ALTITUDEOMICSDB

Complement C4

AltitudeomicsDB

Protein Official symbol	C4A
Aliases	C4A CO4 CPAMD2
Chromosomal Location	6
Length	1744
Uniprot ID	P0C0L4
EC number	None
Protein family Information(Pfam)	PF00207;PF07703;PF07677;PF01821;PF01835;PF17791;PF17789;PF01759;PF07678;
PDB id	1HZF;4FXG;4FXK;4XAM;5JPM;5JPN;5JTW;
InterPro ID	IPR009048;IPR036595;IPR011625;IPR011626;IPR000020;IPR018081;IPR001840;IPR037569;IPR013783;IPR001599;IPR019742;IPR002890;IPR041555;IPR040839;IPR001134;IPR018933;IPR008930;IPR008993;
dbSNP	rs9296005 rs392610 rs2229405 rs1215093373 rs429329 rs147162052 rs17874654 rs28357075 rs28357076 rs201016130

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
FGG	FGA	0.999
APOA1	APOB	0.999
C1QC	C1QB	0.999
C1QA	C1QB	0.999
APOA2	APOA1	0.999
AHSG	ALB	0.998
CD46	C3	0.998
C1R	C1S	0.998
CFB	C3	0.998
C1QA	C1QC	0.997
AHSG	AFP	0.997
CFI	C3	0.997
CD55	C3	0.997
APOA2	APOB	0.997
CR1	C3	0.997
APOE	APOB	0.996
SERPINC1	FGA	0.996
AHSG	APOA1	0.996
APP	APOE	0.995
C4B	C4A	0.995
AHSG	APOA2	0.995
SERPINC1	FGG	0.995
SERPINC1	ITIH2	0.994
MASP1	FCN2	0.994
MBL2	FCN2	0.994
C4B	CD46	0.992
APOE	APOA1	0.991
ALB	APOA1	0.991
C4B	CR1	0.991
AHSG	FGG	0.991
FN1	ALB	0.99
MBL2	MASP1	0.99
C4A	CR1	0.99
MASP2	MBL2	0.99
AHSG	ITIH2	0.99
SERPINC1	PROC	0.989
FGA	APOA1	0.989
AFP	APOA2	0.989
ITIH2	FGG	0.989
AHSG	FGA	0.989
C4A	CD46	0.988
MBL2	FCN3	0.988
AHSG	SERPINC1	0.987
AHSG	APOB	0.987
FCN1	MASP1	0.987
SERPINC1	ALB	0.987
C4B	MASP2	0.986
C4A	MASP2	0.986
ALB	APOB	0.986
APOA2	APOE	0.985
CD55	C2	0.985
ITIH2	FGA	0.985
AHSG	TF	0.985
FGG	APOA1	0.984
C2	C3	0.984
AFP	APOB	0.984
IL6	ALB	0.983
C4A	C1S	0.983
ITIH2	APOA1	0.983
SERPINA1	ALB	0.983
FGA	ALB	0.983
C4B	C1S	0.983
SERPINA1	AFP	0.983
CFB	CFI	0.983
TF	ALB	0.983
TF	APOA2	0.982
CFB	C4B	0.982
MASP1	FCN3	0.981
APOA2	ALB	0.981
APOA5	APOB	0.981
SERPINA1	CP	0.981
ALB	CP	0.98
FGG	ALB	0.98
ITIH2	SERPIND1	0.98
FGG	APOB	0.98
ALB	APOE	0.979
AFP	APOA1	0.979
FGG	SERPIND1	0.979
SERPINC1	APOA1	0.978
TF	APOA1	0.978
CST3	ALB	0.978
CFI	CD46	0.977
C1R	C4A	0.977
C1R	C4B	0.977
C4B	C4BPA	0.977
C1R	C1QB	0.977
FGA	APOB	0.977
COLEC11	MASP1	0.976
CFB	C4A	0.976
C4B	C2	0.976
IL6	CSF1	0.976
AHSG	PROC	0.975
FGA	SERPIND1	0.975
C4B	MASP1	0.975
IL6	KNG1	0.974
APOA2	ITIH2	0.974
SERPINC1	APOB	0.974
ITIH2	APOB	0.974
SERPINA1	AHSG	0.974
COLEC11	FCN3	0.973
IL6	SERPINC1	0.973
C1R	C1QA	0.973
ALB	C3	0.972
SERPINC1	KNG1	0.972
C1S	C1QB	0.972
ITIH2	ALB	0.972
APOA2	FGA	0.972
AFP	ITIH2	0.972
AFP	FGG	0.972
SERPINA1	IL6	0.971
IL6	FN1	0.971
C1S	C1QA	0.971
ALB	KNG1	0.971
IL6	APOA1	0.971
C4B	MBL2	0.97
APOA2	FGG	0.97
C4A	MBL2	0.97
C1S	C1QC	0.97
APOA5	SERPINC1	0.97
SERPINA1	APOA1	0.97
FGA	PROC	0.97
C4B	C4BPB	0.97
APOA5	APOE	0.97
IL6	APOE	0.969
F5	SERPINC1	0.969
C4B	CD55	0.969
C4B	CFI	0.969
APOA5	APOA2	0.969
C4A	CD55	0.969
C4A	CFI	0.969
C1R	C1QC	0.968
APOA1	SERPIND1	0.968
C4B	FCN2	0.967
C3	APOA1	0.967
TF	CP	0.967
TF	ITIH2	0.967
TF	C3	0.967
C4A	MASP1	0.967
C4A	FCN2	0.966
SERPINA1	TF	0.966
TF	AFP	0.966
APOA5	AFP	0.966
AFP	KNG1	0.966
FN1	C3	0.966
ALB	APP	0.965
AFP	FGA	0.965
APOA2	SERPIND1	0.964
FN1	TNC	0.964
C4A	C4BPA	0.964
AHSG	CP	0.964
AHSG	SERPIND1	0.964
APOB	SERPIND1	0.964
C8A	C5	0.963
CP	C3	0.963
C2	C5	0.963
