ALTITUDEOMICSDB

Alpha-2-macroglobulin

AltitudeomicsDB

Protein Official symbol	A2M
Aliases	A2M CPAMD5 FWP007
Chromosomal Location	12
Length	1474
Uniprot ID	P01023
EC number	None
Protein family Information(Pfam)	PF00207;PF07703;PF07677;PF01835;PF17791;PF17789;PF07678;
PDB id	1BV8;2P9R;4ACQ;
InterPro ID	IPR009048;IPR036595;IPR011625;IPR041813;IPR011626;IPR013783;IPR014756;IPR001599;IPR019742;IPR002890;IPR041555;IPR040839;IPR008930;IPR010916;
dbSNP	rs226405 rs1800434 rs3180392 rs1800433 rs669

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
FGA	FGB	0.999
FGG	FGB	0.999
FGG	FGA	0.999
AHSG	ALB	0.998
PLG	SERPINE1	0.997
F8	VWF	0.996
AHSG	APOA1	0.996
ORM2	ORM1	0.995
MMP9	TIMP1	0.995
KNG1	KLKB1	0.993
VEGFA	TGFB1	0.993
VEGFA	EGF	0.993
SERPINF2	PLG	0.993
VEGFA	IGF1	0.993
SERPINA1	A2M	0.992
VEGFA	HGF	0.992
IGF1	EGF	0.992
AHSG	FGG	0.991
ALB	APOA1	0.99
AHSG	FGA	0.989
ORM2	AHSG	0.989
FN1	ALB	0.989
VEGFA	MMP9	0.989
VEGFA	FN1	0.988
FN1	EGF	0.988
PLG	HRG	0.988
AHSG	HRG	0.987
AHSG	ORM1	0.986
VEGFA	ALB	0.986
VEGFA	VWF	0.986
MMP9	PLG	0.986
FGA	HRG	0.985
FN1	TGFB1	0.985
FGG	APOA1	0.984
VEGFA	THBS1	0.984
EGF	HGF	0.984
FGG	HRG	0.983
SERPINA1	ALB	0.983
PLG	VWF	0.983
FGB	HRG	0.982
VEGFA	SERPINE1	0.982
FGA	ALB	0.982
CLU	APP	0.98
FN1	VWF	0.98
VEGFA	IGF2	0.98
FGG	ALB	0.98
A2M	SERPINF2	0.98
PF4	PPBP	0.98
TGFB1	TIMP1	0.98
ALB	ORM1	0.98
PLG	FGA	0.98
ALB	EGF	0.98
ALB	SERPINE1	0.979
ALB	HGF	0.979
SERPINE1	TGFB1	0.979
FN1	SERPINE1	0.979
SERPING1	KNG1	0.979
FN1	PLG	0.979
PLG	FGB	0.979
VEGFA	MMP2	0.979
THBS1	TIMP1	0.978
VWF	THBS1	0.978
PLG	ALB	0.978
FGG	PLG	0.978
EGF	SERPINE1	0.978
IGF1	HGF	0.978
FGA	APOA1	0.978
VWF	SERPINE1	0.978
TGFB2	FN1	0.976
SERPINA1	ORM1	0.976
SERPINE1	TIMP1	0.974
EGF	TIMP1	0.974
PLG	KNG1	0.974
IGF1	ALB	0.974
A2M	ALB	0.974
FN1	SPARC	0.974
SERPINA1	AHSG	0.974
VEGFA	PF4	0.973
AHSG	FGB	0.973
THBS1	HGF	0.973
VEGFA	KNG1	0.973
VEGFA	TIMP1	0.973
ALB	VWF	0.973
EGF	THBS1	0.972
FGG	ORM1	0.972
SERPING1	KLKB1	0.972
FN1	THBS1	0.972
FN1	TIMP1	0.972
ALB	KNG1	0.971
THBS1	TGFB1	0.971
A2M	PLG	0.971
SERPINE1	HGF	0.971
KNG1	HRG	0.971
ORM2	ALB	0.97
SERPINA1	APOA1	0.97
FGA	ORM1	0.97
EGF	KNG1	0.97
HGF	TGFB1	0.97
IGF1	SERPINE1	0.97
VEGFA	PLG	0.969
KNG1	SERPINE1	0.969
FGB	ALB	0.969
PLG	TIMP1	0.969
A2M	SERPING1	0.969
THBS1	SERPINE1	0.969
SERPINA1	PLG	0.969
IGF1	TGFB1	0.969
A2M	APOA1	0.968
FN1	IGF1	0.968
FN1	HGF	0.968
PF4	VWF	0.967
FN1	TGFB3	0.967
PLG	MMP3	0.967
ORM2	FGA	0.967
F8	PLG	0.966
A2M	KLKB1	0.966
PPBP	VWF	0.966
SERPINA1	ORM2	0.965
FGB	ORM1	0.965
EGF	VWF	0.965
IGF2	EGF	0.965
ALB	APP	0.965
EGF	TGFB1	0.965
PLG	EGF	0.964
CLU	IGF1	0.964
MMP9	MMP8	0.964
ORM1	HRG	0.963
SERPINF2	ALB	0.962
TGFB3	SERPINE1	0.962
ORM2	FGG	0.962
SERPINF2	FGA	0.961
CLU	EGF	0.961
AHSG	KNG1	0.961
FGG	SERPINF2	0.961
SERPINF2	HRG	0.961
