ALTITUDEOMICSDB

T-kininogen

AltitudeomicsDB

Protein Official symbol	KNG1
Aliases	KNG1 BDK KNG
Chromosomal Location	16
Length	644
Uniprot ID	P01042
EC number	None
Protein family Information(Pfam)	PF00031;
PDB id	1NY2;2WOK;4ASQ;4ASR;4ECB;4ECC;5I25;6F27;6F3V;6F3W;6F3X;6F3Y;
InterPro ID	IPR000010;IPR002395;IPR027358;IPR018073;
dbSNP	rs5030015 rs1656922 rs2304456 rs5030024 rs5030084 rs710446 rs5030087

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
SERPINC1	F2	0.998
AHSG	ALB	0.998
PLG	SERPINE1	0.997
AHSG	AFP	0.997
SERPINC1	FGG	0.995
NPY	POMC	0.995
TAC1	TACR1	0.995
PDYN	OPRM1	0.994
VEGFA	NOS3	0.993
VEGFA	EGF	0.993
BDKRB2	KNG1	0.993
KNG1	KLKB1	0.993
PDYN	OPRK1	0.992
PDYN	OPRL1	0.992
PDYN	OPRD1	0.992
FGG	F2	0.992
NPS	TAC1	0.992
SERPINA1	A2M	0.992
AHSG	FGG	0.991
NPY	SST	0.991
F2	SERPIND1	0.989
OPRM1	POMC	0.989
PLG	HRG	0.988
POMC	NPS	0.988
TAC1	KNG1	0.988
TAC1	NTS	0.988
AHSG	SERPINC1	0.987
SERPINC1	ALB	0.987
AHSG	HRG	0.987
AGTR1	AGT	0.987
POMC	OPRD1	0.986
NPS	OXT	0.986
PDYN	POMC	0.986
VEGFA	ALB	0.986
POMC	OPRK1	0.986
POMC	AVP	0.986
POMC	OPRL1	0.986
TAC1	GRP	0.985
AHSG	TF	0.985
F11	SERPINC1	0.985
SERPINC1	PLG	0.984
NPS	NTS	0.984
SERPINA1	AFP	0.983
NOS3	KNG1	0.983
FGG	HRG	0.983
SERPINA1	ALB	0.983
IL6	ALB	0.983
GRP	NTS	0.983
VEGFA	SERPINE1	0.982
TF	ALB	0.982
AVP	OXT	0.982
EDN1	AGT	0.981
AGTR2	AGT	0.981
FGG	ALB	0.98
ALB	EGF	0.98
KNG1	F12	0.979
SERPING1	KNG1	0.979
ALB	SERPINE1	0.979
FGG	SERPIND1	0.979
POMC	SST	0.979
NPS	GRP	0.978
PLG	ALB	0.978
FGG	PLG	0.978
EGF	SERPINE1	0.978
KNG1	BDKRB1	0.978
NPS	TACR1	0.975
PDYN	NPY	0.975
SERPINA1	AHSG	0.974
PLG	KNG1	0.974
IL6	KNG1	0.974
A2M	ALB	0.974
VEGFA	KNG1	0.973
IL6	SERPINC1	0.973
AHSG	F2	0.973
SERPINC1	KNG1	0.972
SERPING1	F12	0.972
AFP	FGG	0.972
SERPING1	KLKB1	0.972
ALB	C3	0.972
F11	KNG1	0.972
PDYN	SST	0.972
A2M	PLG	0.971
SERPINA1	IL6	0.971
KNG1	NTS	0.971
EDN1	KNG1	0.971
KNG1	HRG	0.971
ALB	KNG1	0.971
EGF	KNG1	0.97
A2M	SERPING1	0.969
KNG1	SERPINE1	0.969
NPS	AVP	0.969
NPS	KNG1	0.969
AGTR1	KNG1	0.969
SERPINA1	PLG	0.969
VEGFA	PLG	0.969
TAC1	OXT	0.967
BDKRB2	NOS3	0.967
TF	AFP	0.966
AGTR2	KNG1	0.966
AFP	KNG1	0.966
ADRA2C	NPY	0.966
NTS	OXT	0.966
A2M	KLKB1	0.966
SERPINA1	TF	0.966
KNG1	GRP	0.965
NPY	ADRA2A	0.965
AVP	EDN1	0.965
AGTR1	EDN1	0.965
ADRA2B	NPY	0.965
PLG	EGF	0.964
AHSG	SERPIND1	0.964
TAC1	ADRA1B	0.963
PRCP	KLKB1	0.963
SERPINA1	C3	0.963
ADRA1A	TAC1	0.963
AFP	SERPINC1	0.962
KNG1	OXT	0.962
OPRM1	NPY	0.962
ADRA1D	TAC1	0.962
TF	C3	0.961
AHSG	KNG1	0.961
KLKB1	F12	0.961
F2	KNG1	0.961
AHSG	A2M	0.96
SERPINC1	SERPIND1	0.96
F2	ALB	0.959
AGT	KNG1	0.959
VEGFA	IL6	0.959
F11	F12	0.959
AHSG	PLG	0.958