APOA5	ALB	0.963
C4A	C2	0.963
C4B	C1QB	0.963
SERPINA1	C3	0.963
APOA2	SERPINC1	0.963
AFP	SERPINC1	0.962
C4A	C4BPB	0.962
F5	PROC	0.962
SERPINA1	FN1	0.961
C4A	C1QB	0.961
AHSG	KNG1	0.961
APP	KNG1	0.961
APOA2	C3	0.961
SERPINA1	APOA2	0.96
SERPINC1	SERPIND1	0.96
APOA5	FGA	0.96
APOA5	AHSG	0.96
C4A	ALB	0.959
C4A	C1QC	0.959
APOE	C3	0.959
C4B	C1QC	0.959
CFI	C2	0.959
CST3	APOE	0.959
PROC	SERPIND1	0.958
IL6	C3	0.958
C4A	SERPINC1	0.958
C4B	FCN3	0.958
C4A	FCN3	0.958
IL6	APOB	0.957
CP	APOA1	0.957
SERPINA1	FGA	0.957
C4A	AFP	0.957
ITIH2	PROC	0.957
AFP	CP	0.957
AFP	C3	0.957
IL6	APP	0.957
C4B	C1QA	0.957
IL6	CST3	0.956
APP	APOA1	0.956
CST3	APP	0.956
SERPINC1	C3	0.956
SERPINC1	CP	0.956
AHSG	C3	0.956
AFP	ALB	0.956
APOA5	FGG	0.955
MBL2	C2	0.955
C4A	C1QA	0.955
FGG	PROC	0.955
C4A	APOA2	0.955
TF	APOB	0.955
CFI	C4BPA	0.955
SERPINA1	FGG	0.955
SERPINC1	FN1	0.954
KNG1	C3	0.954
FGG	CP	0.954
SERPINA1	KNG1	0.954
TF	KNG1	0.954
APOA5	APOA1	0.953
TF	FGG	0.953
FGG	KNG1	0.953
APOA5	SERPINA1	0.952
SERPINA1	APOB	0.952
ALB	SERPIND1	0.952
CSF1	ALB	0.952
AFP	FN1	0.952
FN1	APOE	0.952
KNG1	SERPIND1	0.952
AFP	SERPIND1	0.952
C4A	APOA1	0.951
MASP2	FCN2	0.951
SERPINA1	C4A	0.951
KNG1	APOA1	0.951
SERPINA1	ITIH2	0.95
C3	APOB	0.95
C4B	FCN1	0.95
TF	SERPINC1	0.95
SERPINA1	APOE	0.95
FN1	KNG1	0.95
C4A	FN1	0.95
C4A	FCN1	0.95
FN1	FGA	0.95
IL6	CP	0.949
CP	APOB	0.949
C4A	KNG1	0.949
APOA5	KNG1	0.949
FGA	KNG1	0.948
FN1	CSF1	0.948
CP	APOE	0.948
C1R	C2	0.948
APP	CP	0.948
COLEC11	C4A	0.947
AHSG	IL6	0.947
C4B	COLEC11	0.947
C3	C5	0.947
ALB	PROC	0.947
CFB	CR1	0.946
CST3	APOA1	0.946
APOA5	TF	0.946
APOA5	C3	0.946
C2	FCN2	0.946
C4A	CST3	0.946
FN1	FGG	0.946
IL6	AFP	0.946
FN1	APP	0.946
CFB	C5	0.946
APOA2	CP	0.946
CD46	C2	0.945
APOA2	KNG1	0.945
FGA	CP	0.945
SERPINA1	F5	0.945
FGA	C3	0.945
C4A	TF	0.945
C4A	APOE	0.944
CFI	CR1	0.944
C4A	IL6	0.944
AHSG	CST3	0.944
FN1	APOA1	0.943
CP	PROC	0.943
KNG1	CP	0.942
AHSG	APOE	0.942
TF	FGA	0.942
ITIH2	CP	0.941
KNG1	APOE	0.941
TF	FN1	0.941
ITIH2	KNG1	0.941
C2	MASP1	0.941
ITIH2	C3	0.94
SERPINA1	CST3	0.94
C4A	CP	0.94
SERPINA1	SERPINC1	0.94
APOA5	ITIH2	0.94
FGG	C3	0.94
F5	FGA	0.939
FN1	CP	0.939
CST3	APOB	0.939
COLEC11	FCN2	0.939
CSF1	APOE	0.939
FN1	APOB	0.938
C4A	FGA	0.938
MBL2	FCN1	0.938
C4A	C3	0.938
C4B	C3	0.938
C4A	F5	0.938
COLEC11	FCN1	0.938
FCN1	FCN2	0.938
APOA5	C4A	0.938
APP	C3	0.937
C4A	AHSG	0.937
CST3	C3	0.937
TF	APOE	0.937
C1QC	C2	0.937
ITIH2	FN1	0.937
APOA5	SERPIND1	0.937
AHSG	FN1	0.936
C4A	SERPIND1	0.936
C4A	FGG	0.936
F5	FGG	0.935
F5	KNG1	0.935
C4A	TNC	0.935
FGG	APOE	0.935
MASP2	MASP1	0.935
TF	SERPIND1	0.934
CST3	FN1	0.934
CFI	C4BPB	0.934
SERPINC1	APOE	0.934
C2	FCN3	0.934
APOA1	PROC	0.933
SPARCL1	FN1	0.933
C4BPA	C4BPB	0.933
FGA	APOE	0.933
KNG1	APOB	0.933
SERPINA1	SERPIND1	0.933
C1QB	C2	0.932
SERPINA1	PROC	0.931
F5	APOE	0.931
APOA5	PROC	0.931
C4A	ITIH2	0.931
C4A	APOB	0.931
F5	APOA1	0.931
F5	C3	0.93
ALB	TNC	0.93
F5	ALB	0.929
C3	SERPIND1	0.929
F5	APOB	0.929
CFB	CD46	0.929
PROC	APOB	0.928
FN1	SERPIND1	0.928
C4A	APP	0.927
SPARCL1	APOE	0.927
C4A	PROC	0.927
APP	APOB	0.927
C1S	C2	0.927
CST3	CP	0.926
CSF1	C3	0.926
APOA2	PROC	0.926
IL6	APOA2	0.926
CST3	APOA2	0.926
APOE	SERPIND1	0.925
SPARCL1	AHSG	0.925
