ALTITUDEOMICSDB

Complement C5

AltitudeomicsDB

Protein Official symbol	C5
Aliases	C5 CPAMD4
Chromosomal Location	9
Length	1676
Uniprot ID	P01031
EC number	None
Protein family Information(Pfam)	PF00207;PF07703;PF07677;PF01821;PF17790;PF01835;PF17791;PF17789;PF01759;PF07678;
PDB id	1CFA;1KJS;1XWE;3CU7;3HQA;3HQB;3KLS;3KM9;3PRX;3PVM;4A5W;4E0S;4P39;4UU9;5B4P;5B71;5HCC;5HCD;5HCE;5I5K;6H03;6H04;6RPT;
InterPro ID	IPR009048;IPR036595;IPR011625;IPR011626;IPR000020;IPR018081;IPR001840;IPR041425;IPR037562;IPR013783;IPR001599;IPR002890;IPR041555;IPR040839;IPR001134;IPR018933;IPR008930;IPR008993;
dbSNP	rs17216529 rs34552775 rs2230213 rs17611 rs373359894 rs56040400 rs41309892 rs41309902 rs2230212 rs41311881 rs41311883 rs41311887 rs17609 rs17610 rs16910245 rs17612

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
CXCR3	CXCL10	0.996
CXCR4	CXCL12	0.996
NPY	POMC	0.995
CXCR3	CXCL9	0.994
CCL5	CXCL10	0.994
CXCL8	CXCR1	0.993
CXCR2	CXCL8	0.993
CXCL1	CXCR2	0.993
BDKRB2	KNG1	0.993
CCL4	CXCL10	0.991
CCL5	CXCL8	0.99
CFB	C3	0.99
CCL5	CXCL9	0.988
AGTR1	AGT	0.987
CCL5	CCR2	0.987
CXCL1	CXCL10	0.987
CXCL8	CXCL10	0.987
F2	CPB2	0.987
CCL5	CXCL1	0.986
CCL4	CXCL8	0.986
CXCL9	CXCL10	0.986
CXCL1	CXCL8	0.985
CCL4	CXCL9	0.985
C8A	C8G	0.983
CXCL2	CXCL8	0.983
CXCL9	CXCL13	0.983
CCL5	CXCR4	0.982
CXCR2	PPBP	0.981
C8B	C8A	0.98
CXCL2	CXCL1	0.98
CXCR4	CXCL8	0.98
CXCL2	CXCR2	0.98
CXCL2	CXCL10	0.979
CCL5	CXCL12	0.978
C8B	C8G	0.978
CCL4	CXCL1	0.978
CCL4	CXCL2	0.978
CCL5	CXCL2	0.977
C5AR1	C5	0.977
CXCL12	CXCL13	0.976
CCL5	CXCR3	0.976
C4B	C4A	0.976
C2	C3	0.975
CFB	C4A	0.975
CCL4	CCR2	0.975
CXCL1	CXCR1	0.974
CXCL9	CXCL8	0.974
CFB	C4B	0.973
CXCL12	CXCL8	0.972
FPR2	CXCL8	0.972
CXCL10	CXCL13	0.972
C5AR1	C3	0.972
C3AR1	C3	0.972
CXCL12	CXCL10	0.971
CXCL10	PPBP	0.971
CXCL10	CCR2	0.971
CXCL12	CCR2	0.971
CCL4	CXCR3	0.971
AGTR1	KNG1	0.969
CXCL12	CCR4	0.969
PPBP	CXCR1	0.969
CXCL12	CXCL1	0.969
CXCL12	CXCR3	0.968
CXCL9	CCR2	0.968
CCL4	CXCR4	0.968
CCL5	CXCR2	0.968
CXCL12	CXCR2	0.968
CCL5	CXCL13	0.967
CXCL8	CCR2	0.967
FPR1	FPR2	0.967
CXCL12	CXCL9	0.967
CCL5	PPBP	0.967
CXCL1	CCR2	0.966
CXCR4	CXCL13	0.966
C8B	C5	0.966
CXCR2	CXCR1	0.966
CXCL2	CXCR1	0.965
CXCL2	CXCL12	0.965
CXCL1	CXCL13	0.965
CCL5	CXCR1	0.965
CXCR4	CXCL10	0.965
CCL4	CXCL13	0.965
CCL4	CXCL12	0.965
CXCR2	CXCL10	0.965
CXCR3	CXCL8	0.965
CXCL2	CCR2	0.964
CXCR3	CXCL13	0.964
CXCR4	CXCL1	0.964
C5AR2	C3	0.963
CXCL10	CXCR1	0.963
C8A	C5	0.963
CXCL12	CXCR1	0.963
C7	CFP	0.962
C4B	C2	0.962
C4A	C2	0.962
F2	KNG1	0.961
C5AR2	C5	0.961
CCL4	CXCR2	0.96
AGT	KNG1	0.959
CCL4	CXCR1	0.959
AGT	F2	0.958
CXCL1	CXCR3	0.958
CXCR4	CXCL9	0.957
FPR1	CXCR2	0.957
CXCL2	CXCL13	0.957
C8A	C6	0.957
CXCL9	CXCR2	0.957
POMC	KNG1	0.957
C9	VTN	0.957
FPR1	C5AR1	0.957
CXCL2	CXCR4	0.956
CXCL9	CXCR1	0.956
C8B	C9	0.956
CXCL12	PPBP	0.955
CXCR2	CXCL13	0.955
FPR2	CXCR1	0.955
C5AR1	CXCL8	0.955
SAA1	CXCL8	0.955
KNG1	C3	0.954
C9	C5	0.954
CXCL2	CXCR3	0.954
CXCL8	C3	0.954
FPR2	SAA1	0.953
CCR2	CXCL13	0.952
CCL4	PPBP	0.952
CXCR1	CXCL13	0.952
NPY	KNG1	0.952
CXCL8	KNG1	0.95
C7	C5	0.95
CD59	C3AR1	0.95
FPR1	CXCL8	0.95
C3AR1	C5	0.949
C6	C5	0.949
C4A	KNG1	0.949
CCL5	AGT	0.948
CCL4	C3AR1	0.948
PPBP	CCR2	0.948
C5	CPB2	0.947
CFB	C5	0.945
ADORA1	KNG1	0.945