A2M	KNG1	0.958
IL6	C3	0.958
AGT	F2	0.958
NPY	OPRK1	0.957
NPY	OPRL1	0.957
OPRL1	KNG1	0.957
AVP	AGT	0.957
AFP	C3	0.957
OPRM1	KNG1	0.957
POMC	KNG1	0.957
PRCP	KNG1	0.956
AHSG	C3	0.956
OPRK1	KNG1	0.956
EDN1	EGF	0.956
SERPINC1	C3	0.956
POMC	ADRA2A	0.956
EDN1	TAC1	0.956
AFP	ALB	0.956
F2	NTS	0.956
KNG1	OPRD1	0.956
OPRM1	SST	0.956
PDYN	KNG1	0.956
NPY	OPRD1	0.956
ADRA2C	POMC	0.956
TACR1	KNG1	0.956
ADRA2B	POMC	0.956
SERPINA1	FGG	0.955
AVP	GRP	0.955
ADRA1A	KNG1	0.955
ADRA2B	KNG1	0.955
EDN1	ADRA1B	0.955
ADRA2C	KNG1	0.955
ADRA1B	KNG1	0.955
SERPINC1	F12	0.954
SST	OPRK1	0.954
OPRL1	SST	0.954
SST	KNG1	0.954
ADRA1B	OXT	0.954
PLG	SERPING1	0.954
KNG1	C3	0.954
ADRA2A	KNG1	0.954
AVP	KNG1	0.954
ADRA1D	KNG1	0.954
SERPINA1	KNG1	0.954
TF	KNG1	0.954
ADRA1D	OXT	0.953
TF	FGG	0.953
FGG	KNG1	0.953
ADRA1A	OXT	0.953
GRP	OXT	0.953
ALB	SERPIND1	0.952
KNG1	SERPIND1	0.952
AFP	SERPIND1	0.952
TACR1	NTS	0.952
ADRA1A	EDN1	0.952
NPY	KNG1	0.952
A2M	HRG	0.952
SST	OPRD1	0.952
AVP	TAC1	0.952
ADRA1D	EDN1	0.952
SERPINA1	HRG	0.951
F11	F2	0.951
TACR1	GRP	0.95
EDN1	F2	0.95
PLG	C3	0.95
EDN1	AGTR2	0.95
HRG	SERPINE1	0.95
TF	SERPINC1	0.95
FGG	A2M	0.95
F11	SERPIND1	0.949
AHSG	IL6	0.947
EDN1	OXT	0.947
ALB	HRG	0.946
AVP	NTS	0.946
IL6	AFP	0.946
NPS	ADRA1B	0.945
AVP	ADRA1D	0.945
ADRA1A	AVP	0.945
NPS	ADRA1D	0.945
AVP	ADRA1B	0.945
NPS	ADRA1A	0.945
SST	ADRA2A	0.945
BDKRB2	TAC1	0.944
NPS	EDN1	0.944
AGT	BDKRB1	0.943
ADRA2B	SST	0.943
ADRA2C	SST	0.943
TAC1	SST	0.943
EDN1	GRP	0.942
ADRA2C	AGTR2	0.942
AFP	F2	0.942
AVP	F2	0.941
EDN1	NOS3	0.941
ADRA2B	AGTR2	0.941
AGTR2	ADRA2A	0.941
BDKRB2	GRP	0.94
FGG	C3	0.94
A2M	SERPINE1	0.94
SERPINA1	SERPINC1	0.94
BDKRB2	BDKRB1	0.938
ALB	SERPING1	0.938
AVP	EGF	0.937
AGTR1	EGF	0.937
AGT	C3	0.936
AGTR1	AVP	0.935
ADRA2B	PDYN	0.935
PDYN	ADRA2A	0.934
SERPINA1	SERPING1	0.934
AGTR1	POMC	0.934
POMC	AGT	0.934
TF	SERPIND1	0.933
VEGFA	SERPINA1	0.933
BDKRB2	AGT	0.933
SERPINA1	SERPIND1	0.933
EDN1	NTS	0.933
PDYN	ADRA2C	0.933
AGT	NTS	0.933
ADRA1A	NTS	0.932
AHSG	SERPINE1	0.932
ADRA1D	NTS	0.932
ADRA1B	NTS	0.932
AHSG	SERPING1	0.931
VEGFA	HRG	0.931
AGTR1	F2	0.931
FGG	SERPING1	0.93
A2M	EGF	0.93
SERPINA1	EGF	0.93
AGTR1	TAC1	0.929
ADRA2B	OPRL1	0.929
AGT	TAC1	0.929
ADRA2B	OPRD1	0.929
BDKRB2	EDN1	0.929
FGG	SERPINE1	0.929
C3	SERPIND1	0.929
ADRA2C	OPRL1	0.929
ADRA2A	OPRD1	0.928
ADRA2B	OPRK1	0.928
OPRL1	ADRA2A	0.928
ADRA2A	OPRK1	0.928
NPY	NPS	0.928
OPRM1	ADRA2A	0.927
ADRA2C	OPRK1	0.927
ADRA2B	OPRM1	0.927
ADRA2C	OPRD1	0.927
OPRM1	ADRA2C	0.927
AGT	ADRA1B	0.927
TACR1	OXT	0.927
VEGFA	A2M	0.926
F2	OXT	0.926
POMC	AGTR2	0.926
AGTR1	ADRA1B	0.925
SERPING1	SERPINE1	0.924
AGT	OXT	0.924