CFB	CD55	0.925
F5	SERPIND1	0.925
AFP	PROC	0.925
FCN1	C2	0.925
SERPINA1	APP	0.925
KNG1	PROC	0.924
C4A	C5	0.924
KNG1	C5	0.923
CSF1	APP	0.923
IL6	TNC	0.923
SPARCL1	C3	0.923
CST3	SERPINC1	0.923
C4B	C5	0.922
C4A	C8A	0.922
C4B	C8A	0.922
IL6	FGA	0.921
CFB	C2	0.921
CR1	C2	0.921
F5	FN1	0.921
AHSG	F5	0.921
APP	TNC	0.921
CR1	CD46	0.921
TNC	APOB	0.921
C4A	CSF1	0.921
IL6	PROC	0.92
COLEC11	MBL2	0.92
AFP	APOE	0.92
SPARCL1	C4A	0.92
TNC	APOA1	0.92
C1QA	C2	0.92
SERPINC1	APP	0.919
AFP	APP	0.919
CP	SERPIND1	0.919
TF	CST3	0.919
F5	CP	0.918
APOA5	IL6	0.918
APOA2	APP	0.918
IL6	FGG	0.918
TF	IL6	0.918
SPARCL1	APP	0.917
AFP	TNC	0.917
F5	ITIH2	0.917
TF	F5	0.917
APOE	PROC	0.916
C3	PROC	0.916
TNC	APOE	0.915
SPARCL1	ALB	0.915
FGA	APP	0.915
IL6	F5	0.914
APOA2	F5	0.914
C4BPA	C2	0.914
SERPINA1	CSF1	0.913
ITIH2	APOE	0.913
CST3	FGA	0.913
CSF1	APOA1	0.913
IL6	SERPIND1	0.913
TNC	PROC	0.913
APOA2	FN1	0.913
AHSG	APP	0.913
APOA5	F5	0.913
TF	PROC	0.913
CSF1	APOB	0.912
APP	PROC	0.911
CST3	AFP	0.911
FCN2	FCN3	0.911
CST3	KNG1	0.911
TF	APP	0.911
COLEC11	C2	0.91
SPARCL1	TF	0.91
SPARCL1	FGG	0.91
AFP	CSF1	0.91
APOA5	CP	0.91
AFP	F5	0.909
FGG	APP	0.909
CST3	CSF1	0.909
APOA2	TNC	0.908
AHSG	TNC	0.908
MASP2	FCN3	0.908
CST3	ITIH2	0.908
CST3	PROC	0.907
CSF1	CP	0.906
FN1	PROC	0.906
FCN1	FCN3	0.906
SPARCL1	CST3	0.906
CST3	SERPIND1	0.906
SPARCL1	TNC	0.906
TNC	C3	0.905
C2	C4BPB	0.905
APP	C5	0.905
CSF1	KNG1	0.905
AHSG	CSF1	0.905
CSF1	TNC	0.905
SPARCL1	APOA1	0.904
FGA	TNC	0.904
TNC	CP	0.904
APP	SERPIND1	0.904
CSF1	FGA	0.904
SPARCL1	KNG1	0.904
SERPINA1	SPARCL1	0.904
F5	APP	0.903
APOA5	FN1	0.903
SPARCL1	APOA2	0.903
CST3	FGG	0.903
FGG	TNC	0.903
SPARCL1	IL6	0.903
SPARCL1	CP	0.903
APOA5	APP	0.903
F5	TNC	0.902
TNC	KNG1	0.902
SPARCL1	FGA	0.902
TNC	SERPIND1	0.902
APOA5	CSF1	0.902
TF	TNC	0.902
ITIH2	APP	0.902
ITIH2	TNC	0.901
IL6	ITIH2	0.901
FGG	CSF1	0.901
SPARCL1	AFP	0.901
SERPINC1	CSF1	0.901
SPARCL1	CSF1	0.901
ITIH2	CSF1	0.9
APOA5	CST3	0.9
APOA2	CSF1	0.9
CST3	TNC	0.9
SPARCL1	SERPIND1	0.9
CST3	F5	0.9
SPARCL1	PROC	0.9
CSF1	SERPIND1	0.9
SPARCL1	APOB	0.9
CSF1	PROC	0.9
SERPINC1	TNC	0.9
APOA5	TNC	0.9
SERPINA1	TNC	0.9
TF	CSF1	0.9
SPARCL1	F5	0.9
APOA5	SPARCL1	0.9
F5	CSF1	0.9
SPARCL1	ITIH2	0.9
SPARCL1	SERPINC1	0.9

Gene Ontology Semantic Similarity

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#	2243 (FGA)	338 (APOB)	713 (C1QB)	335 (APOA1)	213 (ALB)	718 (C3)	716 (C1S)	714 (C1QC)	174 (AFP)	348 (APOE)	720 (C4A)	336 (APOA2)	2266 (FGG)	3698 (ITIH2)	2220 (FCN2)	4179 (CD46)	1378 (CR1)	5648 (MASP1)	4153 (MBL2)	5624 (PROC)	8547 (FCN3)	462 (SERPINC1)	10747 (MASP2)	717 (C2)	7018 (TF)	3426 (CFI)	721 (C4B)	1356 (CP)	3053 (SERPIND1)	722 (C4BPA)	1435 (CSF1)	3827 (KNG1)	197 (AHSG)	712 (C1QA)	3569 (IL6)	2335 (FN1)	725 (C4BPB)	1604 (CD55)	351 (APP)	3371 (TNC)	727 (C5)	1471 (CST3)	5265 (SERPINA1)	2219 (FCN1)	78989 (COLEC11)	2153 (F5)	8404 (SPARCL1)	715 (C1R)	629 (CFB)	116519 (APOA5)
2243 (FGA)	1.00	0.60	0.63	0.62	0.60	0.69	0.65	0.63	1.00	0.62	0.39	0.54	1.00	0.16	0.62	0.67	0.39	0.59	0.65	0.63	0.62	0.66	0.61	0.63	0.63	0.63	0.54	0.49	0.14	0.66	0.74	0.62	0.20	0.63	0.73	0.77	1.00	0.64	0.69	0.90	0.75	0.59	0.66	0.58	0.48	1.00	0.64	0.55	0.65	0.47
