ALTITUDEOMICSDB

Interleukin 6

AltitudeomicsDB

Protein Official symbol	IL6
Aliases	IL6 IFNB2
Chromosomal Location	7
Length	212
Uniprot ID	P05231
EC number	None
Protein family Information(Pfam)	PF00489;
PDB id	1ALU;1IL6;1N2Q;1P9M;2IL6;4CNI;4J4L;4NI7;4NI9;4O9H;4ZS7;5FUC;
InterPro ID	IPR009079;IPR003574;IPR030474;IPR030473;
dbSNP	rs2069830 rs13306435 rs2069860

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
APOA1	APOB	0.999
JUN	FOS	0.999
IL6	IL6R	0.999
JAK2	STAT1	0.998
JAK2	STAT3	0.998
IL6	IL6ST	0.997
JAK1	STAT3	0.997
IL10	IL6	0.997
STAT1	JAK1	0.997
IL6	STAT3	0.997
IL10	TNF	0.997
STAT6	IL4	0.997
IL10	CXCL8	0.996
IL10	IL1B	0.996
APOE	APOB	0.996
IL6	IL4	0.996
JUN	MAPK1	0.996
IL10	STAT3	0.995
IL10	CCL2	0.995
APP	APOE	0.995
JUN	MAPK3	0.995
SOCS3	STAT3	0.995
JAK3	STAT3	0.994
CSF2	IL2	0.994
JAK2	SOCS3	0.994
TYK2	STAT1	0.994
VEGFA	STAT3	0.994
IL17A	STAT3	0.993
IL10	CSF2	0.993
CXCL8	IL1B	0.992
TNF	IL13	0.992
IL6	SOCS3	0.992
CXCL8	IL4	0.992
RELA	NFKB1	0.992
FOS	MAPK1	0.992
TNF	IL4	0.992
IL6R	STAT3	0.992
ALB	APOA1	0.991
IL1B	IL4	0.991
IL6ST	IL6R	0.991
APOE	APOA1	0.991
IL4	CCL2	0.991
JAK1	STAT6	0.99
FN1	ALB	0.99
TNF	RELA	0.99
IL13	STAT6	0.99
JAK3	STAT6	0.989
TNF	IL1B	0.989
STAT3	MAPK1	0.989
TYK2	STAT3	0.988
FOS	STAT3	0.988
IL6	IL13	0.988
VEGFA	FN1	0.988
SERPINC1	ALB	0.987
FOS	MAPK3	0.987
RELA	CXCL8	0.987
IL6ST	STAT3	0.987
MAPK3	MAPK1	0.987
JAK3	STAT1	0.986
TNF	JUN	0.986
STAT1	SOCS3	0.986
VEGFA	ALB	0.986
STAT3	MAPK3	0.986
ALB	APOB	0.986
CXCL1	CXCL8	0.985
IL6	CXCL8	0.985
TNF	IL6	0.984
IL6	IL1B	0.984
IL6	JUN	0.984
VEGFA	JUN	0.983
SERPINA1	ALB	0.983
IL10	CXCL1	0.983
IL6	CEBPB	0.983
IL6	RELA	0.983
IL6	ALB	0.983
CXCL8	IL13	0.983
JAK1	SOCS3	0.983
IL6	STAT1	0.983
CXCL8	STAT3	0.983
IL6	MAPK1	0.982
JAK2	STAT6	0.982
IL10	CSF1	0.982
IL6	CCL2	0.982
IL6	TIMP1	0.982
IL17A	IL2	0.982
IL6	FOS	0.982
IL17A	STAT6	0.982
IL6	STAT6	0.981
JAK3	IL2	0.981
STAT3	CCL2	0.981
IL13	CCL2	0.981
TNF	FOS	0.981
CEBPB	MAPK1	0.98
RELA	JUN	0.98
CXCL8	CCL2	0.98
STAT3	IL4	0.98
ALB	APOE	0.979
CSF2	STAT3	0.979
IL10	TIMP1	0.979
CST3	ALB	0.978
JUN	CCL2	0.978
IL13	STAT3	0.978
SPP1	TIMP1	0.978
JAK1	IL4	0.978
IL6	SPP1	0.978
RELA	IL2	0.978
SPP1	ALB	0.978
SERPINC1	APOA1	0.978
IL10	JAK1	0.978
SPP1	FN1	0.977
JAK3	SOCS3	0.977
IL6	MAPK3	0.976
IL1B	NFKB1	0.976
IL6	CSF1	0.976
IL6R	SOCS3	0.976
TNF	STAT3	0.976
IL6	JAK2	0.975
IL6	KNG1	0.974
SERPINC1	APOB	0.974
CEBPB	STAT3	0.974
IL6	CXCL1	0.974
IL6	SERPINC1	0.973
IL6R	JAK1	0.973
IL10	STAT6	0.973
VEGFA	TIMP1	0.973
CXCL1	STAT3	0.973
TNF	CXCL8	0.973
VEGFA	KNG1	0.973
IGFBP1	APOB	0.973
IL6ST	JAK1	0.973
FN1	TIMP1	0.972
STAT1	MAPK3	0.972
STAT1	MAPK1	0.972
IL13	IL1B	0.972
SERPINC1	KNG1	0.972
IL6	ERBB2	0.972
TNF	STAT1	0.972
IL10	IL4	0.972
STAT1	STAT3	0.972
ALB	C3	0.972
JUN	CEBPB	0.971
IL13	IL4	0.971
ALB	KNG1	0.971
IL6	FN1	0.971
SERPINA1	IL6	0.971
JUN	CXCL8	0.971
STAT3	TIMP1	0.971
TNF	CCL2	0.971
IL6	APOA1	0.971
JUN	IL2	0.971
IL10	IL17A	0.971
IL6	IL17A	0.971
IL6	CRP	0.97
FN1	MAPK3	0.97
IL6	FSTL1	0.97
SERPINA1	APOA1	0.97
JAK1	IL13	0.97
CEBPB	MAPK3	0.97
FOS	CCL2	0.97
STAT3	IL2	0.969
TYK2	STAT6	0.969
SOCS3	IL2	0.969
IL6	IGFBP1	0.969
CXCL8	CEBPB	0.969
IL6	APOE	0.969
ALB	IGFBP1	0.969
TYK2	IL4	0.969
RELA	FOS	0.968
IL6ST	SOCS3	0.968
IL6	JAK1	0.968
TNF	NFKB1	0.968
C3	APOA1	0.967
TYK2	SOCS3	0.967
IL6ST	STAT1	0.967
FN1	C3	0.966
SOCS3	STAT6	0.966
ALB	APP	0.965
STAT1	IL2	0.965
FN1	MAPK1	0.965
IGFBP1	APOA1	0.965
JAK2	IL6ST	0.965
JAK1	IL2	0.965
JAK3	IL4	0.965
STAT3	IL1B	0.965
RELA	CEBPB	0.964
IL4	IL2	0.964
IL6	FGF23	0.963
IL6	NFKB1	0.963
JUN	IL1B	0.963
CEBPB	NFKB1	0.963
SERPINA1	C3	0.963
STAT1	IL13	0.962
JAK2	ERBB2	0.962
JAK2	CSF2	0.962
STAT1	CSF2	0.962
ALB	FGF23	0.962
SERPINA1	FN1	0.961
IL6	HSP90B1	0.961
SPP1	FGF23	0.961
APP	KNG1	0.961
TYK2	IL6	0.961
TYK2	IL10	0.96
JAK2	FN1	0.96
CST3	APOE	0.959
IL6	CSF2	0.959
IL6	IL2	0.959
APOE	C3	0.959
JAK3	IL6	0.959
IL6	TLR4	0.959
VEGFA	IL6	0.959
CXCL8	NFKB1	0.958
IL6	C3	0.958
JAK2	IL6R	0.958
IL6	APOB	0.957
TNF	TLR4	0.957
IL10	IL2	0.957
TNF	IL2	0.957
IL6	APP	0.957
SERPINC1	C3	0.956
APP	APOA1	0.956
VEGFA	ERBB2	0.956
IL6	CST3	0.956
TNF	CSF2	0.956
CST3	APP	0.956
ALB	TIMP1	0.956
APP	MAPK3	0.955
MAPK3	IL2	0.955
TYK2	IL6ST	0.955
CST3	FGF23	0.955
IL17A	IL13	0.955
CSF1	STAT3	0.955
IL6R	STAT1	0.954
JUN	IL4	0.954
FN1	IL4	0.954
NFKB1	MAPK1	0.954
VEGFA	CXCL8	0.954
SERPINA1	KNG1	0.954
IL2	MAPK1	0.954
SERPINC1	FN1	0.954
KNG1	C3	0.954
IL10	IL13	0.954
JAK2	IL4	0.954
CXCL8	C3	0.954
RELA	IL1B	0.954
JAK2	IL2	0.954
CST3	TIMP1	0.953
CXCL1	IL1B	0.953
CST3	SPP1	0.953
CSF2	MAPK3	0.953
RELA	MAPK1	0.952
CSF1	ALB	0.952
FN1	APOE	0.952
SERPINA1	APOB	0.952
CSF2	MAPK1	0.952
KNG1	APOA1	0.951
IL17A	IL4	0.951
SERPINC1	IGFBP1	0.951
SPP1	CSF1	0.95
APP	MAPK1	0.95
FN1	KNG1	0.95
FN1	IL13	0.95
RELA	MAPK3	0.95
IGFBP1	TIMP1	0.95
TYK2	IL6R	0.95
IL10	TLR4	0.95
JAK1	CSF2	0.95
IL1B	CCL2	0.95
CXCL8	KNG1	0.95
MAPK3	NFKB1	0.95
SERPINA1	APOE	0.95
C3	APOB	0.95
SPP1	APOE	0.949
JAK2	IL1B	0.948
FN1	CSF1	0.948
JAK2	IL13	0.947
CSF1	TIMP1	0.946
FN1	APP	0.946
CST3	APOA1	0.946
JAK2	NFKB1	0.946
TYK2	IL13	0.945
JAK3	CSF2	0.945
FN1	IGFBP1	0.945
JAK3	IL6R	0.944
APOE	TIMP1	0.944
FN1	FSTL1	0.944
JAK2	JAK1	0.943
JAK3	JAK1	0.943
HSP90B1	ALB	0.943
FN1	APOA1	0.943
VEGFA	APP	0.943
TYK2	JAK2	0.943
RELA	IL4	0.942
IL6R	STAT6	0.942
TYK2	JAK1	0.941
KNG1	APOE	0.941
HSP90B1	APOB	0.941
SERPINA1	SERPINC1	0.94
SERPINA1	TIMP1	0.94
SERPINA1	CST3	0.94
VEGFA	STAT6	0.94
IL6R	MAPK3	0.939
JAK1	MAPK1	0.939
RELA	CCL2	0.939
CSF1	APOE	0.939
CST3	APOB	0.939
TYK2	JAK3	0.939
RELA	APP	0.938
FN1	APOB	0.938
TLR4	APOB	0.938
CXCL1	NFKB1	0.938
JAK2	MAPK3	0.937
MAPK3	FGF23	0.937
APP	C3	0.937
CST3	C3	0.937
JAK1	MAPK3	0.936
IL13	IL2	0.936
FN1	FGF23	0.935
SERPINC1	APOE	0.934
FN1	HSP90B1	0.934
JAK2	MAPK1	0.934
CST3	FN1	0.934
CXCL8	APP	0.934
KNG1	APOB	0.933
FOS	STAT6	0.933
VEGFA	SERPINA1	0.933
JAK3	JAK2	0.933
APOA1	TIMP1	0.932
SPP1	IGFBP1	0.932
RELA	JAK2	0.932
HSP90B1	APP	0.931
RELA	TLR4	0.931
STAT1	STAT6	0.931
CXCL1	C3	0.931
STAT6	STAT3	0.931
C3	MAPK1	0.931
SPP1	APOA1	0.931
TLR4	CXCL8	0.93
JAK3	MAPK3	0.93
IL6R	ERBB2	0.93
IL17A	CCL2	0.93
SPP1	C3	0.93
JAK3	MAPK1	0.929
TYK2	NFKB1	0.929
IL6R	MAPK1	0.929
APP	APOB	0.927
ALB	CRP	0.927
CSF1	C3	0.926
APP	TIMP1	0.926
TYK2	MAPK3	0.925
TLR4	IL1B	0.925
SERPINA1	APP	0.925
TYK2	MAPK1	0.925
SERPINA1	HSP90B1	0.925
SERPINA1	IGFBP1	0.924
CST3	SERPINC1	0.923
CSF1	APP	0.923
SPP1	KNG1	0.923
HSP90B1	APOE	0.922
CSF1	IGFBP1	0.921
C3	TIMP1	0.921
IGFBP1	C3	0.921
TYK2	RELA	0.921
KNG1	TIMP1	0.921
JUN	STAT3	0.921
CSF2	IL4	0.921
TYK2	IL1B	0.92
FGF23	MAPK1	0.92
TLR4	NFKB1	0.92
SERPINA1	SPP1	0.92
STAT6	TIMP1	0.92
VEGFA	TNF	0.919
SPP1	APOB	0.919
SERPINC1	APP	0.919
FSTL1	TIMP1	0.919
APOB	TIMP1	0.919
ERBB2	STAT3	0.918
SPP1	APP	0.918
CXCL1	KNG1	0.917
CSF1	FSTL1	0.917
APP	NFKB1	0.917
SERPINC1	TIMP1	0.917
ALB	FSTL1	0.917
RELA	APOA1	0.916
IGFBP1	APOE	0.915
TNF	CSF1	0.914
VEGFA	CCL2	0.914
SERPINA1	CSF1	0.913
SPP1	SERPINC1	0.913
JUN	APOA1	0.913
CSF1	APOA1	0.913
CSF2	CCL2	0.913
APOE	FGF23	0.912
TNF	IL17A	0.912
CSF1	APOB	0.912
CXCL1	APP	0.912
CXCL1	IL17A	0.912
IL17A	IL1B	0.911
CSF1	FGF23	0.911
CST3	KNG1	0.911
IGFBP1	KNG1	0.911
CST3	IGFBP1	0.91
FGF23	APOA1	0.91
FGF23	APOB	0.91
STAT1	ERBB2	0.91
HSP90B1	FSTL1	0.91
HSP90B1	APOA1	0.909
CST3	CSF1	0.909
HSP90B1	C3	0.909
CXCL8	CRP	0.909
HSP90B1	FGF23	0.908
CST3	CXCL1	0.908
SERPINC1	HSP90B1	0.907
IGFBP1	FGF23	0.907
SPP1	FSTL1	0.907
SPP1	HSP90B1	0.907
FSTL1	APP	0.907
HSP90B1	TIMP1	0.906
CXCL8	CSF2	0.906
FSTL1	APOE	0.906
SERPINC1	FGF23	0.906
CSF1	HSP90B1	0.905
CSF1	KNG1	0.905
HSP90B1	KNG1	0.904
SERPINA1	FSTL1	0.904
FGF23	TIMP1	0.904
FSTL1	APOB	0.903
APP	IGFBP1	0.903
FSTL1	IGFBP1	0.902
CST3	FSTL1	0.902
CXCL1	CCL2	0.902
KNG1	FGF23	0.902
