C-reactive protein

AltitudeomicsDB
Protein Official symbol CRP
Aliases CRP PTX1
Chromosomal Location 1
Length 224
Uniprot ID P02741
EC number None
Protein family Information(Pfam) PF00354;
PDB id 1B09;1CRV;1GNH;1LJ7;3L2Y;3PVN;3PVO;
InterPro ID IPR013320;IPR030476;IPR001759;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
C1QC C1QB 0.9990000000000001
C1QA C1QB 0.9990000000000001
C1R C1S 0.998
C1QA C1QC 0.997
IL6 CXCL8 0.985
IL6 ALB 0.983
LEP CRP 0.981
C1R C1QB 0.977
INS LEP 0.976
ADIPOQ LEP 0.975
C1R C1QA 0.973
C1S C1QB 0.972
C1S C1QA 0.971
C1S C1QC 0.97
IL6 CRP 0.97
C1R C1QC 0.968
ADIPOQ INS 0.9670000000000001
INS ALB 0.9570000000000001
IGHV3-11 IGLL5 0.955
ADIPOQ CRP 0.9520000000000001
C1QA CRP 0.95
IL6 INS 0.9470000000000001
ADIPOQ IL6 0.946
IL6 LEP 0.943
C1S CRP 0.938
C1R CRP 0.938
IGLL5 C1QA 0.9279999999999999
ALB CRP 0.927
INS CRP 0.922
C1QC CRP 0.92
IGHV3-11 C1S 0.9159999999999999
IGHV3-11 C1R 0.9159999999999999
IGLL5 C1QB 0.9129999999999999
C1QB CRP 0.9109999999999999
CXCL8 CRP 0.909
IGLL5 C1QC 0.909
IGHV3-11 C1QA 0.9
C1R IGLL5 0.9
IGHV3-11 C1QC 0.9
IGLL5 CRP 0.9
IGHV3-11 C1QB 0.9
IGLL5 C1S 0.9
IGHV3-11 CRP 0.9
Gene Ontology Semantic Similarity
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# 714 (C1QC) 712 (C1QA) 715 (C1R) 3569 (IL6) 3952 (LEP) 3630 (INS) 9370 (ADIPOQ) 716 (C1S) 100423062 (IGLL5) 213 (ALB) 713 (C1QB) 3576 (CXCL8) 1401 (CRP)
714 (C1QC) 1.00 1.00 1.00 0.12 0.08 0.12 0.12 1.00 0.12 0.15 1.00 0.12 0.12
712 (C1QA) 1.00 1.00 0.86 0.67 0.52 0.70 0.67 0.96 0.52 0.55 1.00 0.61 0.54
715 (C1R) 1.00 0.86 1.00 0.57 0.40 0.61 0.60 0.86 0.43 0.56 0.86 0.50 0.63
3569 (IL6) 0.12 0.67 0.57 1.00 0.66 0.74 0.80 0.69 0.66 0.60 0.67 0.72 0.61
3952 (LEP) 0.08 0.52 0.40 0.66 1.00 0.70 0.68 0.52 0.60 0.42 0.52 0.58 0.46
3630 (INS) 0.12 0.70 0.61 0.74 0.70 1.00 0.83 0.75 0.62 0.64 0.70 0.71 0.64
9370 (ADIPOQ) 0.12 0.67 0.60 0.80 0.68 0.83 1.00 0.74 0.63 0.68 0.67 0.71 0.65
716 (C1S) 1.00 0.96 0.86 0.69 0.52 0.75 0.74 1.00 0.53 0.60 0.96 0.64 0.57
100423062 (IGLL5) 0.12 0.52 0.43 0.66 0.60 0.62 0.63 0.53 1.00 0.50 0.52 0.58 0.50
213 (ALB) 0.15 0.55 0.56 0.60 0.42 0.64 0.68 0.60 0.50 1.00 0.55 0.57 0.59
713 (C1QB) 1.00 1.00 0.86 0.67 0.52 0.70 0.67 0.96 0.52 0.55 1.00 0.61 0.54
3576 (CXCL8) 0.12 0.61 0.50 0.72 0.58 0.71 0.71 0.64 0.58 0.57 0.61 1.00 0.57
1401 (CRP) 0.12 0.54 0.63 0.61 0.46 0.64 0.65 0.57 0.50 0.59 0.54 0.57 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CRP Rat Plasma - 9754 m 0.5 hours downregulated 0.45 2-DE Northern indo-australian plate Male Sprague-Dawley (SD) 1 Male Sprague-Dawley (SD) rats of weight 150 ± 10 g kept at standard conditions 24067188
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
TBP 6908 CRP 1401 Repression 24440874 TRUSST
REL 5966 CRP 1401 Activation 10075672 TRUSST
RELA 5970 CRP 1401 Activation 22671145 TRUSST
CEBPB 1051 CRP 1401 Repression 10669650 TRUSST
HNF1A 6927 CRP 1401 Unknown 10393213 TRUSST
NFKB1 4790 CRP 1401 Unknown 10393213 TRUSST
FOS 2353 CRP 1401 Unknown 12730302 TRUSST
STAT3 6774 CRP 1401 Unknown 10075672 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT735890 hsa-miR-1184 Homo sapiens CRP 1401 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT736816 hsa-miR-1273g-3p Homo sapiens CRP 1401 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT743326 hsa-miR-4252 Homo sapiens CRP 1401 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT744150 hsa-miR-4418 Homo sapiens CRP 1401 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT749667 hsa-miR-509-3-5p Homo sapiens CRP 1401 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT749703 hsa-miR-509-5p Homo sapiens CRP 1401 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
MIRT759268 hsa-miR-7156-3p Homo sapiens CRP 1401 Homo sapiens PAR-CLIP Functional MTI (Weak) 26701625
Gene Ontology
ID GO ID GO Term GO Type