338 (APOB)	0.60	1.00	0.53	0.73	0.59	0.57	0.56	0.53	1.00	0.73	0.33	0.69	0.60	0.13	0.56	0.56	0.34	0.52	0.56	0.53	0.54	0.58	0.54	0.53	0.54	0.53	0.47	0.42	0.10	0.56	0.63	0.67	0.16	0.53	0.61	0.69	1.00	0.59	0.62	0.58	0.62	0.53	0.58	0.54	0.44	1.00	0.57	0.48	0.56	0.74
713 (C1QB)	0.63	0.53	1.00	0.55	0.55	0.89	0.96	1.00	1.00	0.50	0.80	0.48	0.63	0.13	0.80	0.60	0.36	0.79	0.79	1.00	0.92	0.62	0.85	1.00	0.57	1.00	0.84	0.45	0.11	0.62	0.69	0.53	0.16	1.00	0.67	0.61	1.00	0.59	0.64	0.64	0.68	0.54	0.62	0.74	0.58	1.00	0.61	0.86	0.96	0.40
335 (APOA1)	0.62	0.73	0.55	1.00	0.61	0.59	0.59	0.55	1.00	0.80	0.34	0.84	0.62	0.33	0.56	0.56	0.34	0.55	0.58	0.55	0.55	0.62	0.55	0.55	0.55	0.55	0.48	0.44	0.14	0.57	0.63	0.60	0.42	0.55	0.59	0.65	1.00	0.59	0.66	0.58	0.61	0.66	0.62	0.54	0.49	1.00	0.57	0.52	0.57	0.79
213 (ALB)	0.60	0.59	0.55	0.61	1.00	0.57	0.60	0.55	1.00	0.63	0.34	0.55	0.60	0.16	0.56	0.57	0.35	0.59	0.60	0.55	0.56	0.60	0.56	0.55	0.62	0.55	0.51	0.48	0.12	0.64	0.64	0.62	0.20	0.55	0.60	0.64	1.00	0.58	0.70	0.59	0.59	0.57	0.60	0.57	0.58	1.00	0.61	0.56	0.57	0.50
718 (C3)	0.69	0.57	0.89	0.59	0.57	1.00	0.88	0.89	1.00	0.52	0.67	0.51	0.69	0.13	0.78	0.62	0.37	0.77	0.82	0.89	0.85	0.64	0.81	0.89	0.62	0.89	0.76	0.47	0.10	0.64	0.73	0.61	0.16	0.89	0.73	0.66	1.00	0.61	0.69	0.65	0.76	0.56	0.64	0.77	0.59	1.00	0.63	0.82	0.88	0.45
716 (C1S)	0.65	0.56	0.96	0.59	0.60	0.88	1.00	0.96	1.00	0.53	0.74	0.50	0.65	0.13	0.80	0.64	0.38	0.81	0.80	0.96	0.90	0.70	0.85	0.96	0.60	0.96	0.81	0.48	0.11	0.66	0.76	0.56	0.16	0.96	0.69	0.65	1.00	0.62	0.69	0.67	0.70	0.61	0.70	0.75	0.60	1.00	0.64	0.86	0.94	0.42
714 (C1QC)	0.63	0.53	1.00	0.55	0.55	0.89	0.96	1.00	1.00	0.50	0.80	0.48	0.63	0.13	0.80	0.60	0.36	0.79	0.79	1.00	0.92	0.62	0.85	1.00	0.57	1.00	0.84	0.45	0.11	0.62	0.69	0.53	0.16	1.00	0.67	0.61	1.00	0.59	0.64	0.64	0.68	0.54	0.62	0.74	0.58	1.00	0.61	0.86	0.96	0.40
174 (AFP)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.61	1.00	1.00	0.13	1.00	1.00	0.61	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	0.82	0.13	1.00	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82
348 (APOE)	0.62	0.73	0.50	0.80	0.63	0.52	0.53	0.50	1.00	1.00	0.30	0.80	0.62	0.33	0.51	0.51	0.31	0.56	0.55	0.50	0.50	0.55	0.51	0.50	0.53	0.50	0.45	0.40	0.13	0.51	0.59	0.60	0.42	0.50	0.53	0.64	1.00	0.57	0.58	0.56	0.54	0.59	0.55	0.51	0.49	1.00	0.55	0.51	0.51	0.79
720 (C4A)	0.39	0.33	0.80	0.34	0.34	0.67	0.74	0.80	0.61	0.30	1.00	0.29	0.39	0.08	0.58	0.38	0.42	0.61	0.58	0.80	0.71	0.39	0.74	0.80	0.35	0.80	0.77	0.32	0.07	0.39	0.42	0.33	0.10	0.80	0.42	0.38	0.61	0.36	0.39	0.40	0.42	0.33	0.39	0.56	0.42	0.61	0.38	0.71	0.82	0.25
336 (APOA2)	0.54	0.69	0.48	0.84	0.55	0.51	0.50	0.48	1.00	0.80	0.29	1.00	0.54	0.50	0.50	0.49	0.30	0.52	0.52	0.48	0.48	0.55	0.49	0.48	0.49	0.48	0.43	0.38	0.17	0.49	0.58	0.55	0.63	0.48	0.52	0.57	1.00	0.57	0.58	0.50	0.53	0.55	0.55	0.49	0.44	1.00	0.51	0.46	0.50	0.81
2266 (FGG)	1.00	0.60	0.63	0.62	0.60	0.69	0.65	0.63	1.00	0.62	0.39	0.54	1.00	0.16	0.62	0.67	0.39	0.59	0.65	0.63	0.62	0.66	0.61	0.63	0.63	0.63	0.54	0.49	0.14	0.66	0.74	0.62	0.20	0.63	0.73	0.77	1.00	0.64	0.69	0.90	0.75	0.59	0.66	0.58	0.48	1.00	0.64	0.55	0.65	0.47