AGTR1	ADRA1D	0.924
ADRA2C	AGT	0.924
NPY	AGT	0.924
ADRA1D	AGT	0.924
AGTR1	OXT	0.923
NPS	AGT	0.922
POMC	C3	0.922
AGTR1	NTS	0.921
TAC1	F2	0.921
ADRA1A	AGT	0.92
AGTR2	NTS	0.92
AGTR1	ADRA1A	0.92
SERPINA1	SERPINE1	0.919
AGT	SST	0.919
ADRA1A	GRP	0.919
FGG	EGF	0.919
VEGFA	AHSG	0.919
AVP	TACR1	0.919
TAC1	BDKRB1	0.919
VEGFA	SERPING1	0.919
ADRA1D	GRP	0.919
AGTR1	NPY	0.918
BDKRB2	NPS	0.918
ADRA1B	GRP	0.918
AGTR2	ADRA1B	0.918
AGTR1	SST	0.918
AGTR2	SST	0.918
IL6	FGG	0.918
AGTR1	NPS	0.918
EDN1	BDKRB1	0.918
TF	IL6	0.918
AGT	ADRA2A	0.917
NPS	AGTR2	0.917
EDN1	TACR1	0.917
SERPING1	HRG	0.916
BDKRB2	PDYN	0.916
ADRA2B	AGT	0.916
BDKRB2	ADRA2A	0.916
AHSG	EGF	0.915
NPS	F2	0.915
OPRM1	C3	0.915
EGF	HRG	0.915
AGTR1	AGTR2	0.915
ADRA1B	TACR1	0.915
ADRA1A	TACR1	0.914
ADRA1D	TACR1	0.914
ADRA2B	BDKRB2	0.914
TF	EGF	0.914
BDKRB2	AGTR1	0.913
BDKRB2	C3	0.913
NPY	C3	0.913
IL6	SERPIND1	0.913
AGTR2	F2	0.913
BDKRB2	F2	0.913
ADRA1D	ADRA1B	0.912
NPY	AGTR2	0.912
BDKRB2	AVP	0.912
BDKRB2	ADRA2C	0.911
F11	KLKB1	0.911
C3	BDKRB1	0.911
AGTR1	C3	0.911
TACR1	EGF	0.911
BDKRB2	ADRA1D	0.91
NPS	BDKRB1	0.909
PDYN	AGTR2	0.908
NPY	TAC1	0.908
F2	GRP	0.908
ADRA1D	F2	0.908
BDKRB2	AGTR2	0.908
AGTR2	BDKRB1	0.908
VEGFA	FGG	0.907
BDKRB2	OPRM1	0.907
BDKRB2	OPRK1	0.907
SERPING1	EGF	0.907
OPRK1	C3	0.907
BDKRB2	ADRA1B	0.906
PDYN	AGT	0.906
ADRA2C	ADRA2A	0.906
F2	ADRA1B	0.906
TACR1	BDKRB1	0.906
OPRL1	OPRK1	0.906
AGTR1	TACR1	0.906
OPRM1	OPRD1	0.906
ADRA1A	ADRA1B	0.906
AGTR1	BDKRB1	0.905
AGTR1	OPRL1	0.905
ADRA2B	ADRA2C	0.905
NPY	BDKRB1	0.905
BDKRB2	OPRD1	0.905
OPRM1	OPRK1	0.905
OPRL1	OPRD1	0.905
OPRM1	OPRL1	0.905
OPRK1	OPRD1	0.905
BDKRB2	SST	0.905
AGTR1	OPRM1	0.905
ADRA2B	ADRA2A	0.905
AGTR2	OPRL1	0.905
PDYN	AGTR1	0.905
AGTR1	OPRK1	0.905
AGTR1	OPRD1	0.905
BDKRB2	OPRL1	0.905
BDKRB2	TACR1	0.905
ADRA1A	F2	0.905
BDKRB2	ADRA1A	0.904
BDKRB2	POMC	0.904
OPRM1	AGTR2	0.904
BDKRB2	OXT	0.904
AGTR2	OPRD1	0.903
TF	AVP	0.903
F2	BDKRB1	0.903
AGTR1	GRP	0.903
GRP	BDKRB1	0.903
AGTR2	OPRK1	0.903
AGTR2	GRP	0.902
AGTR1	TF	0.902
BDKRB2	NTS	0.902
BDKRB2	NPY	0.902
OXT	BDKRB1	0.902
ADRA2A	BDKRB1	0.902
ADRA1A	ADRA1D	0.902
AGTR2	C3	0.901
AVP	BDKRB1	0.901
OPRL1	BDKRB1	0.901
OPRD1	BDKRB1	0.901
SST	C3	0.901
PDYN	BDKRB1	0.901
OPRM1	BDKRB1	0.901
AGT	GRP	0.901
ADRA1A	BDKRB1	0.9
AGT	TACR1	0.9
ADRA2B	BDKRB1	0.9
C3	OPRD1	0.9
ADRA2C	BDKRB1	0.9
ADRA1B	BDKRB1	0.9
OPRL1	C3	0.9
AGT	OPRK1	0.9
ADRA2B	C3	0.9
AGT	OPRD1	0.9
F2	TACR1	0.9
SST	BDKRB1	0.9
OPRM1	AGT	0.9
ADRA2A	C3	0.9
AGT	OPRL1	0.9
ADRA2C	C3	0.9
ADRA1D	BDKRB1	0.9
POMC	BDKRB1	0.9
OPRK1	BDKRB1	0.9
PDYN	C3	0.9
NTS	BDKRB1	0.9
TF	TACR1	0.9

Gene Ontology Semantic Similarity