SAA1	CXCL1	0.944
CLU	C9	0.943
CXCR4	PPBP	0.943
CCL5	CCR4	0.943
CFP	C5	0.942
CCL5	C5AR1	0.942
ELANE	C3	0.942
ELANE	CXCL1	0.942
C2	C5	0.942
CD59	C8B	0.941
CXCR3	PPBP	0.941
C3	CPB2	0.941
PPBP	CXCL13	0.941
SAA1	CXCL10	0.941
CD59	C9	0.94
CCL4	C5AR1	0.94
C8A	C9	0.939
SAA1	CXCR3	0.939
C9	C8G	0.939
POMC	CXCL8	0.939
C4A	C3	0.938
FPR1	CXCR1	0.938
C4B	C3	0.938
F2	C5	0.938
CCR4	CXCL8	0.937
CXCL8	C3AR1	0.937
FPR2	CXCR2	0.937
ADORA1	CXCL8	0.937
SAA1	C3	0.936
CD59	C5	0.936
CLU	KNG1	0.936
AGT	C3	0.936
CCL4	SAA1	0.936
CCL5	C3AR1	0.935
FPR3	CXCL8	0.935
C8B	C6	0.935
FPR1	CXCL1	0.935
CCL5	SAA1	0.935
CPN1	C3	0.935
CCL5	C3	0.934
POMC	AGT	0.934
FPR2	CXCL1	0.934
AGTR1	POMC	0.934
CXCL9	FPR3	0.934
NPY	ADORA1	0.934
VTN	C5	0.934
CXCL1	C5AR1	0.934
CCL5	FPR2	0.934
BDKRB2	AGT	0.933
C8B	VTN	0.933
FPR3	C3AR1	0.933
C3AR1	CCR2	0.933
CXCL12	C5AR1	0.933
CXCL10	C3AR1	0.932
CXCL12	C3AR1	0.932
CCL4	CCL5	0.932
CXCL9	C3AR1	0.932
CXCR4	NPY	0.932
FPR1	CXCL2	0.931
CXCL1	C3	0.931
CXCL10	C3	0.931
CXCL2	SAA1	0.931
CCL4	FPR1	0.931
CCL5	FPR1	0.931
CXCR4	ADORA1	0.931
C8A	VTN	0.931
AGT	CPB2	0.931
FPR2	CXCL2	0.931
AGTR1	F2	0.931
CCL4	CCR4	0.93
CXCL8	PPBP	0.93
FPR2	PPBP	0.93
C8G	C5	0.93
SAA1	CXCL9	0.929
CXCL2	C5AR1	0.929
C6	C8G	0.929
C5AR1	CXCL10	0.928
CXCR1	CCR2	0.928
C6	C9	0.928
FPR2	C5AR1	0.928
CLU	C5	0.928
CCR4	CXCL10	0.928
CHRM2	NPY	0.928
ELANE	C5	0.927
CXCR4	KNG1	0.926
FPR1	C3	0.926
CXCR3	CCR2	0.926
CXCL2	C3AR1	0.926
AGTR1	CXCL8	0.926
CPN1	C5	0.926
C5AR1	CCR2	0.926
CCL4	FPR2	0.926
C5AR1	C3AR1	0.925
CCL5	KNG1	0.925
CXCL12	KNG1	0.925
CXCL8	C5	0.925
CXCL12	C3	0.925
CCR2	C3	0.925
FPR1	SAA1	0.925
C5AR1	KNG1	0.925
FPR1	C3AR1	0.925
C7	C6	0.924
C5AR1	CXCR2	0.924
CXCR4	F2	0.924
FPR2	C3	0.924
FPR2	CXCL10	0.924
NPY	AGT	0.924
C4A	C5	0.924
C5AR1	CXCR1	0.924
CXCR3	C3	0.923
NPY	CXCL12	0.923
CXCL1	C3AR1	0.923
CXCL2	C3	0.923
KNG1	C5	0.923
FPR2	CCR2	0.923
C4B	C8A	0.922
C4B	C5	0.922
ELANE	CFP	0.922
CXCL9	C3	0.922
PPBP	KNG1	0.922
FPR1	C5	0.922
CCL5	C5	0.922
POMC	C3	0.922
C4A	C8A	0.922
CCL4	C3	0.922
CXCR4	POMC	0.922
PPBP	C3	0.922
NPY	CXCL8	0.922
CFB	C2	0.921
CCL4	POMC	0.921
FPR1	PPBP	0.921
CXCR4	CCR2	0.921
C6	CFP	0.921
C8B	CLU	0.921
CHRM2	CXCR4	0.921
AGT	CXCL8	0.921
AGT	CXCL10	0.921
CLU	C6	0.921
CXCR4	C3	0.921
C6	VTN	0.921
FPR2	CXCL12	0.921
CXCL1	C5	0.92
POMC	ADORA1	0.92
CD59	C8G	0.92
C3AR1	CXCR1	0.92
POMC	CXCL1	0.92
CXCL2	POMC	0.92
CCL4	NPY	0.92
CXCL12	F2	0.92
SAA1	F2	0.919
FPR1	CXCL12	0.919
NPY	CXCL13	0.919
C7	CLU	0.919
CXCL9	CCR4	0.919
AGT	CCR2	0.919
FPR1	CCR2	0.919
FPR3	CXCL10	0.919
CXCL9	PPBP	0.919
C3	C5	0.919
POMC	CCR2	0.919
ADORA1	FPR3	0.919
CXCR2	C3	0.919
CXCR2	CCR2	0.919
C3AR1	CXCL13	0.918
AGTR1	NPY	0.918
NPY	CXCR2	0.918
CXCL9	C5AR1	0.918
FPR2	CD59	0.918
POMC	CXCL13	0.918
NPY	CXCR3	0.918
CXCL1	ADORA1	0.918
C5AR1	CCR4	0.918
CCL4	FPR3	0.918
CCR2	KNG1	0.918
C5AR1	FPR3	0.918
CD59	C8A	0.918
SAA1	AGT	0.918
CXCL2	FPR3	0.918
CXCL12	ADORA1	0.917
CCL5	NPY	0.917
FPR3	CCR2	0.917
C7	VTN	0.917
C5AR1	PPBP	0.917
CXCL1	FPR3	0.917
C7	C8G	0.917
FPR1	CXCL10	0.917
ADORA1	AGT	0.917
POMC	CXCR3	0.917
SAA1	PPBP	0.917
CXCL2	NPY	0.917
FPR1	KNG1	0.917
CXCL1	KNG1	0.917
BDKRB2	CHRM2	0.916
CXCL10	C5	0.916
FPR3	C5	0.916
SAA1	KNG1	0.916
SAA1	CCR2	0.916
CD59	C7	0.916
CCL5	FPR3	0.916
