Complement C1q subcomponent subunit B

AltitudeomicsDB
Protein Official symbol C1QB
Aliases C1QB
Chromosomal Location 1
Length 253
Uniprot ID P02746
EC number None
Protein family Information(Pfam) PF00386;PF01391;
PDB id 1PK6;2JG8;2JG9;2WNU;2WNV;5HKJ;5HZF;6FCZ;
InterPro ID IPR001073;IPR008160;IPR037573;IPR008983;
dbSNP rs776292843

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
Gene Ontology Semantic Similarity
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# 712 (C1QA) 714 (C1QC) 715 (C1R) 721 (C4B) 716 (C1S) 720 (C4A) 713 (C1QB) 717 (C2) 710 (SERPING1) 1436 (CSF1R)
712 (C1QA) 1.00 1.00 0.86 0.84 0.96 0.80 1.00 1.00 0.56 0.49
714 (C1QC) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.12 0.10
715 (C1R) 0.86 1.00 1.00 0.77 0.86 0.71 0.86 0.86 0.46 0.41
721 (C4B) 0.84 1.00 0.77 1.00 0.81 0.77 0.84 0.84 0.49 0.41
716 (C1S) 0.96 1.00 0.86 0.81 1.00 0.74 0.96 0.96 0.61 0.55
720 (C4A) 0.80 1.00 0.71 0.77 0.74 1.00 0.80 0.80 0.35 0.31
713 (C1QB) 1.00 1.00 0.86 0.84 0.96 0.80 1.00 1.00 0.56 0.49
717 (C2) 1.00 1.00 0.86 0.84 0.96 0.80 1.00 1.00 0.56 0.49
710 (SERPING1) 0.56 0.12 0.46 0.49 0.61 0.35 0.56 0.56 1.00 0.48
1436 (CSF1R) 0.49 0.10 0.41 0.41 0.55 0.31 0.49 0.49 0.48 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
C1QB Human Serum - 2400 m 0.5 hours downregulated 0.157 2-DE Western Europe Germans 0.193 Healthy adults never had ear surgery or problems with pressure equalization 28858246
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT030305 hsa-miR-26b-5p Homo sapiens C1QB 713 Homo sapiens Microarray Functional MTI (Weak) 19088304
Gene Ontology
ID GO ID GO Term GO Type
713 GO:0005581 collagen trimer GOTERM_CC_DIRECT
713 GO:0045087 innate immune response GOTERM_BP_DIRECT
713 GO:0005515 protein binding GOTERM_MF_DIRECT
713 GO:0042803 protein homodimerization activity GOTERM_MF_DIRECT
713 GO:0005602 complement component C1 complex GOTERM_CC_DIRECT
713 GO:0006956 complement activation GOTERM_BP_DIRECT
713 GO:0005576 extracellular region GOTERM_CC_DIRECT
713 GO:0006958 complement activation GOTERM_BP_DIRECT
713 GO:0006508 proteolysis GOTERM_BP_DIRECT
713 GO:0048839 inner ear development GOTERM_BP_DIRECT
713 GO:0004252 serine-type endopeptidase activity GOTERM_MF_DIRECT
713 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
713 GO:0072562 blood microparticle GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
713 hsa04610 Complement and coagulation cascades
713 hsa05020 Prion diseases
713 hsa05133 Pertussis
713 hsa05150 Staphylococcus aureus infection
713 hsa05142 Chagas disease
713 hsa05322 Systemic lupus erythematosus
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
C1QB 713 C1q DEFICIENCY C3150902 Disease or Syndrome 0.71 0.72 0.379 disease
C1QB 713 Ovarian Cysts C0029927 Disease or Syndrome 0.3 0.72 0.379 disease
C1QB 713 Antibody Deficiency Syndrome C0003257 Disease or Syndrome 0.3 0.72 0.379 disease
C1QB 713 Immunologic Deficiency Syndromes C0021051 Disease or Syndrome 0.3 0.72 0.379 group
C1QB 713 IGA Glomerulonephritis C0017661 Disease or Syndrome 0.3 0.72 0.379 disease
C1QB 713 Liver Cirrhosis C0023890 Disease or Syndrome 0.3 0.72 0.379 disease
C1QB 713 Myocardial Ischemia C0151744 Disease or Syndrome 0.3 0.72 0.379 disease
C1QB 713 Corpus Luteum Cyst C0010093 Disease or Syndrome 0.3 0.72 0.379 disease
C1QB 713 Fibrosis, Liver C0239946 Disease or Syndrome 0.3 0.72 0.379 disease
C1QB 713 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.72 0.379 disease
C1QB 713 Schizophrenia C0036341 Mental or Behavioral Dysfunction 0.31 0.72 0.379 disease
C1QB 713 Malignant neoplasm of breast C0006142 Neoplastic Process 0.3 0.72 0.379 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
C1QB 713 6-FLUOROTRYPTOPHAN CHEMBL472222 CHEMBL472222 inhibitor
C1QB 713 FENFLURAMINE FENFLURAMINE CHEMBL87493 inhibitor
C1QB 713 FENCLONINE FENCLONINE CHEMBL1256351 inhibitor
C1QB 713 α-PROPYLDOPACETAMIDE ROPINIROLE CHEMBL589 inhibitor