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#	3827 (KNG1)	2811 (GP1BA)	2814 (GP5)	2812 (GP1BB)	2160 (F11)	710 (SERPING1)	3818 (KLKB1)	2 (A2M)	5547 (PRCP)	4312 (MMP1)	2161 (F12)	4314 (MMP3)	2815 (GP9)	708 (C1QBP)
3827 (KNG1)	1.00	0.53	1.00	0.57	0.53	0.72	0.53	0.72	0.52	0.12	0.56	0.41	1.00	0.58
2811 (GP1BA)	0.53	1.00	1.00	0.73	0.47	0.56	0.47	0.63	0.47	0.12	0.53	0.35	1.00	0.53
2814 (GP5)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.16	1.00	1.00	1.00	1.00
2812 (GP1BB)	0.57	0.73	1.00	1.00	0.62	0.62	0.62	0.64	0.62	0.13	0.65	0.44	1.00	0.59
2160 (F11)	0.53	0.47	1.00	0.62	1.00	0.56	1.00	0.63	0.79	0.70	0.96	0.84	1.00	0.56
710 (SERPING1)	0.72	0.56	1.00	0.62	0.56	1.00	0.56	0.77	0.56	0.13	0.61	0.38	1.00	0.56
3818 (KLKB1)	0.53	0.47	1.00	0.62	1.00	0.56	1.00	0.63	0.79	0.70	0.96	0.84	1.00	0.56
2 (A2M)	0.72	0.63	1.00	0.64	0.63	0.77	0.63	1.00	0.63	0.11	0.64	0.54	1.00	0.61
5547 (PRCP)	0.52	0.47	1.00	0.62	0.79	0.56	0.79	0.63	1.00	0.43	0.79	0.64	1.00	0.56
4312 (MMP1)	0.12	0.12	0.16	0.13	0.70	0.13	0.70	0.11	0.43	1.00	0.60	0.87	0.16	0.11
2161 (F12)	0.56	0.53	1.00	0.65	0.96	0.61	0.96	0.64	0.79	0.60	1.00	0.84	1.00	0.58
4314 (MMP3)	0.41	0.35	1.00	0.44	0.84	0.38	0.84	0.54	0.64	0.87	0.84	1.00	1.00	0.47
2815 (GP9)	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.16	1.00	1.00	1.00	1.00
708 (C1QBP)	0.58	0.53	1.00	0.59	0.56	0.56	0.56	0.61	0.56	0.11	0.58	0.47	1.00	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
KNG1	Rat	Plasma	-	7619 m	24 hours	upregulated	1.06	2-DE	Northern indo-australian plate	Male sprague-dawley	1	8 weeks old male SD rats kept at standard conditions	26882918

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT021957	hsa-miR-128-3p	Homo sapiens	KNG1	3827	Homo sapiens	Microarray	Functional MTI (Weak)	17612493

Gene Ontology

ID	GO ID	GO Term	GO Type
3827	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
3827	GO:0010951	negative regulation of endopeptidase activity	GOTERM_BP_DIRECT
3827	GO:0007597	blood coagulation	GOTERM_BP_DIRECT
3827	GO:0007162	negative regulation of cell adhesion	GOTERM_BP_DIRECT
3827	GO:0005102	receptor binding	GOTERM_MF_DIRECT
3827	GO:0008270	zinc ion binding	GOTERM_MF_DIRECT
3827	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
3827	GO:0072562	blood microparticle	GOTERM_CC_DIRECT
3827	GO:0043065	positive regulation of apoptotic process	GOTERM_BP_DIRECT
3827	GO:0005515	protein binding	GOTERM_MF_DIRECT
3827	GO:0002576	platelet degranulation	GOTERM_BP_DIRECT
3827	GO:0006954	inflammatory response	GOTERM_BP_DIRECT
3827	GO:0007204	positive regulation of cytosolic calcium ion concentration	GOTERM_BP_DIRECT