FSTL1	APOA1	0.902
CST3	HSP90B1	0.901
HSP90B1	IGFBP1	0.901
FSTL1	KNG1	0.901
SERPINC1	CSF1	0.901
FSTL1	FGF23	0.901
C3	FGF23	0.9
SERPINA1	FGF23	0.9
SERPINC1	FSTL1	0.9
IL1B	IL2	0.9
FSTL1	C3	0.9
APP	FGF23	0.9

Gene Ontology Semantic Similarity

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#	335 (APOA1)	3725 (JUN)	3569 (IL6)	3717 (JAK2)	3716 (JAK1)	3586 (IL10)	6772 (STAT1)	6778 (STAT6)	348 (APOE)	351 (APP)	9021 (SOCS3)	3718 (JAK3)	1437 (CSF2)	7297 (TYK2)	7422 (VEGFA)	3605 (IL17A)	3576 (CXCL8)	7124 (TNF)	5970 (RELA)	2353 (FOS)	3570 (IL6R)	213 (ALB)	3553 (IL1B)	3572 (IL6ST)	3565 (IL4)	2335 (FN1)	3596 (IL13)	6774 (STAT3)	462 (SERPINC1)	5595 (MAPK3)	2919 (CXCL1)	5265 (SERPINA1)	1051 (CEBPB)	1471 (CST3)	6696 (SPP1)	3484 (IGFBP1)	718 (C3)	1435 (CSF1)	4790 (NFKB1)	3558 (IL2)	3827 (KNG1)	7184 (HSP90B1)	7099 (TLR4)	8074 (FGF23)	11167 (FSTL1)	338 (APOB)	2064 (ERBB2)	5594 (MAPK1)	6347 (CCL2)	7076 (TIMP1)	1401 (CRP)
335 (APOA1)	1.00	0.54	0.59	0.57	0.54	0.59	0.57	0.55	0.80	0.66	0.56	0.56	0.56	0.53	0.62	1.00	0.56	0.59	0.53	0.52	0.58	0.61	0.59	0.51	0.58	0.65	1.00	0.53	0.62	0.56	0.59	0.62	0.51	0.66	0.58	0.62	0.59	0.63	0.51	0.60	0.60	0.58	0.60	0.50	1.00	0.73	0.58	0.54	0.58	0.58	0.60
3725 (JUN)	0.54	1.00	0.48	0.50	0.48	0.48	0.81	0.77	0.52	0.64	0.45	0.45	0.45	0.43	0.56	1.00	0.46	0.66	0.86	0.85	0.52	0.60	0.48	0.46	0.47	0.53	1.00	0.85	0.50	0.47	0.41	0.50	0.83	0.49	0.46	0.49	0.46	0.54	0.84	0.49	0.46	0.56	0.50	0.42	1.00	0.46	0.52	0.46	0.46	0.47	0.48
3569 (IL6)	0.59	0.48	1.00	0.59	0.57	0.94	0.56	0.56	0.53	0.73	0.60	0.61	0.70	0.60	0.75	1.00	0.72	0.71	0.50	0.55	0.70	0.60	0.84	0.57	0.89	0.68	1.00	0.51	0.69	0.59	0.70	0.69	0.50	0.61	0.75	0.79	0.73	0.87	0.50	0.79	0.66	0.65	0.63	0.50	1.00	0.61	0.58	0.54	0.70	0.65	0.63
3717 (JAK2)	0.57	0.50	0.59	1.00	0.84	0.59	0.56	0.50	0.53	0.62	0.50	0.80	0.81	0.81	0.63	1.00	0.53	0.57	0.52	0.50	0.60	0.56	0.60	0.50	0.58	0.60	1.00	0.54	0.55	0.73	0.50	0.55	0.48	0.53	0.53	0.59	0.56	0.63	0.49	0.64	0.53	0.54	0.55	0.79	1.00	0.51	0.77	0.73	0.74	0.52	0.54
3716 (JAK1)	0.54	0.48	0.57	0.84	1.00	0.57	0.53	0.52	0.49	0.59	0.48	0.91	0.85	0.86	0.58	1.00	0.52	0.53	0.48	0.47	0.56	0.52	0.57	0.46	0.56	0.58	1.00	0.49	0.54	0.72	0.47	0.54	0.43	0.51	0.53	0.59	0.53	0.60	0.44	0.64	0.50	0.58	0.50	0.81	1.00	0.49	0.79	0.72	0.69	0.50	0.52
3586 (IL10)	0.59	0.48	0.94	0.59	0.57	1.00	0.56	0.56	0.53	0.73	0.60	0.61	0.70	0.60	0.75	1.00	0.72	0.71	0.50	0.55	0.68	0.60	0.84	0.54	0.89	0.68	1.00	0.51	0.69	0.59	0.70	0.69	0.50	0.61	0.75	0.79	0.73	0.87	0.50	0.79	0.66	0.65	0.63	0.50	1.00	0.61	0.58	0.54	0.70	0.65	0.63
6772 (STAT1)	0.57	0.81	0.56	0.56	0.53	0.56	1.00	0.81	0.55	0.67	0.51	0.52	0.52	0.52	0.60	1.00	0.54	0.71	0.84	0.80	0.59	0.61	0.56	0.52	0.55	0.61	1.00	0.83	0.57	0.54	0.45	0.57	0.82	0.55	0.55	0.58	0.55	0.62	0.80	0.53	0.53	0.58	0.55	0.48	1.00	0.53	0.55	0.52	0.54	0.52	0.56
6778 (STAT6)	0.55	0.77	0.56	0.50	0.52	0.56	0.81	1.00	0.51	0.63	0.45	0.55	0.48	0.46	0.59	1.00	0.52	0.70	0.77	0.83	0.54	0.57	0.57	0.46	0.55	0.59	1.00	0.84	0.57	0.54	0.41	0.57	0.86	0.52	0.54	0.58	0.52	0.63	0.88	0.50	0.49	0.60	0.53	0.40	1.00	0.49	0.57	0.51	0.51	0.48	0.55
348 (APOE)	0.80	0.52	0.53	0.53	0.49	0.53	0.55	0.51	1.00	0.58	0.51	0.50	0.51	0.48	0.64	1.00	0.51	0.54	0.54	0.50	0.55	0.63	0.53	0.50	0.52	0.64	1.00	0.53	0.55	0.51	0.49	0.55	0.51	0.59	0.52	0.55	0.52	0.59	0.50	0.54	0.60	0.58	0.57	0.47	1.00	0.73	0.55	0.50	0.52	0.54	0.62
351 (APP)	0.66	0.64	0.73	0.62	0.59	0.73	0.67	0.63	0.58	1.00	0.64	0.62	0.63	0.59	0.69	1.00	0.67	0.77	0.61	0.63	0.65	0.70	0.73	0.54	0.71	0.71	1.00	0.65	0.87	0.62	0.63	0.87	0.62	0.81	0.69	0.73	0.69	0.77	0.62	0.66	0.74	0.71	0.64	0.52	1.00	0.62	0.62	0.59	0.67	0.75	0.65
9021 (SOCS3)	0.56	0.45	0.60	0.50	0.48	0.60	0.51	0.45	0.51	0.64	1.00	0.51	0.52	0.44	0.58	1.00	0.53	0.55	0.46	0.47	0.54	0.53	0.60	0.44	0.59	0.58	1.00	0.46	0.63	0.47	0.57	0.63	0.41	0.59	0.58	0.62	0.54	0.63	0.43	0.64	0.55	0.53	0.50	0.40	1.00	0.49	0.53	0.43	0.52	0.59	0.53
3718 (JAK3)	0.56	0.45	0.61	0.80	0.91	0.61	0.52	0.55	0.50	0.62	0.51	1.00	0.91	0.78	0.58	1.00	0.55	0.56	0.47	0.48	0.55	0.54	0.61	0.45	0.60	0.60	1.00	0.50	0.58	0.76	0.49	0.58	0.43	0.53	0.59	0.63	0.55	0.64	0.45	0.69	0.51	0.63	0.52	0.86	1.00	0.51	0.81	0.75	0.68	0.52	0.54
1437 (CSF2)	0.56	0.45	0.70	0.81	0.85	0.70	0.52	0.48	0.51	0.63	0.52	0.91	1.00	0.79	0.62	1.00	0.59	0.62	0.47	0.49	0.55	0.54	0.69	0.46	0.61	0.61	1.00	0.47	0.59	0.72	0.58	0.59	0.44	0.54	0.60	0.66	0.59	0.71	0.45	0.77	0.54	0.55	0.54	0.87	1.00	0.52	0.77	0.72	0.73	0.59	0.55
7297 (TYK2)	0.53	0.43	0.60	0.81	0.86	0.60	0.52	0.46	0.48	0.59	0.44	0.78	0.79	1.00	0.59	1.00	0.54	0.55	0.46	0.47	0.56	0.53	0.61	0.46	0.59	0.59	1.00	0.46	0.55	0.76	0.46	0.55	0.42	0.49	0.56	0.62	0.55	0.64	0.44	0.52	0.50	0.52	0.51	0.75	1.00	0.49	0.71	0.75	0.76	0.48	0.53
7422 (VEGFA)	0.62	0.56	0.75	0.63	0.58	0.75	0.60	0.59	0.64	0.69	0.58	0.58	0.62	0.59	1.00	1.00	0.62	0.66	0.57	0.59	0.69	0.62	0.72	0.61	0.72	0.72	1.00	0.58	0.64	0.60	0.60	0.64	0.60	0.61	0.67	0.68	0.66	0.77	0.57	0.70	0.70	0.60	0.68	0.54	1.00	0.65	0.62	0.58	0.65	0.61	0.62
3605 (IL17A)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
3576 (CXCL8)	0.56	0.46	0.72	0.53	0.52	0.72	0.54	0.52	0.51	0.67	0.53	0.55	0.59	0.54	0.62	1.00	1.00	0.63	0.48	0.52	0.59	0.57	0.71	0.49	0.70	0.64	1.00	0.49	0.65	0.54	0.75	0.65	0.46	0.56	0.70	0.73	0.65	0.73	0.47	0.60	0.58	0.60	0.58	0.43	1.00	0.56	0.55	0.50	0.78	0.56	0.59
7124 (TNF)	0.59	0.66	0.71	0.57	0.53	0.71	0.71	0.70	0.54	0.77	0.55	0.56	0.62	0.55	0.66	1.00	0.63	1.00	0.65	0.73	0.60	0.66	0.70	0.51	0.65	0.68	1.00	0.66	0.71	0.58	0.56	0.71	0.65	0.64	0.64	0.68	0.63	0.76	0.73	0.63	0.59	0.65	0.61	0.48	1.00	0.57	0.58	0.55	0.62	0.65	0.61
5970 (RELA)	0.53	0.86	0.50	0.52	0.48	0.50	0.84	0.77	0.54	0.61	0.46	0.47	0.47	0.46	0.57	1.00	0.48	0.65	1.00	0.82	0.53	0.60	0.50	0.48	0.49	0.55	1.00	0.88	0.50	0.48	0.39	0.50	0.85	0.49	0.49	0.51	0.48	0.55	0.87	0.48	0.48	0.54	0.51	0.44	1.00	0.50	0.51	0.47	0.48	0.47	0.51
2353 (FOS)	0.52	0.85	0.55	0.50	0.47	0.55	0.80	0.83	0.50	0.63	0.47	0.48	0.49	0.47	0.59	1.00	0.52	0.73	0.82	1.00	0.53	0.59	0.56	0.46	0.54	0.56	1.00	0.83	0.53	0.48	0.41	0.53	0.85	0.50	0.53	0.57	0.52	0.58	0.88	0.51	0.49	0.57	0.54	0.43	1.00	0.50	0.54	0.46	0.51	0.49	0.52
3570 (IL6R)	0.58	0.52	0.70	0.60	0.56	0.68	0.59	0.54	0.55	0.65	0.54	0.55	0.55	0.56	0.69	1.00	0.59	0.60	0.53	0.53	1.00	0.57	0.65	0.92	0.68	0.64	1.00	0.55	0.60	0.56	0.53	0.60	0.54	0.57	0.59	0.64	0.61	0.71	0.51	0.63	0.58	0.58	0.75	0.50	1.00	0.56	0.69	0.54	0.60	0.55	0.58
213 (ALB)	0.61	0.60	0.60	0.56	0.52	0.60	0.61	0.57	0.63	0.70	0.53	0.54	0.54	0.53	0.62	1.00	0.57	0.66	0.60	0.59	0.57	1.00	0.60	0.51	0.59	0.64	1.00	0.62	0.60	0.56	0.46	0.60	0.59	0.57	0.59	0.61	0.57	0.64	0.59	0.55	0.62	0.66	0.57	0.49	1.00	0.59	0.56	0.53	0.55	0.58	0.62
3553 (IL1B)	0.59	0.48	0.84	0.60	0.57	0.84	0.56	0.57	0.53	0.73	0.60	0.61	0.69	0.61	0.72	1.00	0.71	0.70	0.50	0.56	0.65	0.60	1.00	0.55	0.79	0.72	1.00	0.52	0.68	0.59	0.66	0.68	0.51	0.61	0.73	0.77	0.71	0.80	0.51	0.73	0.65	0.65	0.63	0.51	1.00	0.61	0.58	0.55	0.69	0.65	0.63
3572 (IL6ST)	0.51	0.46	0.57	0.50	0.46	0.54	0.52	0.46	0.50	0.54	0.44	0.45	0.46	0.46	0.61	1.00	0.49	0.51	0.48	0.46	0.92	0.51	0.55	1.00	0.53	0.54	1.00	0.50	0.50	0.47	0.42	0.50	0.46	0.48	0.49	0.57	0.50	0.60	0.44	0.51	0.48	0.48	0.77	0.41	1.00	0.47	0.71	0.46	0.51	0.46	0.50
3565 (IL4)	0.58	0.47	0.89	0.58	0.56	0.89	0.55	0.55	0.52	0.71	0.59	0.60	0.61	0.59	0.72	1.00	0.70	0.65	0.49	0.54	0.68	0.59	0.79	0.53	1.00	0.67	1.00	0.50	0.69	0.57	0.65	0.69	0.49	0.60	0.76	0.78	0.71	0.83	0.49	0.74	0.64	0.64	0.62	0.47	1.00	0.60	0.57	0.53	0.67	0.58	0.63
