Plasma kallikrein

AltitudeomicsDB
Protein Official symbol KLKB1
Aliases KLKB1 KLK3
Chromosomal Location 4
Length 638
Uniprot ID P03952
EC number 3.4.21.34
Protein family Information(Pfam) PF00024;PF00089;
PDB id 2ANW;2ANY;4OGX;4OGY;5F8T;5F8X;5F8Z;5TJX;6I44;6O1G;6O1S;
InterPro ID IPR000177;IPR003609;IPR009003;IPR001314;IPR001254;IPR018114;IPR033116;
dbSNP rs121964952 rs3733402 rs4253257 rs4253373 rs145640112 rs2278542 rs4253376 rs4253377 rs4253379 rs4253301 rs4253316 rs121964951 rs4253325

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
KNG1 KLKB1 0.995
GP1BB GP1BA 0.991
KNG1 F12 0.985
SERPING1 KNG1 0.979
SERPING1 KLKB1 0.975
SERPING1 F12 0.974
KLKB1 F12 0.974
A2M SERPING1 0.969
A2M KLKB1 0.966
KNG1 C1QBP 0.964
PRCP KLKB1 0.963
A2M KNG1 0.958
GP1BA F12 0.957
PRCP KNG1 0.956
MMP1 MMP3 0.953
GP1BA KNG1 0.946
PRCP C1QBP 0.938
A2M MMP1 0.932
KLKB1 C1QBP 0.93
F12 C1QBP 0.928
A2M MMP3 0.926
SERPING1 C1QBP 0.923
MMP1 KLKB1 0.92
MMP3 KLKB1 0.917
GP1BB F12 0.916
GP1BB KLKB1 0.915
GP1BA KLKB1 0.912
GP1BA C1QBP 0.909
GP1BB KNG1 0.904
A2M C1QBP 0.901
GP1BB C1QBP 0.9
A2M F12 0.551
Gene Ontology Semantic Similarity
Download Tab separated file
# 3818 (KLKB1) 2811 (GP1BA) 2161 (F12) 3827 (KNG1) 710 (SERPING1) 708 (C1QBP) 4314 (MMP3) 4312 (MMP1) 2812 (GP1BB) 2 (A2M) 5547 (PRCP)
3818 (KLKB1) 1.00 0.56 0.96 0.53 0.56 0.54 0.84 0.70 0.62 0.63 0.72
2811 (GP1BA) 0.56 1.00 0.61 0.53 0.56 0.54 0.38 0.13 0.85 0.63 0.47
2161 (F12) 0.96 0.61 1.00 0.56 0.61 0.56 0.84 0.60 0.65 0.64 0.73
3827 (KNG1) 0.53 0.53 0.56 1.00 0.72 0.56 0.41 0.12 0.57 0.72 0.48
710 (SERPING1) 0.56 0.56 0.61 0.72 1.00 0.54 0.38 0.13 0.62 0.77 0.47
708 (C1QBP) 0.54 0.54 0.56 0.56 0.54 1.00 0.46 0.11 0.57 0.60 0.51
4314 (MMP3) 0.84 0.38 0.84 0.41 0.38 0.46 1.00 0.87 0.44 0.54 0.66
4312 (MMP1) 0.70 0.13 0.60 0.12 0.13 0.11 0.87 1.00 0.13 0.11 0.48
2812 (GP1BB) 0.62 0.85 0.65 0.57 0.62 0.57 0.44 0.13 1.00 0.64 0.53
2 (A2M) 0.63 0.63 0.64 0.72 0.77 0.60 0.54 0.11 0.64 1.00 0.59
5547 (PRCP) 0.72 0.47 0.73 0.48 0.47 0.51 0.66 0.48 0.53 0.59 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
KLKB1 Human Peripheral venous blood - 4875 m 9 hours upregulated 1.4 LTQ-XL Mass Spectrometry Western US Americans 1 Men and women living near Denver, Colorado (1,609 m) 24265281
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
3818 GO:0006508 proteolysis GOTERM_BP_DIRECT
3818 GO:0020037 heme binding GOTERM_MF_DIRECT
3818 GO:0002542 Factor XII activation GOTERM_BP_DIRECT
3818 GO:0031638 zymogen activation GOTERM_BP_DIRECT
3818 GO:0042730 fibrinolysis GOTERM_BP_DIRECT
3818 GO:0005515 protein binding GOTERM_MF_DIRECT
3818 GO:0005576 extracellular region GOTERM_CC_DIRECT
3818 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
3818 GO:0005886 plasma membrane GOTERM_CC_DIRECT
3818 GO:0004497 monooxygenase activity GOTERM_MF_DIRECT
3818 GO:0016705 oxidoreductase activity GOTERM_MF_DIRECT
3818 GO:0022617 extracellular matrix disassembly GOTERM_BP_DIRECT
3818 GO:0031639 plasminogen activation GOTERM_BP_DIRECT
3818 GO:0004252 serine-type endopeptidase activity GOTERM_MF_DIRECT
3818 GO:0005506 iron ion binding GOTERM_MF_DIRECT
3818 GO:0007597 blood coagulation GOTERM_BP_DIRECT
3818 GO:0005615 extracellular space GOTERM_CC_DIRECT
3818 GO:0051919 positive regulation of fibrinolysis GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
3818 hsa04610 Complement and coagulation cascades
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
KLKB1 3818 External Carotid Artery Thrombosis C0750989 Disease or Syndrome 0.3 0.663 0.448 disease
KLKB1 3818 Pulmonary Embolism C0034065 Disease or Syndrome 0.3 0.663 0.448 disease
KLKB1 3818 Thrombus C0087086 Pathologic Function 0.3 0.663 0.448 phenotype
KLKB1 3818 Carotid Artery Thrombosis C0007274 Disease or Syndrome 0.3 0.663 0.448 disease
KLKB1 3818 Pulmonary Thromboembolisms C0524702 Disease or Syndrome 0.3 0.663 0.448 disease
KLKB1 3818 Thrombosis C0040053 Pathologic Function 0.3 0.663 0.448 phenotype
KLKB1 3818 Common Carotid Artery Thrombosis C0750988 Disease or Syndrome 0.3 0.663 0.448 disease
KLKB1 3818 Internal Carotid Artery Thrombosis C0750990 Disease or Syndrome 0.3 0.663 0.448 disease
KLKB1 3818 Prekallikrein deficiency C0272339 Disease or Syndrome 0.72 0.663 0.448 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
KLKB1 3818 ANTITHROMBIN None None None
KLKB1 3818 BCX4161 None None None
KLKB1 3818 COMPOUND 11 [PMID: 16413183] None None inhibitor
KLKB1 3818 ECALLANTIDE ECALLANTIDE CHEMBL1201837 inhibitor