3698 (ITIH2)	0.16	0.13	0.13	0.33	0.16	0.13	0.13	0.13	0.13	0.33	0.08	0.50	0.16	1.00	0.13	0.13	0.08	0.13	0.13	0.13	0.13	0.90	0.13	0.13	0.13	0.13	0.13	0.10	1.00	0.13	0.13	0.90	0.46	0.13	0.13	0.13	0.13	0.13	0.90	0.13	0.13	1.00	0.90	0.13	0.13	0.13	0.13	0.13	0.13	0.40
2220 (FCN2)	0.62	0.56	0.80	0.56	0.56	0.78	0.80	0.80	1.00	0.51	0.58	0.50	0.62	0.13	1.00	0.60	0.36	0.76	0.76	0.80	0.87	0.61	0.79	0.80	0.58	0.80	0.74	0.46	0.10	0.61	0.66	0.56	0.16	0.80	0.64	0.61	1.00	0.59	0.63	0.62	0.64	0.56	0.61	0.69	0.60	1.00	0.61	0.76	0.80	0.43
4179 (CD46)	0.67	0.56	0.60	0.56	0.57	0.62	0.64	0.60	1.00	0.51	0.38	0.49	0.67	0.13	0.60	1.00	0.58	0.56	0.60	0.60	0.60	0.65	0.58	0.60	0.60	0.60	0.52	0.46	0.11	0.65	0.70	0.56	0.16	0.60	0.69	0.63	1.00	0.74	0.65	0.66	0.69	0.56	0.65	0.67	0.45	1.00	0.64	0.50	0.64	0.42
1378 (CR1)	0.39	0.34	0.36	0.34	0.35	0.37	0.38	0.36	0.61	0.31	0.42	0.30	0.39	0.08	0.36	0.58	1.00	0.33	0.36	0.36	0.36	0.38	0.48	0.36	0.35	0.36	0.42	0.27	0.07	0.38	0.41	0.34	0.10	0.36	0.40	0.38	0.61	0.46	0.39	0.39	0.40	0.34	0.38	0.44	0.28	0.61	0.38	0.30	0.45	0.26
5648 (MASP1)	0.59	0.52	0.79	0.55	0.59	0.77	0.81	0.79	1.00	0.56	0.61	0.52	0.59	0.13	0.76	0.56	0.33	1.00	0.86	0.79	0.77	0.59	0.87	0.79	0.61	0.79	0.70	0.48	0.10	0.56	0.69	0.57	0.16	0.79	0.60	0.60	1.00	0.55	0.61	0.58	0.60	0.53	0.59	0.68	0.67	1.00	0.70	0.89	0.79	0.41
4153 (MBL2)	0.65	0.56	0.79	0.58	0.60	0.82	0.80	0.79	1.00	0.55	0.58	0.52	0.65	0.13	0.76	0.60	0.36	0.86	1.00	0.79	0.77	0.61	0.79	0.79	0.66	0.79	0.73	0.46	0.10	0.61	0.69	0.64	0.16	0.79	0.68	0.64	1.00	0.59	0.65	0.62	0.69	0.55	0.61	0.70	0.81	1.00	0.73	0.88	0.80	0.45
5624 (PROC)	0.63	0.53	1.00	0.55	0.55	0.89	0.96	1.00	1.00	0.50	0.80	0.48	0.63	0.13	0.80	0.60	0.36	0.79	0.79	1.00	0.92	0.62	0.85	1.00	0.57	1.00	0.84	0.45	0.11	0.62	0.69	0.53	0.16	1.00	0.67	0.61	1.00	0.59	0.64	0.64	0.68	0.54	0.62	0.74	0.58	1.00	0.61	0.86	0.96	0.40
8547 (FCN3)	0.62	0.54	0.92	0.55	0.56	0.85	0.90	0.92	1.00	0.50	0.71	0.48	0.62	0.13	0.87	0.60	0.36	0.77	0.77	0.92	1.00	0.62	0.82	0.92	0.57	0.92	0.80	0.45	0.11	0.62	0.68	0.53	0.16	0.92	0.66	0.61	1.00	0.59	0.63	0.63	0.66	0.54	0.62	0.72	0.58	1.00	0.61	0.83	0.90	0.41
462 (SERPINC1)	0.66	0.58	0.62	0.62	0.60	0.64	0.70	0.62	1.00	0.55	0.39	0.55	0.66	0.90	0.61	0.65	0.38	0.59	0.61	0.62	0.62	1.00	0.60	0.62	0.61	0.62	0.53	0.47	0.54	0.67	0.75	0.73	0.42	0.62	0.69	0.69	1.00	0.63	0.87	0.67	0.70	0.90	1.00	0.54	0.47	1.00	0.65	0.53	0.65	0.48
10747 (MASP2)	0.61	0.54	0.85	0.55	0.56	0.81	0.85	0.85	1.00	0.51	0.74	0.49	0.61	0.13	0.79	0.58	0.48	0.87	0.79	0.85	0.82	0.60	1.00	0.85	0.56	0.85	0.77	0.51	0.10	0.59	0.65	0.53	0.16	0.85	0.63	0.60	1.00	0.57	0.62	0.60	0.63	0.54	0.60	0.71	0.60	1.00	0.59	0.81	0.87	0.41
717 (C2)	0.63	0.53	1.00	0.55	0.55	0.89	0.96	1.00	1.00	0.50	0.80	0.48	0.63	0.13	0.80	0.60	0.36	0.79	0.79	1.00	0.92	0.62	0.85	1.00	0.57	1.00	0.84	0.45	0.11	0.62	0.69	0.53	0.16	1.00	0.67	0.61	1.00	0.59	0.64	0.64	0.68	0.54	0.62	0.74	0.58	1.00	0.61	0.86	0.96	0.40
7018 (TF)	0.63	0.54	0.57	0.55	0.62	0.62	0.60	0.57	1.00	0.53	0.35	0.49	0.63	0.13	0.58	0.60	0.35	0.61	0.66	0.57	0.57	0.61	0.56	0.57	1.00	0.57	0.50	0.43	0.10	0.61	0.67	0.67	0.16	0.57	0.66	0.62	1.00	0.58	0.64	0.62	0.68	0.54	0.61	0.51	0.50	1.00	0.70	0.58	0.60	0.43