3827	GO:0042311	vasodilation	GOTERM_BP_DIRECT
3827	GO:0008201	heparin binding	GOTERM_MF_DIRECT
3827	GO:0045861	negative regulation of proteolysis	GOTERM_BP_DIRECT
3827	GO:0004869	cysteine-type endopeptidase inhibitor activity	GOTERM_MF_DIRECT
3827	GO:0005615	extracellular space	GOTERM_CC_DIRECT
3827	GO:0031093	platelet alpha granule lumen	GOTERM_CC_DIRECT
3827	GO:0030195	negative regulation of blood coagulation	GOTERM_BP_DIRECT
3827	GO:0005576	extracellular region	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
3827	hsa04610	Complement and coagulation cascades

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
KNG1	3827	Hypersensitivity	C0020517	Pathologic Function	0.3	0.53	0.862	group
KNG1	3827	Myocardial Reperfusion Injury	C0027055	Pathologic Function	0.3	0.53	0.862	phenotype
KNG1	3827	Reactive Hyperemia	C0178824	Pathologic Function	0.3	0.53	0.862	phenotype
KNG1	3827	Active Hyperemia	C0333233	Pathologic Function	0.3	0.53	0.862	phenotype
KNG1	3827	anaphylaxis	C0002792	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Extravasation of Contrast Media	C0015378	Pathologic Function	0.3	0.53	0.862	phenotype
KNG1	3827	Tachycardia	C0039231	Finding	0.3	0.53	0.862	phenotype
KNG1	3827	Pain, Burning	C0234230	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Edema	C0013604	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Hepatitis, Toxic	C0019193	Injury or Poisoning	0.3	0.53	0.862	disease
KNG1	3827	Tactile Allodynia	C0751213	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Drug-Induced Acute Liver Injury	C3658290	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Extravasation of Diagnostic and Therapeutic Materials	C0015379	Injury or Poisoning	0.3	0.53	0.862	disease
KNG1	3827	Hyperesthesia, Thermal	C0751216	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Kidney Failure, Acute	C0022660	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Hyperalgesia, Primary	C0751211	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.53	0.862	disease
KNG1	3827	Pain, Migratory	C0751407	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Mammary Carcinoma, Animal	C1257925	Neoplastic Process	0.3	0.53	0.862	disease
KNG1	3827	Acute Kidney Insufficiency	C1565662	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Chemical and Drug Induced Liver Injury	C4277682	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Chemically-Induced Liver Toxicity	C4279912	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Cardiac Arrhythmia	C0003811	Finding	0.3	0.53	0.862	phenotype