2335 (FN1)	0.65	0.53	0.68	0.60	0.58	0.68	0.61	0.59	0.64	0.71	0.58	0.60	0.61	0.59	0.72	1.00	0.64	0.68	0.55	0.56	0.64	0.64	0.72	0.54	0.67	1.00	1.00	0.56	0.69	0.61	0.56	0.69	0.54	0.65	0.65	0.69	0.66	0.71	0.54	0.62	0.70	0.63	0.63	0.53	1.00	0.69	0.62	0.58	0.64	0.63	0.63
3596 (IL13)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
6774 (STAT3)	0.53	0.85	0.51	0.54	0.49	0.51	0.83	0.84	0.53	0.65	0.46	0.50	0.47	0.46	0.58	1.00	0.49	0.66	0.88	0.83	0.55	0.62	0.52	0.50	0.50	0.56	1.00	1.00	0.52	0.51	0.39	0.52	0.84	0.50	0.50	0.52	0.49	0.58	0.84	0.48	0.47	0.59	0.53	0.43	1.00	0.48	0.56	0.50	0.49	0.47	0.52
462 (SERPINC1)	0.62	0.50	0.69	0.55	0.54	0.69	0.57	0.57	0.55	0.87	0.63	0.58	0.59	0.55	0.64	1.00	0.65	0.71	0.50	0.53	0.60	0.60	0.68	0.50	0.69	0.69	1.00	0.52	1.00	0.60	0.58	1.00	0.49	0.90	0.70	0.70	0.64	0.75	0.51	0.62	0.73	0.62	0.60	0.48	1.00	0.58	0.59	0.55	0.60	0.80	0.64
5595 (MAPK3)	0.56	0.47	0.59	0.73	0.72	0.59	0.54	0.54	0.51	0.62	0.47	0.76	0.72	0.76	0.60	1.00	0.54	0.58	0.48	0.48	0.56	0.56	0.59	0.47	0.57	0.61	1.00	0.51	0.60	1.00	0.43	0.60	0.45	0.54	0.57	0.60	0.55	0.65	0.47	0.52	0.50	0.57	0.55	0.71	1.00	0.51	0.72	0.99	0.74	0.49	0.56
2919 (CXCL1)	0.59	0.41	0.70	0.50	0.47	0.70	0.45	0.41	0.49	0.63	0.57	0.49	0.58	0.46	0.60	0.82	0.75	0.56	0.39	0.41	0.53	0.46	0.66	0.42	0.65	0.56	0.82	0.39	0.58	0.43	1.00	0.58	0.37	0.53	0.56	0.64	0.62	0.68	0.38	0.73	0.58	0.51	0.51	0.39	0.82	0.48	0.49	0.40	0.73	0.59	0.50
5265 (SERPINA1)	0.62	0.50	0.69	0.55	0.54	0.69	0.57	0.57	0.55	0.87	0.63	0.58	0.59	0.55	0.64	1.00	0.65	0.71	0.50	0.53	0.60	0.60	0.68	0.50	0.69	0.69	1.00	0.52	1.00	0.60	0.58	1.00	0.49	0.90	0.70	0.70	0.64	0.75	0.51	0.62	0.73	0.62	0.60	0.48	1.00	0.58	0.59	0.55	0.60	0.80	0.64
1051 (CEBPB)	0.51	0.83	0.50	0.48	0.43	0.50	0.82	0.86	0.51	0.62	0.41	0.43	0.44	0.42	0.60	1.00	0.46	0.65	0.85	0.85	0.54	0.59	0.51	0.46	0.49	0.54	1.00	0.84	0.49	0.45	0.37	0.49	1.00	0.46	0.48	0.53	0.47	0.59	0.89	0.46	0.44	0.54	0.51	0.37	1.00	0.45	0.52	0.43	0.47	0.44	0.49
1471 (CST3)	0.66	0.49	0.61	0.53	0.51	0.61	0.55	0.52	0.59	0.81	0.59	0.53	0.54	0.49	0.61	1.00	0.56	0.64	0.49	0.50	0.57	0.57	0.61	0.48	0.60	0.65	1.00	0.50	0.90	0.54	0.53	0.90	0.46	1.00	0.59	0.62	0.56	0.67	0.48	0.58	0.75	0.55	0.56	0.45	1.00	0.53	0.56	0.51	0.54	0.78	0.58
6696 (SPP1)	0.58	0.46	0.75	0.53	0.53	0.75	0.55	0.54	0.52	0.69	0.58	0.59	0.60	0.56	0.67	1.00	0.70	0.64	0.49	0.53	0.59	0.59	0.73	0.49	0.76	0.65	1.00	0.50	0.70	0.57	0.56	0.70	0.48	0.59	1.00	0.76	0.68	0.75	0.48	0.61	0.59	0.65	0.58	0.45	1.00	0.59	0.57	0.52	0.62	0.57	0.62
3484 (IGFBP1)	0.62	0.49	0.79	0.59	0.59	0.79	0.58	0.58	0.55	0.73	0.62	0.63	0.66	0.62	0.68	1.00	0.73	0.68	0.51	0.57	0.64	0.61	0.77	0.57	0.78	0.69	1.00	0.52	0.70	0.60	0.64	0.70	0.53	0.62	0.76	1.00	0.74	0.78	0.52	0.68	0.66	0.68	0.64	0.53	1.00	0.63	0.62	0.56	0.70	0.62	0.66
718 (C3)	0.59	0.46	0.73	0.56	0.53	0.73	0.55	0.52	0.52	0.69	0.54	0.55	0.59	0.55	0.66	1.00	0.65	0.63	0.48	0.52	0.61	0.57	0.71	0.50	0.71	0.66	1.00	0.49	0.64	0.55	0.62	0.64	0.47	0.56	0.68	0.74	1.00	0.73	0.48	0.62	0.61	0.61	0.60	0.45	1.00	0.57	0.56	0.51	0.66	0.56	0.60
1435 (CSF1)	0.63	0.54	0.87	0.63	0.60	0.87	0.62	0.63	0.59	0.77	0.63	0.64	0.71	0.64	0.77	1.00	0.73	0.76	0.55	0.58	0.71	0.64	0.80	0.60	0.83	0.71	1.00	0.58	0.75	0.65	0.68	0.75	0.59	0.67	0.75	0.78	0.73	1.00	0.56	0.76	0.68	0.67	0.69	0.54	1.00	0.63	0.62	0.61	0.72	0.67	0.69
4790 (NFKB1)	0.51	0.84	0.50	0.49	0.44	0.50	0.80	0.88	0.50	0.62	0.43	0.45	0.45	0.44	0.57	1.00	0.47	0.73	0.87	0.88	0.51	0.59	0.51	0.44	0.49	0.54	1.00	0.84	0.51	0.47	0.38	0.51	0.89	0.48	0.48	0.52	0.48	0.56	1.00	0.47	0.46	0.53	0.52	0.40	1.00	0.46	0.52	0.45	0.47	0.45	0.50
3558 (IL2)	0.60	0.49	0.79	0.64	0.64	0.79	0.53	0.50	0.54	0.66	0.64	0.69	0.77	0.52	0.70	1.00	0.60	0.63	0.48	0.51	0.63	0.55	0.73	0.51	0.74	0.62	1.00	0.48	0.62	0.52	0.73	0.62	0.46	0.58	0.61	0.68	0.62	0.76	0.47	1.00	0.60	0.57	0.57	0.60	1.00	0.54	0.63	0.49	0.61	0.63	0.56
3827 (KNG1)	0.60	0.46	0.66	0.53	0.50	0.66	0.53	0.49	0.60	0.74	0.55	0.51	0.54	0.50	0.70	1.00	0.58	0.59	0.48	0.49	0.58	0.62	0.65	0.48	0.64	0.70	1.00	0.47	0.73	0.50	0.58	0.73	0.44	0.75	0.59	0.66	0.61	0.68	0.46	0.60	1.00	0.62	0.56	0.42	1.00	0.67	0.54	0.47	0.60	0.81	0.62
7184 (HSP90B1)	0.58	0.56	0.65	0.54	0.58	0.65	0.58	0.60	0.58	0.71	0.53	0.63	0.55	0.52	0.60	1.00	0.60	0.65	0.54	0.57	0.58	0.66	0.65	0.48	0.64	0.63	1.00	0.59	0.62	0.57	0.51	0.62	0.54	0.55	0.65	0.68	0.61	0.67	0.53	0.57	0.62	1.00	0.56	0.45	1.00	0.63	0.59	0.53	0.58	0.59	0.76
7099 (TLR4)	0.60	0.50	0.63	0.55	0.50	0.63	0.55	0.53	0.57	0.64	0.50	0.52	0.54	0.51	0.68	1.00	0.58	0.61	0.51	0.54	0.75	0.57	0.63	0.77	0.62	0.63	1.00	0.53	0.60	0.55	0.51	0.60	0.51	0.56	0.58	0.64	0.60	0.69	0.52	0.57	0.56	0.56	1.00	0.45	1.00	0.55	0.73	0.53	0.59	0.53	0.58
8074 (FGF23)	0.50	0.42	0.50	0.79	0.81	0.50	0.48	0.40	0.47	0.52	0.40	0.86	0.87	0.75	0.54	1.00	0.43	0.48	0.44	0.43	0.50	0.49	0.51	0.41	0.47	0.53	1.00	0.43	0.48	0.71	0.39	0.48	0.37	0.45	0.45	0.53	0.45	0.54	0.40	0.60	0.42	0.45	0.45	1.00	1.00	0.43	0.80	0.71	0.68	0.44	0.47
11167 (FSTL1)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
338 (APOB)	0.73	0.46	0.61	0.51	0.49	0.61	0.53	0.49	0.73	0.62	0.49	0.51	0.52	0.49	0.65	1.00	0.56	0.57	0.50	0.50	0.56	0.59	0.61	0.47	0.60	0.69	1.00	0.48	0.58	0.51	0.48	0.58	0.45	0.53	0.59	0.63	0.57	0.63	0.46	0.54	0.67	0.63	0.55	0.43	1.00	1.00	0.53	0.48	0.55	0.51	0.62
2064 (ERBB2)	0.58	0.52	0.58	0.77	0.79	0.58	0.55	0.57	0.55	0.62	0.53	0.81	0.77	0.71	0.62	1.00	0.55	0.58	0.51	0.54	0.69	0.56	0.58	0.71	0.57	0.62	1.00	0.56	0.59	0.72	0.49	0.59	0.52	0.56	0.57	0.62	0.56	0.62	0.52	0.63	0.54	0.59	0.73	0.80	1.00	0.53	1.00	0.72	0.68	0.54	0.57
5594 (MAPK1)	0.54	0.46	0.54	0.73	0.72	0.54	0.52	0.51	0.50	0.59	0.43	0.75	0.72	0.75	0.58	1.00	0.50	0.55	0.47	0.46	0.54	0.53	0.55	0.46	0.53	0.58	1.00	0.50	0.55	0.99	0.40	0.55	0.43	0.51	0.52	0.56	0.51	0.61	0.45	0.49	0.47	0.53	0.53	0.71	1.00	0.48	0.72	1.00	0.75	0.47	0.53
6347 (CCL2)	0.58	0.46	0.70	0.74	0.69	0.70	0.54	0.51	0.52	0.67	0.52	0.68	0.73	0.76	0.65	1.00	0.78	0.62	0.48	0.51	0.60	0.55	0.69	0.51	0.67	0.64	1.00	0.49	0.60	0.74	0.73	0.60	0.47	0.54	0.62	0.70	0.66	0.72	0.47	0.61	0.60	0.58	0.59	0.68	1.00	0.55	0.68	0.75	1.00	0.56	0.58
7076 (TIMP1)	0.58	0.47	0.65	0.52	0.50	0.65	0.52	0.48	0.54	0.75	0.59	0.52	0.59	0.48	0.61	1.00	0.56	0.65	0.47	0.49	0.55	0.58	0.65	0.46	0.58	0.63	1.00	0.47	0.80	0.49	0.59	0.80	0.44	0.78	0.57	0.62	0.56	0.67	0.45	0.63	0.81	0.59	0.53	0.44	1.00	0.51	0.54	0.47	0.56	1.00	0.59
1401 (CRP)	0.60	0.48	0.63	0.54	0.52	0.63	0.56	0.55	0.62	0.65	0.53	0.54	0.55	0.53	0.62	1.00	0.59	0.61	0.51	0.52	0.58	0.62	0.63	0.50	0.63	0.63	1.00	0.52	0.64	0.56	0.50	0.64	0.49	0.58	0.62	0.66	0.60	0.69	0.50	0.56	0.62	0.76	0.58	0.47	1.00	0.62	0.57	0.53	0.58	0.59	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
IL6	Human	Vastus Lateralis Biopsy Samples	-	4300 m	1 day	upregulated	-	RT-PCR	Western US	Americans	-	Ameriacans at 50 m, Natick, Massachusetts, USA	30009538
IL6	Human	Venous Blood Samples	-	3500 m	3 month	downregulated	-	Exons PCR and sequencing	-	Chinese	-	Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) -	29587872

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
RAD21	5885	IL6	3569	proximal_filtered	22955619	TRANSFAC
EP300	2033	IL6	3569	proximal_filtered	22955619	TRANSFAC
CTCF	10664	IL6	3569	proximal_filtered	22955619	TRANSFAC
SP1	6667	IL6	3569	Unknown	17897941	TRUSST
ZNF300	91975	IL6	3569	Unknown	1508207	TRUSST
ATF4	468	IL6	3569	Activation	15659537	TRUSST
CREB1	1385	IL6	3569	Activation	9231796	TRUSST
RBPJ	3516	IL6	3569	Unknown	19229036	TRUSST
RELA	5970	IL6	3569	Activation	19486887	TRUSST
DDIT3	1649	IL6	3569	Repression	9231796	TRUSST
FOXO1	2308	IL6	3569	Activation	18270252	TRUSST
MYC	4609	IL6	3569	Activation	16807381	TRUSST
CEBPB	1051	IL6	3569	Repression	9231796	TRUSST
JUND	3727	IL6	3569	Repression	18270252	TRUSST