CLU	PPBP	0.916
CXCL13	C3	0.916
FPR2	CXCL9	0.916
CCL5	ADORA1	0.916
FPR1	CXCL13	0.916
SAA1	CXCL13	0.916
FPR2	C3AR1	0.916
POMC	C3AR1	0.915
CXCL1	CXCL9	0.915
FPR1	ADORA1	0.915
FPR2	KNG1	0.915
POMC	CXCL12	0.915
SAA1	C3AR1	0.915
C7	C9	0.915
C3AR1	KNG1	0.915
CHRM2	POMC	0.915
VTN	C8G	0.915
POMC	CXCR2	0.915
FPR1	FPR3	0.915
CXCL2	C5	0.915
CXCR4	CXCR3	0.915
CXCR2	KNG1	0.915
POMC	CXCL10	0.915
CXCR4	CXCR2	0.914
CCR4	CXCL13	0.914
CXCR2	C5	0.914
CXCR2	C3AR1	0.914
FPR2	C5	0.914
CXCR4	C5	0.913
CXCR3	CXCR1	0.913
CXCL2	CXCL9	0.913
C8A	C7	0.913
FPR2	CXCR4	0.913
C5AR1	CXCL13	0.913
CXCR4	C5AR1	0.913
NPY	C3	0.913
ADORA1	CXCL10	0.913
CXCL10	KNG1	0.913
ADORA1	CCR2	0.913
CXCR4	CXCR1	0.913
ADORA1	C5AR1	0.913
BDKRB2	C3	0.913
BDKRB2	F2	0.913
BDKRB2	AGTR1	0.913
CXCL2	CCR4	0.912
CCL4	ADORA1	0.912
C3AR1	PPBP	0.912
FPR3	PPBP	0.912
BDKRB2	ADORA1	0.912
CXCR4	C3AR1	0.912
FPR2	ADORA1	0.912
SAA1	CXCR2	0.912
SAA1	CXCL12	0.912
CXCR3	CXCR2	0.912
CXCL8	CXCL13	0.912
CCR4	C3AR1	0.912
FPR1	CXCR4	0.912
FPR2	CXCL13	0.912
CCL5	POMC	0.912
AGT	C5	0.912
CXCL1	CCR4	0.912
FPR1	CXCL9	0.912
CXCL9	KNG1	0.911
CXCR1	C5	0.911
FPR3	CXCL13	0.911
AGT	C5AR1	0.911
CLU	C8G	0.911
PPBP	CFP	0.911
FPR3	CXCR1	0.911
FPR3	C3	0.911
AGTR1	C3	0.911
BDKRB2	C5	0.911
BDKRB2	CXCL8	0.91
CXCR3	CCR4	0.91
CXCL2	PPBP	0.91
CXCL9	C5	0.91
CXCR1	KNG1	0.91
SAA1	FPR3	0.91
CXCL12	C5	0.91
CXCL2	ADORA1	0.91
SAA1	POMC	0.91
CCR4	C5	0.91
CXCL12	FPR3	0.91
CXCR3	C3AR1	0.91
CXCR3	C5AR1	0.91
CCR4	CXCR2	0.909
FPR2	FPR3	0.909
CXCR4	FPR3	0.909
CXCL1	PPBP	0.909
CXCR4	AGT	0.909
FPR1	POMC	0.909
POMC	C5	0.908
AGTR1	C5	0.908
CCL4	F2	0.908
NPY	CXCL10	0.908
SAA1	C5	0.908
CCR2	C5	0.908
CXCR3	C5	0.908
CXCR1	C3	0.908
FPR2	POMC	0.908
CXCL12	AGT	0.907
FPR3	CXCR2	0.907
CXCR3	ADORA1	0.907
NPY	CCR2	0.907
CXCL1	CFP	0.907
BDKRB2	CXCL12	0.907
CXCL13	C5	0.907
FPR1	CHRM2	0.907
C8A	CLU	0.907
C8B	C7	0.907
FPR2	CXCR3	0.907
ADORA1	C3AR1	0.907
SAA1	C5AR1	0.907
AGTR1	CHRM2	0.907
CXCL2	KNG1	0.907
CHRM2	C5	0.907
CD59	C6	0.907
CXCR4	CCR4	0.907
ADORA1	CXCL9	0.907
AGT	C3AR1	0.907
ADORA1	CCR4	0.906
FPR3	KNG1	0.906
FPR1	CXCR3	0.906
NPY	C5	0.906
CCL4	C5	0.906
PPBP	C5	0.906
FPR1	NPY	0.905
ADORA1	CXCR2	0.905
CCR4	KNG1	0.905
CXCR3	FPR3	0.905
POMC	FPR3	0.905
CHRM2	KNG1	0.905
BDKRB2	CXCL1	0.905
CXCR3	KNG1	0.905
NPY	CXCR1	0.905
ADORA1	C5	0.905
CCR4	PPBP	0.905
CHRM2	C5AR1	0.905
CCR4	CXCR1	0.905
CXCR4	SAA1	0.905
CCR4	C3	0.905
NPY	FPR3	0.904
SAA1	NPY	0.904
NPY	CXCL1	0.904
CHRM2	C3	0.904
BDKRB2	C3AR1	0.904
SAA1	CXCR1	0.904
ADORA1	CXCR1	0.904
BDKRB2	C5AR1	0.904
BDKRB2	POMC	0.904
NPY	CXCL9	0.904
POMC	CXCL9	0.904
BDKRB2	SAA1	0.904
CCR4	CCR2	0.903
CHRM2	CXCL8	0.903
FPR2	BDKRB2	0.903
SAA1	ADORA1	0.903
CHRM2	AGT	0.903
FPR1	F2	0.903
POMC	CXCR1	0.903
CHRM2	CXCR3	0.903
FPR2	CHRM2	0.903
CCL4	KNG1	0.903
POMC	CCR4	0.903
CCL5	BDKRB2	0.903
AGT	CCR4	0.903
NPY	CCR4	0.903
CXCL1	AGT	0.903
AGTR1	C3AR1	0.903
FPR2	NPY	0.903
CHRM2	FPR3	0.903
CHRM2	ADORA1	0.903
ADORA1	C3	0.902
BDKRB2	CXCR3	0.902
AGT	CXCL13	0.902
BDKRB2	CXCR4	0.902
AGTR1	SAA1	0.902
BDKRB2	PPBP	0.902
NPY	C3AR1	0.902
CHRM2	PPBP	0.902
AGT	CXCR2	0.902
CXCR3	AGT	0.902
CHRM2	CCR2	0.902
CHRM2	C3AR1	0.902
BDKRB2	CXCL2	0.902
BDKRB2	NPY	0.902
AGTR1	C5AR1	0.902
BDKRB2	CXCL10	0.902
CCL4	BDKRB2	0.902