1401 GO:0010745 negative regulation of macrophage derived foam cell differentiation GOTERM_BP_DIRECT
1401 GO:2000482 regulation of interleukin-8 secretion GOTERM_BP_DIRECT
1401 GO:0033265 acetylcholine receptor binding GOTERM_MF_DIRECT
1401 GO:0005576 extracellular region GOTERM_CC_DIRECT
1401 GO:0045908 negative regulation of vasodilation GOTERM_BP_DIRECT
1401 GO:0006953 acute-phase response GOTERM_BP_DIRECT
1401 GO:0006954 inflammatory response GOTERM_BP_DIRECT
1401 GO:0032930 positive regulation of superoxide anion generation GOTERM_BP_DIRECT
1401 GO:0005515 protein binding GOTERM_MF_DIRECT
1401 GO:0010888 negative regulation of lipid storage GOTERM_BP_DIRECT
1401 GO:0008228 opsonization GOTERM_BP_DIRECT
1401 GO:0005509 calcium ion binding GOTERM_MF_DIRECT
1401 GO:0010628 positive regulation of gene expression GOTERM_BP_DIRECT
1401 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
1401 GO:0050830 defense response to Gram-positive bacterium GOTERM_BP_DIRECT
1401 GO:0046790 SMAD binding GOTERM_MF_DIRECT
1401 GO:0001849 phosphatidylserine binding GOTERM_MF_DIRECT
1401 GO:0030169 benzodiazepine receptor binding GOTERM_MF_DIRECT
1401 GO:0050750 androgen receptor binding GOTERM_MF_DIRECT
1401 GO:0005615 extracellular space GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CRP 1401 Lung Neoplasms C0024121 Neoplastic Process 0.31 0.399 0.862 group
CRP 1401 Obesity C0028754 Disease or Syndrome 0.4 0.399 0.862 disease
CRP 1401 Arthritis, Collagen-Induced C0971858 Experimental Model of Disease 0.3 0.399 0.862 disease
CRP 1401 Diabetes Mellitus, Insulin-Dependent C0011854 Disease or Syndrome 0.39 0.399 0.862 disease
CRP 1401 Carditis C0869523 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Rheumatoid Arthritis C0003873 Disease or Syndrome 0.6 0.399 0.862 disease
CRP 1401 Heart Diseases C0018799 Disease or Syndrome 0.37 0.399 0.862 group
CRP 1401 Anxiety Disorders C0003469 Mental or Behavioral Dysfunction 0.3 0.399 0.862 group
CRP 1401 Metabolic Diseases C0025517 Disease or Syndrome 0.35 0.399 0.862 group
CRP 1401 Libman-Sacks Disease C0242380 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Atherosclerosis C0004153 Disease or Syndrome 0.4 0.399 0.862 disease
CRP 1401 Meningitis C0025289 Disease or Syndrome 0.31 0.399 0.862 disease
CRP 1401 Pericementitis C0031051 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Myocardial Ischemia C0151744 Disease or Syndrome 0.4 0.399 0.862 disease
CRP 1401 Hyperparathyroidism, Secondary C0020503 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Left-Sided Heart Failure C0023212 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Nervous System, Organic Arsenic Poisoning C0274862 Injury or Poisoning 0.3 0.399 0.862 disease
CRP 1401 Diabetes, Autoimmune C0205734 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Arthritis, Adjuvant-Induced C0003865 Experimental Model of Disease 0.3 0.399 0.862 disease
CRP 1401 Hypertriglyceridemia C0020557 Disease or Syndrome 0.34 0.399 0.862 phenotype
CRP 1401 Leishmaniasis, Visceral C0023290 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Lupus Erythematosus, Systemic C0024141 Disease or Syndrome 0.4 0.399 0.862 disease
CRP 1401 Brittle diabetes C0342302 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Infection C3714514 Pathologic Function 0.35 0.399 0.862 group
CRP 1401 Inflammation C0021368 Pathologic Function 0.4 0.399 0.862 phenotype
CRP 1401 Periodontitis C0031099 Disease or Syndrome 0.38 0.399 0.862 disease
CRP 1401 Thrombosis C0040053 Pathologic Function 0.31 0.399 0.862 phenotype
CRP 1401 Malignant neoplasm of lung C0242379 Neoplastic Process 0.35 0.399 0.862 disease
CRP 1401 Hypertensive disease C0020538 Disease or Syndrome 0.6 0.399 0.862 group
CRP 1401 Substance Withdrawal Syndrome C0038587 Mental or Behavioral Dysfunction 0.3 0.399 0.862 disease