NFKB1	4790	IL6	3569	Unknown	11801594	TRUSST
STAT3	6774	IL6	3569	Unknown	20692357	TRUSST
ZMYND11	10771	IL6	3569	Activation	12813038	TRUSST
XBP1	7494	IL6	3569	Activation	12813038	TRUSST
VDR	7421	IL6	3569	Repression	9710587	TRUSST
JUN	3725	IL6	3569	Activation	16807381	TRUSST
OTX2	5015	IL6	3569	Activation	14960326	TRUSST
PPARA	5465	IL6	3569	Activation	23349863	TRUSST
EGR2	1959	IL6	3569	Activation	18270252	TRUSST
KLF4	9314	IL6	3569	Repression	18270252	TRUSST
REL	5966	IL6	3569	Unknown	20180806	TRUSST
TBP	6908	IL6	3569	Activation	2247079	TRUSST
ZFP36	7538	IL6	3569	Unknown	1508207	TRUSST
CEBPA	1050	IL6	3569	Unknown	17551100	TRUSST
EGR1	1958	IL6	3569	Unknown	10419022	TRUSST
AHR	196	IL6	3569	Repression	15591138	TRUSST
STAT1	6772	IL6	3569	Unknown	17404501	TRUSST
GBX2	2637	IL6	3569	Unknown	17538076	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT005420	hsa-let-7a-5p	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	19878981
MIRT006061	hsa-miR-203a-3p	Homo sapiens	IL6	3569	Homo sapiens	ELISA//qRT-PCR	Functional MTI (Weak)	21279994
MIRT006790	hsa-miR-142-3p	Homo sapiens	IL6	3569	Homo sapiens	ELISA//Immunoblot//Microarray//qRT-PCR	Functional MTI (Weak)	21474672
MIRT007374	hsa-miR-26a-5p	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay	Functional MTI	23389848
MIRT016949	hsa-miR-335-5p	Homo sapiens	IL6	3569	Homo sapiens	Microarray	Functional MTI (Weak)	18185580
MIRT020073	hsa-miR-365a-3p	Homo sapiens	IL6	3569	Homo sapiens	Reporter assay	Functional MTI	21518763
MIRT021049	hsa-miR-155-5p	Homo sapiens	IL6	3569	Homo sapiens	Proteomics	Functional MTI (Weak)	20584899
MIRT021049	hsa-miR-155-5p	Homo sapiens	IL6	3569	Homo sapiens	Proteomics	Functional MTI (Weak)	18668040
MIRT022183	hsa-miR-124-3p	Homo sapiens	IL6	3569	Homo sapiens	Microarray	Functional MTI (Weak)	18668037
MIRT023501	hsa-miR-1-3p	Homo sapiens	IL6	3569	Homo sapiens	Microarray	Functional MTI (Weak)	18668037
MIRT027449	hsa-miR-98-5p	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Non-Functional MTI	26367177
MIRT027449	hsa-miR-98-5p	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26587789
MIRT027449	hsa-miR-98-5p	Homo sapiens	IL6	3569	Homo sapiens	Microarray	Functional MTI (Weak)	19088304
MIRT054777	hsa-miR-107	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot//Coimmunoprecipitation//Chromatin immunoprecipitation//Immunofluorescence microscopy	Functional MTI	24429361
MIRT438050	hsa-let-7c-5p	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay//qRT-PCR//ELISA	Functional MTI	23977098
MIRT438284	hsa-miR-223-3p	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay	Functional MTI	24084739
MIRT438344	hsa-miR-149-5p	Homo sapiens	IL6	3569	Homo sapiens	ELISA//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	25916550
MIRT731346	hsa-miR-9-5p	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay	Functional MTI	25809226
MIRT731232	hsa-miR-146b-5p	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26338965
MIRT731223	hsa-let-7f-5p	Homo sapiens	IL6	3569	Homo sapiens	ELISA//Luciferase reporter assay	Functional MTI	26810534
MIRT732454	hsa-miR-146a-5p	Homo sapiens	IL6	3569	Homo sapiens	Microarray//Luciferase reporter assay//	Functional MTI	25265569
MIRT733375	hsa-miR-125a-3p	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26563755
MIRT734163	hsa-miR-106a-5p	Homo sapiens	IL6	3569	Homo sapiens	qRT-PCR	Functional MTI (Weak)	25950430
MIRT734880	hsa-miR-136-5p	Homo sapiens	IL6	3569	Homo sapiens	Immunofluorescence//Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	26450567
MIRT735462	hsa-miR-451a	Homo sapiens	IL6	3569	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	27461244

Gene Ontology

ID	GO ID	GO Term	GO Type
3569	GO:0006959	humoral immune response	GOTERM_BP_DIRECT
3569	GO:0019221	cytokine-mediated signaling pathway	GOTERM_BP_DIRECT
3569	GO:0032755	positive regulation of interleukin-6 production	GOTERM_BP_DIRECT
3569	GO:0043200	response to amino acid	GOTERM_BP_DIRECT
3569	GO:0046716	muscle cell cellular homeostasis	GOTERM_BP_DIRECT
3569	GO:1990646	cellular response to prolactin	GOTERM_BP_DIRECT
3569	GO:0001878	response to yeast	GOTERM_BP_DIRECT
3569	GO:0002384	hepatic immune response	GOTERM_BP_DIRECT
3569	GO:0002675	positive regulation of acute inflammatory response	GOTERM_BP_DIRECT
3569	GO:0032722	positive regulation of chemokine production	GOTERM_BP_DIRECT
3569	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	GOTERM_BP_DIRECT
3569	GO:0045779	negative regulation of bone resorption	GOTERM_BP_DIRECT
3569	GO:0046427	positive regulation of JAK-STAT cascade	GOTERM_BP_DIRECT
3569	GO:0071222	cellular response to lipopolysaccharide	GOTERM_BP_DIRECT
3569	GO:0002548	monocyte chemotaxis	GOTERM_BP_DIRECT
3569	GO:0043066	negative regulation of apoptotic process	GOTERM_BP_DIRECT
3569	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GOTERM_BP_DIRECT
3569	GO:0045454	cell redox homeostasis	GOTERM_BP_DIRECT
3569	GO:0045893	positive regulation of transcription	GOTERM_BP_DIRECT
3569	GO:0050871	positive regulation of B cell activation	GOTERM_BP_DIRECT
3569	GO:0005515	protein binding	GOTERM_MF_DIRECT
3569	GO:0005615	extracellular space	GOTERM_CC_DIRECT
3569	GO:0010628	positive regulation of gene expression	GOTERM_BP_DIRECT
3569	GO:0030168	platelet activation	GOTERM_BP_DIRECT
3569	GO:0032966	negative regulation of collagen biosynthetic process	GOTERM_BP_DIRECT
3569	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GOTERM_BP_DIRECT
3569	GO:0042832	defense response to protozoan	GOTERM_BP_DIRECT
3569	GO:0045188	regulation of circadian sleep/wake cycle	GOTERM_BP_DIRECT
3569	GO:0045429	positive regulation of nitric oxide biosynthetic process	GOTERM_BP_DIRECT
3569	GO:0045630	positive regulation of T-helper 2 cell differentiation	GOTERM_BP_DIRECT
3569	GO:0046888	negative regulation of hormone secretion	GOTERM_BP_DIRECT
3569	GO:0051897	positive regulation of protein kinase B signaling	GOTERM_BP_DIRECT
3569	GO:0070102	interleukin-6-mediated signaling pathway	GOTERM_BP_DIRECT
3569	GO:0071347	cellular response to interleukin-1	GOTERM_BP_DIRECT
3569	GO:0010976	positive regulation of neuron projection development	GOTERM_BP_DIRECT
3569	GO:0016049	cell growth	GOTERM_BP_DIRECT
3569	GO:0031018	endocrine pancreas development	GOTERM_BP_DIRECT
3569	GO:0045721	negative regulation of gluconeogenesis	GOTERM_BP_DIRECT
3569	GO:0046849	bone remodeling	GOTERM_BP_DIRECT
3569	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	GOTERM_BP_DIRECT
3569	GO:0005138	erythropoietin receptor binding	GOTERM_MF_DIRECT
3569	GO:0008083	growth factor activity	GOTERM_MF_DIRECT
3569	GO:0006954	inflammatory response	GOTERM_BP_DIRECT
3569	GO:0007568	aging	GOTERM_BP_DIRECT
3569	GO:0009409	response to cold	GOTERM_BP_DIRECT
3569	GO:0031669	cellular response to nutrient levels	GOTERM_BP_DIRECT
3569	GO:0042593	glucose homeostasis	GOTERM_BP_DIRECT
3569	GO:0045740	positive regulation of DNA replication	GOTERM_BP_DIRECT
3569	GO:0045837	negative regulation of membrane potential	GOTERM_BP_DIRECT
3569	GO:0051607	defense response to virus	GOTERM_BP_DIRECT
3569	GO:0071392	cellular response to estradiol stimulus	GOTERM_BP_DIRECT
3569	GO:0001781	neutrophil apoptotic process	GOTERM_BP_DIRECT
3569	GO:0045669	positive regulation of osteoblast differentiation	GOTERM_BP_DIRECT
3569	GO:0048635	negative regulation of muscle organ development	GOTERM_BP_DIRECT
3569	GO:0002446	neutrophil mediated immunity	GOTERM_BP_DIRECT
3569	GO:0008284	positive regulation of cell proliferation	GOTERM_BP_DIRECT
3569	GO:0048661	positive regulation of smooth muscle cell proliferation	GOTERM_BP_DIRECT