3426 (CFI)	0.63	0.53	1.00	0.55	0.55	0.89	0.96	1.00	1.00	0.50	0.80	0.48	0.63	0.13	0.80	0.60	0.36	0.79	0.79	1.00	0.92	0.62	0.85	1.00	0.57	1.00	0.84	0.45	0.11	0.62	0.69	0.53	0.16	1.00	0.67	0.61	1.00	0.59	0.64	0.64	0.68	0.54	0.62	0.74	0.58	1.00	0.61	0.86	0.96	0.40
721 (C4B)	0.54	0.47	0.84	0.48	0.51	0.76	0.81	0.84	0.82	0.45	0.77	0.43	0.54	0.13	0.74	0.52	0.42	0.70	0.73	0.84	0.80	0.53	0.77	0.84	0.50	0.84	1.00	0.40	0.11	0.54	0.57	0.47	0.16	0.84	0.56	0.51	0.82	0.52	0.54	0.54	0.56	0.47	0.53	0.66	0.66	0.82	0.54	0.77	0.90	0.37
1356 (CP)	0.49	0.42	0.45	0.44	0.48	0.47	0.48	0.45	0.82	0.40	0.32	0.38	0.49	0.10	0.46	0.46	0.27	0.48	0.46	0.45	0.45	0.47	0.51	0.45	0.43	0.45	0.40	1.00	0.10	0.46	0.53	0.41	0.13	0.45	0.51	0.52	0.82	0.44	0.49	0.48	0.51	0.42	0.47	0.40	0.35	0.82	0.47	0.41	0.48	0.32
3053 (SERPIND1)	0.14	0.10	0.11	0.14	0.12	0.10	0.11	0.11	0.13	0.13	0.07	0.17	0.14	1.00	0.10	0.11	0.07	0.10	0.10	0.11	0.11	0.54	0.10	0.11	0.10	0.11	0.11	0.10	1.00	0.11	0.10	0.43	0.46	0.11	0.10	0.10	0.13	0.12	0.39	0.12	0.11	0.53	0.54	0.10	0.09	0.13	0.11	0.10	0.11	0.18
722 (C4BPA)	0.66	0.56	0.62	0.57	0.64	0.64	0.66	0.62	1.00	0.51	0.39	0.49	0.66	0.13	0.61	0.65	0.38	0.56	0.61	0.62	0.62	0.67	0.59	0.62	0.61	0.62	0.54	0.46	0.11	1.00	0.72	0.56	0.16	0.62	0.71	0.63	1.00	0.63	0.75	0.69	0.73	0.57	0.67	0.52	0.51	1.00	0.66	0.50	0.66	0.42
1435 (CSF1)	0.74	0.63	0.69	0.63	0.64	0.73	0.76	0.69	1.00	0.59	0.42	0.58	0.74	0.13	0.66	0.70	0.41	0.69	0.69	0.69	0.68	0.75	0.65	0.69	0.67	0.69	0.57	0.53	0.10	0.72	1.00	0.68	0.16	0.69	0.87	0.71	1.00	0.69	0.77	0.72	0.82	0.67	0.75	0.61	0.53	1.00	0.70	0.60	0.70	0.47
3827 (KNG1)	0.62	0.67	0.53	0.60	0.62	0.61	0.56	0.53	1.00	0.60	0.33	0.55	0.62	0.90	0.56	0.56	0.34	0.57	0.64	0.53	0.53	0.73	0.53	0.53	0.67	0.53	0.47	0.41	0.43	0.56	0.68	1.00	0.42	0.53	0.66	0.70	1.00	0.55	0.74	0.58	0.66	0.75	0.73	0.55	0.47	1.00	0.64	0.53	0.56	0.56
197 (AHSG)	0.20	0.16	0.16	0.42	0.20	0.16	0.16	0.16	0.16	0.42	0.10	0.63	0.20	0.46	0.16	0.16	0.10	0.16	0.16	0.16	0.16	0.42	0.16	0.16	0.16	0.16	0.16	0.13	0.46	0.16	0.16	0.42	1.00	0.16	0.16	0.16	0.16	0.16	0.42	0.16	0.16	0.46	0.42	0.16	0.16	0.16	0.16	0.16	0.16	0.49
712 (C1QA)	0.63	0.53	1.00	0.55	0.55	0.89	0.96	1.00	1.00	0.50	0.80	0.48	0.63	0.13	0.80	0.60	0.36	0.79	0.79	1.00	0.92	0.62	0.85	1.00	0.57	1.00	0.84	0.45	0.11	0.62	0.69	0.53	0.16	1.00	0.67	0.61	1.00	0.59	0.64	0.64	0.68	0.54	0.62	0.74	0.58	1.00	0.61	0.86	0.96	0.40
3569 (IL6)	0.73	0.61	0.67	0.59	0.60	0.73	0.69	0.67	1.00	0.53	0.42	0.52	0.73	0.13	0.64	0.69	0.40	0.60	0.68	0.67	0.66	0.69	0.63	0.67	0.66	0.67	0.56	0.51	0.10	0.71	0.87	0.66	0.16	0.67	1.00	0.68	1.00	0.67	0.73	0.71	0.83	0.61	0.69	0.58	0.49	1.00	0.69	0.57	0.69	0.46
2335 (FN1)	0.77	0.69	0.61	0.65	0.64	0.66	0.65	0.61	1.00	0.64	0.38	0.57	0.77	0.13	0.61	0.63	0.38	0.60	0.64	0.61	0.61	0.69	0.60	0.61	0.62	0.61	0.51	0.52	0.10	0.63	0.71	0.70	0.16	0.61	0.68	1.00	1.00	0.62	0.71	0.73	0.69	0.65	0.69	0.61	0.52	1.00	0.68	0.57	0.63	0.57
725 (C4BPB)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.61	1.00	1.00	0.13	1.00	1.00	0.61	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	0.82	0.13	1.00	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82
