1 5230 distal 22955619 TRANSFAC
SPI1 6688 PGK1 5230 distal 22955619 TRANSFAC
JUND 3727 PGK1 5230 distal 22955619 TRANSFAC
MEF2C 4208 PGK1 5230 distal 22955619 TRANSFAC
PAX5 5079 PGK1 5230 distal 22955619 TRANSFAC
SP1 6667 PGK1 5230 distal 22955619 TRANSFAC
BCL11A 53335 PGK1 5230 distal 22955619 TRANSFAC
CEBPB 1051 PGK1 5230 distal 22955619 TRANSFAC
POU2F2 5452 PGK1 5230 distal 22955619 TRANSFAC
STAT3 6774 PGK1 5230 distal 22955619 TRANSFAC
BATF 10538 PGK1 5230 distal 22955619 TRANSFAC
MAX 4149 PGK1 5230 distal 22955619 TRANSFAC
RAD21 5885 PGK1 5230 distal 22955619 TRANSFAC
SRF 6722 PGK1 5230 distal 22955619 TRANSFAC
HIF1A 3091 PGK1 5230 Unknown 15937477 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT040970 hsa-miR-18a-3p Homo sapiens PGK1 5230 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT040970 hsa-miR-18a-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT043151 hsa-miR-324-5p Homo sapiens PGK1 5230 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT050550 hsa-miR-20a-5p Homo sapiens PGK1 5230 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT176163 hsa-miR-548c-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT176151 hsa-miR-141-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT176177 hsa-miR-3185 Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT176153 hsa-miR-200a-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT329671 hsa-miR-548az-5p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT329670 hsa-miR-548at-5p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT329669 hsa-miR-548t-5p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT329668 hsa-miR-548n Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT445727 hsa-miR-3646 Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445730 hsa-miR-548aq-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445725 hsa-miR-27b-5p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445732 hsa-miR-548aj-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445734 hsa-miR-548ae-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445729 hsa-miR-548j-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445731 hsa-miR-548am-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445733 hsa-miR-548ah-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445726 hsa-miR-5582-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT445728 hsa-miR-548x-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22100165
MIRT528397 hsa-miR-3133 Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT528392 hsa-miR-610 Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT528393 hsa-miR-570-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT528394 hsa-miR-4744 Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT528395 hsa-miR-548b-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT528396 hsa-miR-186-5p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT544139 hsa-miR-96-5p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT544141 hsa-miR-548e-5p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT544140 hsa-miR-6835-3p Homo sapiens PGK1 5230 Homo sapiens PAR-CLIP Functional MTI (Weak) 21572407
MIRT622779 hsa-miR-6878-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622787 hsa-miR-324-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622788 hsa-miR-1913 Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT622782 hsa-miR-6744-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622783 hsa-miR-4757-5p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622788 hsa-miR-1913 Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622794 hsa-miR-6507-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622793 hsa-miR-6838-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622791 hsa-miR-6852-5p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622781 hsa-miR-1343-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622789 hsa-miR-212-5p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622784 hsa-miR-4707-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622792 hsa-miR-125a-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622786 hsa-miR-619-5p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622787 hsa-miR-324-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT622780 hsa-miR-6783-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622785 hsa-miR-6506-5p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT622790 hsa-miR-6742-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT717323 hsa-miR-4433a-5p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717322 hsa-miR-6509-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717321 hsa-miR-4433b-5p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717329 hsa-miR-4286 Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717331 hsa-miR-181a-2-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717327 hsa-miR-4758-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717324 hsa-miR-6882-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717326 hsa-miR-5699-5p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717320 hsa-miR-4646-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717325 hsa-miR-3189-5p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717328 hsa-miR-6845-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT717330 hsa-miR-1273g-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 19536157
MIRT726963 hsa-miR-19b-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT726964 hsa-miR-19a-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 22473208
MIRT783033 hsa-let-7f-2-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783113 hsa-miR-1185-2-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT783111 hsa-miR-1185-1-3p Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
MIRT787737 hsa-miR-5683 Homo sapiens PGK1 5230 Homo sapiens HITS-CLIP Functional MTI (Weak) 27418678
Gene Ontology
ID GO ID GO Term GO Type
5230 GO:0005829 cytosol GOTERM_CC_DIRECT
5230 GO:0004618 phosphatidylserine decarboxylase activity GOTERM_MF_DIRECT
5230 GO:0016020 membrane GOTERM_CC_DIRECT
5230 GO:0006096 glycolytic process GOTERM_BP_DIRECT
5230 GO:0030855 epithelial cell differentiation GOTERM_BP_DIRECT
5230 GO:0005524 ATP binding GOTERM_MF_DIRECT
5230 GO:0045121 membrane raft GOTERM_CC_DIRECT
5230 GO:0005515 protein binding GOTERM_MF_DIRECT
5230 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
5230 GO:0006094 gluconeogenesis GOTERM_BP_DIRECT
5230 GO:0016310 phosphorylation GOTERM_BP_DIRECT
5230 GO:0061621 canonical glycolysis GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
5230 hsa00010 Glycolysis / Gluconeogenesis
5230 hsa01100 Metabolic pathways
5230 hsa01200 Carbon metabolism
5230 hsa01130 Biosynthesis of antibiotics
5230 hsa01230 Biosynthesis of amino acids
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
PGK1 5230 Collecting Duct Carcinoma of the Kidney C1266044 Neoplastic Process 0.3 0.6 0.69 disease
PGK1 5230 Liver carcinoma C2239176 Neoplastic Process 0.33 0.6 0.69 disease
PGK1 5230 Renal Cell Carcinoma C0007134 Neoplastic Process 0.3 0.6 0.69 disease
PGK1 5230 Conventional (Clear Cell) Renal Cell Carcinoma C0279702 Neoplastic Process 0.3 0.6 0.69 disease
PGK1 5230 Papillary Renal Cell Carcinoma C1306837 Neoplastic Process 0.3 0.6 0.69 disease
PGK1 5230 Sarcomatoid Renal Cell Carcinoma C1266043 Neoplastic Process 0.3 0.6 0.69 disease
PGK1 5230 Chromophobe Renal Cell Carcinoma C1266042 Neoplastic Process 0.3 0.6 0.69 disease
PGK1 5230 Phosphoglycerate Kinase 1 Deficiency C1970848 Disease or Syndrome 0.75 0.6 0.69 disease
PGK1 5230 Ketotic hypoglycemia C0271713 Disease or Syndrome 0.3 0.6 0.69 phenotype
PGK1 5230 Rhabdomyolysis C0035410 Pathologic Function 0.4 0.6 0.69 phenotype
PGK1 5230 Intellectual Disability C3714756 Mental or Behavioral Dysfunction 0.41 0.6 0.69 group
PGK1 5230 Deficiency of phosphoglycerate kinase C0684324 Disease or Syndrome 0.33 0.6 0.69 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types