3569	GO:0051592	response to calcium ion	GOTERM_BP_DIRECT
3569	GO:0051971	positive regulation of transmission of nerve impulse	GOTERM_BP_DIRECT
3569	GO:0072540	T-helper 17 cell lineage commitment	GOTERM_BP_DIRECT
3569	GO:0008285	negative regulation of cell proliferation	GOTERM_BP_DIRECT
3569	GO:0031175	neuron projection development	GOTERM_BP_DIRECT
3569	GO:0050679	positive regulation of epithelial cell proliferation	GOTERM_BP_DIRECT
3569	GO:0002526	acute inflammatory response	GOTERM_BP_DIRECT
3569	GO:0002690	positive regulation of leukocyte chemotaxis	GOTERM_BP_DIRECT
3569	GO:0009408	response to heat	GOTERM_BP_DIRECT
3569	GO:0035729	cellular response to hepatocyte growth factor stimulus	GOTERM_BP_DIRECT
3569	GO:0042493	response to drug	GOTERM_BP_DIRECT
3569	GO:0045079	negative regulation of chemokine biosynthetic process	GOTERM_BP_DIRECT
3569	GO:0050830	defense response to Gram-positive bacterium	GOTERM_BP_DIRECT
3569	GO:0006469	negative regulation of protein kinase activity	GOTERM_BP_DIRECT
3569	GO:0006953	acute-phase response	GOTERM_BP_DIRECT
3569	GO:0008360	regulation of cell shape	GOTERM_BP_DIRECT
3569	GO:0042060	wound healing	GOTERM_BP_DIRECT
3569	GO:0043410	positive regulation of MAPK cascade	GOTERM_BP_DIRECT
3569	GO:0045765	regulation of angiogenesis	GOTERM_BP_DIRECT
3569	GO:0050829	defense response to Gram-negative bacterium	GOTERM_BP_DIRECT
3569	GO:0031000	response to caffeine	GOTERM_BP_DIRECT
3569	GO:0042102	positive regulation of T cell proliferation	GOTERM_BP_DIRECT
3569	GO:0051024	positive regulation of immunoglobulin secretion	GOTERM_BP_DIRECT
3569	GO:0071864	positive regulation of cell proliferation in bone marrow	GOTERM_BP_DIRECT
3569	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GOTERM_BP_DIRECT
3569	GO:0070301	cellular response to hydrogen peroxide	GOTERM_BP_DIRECT
3569	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
3569	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GOTERM_BP_DIRECT
3569	GO:0071356	cellular response to tumor necrosis factor	GOTERM_BP_DIRECT
3569	GO:1901215	negative regulation of neuron death	GOTERM_BP_DIRECT
3569	GO:0005896	interleukin-6 receptor complex	GOTERM_CC_DIRECT
3569	GO:0051384	response to glucocorticoid	GOTERM_BP_DIRECT
3569	GO:0060445	branching involved in salivary gland morphogenesis	GOTERM_BP_DIRECT
3569	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	GOTERM_BP_DIRECT
3569	GO:0071549	cellular response to dexamethasone stimulus	GOTERM_BP_DIRECT
3569	GO:0043065	positive regulation of apoptotic process	GOTERM_BP_DIRECT
3569	GO:0045599	negative regulation of fat cell differentiation	GOTERM_BP_DIRECT
3569	GO:0046677	response to antibiotic	GOTERM_BP_DIRECT
3569	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GOTERM_BP_DIRECT
3569	GO:2000366	positive regulation of STAT protein import into nucleus	GOTERM_BP_DIRECT
3569	GO:0005576	extracellular region	GOTERM_CC_DIRECT
3569	GO:0010888	negative regulation of lipid storage	GOTERM_BP_DIRECT
3569	GO:0032868	response to insulin	GOTERM_BP_DIRECT
3569	GO:0033160	positive regulation of protein import into nucleus	GOTERM_BP_DIRECT
3569	GO:0045727	positive regulation of translation	GOTERM_BP_DIRECT
3569	GO:0006955	immune response	GOTERM_BP_DIRECT
3569	GO:0010996	response to auditory stimulus	GOTERM_BP_DIRECT
3569	GO:0032494	response to peptidoglycan	GOTERM_BP_DIRECT
3569	GO:0050710	negative regulation of cytokine secretion	GOTERM_BP_DIRECT
3569	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	GOTERM_BP_DIRECT
3569	GO:0005125	death receptor binding	GOTERM_MF_DIRECT
3569	GO:0010574	regulation of vascular endothelial growth factor production	GOTERM_BP_DIRECT
3569	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GOTERM_BP_DIRECT
3569	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	GOTERM_BP_DIRECT
3569	GO:0051602	response to electrical stimulus	GOTERM_BP_DIRECT
3569	GO:0070091	glucagon secretion	GOTERM_BP_DIRECT
3569	GO:2000553	positive regulation of T-helper 2 cell cytokine production	GOTERM_BP_DIRECT
3569	GO:0009897	external side of plasma membrane	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
3569	hsa04060	Cytokine-cytokine receptor interaction
3569	hsa04066	HIF-1 signaling pathway
3569	hsa04068	FoxO signaling pathway
3569	hsa04151	PI3K-Akt signaling pathway
3569	hsa04640	Hematopoietic cell lineage
3569	hsa04620	Toll-like receptor signaling pathway
3569	hsa04621	NOD-like receptor signaling pathway
3569	hsa04630	Jak-STAT signaling pathway
3569	hsa04623	Cytosolic DNA-sensing pathway
3569	hsa04668	TNF signaling pathway
3569	hsa04672	Intestinal immune network for IgA production
3569	hsa04932	Non-alcoholic fatty liver disease
3569	hsa04931	Insulin resistance
3569	hsa05020	Prion diseases
3569	hsa05133	Pertussis
3569	hsa05132	Salmonella infection
3569	hsa05143	African trypanosomiasis
3569	hsa05134	Legionellosis
3569	hsa05200	Pathways in cancer
3569	hsa05144	Malaria
3569	hsa05164	Influenza A
3569	hsa05202	Transcriptional misregulation in cancer
3569	hsa05162	Measles
3569	hsa05152	Tuberculosis
3569	hsa05168	Herpes simplex infection
3569	hsa05161	Hepatitis B
3569	hsa05146	Amoebiasis
3569	hsa05166	HTLV-I infection
3569	hsa05142	Chagas disease
3569	hsa05321	Inflammatory bowel disease
3569	hsa05323	Rheumatoid arthritis
3569	hsa05410	Hypertrophic cardiomyopathy
3569	hsa05332	Graft-versus-host disease

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
IL6	3569	Alloxan Diabetes	C0002152	Experimental Model of Disease	0.3	0.287	0.966	disease
IL6	3569	Hypertensive disease	C0020538	Disease or Syndrome	0.4	0.287	0.966	group
IL6	3569	Spontaneous abortion	C0000786	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Squamous cell carcinoma	C0007137	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Neoplastic Cell Transformation	C0007621	Neoplastic Process	0.3	0.287	0.966	phenotype
IL6	3569	Diabetes Mellitus, Experimental	C0011853	Experimental Model of Disease	0.3	0.287	0.966	disease
IL6	3569	Fever	C0015967	Sign or Symptom	0.4	0.287	0.966	phenotype
IL6	3569	Glomerulonephritis	C0017658	Disease or Syndrome	0.32	0.287	0.966	disease
IL6	3569	Autoimmune Diseases	C0004364	Disease or Syndrome	0.5	0.287	0.966	group
IL6	3569	Cachexia	C0006625	Sign or Symptom	0.4	0.287	0.966	phenotype
IL6	3569	Basal cell carcinoma	C0007117	Neoplastic Process	0.31	0.287	0.966	disease
IL6	3569	Renal Cell Carcinoma	C0007134	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Crohn Disease	C0010346	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Inflammation	C0021368	Pathologic Function	0.37	0.287	0.966	phenotype
IL6	3569	Osteoporosis, Age-Related	C0001787	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Congestive heart failure	C0018802	Disease or Syndrome	0.6	0.287	0.966	disease
IL6	3569	Heat Stroke	C0018843	Injury or Poisoning	0.3	0.287	0.966	disease
IL6	3569	Rheumatoid Arthritis	C0003873	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Premature Obstetric Labor	C0022876	Pathologic Function	0.39	0.287	0.966	phenotype
IL6	3569	Atherosclerosis	C0004153	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Chemical Burns	C0006435	Injury or Poisoning	0.3	0.287	0.966	group
IL6	3569	Cholestasis	C0008370	Disease or Syndrome	0.31	0.287	0.966	disease
IL6	3569	Headache	C0018681	Sign or Symptom	0.32	0.287	0.966	phenotype
IL6	3569	Kidney Failure, Acute	C0022660	Disease or Syndrome	0.32	0.287	0.966	disease
IL6	3569	Cholestasis, Extrahepatic	C0005398	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Intracranial Arteriovenous Malformation	C0007772	Congenital Abnormality	0.3	0.287	0.966	disease