1604 (CD55)	0.64	0.59	0.59	0.59	0.58	0.61	0.62	0.59	1.00	0.57	0.36	0.57	0.64	0.13	0.59	0.74	0.46	0.55	0.59	0.59	0.59	0.63	0.57	0.59	0.58	0.59	0.52	0.44	0.12	0.63	0.69	0.55	0.16	0.59	0.67	0.62	1.00	1.00	0.64	0.65	0.68	0.55	0.63	0.58	0.44	1.00	0.62	0.49	0.62	0.50
351 (APP)	0.69	0.62	0.64	0.66	0.70	0.69	0.69	0.64	1.00	0.58	0.39	0.58	0.69	0.90	0.63	0.65	0.39	0.61	0.65	0.64	0.63	0.87	0.62	0.64	0.64	0.64	0.54	0.49	0.39	0.75	0.77	0.74	0.42	0.64	0.73	0.71	1.00	0.64	1.00	0.67	0.74	0.81	0.87	0.59	0.59	1.00	0.65	0.57	0.66	0.54
3371 (TNC)	0.90	0.58	0.64	0.58	0.59	0.65	0.67	0.64	1.00	0.56	0.40	0.50	0.90	0.13	0.62	0.66	0.39	0.58	0.62	0.64	0.63	0.67	0.60	0.64	0.62	0.64	0.54	0.48	0.12	0.69	0.72	0.58	0.16	0.64	0.71	0.73	1.00	0.65	0.67	1.00	0.72	0.58	0.67	0.54	0.46	1.00	0.66	0.53	0.67	0.43
727 (C5)	0.75	0.62	0.68	0.61	0.59	0.76	0.70	0.68	1.00	0.54	0.42	0.53	0.75	0.13	0.64	0.69	0.40	0.60	0.69	0.68	0.66	0.70	0.63	0.68	0.68	0.68	0.56	0.51	0.11	0.73	0.82	0.66	0.16	0.68	0.83	0.69	1.00	0.68	0.74	0.72	1.00	0.60	0.70	0.61	0.48	1.00	0.69	0.56	0.70	0.46
1471 (CST3)	0.59	0.53	0.54	0.66	0.57	0.56	0.61	0.54	1.00	0.59	0.33	0.55	0.59	1.00	0.56	0.56	0.34	0.53	0.55	0.54	0.54	0.90	0.54	0.54	0.54	0.54	0.47	0.42	0.53	0.57	0.67	0.75	0.46	0.54	0.61	0.65	1.00	0.55	0.81	0.58	0.60	1.00	0.90	0.49	0.44	1.00	0.57	0.48	0.57	0.48
5265 (SERPINA1)	0.66	0.58	0.62	0.62	0.60	0.64	0.70	0.62	1.00	0.55	0.39	0.55	0.66	0.90	0.61	0.65	0.38	0.59	0.61	0.62	0.62	1.00	0.60	0.62	0.61	0.62	0.53	0.47	0.54	0.67	0.75	0.73	0.42	0.62	0.69	0.69	1.00	0.63	0.87	0.67	0.70	0.90	1.00	0.54	0.47	1.00	0.65	0.53	0.65	0.48
2219 (FCN1)	0.58	0.54	0.74	0.54	0.57	0.77	0.75	0.74	1.00	0.51	0.56	0.49	0.58	0.13	0.69	0.67	0.44	0.68	0.70	0.74	0.72	0.54	0.71	0.74	0.51	0.74	0.66	0.40	0.10	0.52	0.61	0.55	0.16	0.74	0.58	0.61	1.00	0.58	0.59	0.54	0.61	0.49	0.54	1.00	0.54	1.00	0.54	0.70	0.75	0.44
78989 (COLEC11)	0.48	0.44	0.58	0.49	0.58	0.59	0.60	0.58	1.00	0.49	0.42	0.44	0.48	0.13	0.60	0.45	0.28	0.67	0.81	0.58	0.58	0.47	0.60	0.58	0.50	0.58	0.66	0.35	0.09	0.51	0.53	0.47	0.16	0.58	0.49	0.52	1.00	0.44	0.59	0.46	0.48	0.44	0.47	0.54	1.00	1.00	0.56	0.68	0.60	0.39
2153 (F5)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.61	1.00	1.00	0.13	1.00	1.00	0.61	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	0.82	0.13	1.00	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82
8404 (SPARCL1)	0.64	0.57	0.61	0.57	0.61	0.63	0.64	0.61	1.00	0.55	0.38	0.51	0.64	0.13	0.61	0.64	0.38	0.70	0.73	0.61	0.61	0.65	0.59	0.61	0.70	0.61	0.54	0.47	0.11	0.66	0.70	0.64	0.16	0.61	0.69	0.68	1.00	0.62	0.65	0.66	0.69	0.57	0.65	0.54	0.56	1.00	1.00	0.68	0.64	0.44
715 (C1R)	0.55	0.48	0.86	0.52	0.56	0.82	0.86	0.86	1.00	0.51	0.71	0.46	0.55	0.13	0.76	0.50	0.30	0.89	0.88	0.86	0.83	0.53	0.81	0.86	0.58	0.86	0.77	0.41	0.10	0.50	0.60	0.53	0.16	0.86	0.57	0.57	1.00	0.49	0.57	0.53	0.56	0.48	0.53	0.70	0.68	1.00	0.68	1.00	0.86	0.39
629 (CFB)	0.65	0.56	0.96	0.57	0.57	0.88	0.94	0.96	1.00	0.51	0.82	0.50	0.65	0.13	0.80	0.64	0.45	0.79	0.80	0.96	0.90	0.65	0.87	0.96	0.60	0.96	0.90	0.48	0.11	0.66	0.70	0.56	0.16	0.96	0.69	0.63	1.00	0.62	0.66	0.67	0.70	0.57	0.65	0.75	0.60	1.00	0.64	0.86	1.00	0.42