FPR1	BDKRB2	0.901
CHRM2	CXCR1	0.901
BDKRB2	CXCR2	0.901
AGT	PPBP	0.901
FPR2	CCR4	0.901
BDKRB2	CCR2	0.901
CXCL13	KNG1	0.901
CHRM2	CCR4	0.901
FPR1	CCR4	0.901
FPR2	AGTR1	0.901
NPY	PPBP	0.901
SAA1	CCR4	0.901
AGT	CXCR1	0.901
CCL4	AGT	0.9
CCL4	CHRM2	0.9
AGT	CXCL9	0.9
BDKRB2	CXCL9	0.9
BDKRB2	CXCR1	0.9
CHRM2	CXCR2	0.9
BDKRB2	CCR4	0.9
NPY	C5AR1	0.9
CHRM2	CXCL9	0.9
ADORA1	PPBP	0.9
CCL5	CHRM2	0.9
FPR2	F2	0.9
FPR3	CCR4	0.9
POMC	PPBP	0.9
CHRM2	CXCL12	0.9
CHRM2	CXCL10	0.9
CHRM2	CXCL13	0.9
CHRM2	SAA1	0.9
CFP	C3	0.9
CXCL2	CHRM2	0.9
POMC	C5AR1	0.9
CXCL2	AGT	0.9
FPR1	AGT	0.9
CHRM2	CXCL1	0.9
BDKRB2	FPR3	0.9
AGT	FPR3	0.9
ADORA1	CXCL13	0.9
BDKRB2	CXCL13	0.9
FPR2	AGT	0.9

Gene Ontology Semantic Similarity

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#	2833 (CXCR3)	7852 (CXCR4)	4852 (NPY)	6352 (CCL5)	3576 (CXCL8)	3579 (CXCR2)	2919 (CXCL1)	624 (BDKRB2)	6351 (CCL4)	629 (CFB)	185 (AGTR1)	2147 (F2)	4283 (CXCL9)	2920 (CXCL2)	728 (C5AR1)	6387 (CXCL12)	721 (C4B)	717 (C2)	2358 (FPR2)	3627 (CXCL10)	719 (C3AR1)	5473 (PPBP)	2357 (FPR1)	27202 (C5AR2)	720 (C4A)	183 (AGT)	5443 (POMC)	6288 (SAA1)	3827 (KNG1)	729230 (CCR2)	3577 (CXCR1)	966 (CD59)	729 (C6)	727 (C5)	134 (ADORA1)	1191 (CLU)	5199 (CFP)	1991 (ELANE)	718 (C3)	1233 (CCR4)	2359 (FPR3)	1369 (CPN1)	7448 (VTN)	1129 (CHRM2)	10563 (CXCL13)	1361 (CPB2)
2833 (CXCR3)	1.00	0.77	0.50	0.33	0.40	0.91	0.32	0.55	0.40	0.40	0.61	0.45	0.41	0.41	0.45	0.41	0.33	0.38	0.56	0.37	0.46	0.37	0.66	0.65	0.23	0.39	0.36	0.30	0.36	0.85	0.94	0.46	0.69	0.43	0.69	0.44	0.38	0.37	0.40	0.97	0.51	0.07	0.39	0.57	0.32	0.07
7852 (CXCR4)	0.77	1.00	0.63	0.47	0.49	0.89	0.39	0.67	0.52	0.49	0.68	0.61	0.51	0.50	0.42	0.52	0.40	0.47	0.62	0.48	0.43	0.47	0.75	0.74	0.29	0.50	0.45	0.36	0.47	0.82	0.81	0.52	1.00	0.52	1.00	0.59	0.47	0.46	0.50	0.85	0.44	0.11	0.48	0.69	0.41	0.11
4852 (NPY)	0.50	0.63	1.00	0.52	0.57	0.65	0.64	0.60	0.61	0.51	0.68	0.62	0.60	0.56	0.40	0.68	0.41	0.49	0.69	0.61	0.40	0.51	0.80	0.70	0.30	0.63	0.73	0.62	0.56	0.61	0.57	0.56	0.82	0.67	0.82	0.55	0.49	0.42	0.62	0.62	0.41	0.08	0.52	0.64	0.51	0.08
6352 (CCL5)	0.33	0.47	0.52	1.00	0.63	0.45	0.63	0.57	0.76	0.50	0.51	0.52	0.63	0.62	0.10	0.69	0.41	0.48	0.38	0.65	0.10	0.59	0.54	0.46	0.30	0.52	0.53	0.57	0.52	0.61	0.32	0.51	1.00	0.63	1.00	0.54	0.48	0.48	0.54	0.47	0.10	0.15	0.49	0.36	0.61	0.15
3576 (CXCL8)	0.40	0.49	0.57	0.63	1.00	0.47	0.75	0.56	0.82	0.64	0.57	0.56	0.90	0.93	0.11	0.88	0.51	0.61	0.40	0.76	0.11	0.80	0.60	0.53	0.38	0.61	0.64	0.60	0.58	0.60	0.36	0.74	1.00	0.91	1.00	0.68	0.61	0.49	0.65	0.55	0.11	0.11	0.61	0.36	0.72	0.11
3579 (CXCR2)	0.91	0.89	0.65	0.45	0.47	1.00	0.37	0.67	0.51	0.47	0.70	0.58	0.49	0.47	0.50	0.50	0.39	0.44	0.65	0.46	0.51	0.44	0.78	0.77	0.27	0.49	0.45	0.35	0.45	0.88	0.97	0.51	1.00	0.50	1.00	0.55	0.44	0.45	0.48	0.94	0.52	0.11	0.46	0.70	0.41	0.11
2919 (CXCL1)	0.32	0.39	0.64	0.63	0.75	0.37	1.00	0.47	0.74	0.51	0.48	0.53	0.77	0.77	0.10	0.80	0.41	0.48	0.39	0.74	0.11	0.66	0.51	0.42	0.30	0.65	0.70	0.58	0.58	0.49	0.28	0.59	0.82	0.84	0.82	0.56	0.48	0.39	0.62	0.44	0.10	0.08	0.52	0.29	0.62	0.08
624 (BDKRB2)	0.55	0.67	0.60	0.57	0.56	0.67	0.47	1.00	0.58	0.58	0.76	0.59	0.58	0.58	0.32	0.59	0.47	0.55	0.57	0.54	0.32	0.53	0.74	0.68	0.35	0.65	0.55	0.47	0.53	0.66	0.58	0.62	1.00	0.62	1.00	0.62	0.55	0.55	0.59	0.68	0.37	0.15	0.55	0.59	0.52	0.15