IL6	3569	Hyperalgesia	C0020429	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Hyperparathyroidism, Secondary	C0020503	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Inflammatory Bowel Diseases	C0021390	Disease or Syndrome	0.4	0.287	0.966	group
IL6	3569	Amnesia	C0002622	Mental or Behavioral Dysfunction	0.31	0.287	0.966	disease
IL6	3569	Malignant neoplasm of breast	C0006142	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Hepatoma, Novikoff	C0019208	Experimental Model of Disease; Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Ischemia	C0022116	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Jacksonian Seizure	C0022333	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Albuminuria	C0001925	Finding	0.3	0.287	0.966	phenotype
IL6	3569	Berylliosis	C0005138	Injury or Poisoning	0.3	0.287	0.966	disease
IL6	3569	Brain Ischemia	C0007786	Disease or Syndrome	0.31	0.287	0.966	disease
IL6	3569	Endogenous depression	C0011573	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Hypersensitivity	C0020517	Pathologic Function	0.3	0.287	0.966	group
IL6	3569	Kidney Failure, Chronic	C0022661	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Coxsackievirus Infections	C0010246	Disease or Syndrome	0.3	0.287	0.966	group
IL6	3569	Angiolymphoid hyperplasia	C0017531	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Hemolytic-Uremic Syndrome	C0019061	Disease or Syndrome	0.31	0.287	0.966	disease
IL6	3569	Hypercalcemia	C0020437	Disease or Syndrome	0.33	0.287	0.966	disease
IL6	3569	Colitis	C0009319	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Hypotension	C0020649	Finding	0.3	0.287	0.966	phenotype
IL6	3569	Left-Sided Heart Failure	C0023212	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Abortion, Tubal	C0000822	Pathologic Function	0.3	0.287	0.966	disease
IL6	3569	Heart failure	C0018801	Disease or Syndrome	0.6	0.287	0.966	disease
IL6	3569	Autistic Disorder	C0004352	Mental or Behavioral Dysfunction	0.32	0.287	0.966	group
IL6	3569	Dermatitis, Atopic	C0011615	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Hepatolenticular Degeneration	C0019202	Disease or Syndrome	0.32	0.287	0.966	disease
IL6	3569	Hyperoxaluria	C0020500	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Arthritis, Adjuvant-Induced	C0003865	Experimental Model of Disease	0.3	0.287	0.966	disease
IL6	3569	Burn injury	C0006434	Injury or Poisoning	0.3	0.287	0.966	group
IL6	3569	Edema	C0013604	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Entamoebiasis	C0014324	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Hepatoma, Morris	C0019207	Experimental Model of Disease; Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Diaphragmatic Hernia	C0019284	Anatomical Abnormality	0.3	0.287	0.966	phenotype
IL6	3569	Hepatitis, Toxic	C0019193	Injury or Poisoning	0.3	0.287	0.966	disease
IL6	3569	Milk-Alkali Syndrome	C0026141	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Osteoporosis, Postmenopausal	C0029458	Disease or Syndrome	0.34	0.287	0.966	disease
IL6	3569	Anasarca	C0151603	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Leishmaniasis, Visceral	C0023290	Disease or Syndrome	0.31	0.287	0.966	disease
IL6	3569	Chronic Obstructive Airway Disease	C0024117	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Aseptic Meningitis	C0025290	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Ocular Headache	C0028838	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Liver Cirrhosis, Alcoholic	C0023891	Disease or Syndrome	0.32	0.287	0.966	disease
IL6	3569	Pustulosis of Palms and Soles	C0030246	Disease or Syndrome	0.31	0.287	0.966	disease
IL6	3569	Parkinson Disease	C0030567	Disease or Syndrome	0.35	0.287	0.966	disease
IL6	3569	Experimental Hepatoma	C0086404	Experimental Model of Disease; Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Thyroid Gland Follicular Adenoma	C0151468	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Obesity	C0028754	Disease or Syndrome	0.6	0.287	0.966	disease
IL6	3569	Respiratory Hypersensitivity	C0035228	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Seizures	C0036572	Sign or Symptom	0.34	0.287	0.966	phenotype
IL6	3569	Thyroid Neoplasm	C0040136	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Injury wounds	C0043250	Injury or Poisoning	0.3	0.287	0.966	group
IL6	3569	Megaconial Myopathies	C0162668	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Epileptic drop attack	C0270846	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Condition, Preneoplastic	C0282313	Neoplastic Process	0.3	0.287	0.966	phenotype
IL6	3569	Throbbing Headache	C0423618	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Amnestic State	C0750907	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Vertex Headache	C0751192	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Visual seizure	C0270824	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	HIV Wasting Syndrome	C0343755	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Thyroid carcinoma	C0549473	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Breast Carcinoma	C0678222	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Middle Cerebral Artery Occlusion	C0740391	Acquired Abnormality	0.32	0.287	0.966	phenotype
IL6	3569	Atonic Absence Seizures	C0751123	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Allergic Reaction	C1527304	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Nonepileptic Seizures	C3495874	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Heart Failure, Right-Sided	C0235527	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Hepatitis, Autoimmune	C0241910	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Brain Lacerations	C0272945	Injury or Poisoning	0.3	0.287	0.966	disease
IL6	3569	Bilateral Headache	C0423623	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Single Seizure	C0751110	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Middle Cerebral Artery Embolus	C0751845	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Liver carcinoma	C2239176	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Pneumonitis	C3714636	Disease or Syndrome	0.38	0.287	0.966	disease
IL6	3569	Allodynia	C0458247	Finding	0.3	0.287	0.966	phenotype
IL6	3569	Non-epileptic convulsion	C0751056	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Seizures, Sensory	C0751496	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Left Middle Cerebral Artery Infarction	C0751846	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Epileptic Seizures	C4317109	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Absence Seizures	C4316903	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Liver Neoplasms, Experimental	C0023904	Experimental Model of Disease; Neoplastic Process	0.3	0.287	0.966	group
IL6	3569	Lupus Erythematosus, Systemic	C0024141	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Lobar Pneumonia	C0032300	Disease or Syndrome	0.31	0.287	0.966	disease
IL6	3569	Psoriasis	C0033860	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Premature Birth	C0151526	Pathologic Function	0.32	0.287	0.966	phenotype
IL6	3569	Liver Cirrhosis	C0023890	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Necrosis	C0027540	Organ or Tissue Function	0.3	0.287	0.966	phenotype
IL6	3569	Pleural Diseases	C0032226	Disease or Syndrome	0.3	0.287	0.966	group
IL6	3569	Stomach Neoplasms	C0038356	Neoplastic Process	0.36	0.287	0.966	group
IL6	3569	Injuries, Acute Brain	C0085742	Injury or Poisoning	0.3	0.287	0.966	group