CRP 1401 Kidney Failure, Chronic C0022661 Disease or Syndrome 0.34 0.399 0.862 disease
CRP 1401 Pustulosis of Palms and Soles C0030246 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Pasteurellaceae Infections C0085397 Disease or Syndrome 0.3 0.399 0.862 group
CRP 1401 Thrombus C0087086 Pathologic Function 0.3 0.399 0.862 phenotype
CRP 1401 Liver carcinoma C2239176 Neoplastic Process 0.4 0.399 0.862 disease
CRP 1401 Coronary Arteriosclerosis C0010054 Disease or Syndrome 0.4 0.399 0.862 disease
CRP 1401 Congestive heart failure C0018802 Disease or Syndrome 0.38 0.399 0.862 disease
CRP 1401 Withdrawal Symptoms C0087169 Sign or Symptom 0.3 0.399 0.862 phenotype
CRP 1401 Crohn's disease of large bowel C0156147 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Leishmaniasis C0023281 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Myocarditis C0027059 Disease or Syndrome 0.31 0.399 0.862 disease
CRP 1401 Pachymeningitis C0030167 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Nephritis, Tubulointerstitial C0041349 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Heart Failure, Right-Sided C0235527 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Arsenic Poisoning, Inorganic C0274861 Injury or Poisoning 0.3 0.399 0.862 disease
CRP 1401 Acute Coronary Syndrome C0948089 Disease or Syndrome 0.4 0.399 0.862 disease
CRP 1401 Crohn's disease of the ileum C0267380 Disease or Syndrome 0.31 0.399 0.862 disease
CRP 1401 Arsenic Encephalopathy C0751851 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Cardiovascular Diseases C0007222 Disease or Syndrome 0.4 0.399 0.862 group
CRP 1401 Malaria C0024530 Disease or Syndrome 0.36 0.399 0.862 disease
CRP 1401 Drug Withdrawal Symptoms C0086189 Sign or Symptom 0.3 0.399 0.862 phenotype
CRP 1401 IIeocolitis C0949272 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Atherogenesis C1563937 Pathologic Function 0.3 0.399 0.862 phenotype
CRP 1401 Psoriasis C0033860 Disease or Syndrome 0.35 0.399 0.862 disease
CRP 1401 Arthritis, Experimental C0993582 Experimental Model of Disease 0.3 0.399 0.862 disease
CRP 1401 Heart Decompensation C1961112 Pathologic Function 0.3 0.399 0.862 phenotype
CRP 1401 Heart failure C0018801 Disease or Syndrome 0.38 0.399 0.862 disease
CRP 1401 Diabetes Mellitus, Ketosis-Prone C3837958 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Arsenic Poisoning C0311375 Injury or Poisoning 0.3 0.399 0.862 disease
CRP 1401 Arsenic Induced Polyneuropathy C0751852 Injury or Poisoning 0.3 0.399 0.862 disease
CRP 1401 Coronary Artery Disease C1956346 Disease or Syndrome 0.4 0.399 0.862 disease
CRP 1401 Myocardial Failure C1959583 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Crohn Disease C0010346 Disease or Syndrome 0.4 0.399 0.862 disease
CRP 1401 Diabetic Retinopathy C0011884 Disease or Syndrome 0.32 0.399 0.862 disease
CRP 1401 Nephritis, Interstitial C0027707 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Anxiety States, Neurotic C0376280 Mental or Behavioral Dysfunction 0.3 0.399 0.862 disease
CRP 1401 Metabolic Syndrome X C0524620 Disease or Syndrome 0.4 0.399 0.862 disease
CRP 1401 Regional enteritis C0678202 Disease or Syndrome 0.3 0.399 0.862 disease
CRP 1401 Anxiety neurosis (finding) C1279420 Mental or Behavioral Dysfunction 0.3 0.399 0.862 disease
CRP 1401 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.38 0.399 0.862 disease
CRP 1401 Unipolar Depression C0041696 Mental or Behavioral Dysfunction 0.3 0.399 0.862 disease
CRP 1401 Depressed mood C0344315 Finding 0.3 0.399 0.862 phenotype
CRP 1401 Major Depressive Disorder C1269683 Mental or Behavioral Dysfunction 0.34 0.399 0.862 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
CRP 1401 ISIS-CRPRX None None None
CRP 1401 ISIS-CRP CHEMBL406845 CHEMBL406845 antisense
CRP 1401 ISIS 353512 None None None