6351 (CCL4)	0.40	0.52	0.61	0.76	0.82	0.51	0.74	0.58	1.00	0.63	0.60	0.61	0.87	0.84	0.10	0.86	0.50	0.61	0.45	0.75	0.10	0.77	0.64	0.56	0.37	0.62	0.67	0.62	0.62	0.70	0.37	0.69	1.00	0.85	1.00	0.66	0.61	0.52	0.67	0.57	0.10	0.11	0.61	0.40	0.72	0.11
629 (CFB)	0.40	0.49	0.51	0.50	0.64	0.47	0.51	0.58	0.63	1.00	0.56	0.72	0.65	0.68	0.12	0.64	0.90	0.96	0.36	0.57	0.12	0.58	0.56	0.53	0.82	0.61	0.58	0.49	0.56	0.55	0.36	0.82	1.00	0.70	1.00	0.68	0.96	0.74	0.88	0.55	0.12	0.37	0.62	0.36	0.48	0.37
185 (AGTR1)	0.61	0.68	0.68	0.51	0.57	0.70	0.48	0.76	0.60	0.56	1.00	0.60	0.59	0.58	0.43	0.61	0.45	0.52	0.64	0.55	0.43	0.52	0.82	0.74	0.32	0.57	0.59	0.50	0.52	0.70	0.62	0.62	1.00	0.63	1.00	0.62	0.52	0.46	0.58	0.72	0.48	0.11	0.53	0.64	0.55	0.11
2147 (F2)	0.45	0.61	0.62	0.52	0.56	0.58	0.53	0.59	0.61	0.72	0.60	1.00	0.59	0.57	0.26	0.64	0.64	0.71	0.54	0.68	0.27	0.52	0.64	0.61	0.52	0.63	0.61	0.48	0.67	0.58	0.48	0.59	1.00	0.64	1.00	0.61	0.71	0.74	0.76	0.58	0.26	0.37	0.54	0.55	0.58	0.37
4283 (CXCL9)	0.41	0.51	0.60	0.63	0.90	0.49	0.77	0.58	0.87	0.65	0.59	0.59	1.00	0.89	0.11	0.88	0.52	0.62	0.44	0.82	0.11	0.78	0.62	0.55	0.38	0.62	0.67	0.62	0.62	0.61	0.37	0.74	1.00	0.91	1.00	0.68	0.62	0.51	0.68	0.56	0.11	0.11	0.63	0.38	0.75	0.11
2920 (CXCL2)	0.41	0.50	0.56	0.62	0.93	0.47	0.77	0.58	0.84	0.68	0.58	0.57	0.89	1.00	0.12	0.86	0.54	0.64	0.39	0.74	0.12	0.82	0.60	0.54	0.40	0.63	0.64	0.59	0.59	0.60	0.36	0.82	1.00	0.96	1.00	0.70	0.64	0.49	0.67	0.56	0.12	0.11	0.64	0.36	0.68	0.11
728 (C5AR1)	0.45	0.42	0.40	0.10	0.11	0.50	0.10	0.32	0.10	0.12	0.43	0.26	0.11	0.12	1.00	0.10	0.12	0.12	0.66	0.10	0.87	0.11	0.61	0.83	0.08	0.10	0.09	0.15	0.11	0.34	0.55	0.13	0.14	0.12	0.14	0.12	0.12	0.11	0.11	0.41	0.86	0.06	0.13	0.69	0.12	0.06
6387 (CXCL12)	0.41	0.52	0.68	0.69	0.88	0.50	0.80	0.59	0.86	0.64	0.61	0.64	0.88	0.86	0.10	1.00	0.51	0.61	0.49	0.81	0.10	0.78	0.66	0.56	0.38	0.67	0.75	0.67	0.65	0.64	0.37	0.70	1.00	0.91	1.00	0.67	0.61	0.52	0.72	0.57	0.10	0.11	0.73	0.40	0.74	0.11
721 (C4B)	0.33	0.40	0.41	0.41	0.51	0.39	0.41	0.47	0.50	0.90	0.45	0.64	0.52	0.54	0.12	0.51	1.00	0.84	0.30	0.47	0.12	0.47	0.45	0.43	0.77	0.49	0.46	0.40	0.47	0.44	0.30	0.71	0.82	0.56	0.82	0.56	0.84	0.66	0.76	0.45	0.12	0.37	0.50	0.30	0.39	0.37
717 (C2)	0.38	0.47	0.49	0.48	0.61	0.44	0.48	0.55	0.61	0.96	0.52	0.71	0.62	0.64	0.12	0.61	0.84	1.00	0.33	0.54	0.12	0.54	0.51	0.48	0.80	0.59	0.57	0.47	0.53	0.52	0.34	0.73	1.00	0.68	1.00	0.66	1.00	0.73	0.89	0.52	0.12	0.37	0.58	0.32	0.48	0.37
2358 (FPR2)	0.56	0.62	0.69	0.38	0.40	0.65	0.39	0.57	0.45	0.36	0.64	0.54	0.44	0.39	0.66	0.49	0.30	0.33	1.00	0.41	0.67	0.34	0.81	0.75	0.20	0.44	0.49	0.38	0.38	0.57	0.63	0.40	0.69	0.47	0.69	0.43	0.33	0.30	0.43	0.60	0.75	0.08	0.37	0.72	0.38	0.08
3627 (CXCL10)	0.37	0.48	0.61	0.65	0.76	0.46	0.74	0.54	0.75	0.57	0.55	0.68	0.82	0.74	0.10	0.81	0.47	0.54	0.41	1.00	0.11	0.67	0.57	0.50	0.34	0.63	0.66	0.55	0.72	0.56	0.34	0.63	1.00	0.79	1.00	0.63	0.54	0.58	0.63	0.52	0.10	0.11	0.56	0.36	0.78	0.11
719 (C3AR1)	0.46	0.43	0.40	0.10	0.11	0.51	0.11	0.32	0.10	0.12	0.43	0.27	0.11	0.12	0.87	0.10	0.12	0.12	0.67	0.11	1.00	0.11	0.62	0.72	0.08	0.10	0.09	0.16	0.11	0.34	0.55	0.13	0.14	0.12	0.14	0.12	0.12	0.11	0.11	0.41	0.87	0.06	0.13	0.70	0.12	0.06