IL6	3569	Chronic Lymphocytic Leukemia	C0023434	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Lung Neoplasms	C0024121	Neoplastic Process	0.4	0.287	0.966	group
IL6	3569	Melancholia	C0025193	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Myocardial Diseases, Secondary	C0036529	Disease or Syndrome	0.3	0.287	0.966	group
IL6	3569	Neoplasm Invasiveness	C0027626	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Pleurisy	C0032231	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.4	0.287	0.966	disease
IL6	3569	Wounds and Injuries	C0043251	Injury or Poisoning	0.3	0.287	0.966	group
IL6	3569	Complex partial seizures	C0149958	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Myocardial Ischemia	C0151744	Disease or Syndrome	0.35	0.287	0.966	disease
IL6	3569	Dissociative Amnesia	C0236795	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Middle Cerebral Artery Syndrome	C0238281	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Malignant neoplasm of lung	C0242379	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Polymyositis Ossificans	C0263984	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Neurodegenerative Disorders	C0524851	Disease or Syndrome	0.35	0.287	0.966	group
IL6	3569	Seizures, Focal	C0751495	Disease or Syndrome	0.3	0.287	0.966	phenotype
IL6	3569	Arthritis, Collagen-Induced	C0971858	Experimental Model of Disease	0.3	0.287	0.966	disease
IL6	3569	Heart Decompensation	C1961112	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Lung Injury	C0273115	Injury or Poisoning	0.3	0.287	0.966	disease
IL6	3569	Nicotine Use Disorder	C0376384	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Middle Cerebral Artery Thrombosis	C0740376	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Post-Traumatic Osteoporosis	C0751406	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Right Middle Cerebral Artery Infarction	C0751849	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Pleoconial Myopathies	C0162669	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Crohn's disease of the ileum	C0267380	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Generalized Headache	C0474366	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Retro-Ocular Headache	C0751189	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Carditis	C0869523	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Acute Coronary Syndrome	C0948089	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Oxalosis	C1298681	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Atherogenesis	C1563937	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Temporary Amnesia	C0233796	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Intracranial Arteriovenous Malformation, Ruptured	C0751008	Congenital Abnormality	0.3	0.287	0.966	disease
IL6	3569	Periorbital Headache	C0751187	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Tactile Allodynia	C0751213	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Hyperalgesia, Thermal	C0751214	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Degenerative Diseases, Spinal Cord	C0751733	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Pregnancy Complications, Cardiovascular	C0032963	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Dermatologic disorders	C0037274	Disease or Syndrome	0.35	0.287	0.966	group
IL6	3569	Polymyositis	C0085655	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Multiple Myeloma	C0026764	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Myocardial Infarction	C0027051	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Nicotine Dependence	C0028043	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Osteoporosis	C0029456	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Cardiomyopathies, Primary	C0033141	Disease or Syndrome	0.3	0.287	0.966	group
IL6	3569	Prostatic Neoplasms	C0033578	Neoplastic Process	0.4	0.287	0.966	group
IL6	3569	Depressive Syndrome	C0086133	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Neoplasm Metastasis	C0027627	Neoplastic Process	0.4	0.287	0.966	phenotype
IL6	3569	Osteoporosis, Senile	C0029459	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Peripheral Neuropathy	C0031117	Disease or Syndrome	0.31	0.287	0.966	group
IL6	3569	Cerebrovascular accident	C0038454	Disease or Syndrome	0.4	0.287	0.966	group
IL6	3569	Eczema, Infantile	C0086196	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Cholangiocarcinoma	C0206698	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Fibrosis, Liver	C0239946	Disease or Syndrome	0.34	0.287	0.966	disease
IL6	3569	Conventional (Clear Cell) Renal Cell Carcinoma	C0279702	Neoplastic Process	0.33	0.287	0.966	disease
IL6	3569	Vertiginous seizure	C0422855	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Sharp Headache	C0751190	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Convulsive Seizures	C0751494	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Cerebral Ischemia	C0917798	Disease or Syndrome	0.34	0.287	0.966	disease
IL6	3569	Arteriovenous Malformations, Cerebral	C0917804	Congenital Abnormality	0.3	0.287	0.966	group
IL6	3569	Collecting Duct Carcinoma of the Kidney	C1266044	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Chronic Airflow Obstruction	C1527303	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Seizures, Clonic	C0234535	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Libman-Sacks Disease	C0242380	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Brain Injuries	C0270611	Injury or Poisoning	0.3	0.287	0.966	group
IL6	3569	Seizures, Auditory	C0422852	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Regional enteritis	C0678202	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Chromophobe Renal Cell Carcinoma	C1266042	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Papillary Renal Cell Carcinoma	C1306837	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Beryllium Disease	C2350873	Disease or Syndrome	0.31	0.287	0.966	disease
IL6	3569	Research-Related Injuries	C4046002	Injury or Poisoning	0.3	0.287	0.966	group
IL6	3569	Generalized seizures	C0234533	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Hypoalbuminemia	C0239981	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Hyperalgesia, Primary	C0751211	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	IIeocolitis	C0949272	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Crohn's disease of large bowel	C0156147	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Hysterical amnesia	C0233750	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Malignant mesothelioma	C0345967	Neoplastic Process	0.31	0.287	0.966	disease
IL6	3569	Gustatory seizure	C0422854	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Metabolic Syndrome X	C0524620	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Infarction, Middle Cerebral Artery	C0740392	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Pigmented Basal Cell Carcinoma	C1368275	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Mammary Neoplasms	C1458155	Neoplastic Process	0.4	0.287	0.966	group
IL6	3569	Hepatic Form of Wilson Disease	C1527352	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Mechanical Allodynia	C2936719	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Chemical and Drug Induced Liver Injury	C4277682	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Leishmaniasis	C0023281	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Hamman-Rich syndrome	C0085786	Disease or Syndrome	0.51	0.287	0.966	disease
IL6	3569	Reperfusion Injury	C0035126	Injury or Poisoning	0.3	0.287	0.966	disease