KNG1	3827	Hyperalgesia, Thermal	C0751214	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Allergic Reaction	C1527304	Pathologic Function	0.3	0.53	0.862	phenotype
KNG1	3827	Tachyarrhythmia	C0080203	Finding	0.3	0.53	0.862	phenotype
KNG1	3827	Hyperalgesia, Secondary	C0751212	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Coughing	C0010200	Sign or Symptom	0.36	0.53	0.862	phenotype
KNG1	3827	Angioedemas, Hereditary	C0019243	Disease or Syndrome	0.4	0.53	0.862	group
KNG1	3827	Hyperemia	C0020452	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Ache	C0234238	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Morbilliform Drug Reaction	C0406537	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Allodynia	C0458247	Finding	0.3	0.53	0.862	phenotype
KNG1	3827	Hyperesthesia, Tactile	C0751215	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Hepatitis, Drug-Induced	C1262760	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Hypertensive disease	C0020538	Disease or Syndrome	0.4	0.53	0.862	group
KNG1	3827	Hyperalgesia	C0020429	Sign or Symptom	0.32	0.53	0.862	phenotype
KNG1	3827	Anasarca	C0151603	Pathologic Function	0.3	0.53	0.862	phenotype
KNG1	3827	Pain, Splitting	C0458257	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Hypotension	C0020649	Finding	0.3	0.53	0.862	phenotype
KNG1	3827	Animal Mammary Neoplasms	C0024667	Neoplastic Process	0.3	0.53	0.862	group
KNG1	3827	Radiating pain	C0234254	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Bradycardia	C0428977	Pathologic Function	0.3	0.53	0.862	phenotype
KNG1	3827	Suffering, Physical	C0751408	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Drug Eruptions	C0011609	Disease or Syndrome	0.3	0.53	0.862	group
KNG1	3827	Hyperesthesia	C0020453	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Pain, Crushing	C0458259	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Pain	C0030193	Sign or Symptom	0.38	0.53	0.862	phenotype
KNG1	3827	Acute kidney injury	C2609414	Injury or Poisoning	0.3	0.53	0.862	disease
KNG1	3827	Mechanical Allodynia	C2936719	Sign or Symptom	0.3	0.53	0.862	phenotype
KNG1	3827	Acquired angioedema	C2931758	Disease or Syndrome	0.34	0.53	0.862	disease
KNG1	3827	Venous Engorgement	C0042484	Pathologic Function	0.3	0.53	0.862	phenotype
KNG1	3827	Drug-Induced Liver Disease	C0860207	Disease or Syndrome	0.3	0.53	0.862	disease
KNG1	3827	Kininogen Deficiency, Total	C1856719	Disease or Syndrome	0.4	0.53	0.862	disease
KNG1	3827	High molecular weight kininogen deficiency	C0272340	Disease or Syndrome	0.64	0.53	0.862	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types