5473 (PPBP)	0.37	0.47	0.51	0.59	0.80	0.44	0.66	0.53	0.77	0.58	0.52	0.52	0.78	0.82	0.11	0.78	0.47	0.54	0.34	0.67	0.11	1.00	0.53	0.47	0.34	0.58	0.58	0.50	0.53	0.55	0.33	0.68	1.00	0.82	1.00	0.64	0.54	0.46	0.59	0.51	0.11	0.11	0.55	0.33	0.63	0.11
2357 (FPR1)	0.66	0.75	0.80	0.54	0.60	0.78	0.51	0.74	0.64	0.56	0.82	0.64	0.62	0.60	0.61	0.66	0.45	0.51	0.81	0.57	0.62	0.53	1.00	0.88	0.32	0.61	0.66	0.56	0.52	0.73	0.71	0.63	1.00	0.66	1.00	0.62	0.51	0.45	0.60	0.76	0.71	0.11	0.53	0.78	0.54	0.11
27202 (C5AR2)	0.65	0.74	0.70	0.46	0.53	0.77	0.42	0.68	0.56	0.53	0.74	0.61	0.55	0.54	0.83	0.56	0.43	0.48	0.75	0.50	0.72	0.47	0.88	1.00	0.30	0.54	0.52	0.41	0.48	0.69	0.72	0.62	1.00	0.59	1.00	0.62	0.48	0.43	0.53	0.73	0.72	0.11	0.50	0.80	0.46	0.11
720 (C4A)	0.23	0.29	0.30	0.30	0.38	0.27	0.30	0.35	0.37	0.82	0.32	0.52	0.38	0.40	0.08	0.38	0.77	0.80	0.20	0.34	0.08	0.34	0.32	0.30	1.00	0.36	0.35	0.30	0.33	0.32	0.21	0.56	0.61	0.42	0.61	0.41	0.80	0.57	0.67	0.32	0.08	0.37	0.36	0.20	0.29	0.37
183 (AGT)	0.39	0.50	0.63	0.52	0.61	0.49	0.65	0.65	0.62	0.61	0.57	0.63	0.62	0.63	0.10	0.67	0.49	0.59	0.44	0.63	0.10	0.58	0.61	0.54	0.36	1.00	0.69	0.61	0.73	0.55	0.36	0.67	1.00	0.71	1.00	0.65	0.59	0.51	0.66	0.55	0.10	0.11	0.60	0.38	0.49	0.11
5443 (POMC)	0.36	0.45	0.73	0.53	0.64	0.45	0.70	0.55	0.67	0.58	0.59	0.61	0.67	0.64	0.09	0.75	0.46	0.57	0.49	0.66	0.09	0.58	0.66	0.52	0.35	0.69	1.00	0.73	0.62	0.52	0.33	0.64	0.82	0.77	0.82	0.60	0.57	0.47	0.71	0.52	0.09	0.08	0.59	0.37	0.54	0.08
6288 (SAA1)	0.30	0.36	0.62	0.57	0.60	0.35	0.58	0.47	0.62	0.49	0.50	0.48	0.62	0.59	0.15	0.67	0.40	0.47	0.38	0.55	0.16	0.50	0.56	0.41	0.30	0.61	0.73	1.00	0.47	0.43	0.27	0.57	0.69	0.67	0.69	0.50	0.47	0.38	0.60	0.40	0.15	0.14	0.52	0.29	0.51	0.14
3827 (KNG1)	0.36	0.47	0.56	0.52	0.58	0.45	0.58	0.53	0.62	0.56	0.52	0.67	0.62	0.59	0.11	0.65	0.47	0.53	0.38	0.72	0.11	0.53	0.52	0.48	0.33	0.73	0.62	0.47	1.00	0.52	0.34	0.63	1.00	0.66	1.00	0.63	0.53	0.57	0.61	0.51	0.11	0.11	0.56	0.34	0.61	0.11
729230 (CCR2)	0.85	0.82	0.61	0.61	0.60	0.88	0.49	0.66	0.70	0.55	0.70	0.58	0.61	0.60	0.34	0.64	0.44	0.52	0.57	0.56	0.34	0.55	0.73	0.69	0.32	0.55	0.52	0.43	0.52	1.00	0.84	0.60	1.00	0.62	1.00	0.61	0.52	0.49	0.56	0.92	0.37	0.11	0.53	0.59	0.54	0.11
3577 (CXCR1)	0.94	0.81	0.57	0.32	0.36	0.97	0.28	0.58	0.37	0.36	0.62	0.48	0.37	0.36	0.55	0.37	0.30	0.34	0.63	0.34	0.55	0.33	0.71	0.72	0.21	0.36	0.33	0.27	0.34	0.84	1.00	0.39	0.69	0.38	0.69	0.40	0.34	0.36	0.36	0.92	0.57	0.07	0.35	0.67	0.31	0.07
966 (CD59)	0.46	0.52	0.56	0.51	0.74	0.51	0.59	0.62	0.69	0.82	0.62	0.59	0.74	0.82	0.13	0.70	0.71	0.73	0.40	0.63	0.13	0.68	0.63	0.62	0.56	0.67	0.64	0.57	0.63	0.60	0.39	1.00	1.00	0.82	1.00	0.73	0.73	0.53	0.72	0.61	0.13	0.11	0.72	0.40	0.52	0.11
729 (C6)	0.69	1.00	0.82	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.14	1.00	0.82	1.00	0.69	1.00	0.14	1.00	1.00	1.00	0.61	1.00	0.82	0.69	1.00	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.14	0.11	1.00	0.82	0.69	0.11
727 (C5)	0.43	0.52	0.67	0.63	0.91	0.50	0.84	0.62	0.85	0.70	0.63	0.64	0.91	0.96	0.12	0.91	0.56	0.68	0.47	0.79	0.12	0.82	0.66	0.59	0.42	0.71	0.77	0.67	0.66	0.62	0.38	0.82	1.00	1.00	1.00	0.72	0.68	0.52	0.76	0.59	0.12	0.11	0.69	0.40	0.69	0.11