116519 (APOA5)	0.47	0.74	0.40	0.79	0.50	0.45	0.42	0.40	0.82	0.79	0.25	0.81	0.47	0.40	0.43	0.42	0.26	0.41	0.45	0.40	0.41	0.48	0.41	0.40	0.43	0.40	0.37	0.32	0.18	0.42	0.47	0.56	0.49	0.40	0.46	0.57	0.82	0.50	0.54	0.43	0.46	0.48	0.48	0.44	0.39	0.82	0.44	0.39	0.42	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
C4A	Human	Plasma	-	3500 m	4 day	downregulated	1.112±0.221	2-DE	Northern indo-australian plate	Indians	0.466±0.085	healthy sea level controls	21755356
C4A	Human	Plasma	-	3500-4000m	Native	upregulated	-1.83	2-DE	Northern indo-australian plate	Ladakhi	1	Sea level healthy individuals	23844025
C4A	Rat	Plasma	-	7620 m	6 hours	upregulated	0.55	2-DE	Northern indo-australian plate	Sprague-dawley rats	1	Male SD rats weighing 220g	24842778
C4A	Rat	Plasma	-	9754 m	0.5 hours	upregulated	1.09	2-DE	Northern indo-australian plate	Male Sprague-Dawley (SD)	1	Male Sprague-Dawley (SD) rats of weight 150 ± 10 g kept at standard conditions	24067188
C4A	Rat	Plasma	-	7620 m	24 hours	upregulated	0.53	2-DE	Northern indo-australian plate	Sprague-dawley rats	1	Male SD rats weighing 220g	24842778

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
SP1	6667	C4A	720	Unknown	15632413	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)

Gene Ontology

ID	GO ID	GO Term	GO Type
720	GO:0006954	inflammatory response	GOTERM_BP_DIRECT
720	GO:0010951	negative regulation of endopeptidase activity	GOTERM_BP_DIRECT
720	GO:0072562	blood microparticle	GOTERM_CC_DIRECT
720	GO:0030424	axon	GOTERM_CC_DIRECT
720	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
720	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
720	GO:0006958	complement activation	GOTERM_BP_DIRECT
720	GO:0005576	extracellular region	GOTERM_CC_DIRECT
720	GO:0005615	extracellular space	GOTERM_CC_DIRECT
720	GO:0030449	regulation of complement activation	GOTERM_BP_DIRECT
720	GO:0045087	innate immune response	GOTERM_BP_DIRECT
720	GO:0004252	serine-type endopeptidase activity	GOTERM_MF_DIRECT
720	GO:0043025	neuronal cell body	GOTERM_CC_DIRECT
720	GO:0045202	synapse	GOTERM_CC_DIRECT
720	GO:0006508	proteolysis	GOTERM_BP_DIRECT
720	GO:0006956	complement activation	GOTERM_BP_DIRECT
720	GO:2000427	positive regulation of apoptotic cell clearance	GOTERM_BP_DIRECT
720	GO:0030054	cell junction	GOTERM_CC_DIRECT
720	GO:0001849	complement binding	GOTERM_MF_DIRECT
720	GO:0004866	endopeptidase inhibitor activity	GOTERM_MF_DIRECT
720	GO:0030425	dendrite	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
720	hsa04610	Complement and coagulation cascades
720	hsa05133	Pertussis
720	hsa05150	Staphylococcus aureus infection
720	hsa05322	Systemic lupus erythematosus

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
C4A	720	Immunologic Deficiency Syndromes	C0021051	Disease or Syndrome	0.3	0.604	0.69	group
C4A	720	Complement Component 4a Deficiency	C3280642	Disease or Syndrome	0.31	0.604	0.69	disease
C4A	720	Antibody Deficiency Syndrome	C0003257	Disease or Syndrome	0.3	0.604	0.69	disease
C4A	720	Behcet Syndrome	C0004943	Disease or Syndrome	0.3	0.604	0.69	disease
C4A	720	SYSTEMIC LUPUS ERYTHEMATOSUS 16	C3280742	Disease or Syndrome	0.3	0.604	0.69	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types