IL6	3569	Shock, Hemorrhagic	C0036982	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Streptozotocin Diabetes	C0038433	Experimental Model of Disease	0.3	0.287	0.966	disease
IL6	3569	Pneumonia	C0032285	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Pulmonary Fibrosis	C0034069	Disease or Syndrome	0.4	0.287	0.966	disease
IL6	3569	Tobacco Dependence	C0040332	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Tobacco Use Disorder	C0040336	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Myocarditis	C0027059	Disease or Syndrome	0.33	0.287	0.966	disease
IL6	3569	Precancerous Conditions	C0032927	Neoplastic Process	0.32	0.287	0.966	group
IL6	3569	Kaposi Sarcoma	C0036220	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Ventricular Dysfunction, Left	C0242698	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Tonic Seizures	C0270844	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Depression, Neurotic	C0282126	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Intrahepatic Cholangiocarcinoma	C0345905	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Seizures, Somatosensory	C0422850	Pathologic Function	0.3	0.287	0.966	phenotype
IL6	3569	Olfactory seizure	C0422853	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Brain Injuries, Focal	C0452047	Injury or Poisoning	0.3	0.287	0.966	group
IL6	3569	Hemicrania	C0877781	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	ovarian neoplasm	C0919267	Neoplastic Process	0.36	0.287	0.966	disease
IL6	3569	Arthritis, Experimental	C0993582	Experimental Model of Disease	0.3	0.287	0.966	disease
IL6	3569	Bright Disease	C1704377	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Global Amnesia	C0262497	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Degenerative Diseases, Central Nervous System	C0270715	Disease or Syndrome	0.3	0.287	0.966	group
IL6	3569	Tactile Amnesia	C0750906	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Orthostatic Headache	C0751186	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Hyperalgesia, Secondary	C0751212	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Drug-Induced Liver Disease	C0860207	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Experimental Lung Inflammation	C0887898	Experimental Model of Disease	0.3	0.287	0.966	disease
IL6	3569	Malignant neoplasm of ovary	C1140680	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Acute Kidney Insufficiency	C1565662	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Myocardial Failure	C1959583	Disease or Syndrome	0.31	0.287	0.966	disease
IL6	3569	Extrahepatic Cholangiocarcinoma	C3805278	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Malignant neoplasm of prostate	C0376358	Neoplastic Process	0.4	0.287	0.966	disease
IL6	3569	Embolic Infarction, Middle Cerebral Artery	C0751847	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Thrombotic Infarction, Middle Cerebral Artery	C0751848	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Acute Cerebrovascular Accidents	C0751956	Disease or Syndrome	0.32	0.287	0.966	disease
IL6	3569	Mammary Neoplasms, Human	C1257931	Neoplastic Process	0.3	0.287	0.966	group
IL6	3569	Rheumatoid Arthritis, Systemic Juvenile	C1858558	Disease or Syndrome	0.31	0.287	0.966	disease
IL6	3569	Traumatic injury	C3263723	Injury or Poisoning	0.3	0.287	0.966	group
IL6	3569	Drug-Induced Acute Liver Injury	C3658290	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Mitochondrial Myopathies	C0162670	Disease or Syndrome	0.3	0.287	0.966	group
IL6	3569	Lichenoid Eruptions	C0162848	Disease or Syndrome	0.3	0.287	0.966	group
IL6	3569	Tonic - clonic seizures	C0494475	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Polymyositis, Idiopathic	C0554591	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Cardiomyopathies	C0878544	Disease or Syndrome	0.32	0.287	0.966	group
IL6	3569	Luft Disease	C0949496	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Hepatitis, Drug-Induced	C1262760	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Sarcomatoid Renal Cell Carcinoma	C1266043	Neoplastic Process	0.3	0.287	0.966	disease
IL6	3569	Chronic Lung Injury	C2350344	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Acute kidney injury	C2609414	Injury or Poisoning	0.3	0.287	0.966	disease
IL6	3569	Generalized Absence Seizures	C4505436	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Entamoeba histolytica Infection	C4316791	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Chemically-Induced Liver Toxicity	C4279912	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Convulsions	C4048158	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Myoclonic Seizures	C4317123	Sign or Symptom	0.3	0.287	0.966	phenotype
IL6	3569	Unipolar Depression	C0041696	Mental or Behavioral Dysfunction	0.57	0.287	0.966	disease
IL6	3569	Depressive disorder	C0011581	Mental or Behavioral Dysfunction	0.6	0.287	0.966	disease
IL6	3569	Familial Ménière disease	C4302111	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Systemic onset juvenile chronic arthritis	C1384600	Disease or Syndrome	0.38	0.287	0.966	disease
IL6	3569	Juvenile-Onset Still Disease	C0087031	Disease or Syndrome	0.3	0.287	0.966	disease
IL6	3569	Alcoholic Intoxication, Chronic	C0001973	Mental or Behavioral Dysfunction	0.32	0.287	0.966	disease
IL6	3569	Bipolar Disorder	C0005586	Mental or Behavioral Dysfunction	0.32	0.287	0.966	disease
IL6	3569	Major Depressive Disorder	C1269683	Mental or Behavioral Dysfunction	0.38	0.287	0.966	disease
IL6	3569	Delirium	C0011206	Mental or Behavioral Dysfunction	0.34	0.287	0.966	disease
IL6	3569	Drug-induced depressive state	C0338715	Mental or Behavioral Dysfunction	0.3	0.287	0.966	disease
IL6	3569	Mental Depression	C0011570	Mental or Behavioral Dysfunction	0.6	0.287	0.966	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
IL6	3569	ALD518	CLAZAKIZUMAB	CHEMBL2108589	None
IL6	3569	ARSENIC TRIOXIDE	ARSENIC TRIOXIDE	CHEMBL1200978	None
IL6	3569	BIAFINE	None	None	None
IL6	3569	C326	None	None	inhibitor
IL6	3569	CDP6038	CDP-6038	CHEMBL2109652	None
IL6	3569	CGP41251	MIDOSTAURIN	CHEMBL608533	None
IL6	3569	CLAZAKIZUMAB	CLAZAKIZUMAB	CHEMBL2108589	inhibitor
IL6	3569	CHINESE HERBS	None	None	None
IL6	3569	DIHYDROSPHINGOSINE	DIHYDROSPINGOSINE	CHEMBL448741	None
IL6	3569	ELSILIMOMAB	ELSILIMOMAB	CHEMBL2108591	inhibitor
IL6	3569	ENZYME INHIBITOR	None	None	None
IL6	3569	ECHINACEA	None	None	None
IL6	3569	FENTANYL	FENTANYL	CHEMBL596	None
IL6	3569	GALLIUM NITRATE	GALLIUM NITRATE	CHEMBL1200983	None
IL6	3569	GEMFIBROZIL	GEMFIBROZIL	CHEMBL457	None
IL6	3569	HMG-COA REDUCTASE INHIBITOR	None	None	None
IL6	3569	IBUDILAST	IBUDILAST	CHEMBL19449	inhibitor
IL6	3569	IFOSFAMIDE	IFOSFAMIDE	CHEMBL1024	None
IL6	3569	IMIPENEM CILASTATIN SODIUM	None	None	None
IL6	3569	INSULIN	None	None	None
IL6	3569	INTERFERON ALPHA-2B	INTERFERON ALFA-2B	CHEMBL1201558	None
IL6	3569	LEVOFLOXACIN	LEVOFLOXACIN	CHEMBL33	None
IL6	3569	LINEZOLID	LINEZOLID	CHEMBL126	None
IL6	3569	METRONIDAZOLE	METRONIDAZOLE	CHEMBL137	None
IL6	3569	NELFINAVIR	NELFINAVIR	CHEMBL584	None
IL6	3569	OLOKIZUMAB	OLOKIZUMAB	CHEMBL1743050	inhibitor
IL6	3569	PF-04236921	PF-04236921	CHEMBL2109613	inhibitor
IL6	3569	RECOMBINANT HUMAN IL-4	None	None	None
IL6	3569	RETINYL PALMITATE	None	None	None
IL6	3569	SAQUINAVIR	SAQUINAVIR	CHEMBL114	None
IL6	3569	SELENIUM	None	None	None
IL6	3569	SELECTIVE ESTROGEN RECEPTOR MODULATORS	None	None	None
IL6	3569	SERM	None	None	None
IL6	3569	SILTUXIMAB	SILTUXIMAB	CHEMBL1743070	inhibitor
IL6	3569	SIGNAL TRANSDUCTION INHIBITORS	None	None	None
IL6	3569	SILTUXIMAB	SILTUXIMAB	CHEMBL1743070	antibody
IL6	3569	SIRUKUMAB	SIRUKUMAB	CHEMBL1743071	inhibitor
IL6	3569	VITAMIN K	VITAMIN K	CHEMBL1201519	None