134 (ADORA1)	0.69	1.00	0.82	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.14	1.00	0.82	1.00	0.69	1.00	0.14	1.00	1.00	1.00	0.61	1.00	0.82	0.69	1.00	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.14	0.11	1.00	0.82	0.69	0.11
1191 (CLU)	0.44	0.59	0.55	0.54	0.68	0.55	0.56	0.62	0.66	0.68	0.62	0.61	0.68	0.70	0.12	0.67	0.56	0.66	0.43	0.63	0.12	0.64	0.62	0.62	0.41	0.65	0.60	0.50	0.63	0.61	0.40	0.73	1.00	0.72	1.00	1.00	0.66	0.56	0.68	0.62	0.12	0.11	0.66	0.45	0.49	0.11
5199 (CFP)	0.38	0.47	0.49	0.48	0.61	0.44	0.48	0.55	0.61	0.96	0.52	0.71	0.62	0.64	0.12	0.61	0.84	1.00	0.33	0.54	0.12	0.54	0.51	0.48	0.80	0.59	0.57	0.47	0.53	0.52	0.34	0.73	1.00	0.68	1.00	0.66	1.00	0.73	0.89	0.52	0.12	0.37	0.58	0.32	0.48	0.37
1991 (ELANE)	0.37	0.46	0.42	0.48	0.49	0.45	0.39	0.55	0.52	0.74	0.46	0.74	0.51	0.49	0.11	0.52	0.66	0.73	0.30	0.58	0.11	0.46	0.45	0.43	0.57	0.51	0.47	0.38	0.57	0.49	0.36	0.53	1.00	0.52	1.00	0.56	0.73	1.00	0.72	0.48	0.11	0.49	0.48	0.32	0.49	0.49
718 (C3)	0.40	0.50	0.62	0.54	0.65	0.48	0.62	0.59	0.67	0.88	0.58	0.76	0.68	0.67	0.11	0.72	0.76	0.89	0.43	0.63	0.11	0.59	0.60	0.53	0.67	0.66	0.71	0.60	0.61	0.56	0.36	0.72	1.00	0.76	1.00	0.68	0.89	0.72	1.00	0.55	0.11	0.37	0.62	0.37	0.53	0.37
1233 (CCR4)	0.97	0.85	0.62	0.47	0.55	0.94	0.44	0.68	0.57	0.55	0.72	0.58	0.56	0.56	0.41	0.57	0.45	0.52	0.60	0.52	0.41	0.51	0.76	0.73	0.32	0.55	0.52	0.40	0.51	0.92	0.92	0.61	1.00	0.59	1.00	0.62	0.52	0.48	0.55	1.00	0.45	0.11	0.53	0.62	0.45	0.11
2359 (FPR3)	0.51	0.44	0.41	0.10	0.11	0.52	0.10	0.37	0.10	0.12	0.48	0.26	0.11	0.12	0.86	0.10	0.12	0.12	0.75	0.10	0.87	0.11	0.71	0.72	0.08	0.10	0.09	0.15	0.11	0.37	0.57	0.13	0.14	0.12	0.14	0.12	0.12	0.11	0.11	0.45	1.00	0.06	0.12	0.71	0.11	0.06
1369 (CPN1)	0.07	0.11	0.08	0.15	0.11	0.11	0.08	0.15	0.11	0.37	0.11	0.37	0.11	0.11	0.06	0.11	0.37	0.37	0.08	0.11	0.06	0.11	0.11	0.11	0.37	0.11	0.08	0.14	0.11	0.11	0.07	0.11	0.11	0.11	0.11	0.11	0.37	0.49	0.37	0.11	0.06	1.00	0.11	0.08	0.07	1.00
7448 (VTN)	0.39	0.48	0.52	0.49	0.61	0.46	0.52	0.55	0.61	0.62	0.53	0.54	0.63	0.64	0.13	0.73	0.50	0.58	0.37	0.56	0.13	0.55	0.53	0.50	0.36	0.60	0.59	0.52	0.56	0.53	0.35	0.72	1.00	0.69	1.00	0.66	0.58	0.48	0.62	0.53	0.12	0.11	1.00	0.35	0.48	0.11
1129 (CHRM2)	0.57	0.69	0.64	0.36	0.36	0.70	0.29	0.59	0.40	0.36	0.64	0.55	0.38	0.36	0.69	0.40	0.30	0.32	0.72	0.36	0.70	0.33	0.78	0.80	0.20	0.38	0.37	0.29	0.34	0.59	0.67	0.40	0.82	0.40	0.82	0.45	0.32	0.32	0.37	0.62	0.71	0.08	0.35	1.00	0.35	0.08
10563 (CXCL13)	0.32	0.41	0.51	0.61	0.72	0.41	0.62	0.52	0.72	0.48	0.55	0.58	0.75	0.68	0.12	0.74	0.39	0.48	0.38	0.78	0.12	0.63	0.54	0.46	0.29	0.49	0.54	0.51	0.61	0.54	0.31	0.52	0.69	0.69	0.69	0.49	0.48	0.49	0.53	0.45	0.11	0.07	0.48	0.35	1.00	0.07
1361 (CPB2)	0.07	0.11	0.08	0.15	0.11	0.11	0.08	0.15	0.11	0.37	0.11	0.37	0.11	0.11	0.06	0.11	0.37	0.37	0.08	0.11	0.06	0.11	0.11	0.11	0.37	0.11	0.08	0.14	0.11	0.11	0.07	0.11	0.11	0.11	0.11	0.11	0.37	0.49	0.37	0.11	0.06	1.00	0.11	0.08	0.07	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
C5	Human	Blood	-	3600 m	Native	upregulated	-	TMT-based proteomic analysis/LC-MS	Central Asia	Tibetans	-	High altitude native vs. low Lander	30908922

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
FOXA1	3169	C5	727	proximal_filtered	22955619	TRANSFAC

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT016535	hsa-miR-193b-3p	Homo sapiens	C5	727	Homo sapiens	Microarray	Functional MTI (Weak)	20304954
MIRT047564	hsa-miR-10a-5p	Homo sapiens	C5	727	Homo sapiens	CLASH	Functional MTI (Weak)	23622248

Gene Ontology

ID	GO ID	GO Term	GO Type
727	GO:0010575	positive regulation of vascular endothelial growth factor production	GOTERM_BP_DIRECT
727	GO:0010951	negative regulation of endopeptidase activity	GOTERM_BP_DIRECT
727	GO:0090197	positive regulation of chemokine secretion	GOTERM_BP_DIRECT
727	GO:0005102	receptor binding	GOTERM_MF_DIRECT
727	GO:0007186	G-protein coupled receptor signaling pathway	GOTERM_BP_DIRECT
727	GO:0045766	positive regulation of angiogenesis	GOTERM_BP_DIRECT
727	GO:0005579	membrane attack complex	GOTERM_CC_DIRECT
727	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
727	GO:0001701	in utero embryonic development	GOTERM_BP_DIRECT
727	GO:0005615	extracellular space	GOTERM_CC_DIRECT
727	GO:0006956	complement activation	GOTERM_BP_DIRECT
727	GO:0006957	complement activation	GOTERM_BP_DIRECT
727	GO:0006958	complement activation	GOTERM_BP_DIRECT
727	GO:0008009	chemokine activity	GOTERM_MF_DIRECT
727	GO:0006954	inflammatory response	GOTERM_BP_DIRECT
727	GO:0010760	negative regulation of macrophage chemotaxis	GOTERM_BP_DIRECT
727	GO:0004866	endopeptidase inhibitor activity	GOTERM_MF_DIRECT
727	GO:0005576	extracellular region	GOTERM_CC_DIRECT
727	GO:0030449	regulation of complement activation	GOTERM_BP_DIRECT
727	GO:0000187	activation of MAPK activity	GOTERM_BP_DIRECT
727	GO:0006950	response to stress	GOTERM_BP_DIRECT
727	GO:0005515	protein binding	GOTERM_MF_DIRECT
727	GO:0006935	chemotaxis	GOTERM_BP_DIRECT
727	GO:0007166	cell surface receptor signaling pathway	GOTERM_BP_DIRECT
727	GO:0060326	cell chemotaxis	GOTERM_BP_DIRECT
727	GO:0019835	cytolysis	GOTERM_BP_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
727	hsa04610	Complement and coagulation cascades
727	hsa05020	Prion diseases
727	hsa05133	Pertussis
727	hsa05150	Staphylococcus aureus infection
727	hsa05168	Herpes simplex infection
727	hsa05322	Systemic lupus erythematosus

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
C5	727	Immunologic Deficiency Syndromes	C0021051	Disease or Syndrome	0.3	0.611	0.655	group
C5	727	Peritonitis	C0031154	Pathologic Function	0.3	0.611	0.655	disease
C5	727	Primary Peritonitis	C1449646	Disease or Syndrome	0.3	0.611	0.655	disease
C5	727	Secondary Peritonitis	C1449647	Disease or Syndrome	0.3	0.611	0.655	disease
C5	727	Antibody Deficiency Syndrome	C0003257	Disease or Syndrome	0.3	0.611	0.655	disease
C5	727	Complement component 5 deficiency	C0343047	Disease or Syndrome	0.4	0.611	0.655	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
C5	727	ARC1905	None	None	None
C5	727	ECULIZUMAB	ECULIZUMAB	CHEMBL1201828	None
C5	727	ECULIZUMAB	ECULIZUMAB	CHEMBL1201828	inhibitor
C5	727	ECULIZUMAB	ECULIZUMAB	CHEMBL1201828	None
C5	727	ECULIZUMAB	ECULIZUMAB	CHEMBL1201828	antibody
C5	727	PEXELIZUMAB	PEXELIZUMAB	CHEMBL2107979	inhibitor