A2M	ORM1	0.961
MMP9	MMP1	0.961
IGF1	MMP2	0.96
MMP1	PLG	0.96
AHSG	A2M	0.96
MMP9	MMP3	0.959
THBS1	HRG	0.959
MMP9	THBS1	0.959
ALB	TGFB1	0.959
CLU	ALB	0.958
A2M	KNG1	0.958
F8	ALB	0.958
AHSG	PLG	0.958
IGF2	ALB	0.958
PLG	THBS1	0.958
AHSG	MMRN1	0.957
MMP1	TIMP1	0.957
FN1	A2M	0.957
HGF	TIMP1	0.957
ORM2	HRG	0.957
PLG	PPBP	0.957
AHSG	A1BG	0.957
SERPINA1	FGA	0.957
MMP2	TIMP1	0.957
AHSG	SERPINF2	0.957
THBS1	SPARC	0.957
PLG	IGF1	0.956
SERPINF2	VWF	0.956
FGB	F13A1	0.956
ALB	TIMP1	0.956
FGA	F13A1	0.956
SERPINF2	PPBP	0.956
ORM2	FGB	0.955
PLG	TGFB1	0.955
SERPINA1	FGG	0.955
PF4	THBS1	0.955
A2M	CLU	0.955
SERPINA1	TGFB1	0.954
F8	SERPINE1	0.954
SERPINA1	KNG1	0.954
PLG	SERPING1	0.954
PLG	PF4	0.954
PLG	MMP8	0.954
FGG	KNG1	0.953
MMP1	MMP3	0.953
VEGFA	TGFB2	0.953
IGF1	TIMP1	0.953
IGF2	FN1	0.953
CFD	SERPINE1	0.952
SERPINF2	FGB	0.952
TGFB2	EGF	0.952
FN1	PF4	0.952
A2M	HRG	0.952
SERPINF2	PF4	0.952
A2M	VWF	0.952
FGG	F13A1	0.952
MMP12	PLG	0.952
SERPINA1	CLU	0.951
VEGFA	SPARC	0.951
KNG1	APOA1	0.951
SERPINA1	HRG	0.951
IGF1	VWF	0.951
ORM2	A2M	0.951
TGFB2	IGF1	0.951
A2M	IGF1	0.951
PPBP	SERPINE1	0.951
KNG1	VWF	0.951
SERPINA1	FGB	0.951
FN1	KNG1	0.95
F13A1	VWF	0.95
A2M	FGA	0.95
FGG	A2M	0.95
A2M	APP	0.95
HRG	SERPINE1	0.95
ALB	SPARC	0.95
IGF2	HGF	0.95
SERPINF2	KNG1	0.95
IGF1	APP	0.95
SERPINA1	A1BG	0.95
IGF1	TGFB3	0.949
SERPINA1	FN1	0.949
APP	EGF	0.949
SERPINA1	SERPINF2	0.949
THBS1	MMP2	0.949
PLG	MMP13	0.949
FGA	KNG1	0.948
VWF	HGF	0.948
A2M	TIMP1	0.948
TGFB2	THBS1	0.947
FGB	KNG1	0.947
A2M	FGB	0.947
SPARC	TIMP1	0.947
CLU	SERPING1	0.947
VWF	TIMP1	0.947
SERPINF2	ORM1	0.946
EGF	SPARC	0.946
TGFB2	SERPINE1	0.946
FN1	APP	0.946
F8	SERPINF2	0.946
IGF2	TGFB1	0.946
AHSG	CLU	0.946
PF4	SERPINE1	0.946
ALB	HRG	0.946
MMP1	IGF1	0.945
PROS1	HRG	0.945
FN1	CLU	0.945
SPARC	MMP2	0.945
IGF2	MMP2	0.945
A1BG	HRG	0.945
SERPINA1	F5	0.945
VEGFA	F13A1	0.944
CFD	SERPING1	0.944
PF4	HRG	0.944
F5	PLG	0.944
MMP9	PPBP	0.944
ALB	A1BG	0.943
VEGFA	APP	0.943
PROS1	ALB	0.943
PROS1	FGB	0.943
SERPINA1	PROS1	0.943
PROS1	F5	0.943
CLU	TIMP1	0.943
ORM2	SERPINF2	0.943
IGF1	THBS1	0.943
EGF	TGFB3	0.943
ACTN1	FN1	0.942
FGA	VWF	0.942
PF4	ALB	0.942
ALB	THBS1	0.942
PROS1	A2M	0.942
AHSG	SPARC	0.942
PLG	ACTN4	0.942
PROS1	FGG	0.942
A2M	A1BG	0.941
IGF1	SPARC	0.941
VEGFA	TGFB3	0.941
VWF	SPARC	0.941
VEGFA	CLU	0.941
FN1	SERPINF2	0.941
IGF2	TGFB2	0.941
TGFB2	TIMP1	0.941
F5	F13A1	0.941
FN1	PPBP	0.941
SPARC	TGFB1	0.941
PF4	TIMP1	0.941
VEGFA	PPBP	0.94
F5	SERPINE1	0.94
A2M	SERPINE1	0.94
APP	KNG1	0.94
TGFB2	SRGN	0.94
ORM2	A1BG	0.94
SERPINA1	TIMP1	0.94
FGB	SERPINE1	0.94
A1BG	ORM1	0.94
KNG1	ORM1	0.94
KNG1	A1BG	0.94
SRGN	SERPINE1	0.94
PROS1	FGA	0.939
PF4	EGF	0.939
F8	FN1	0.939
FN1	APOA1	0.939
F5	VWF	0.939
MMRN1	VWF	0.939
F5	FGA	0.939
F8	PPBP	0.938
VEGFA	F8	0.938
TGFB3	TIMP1	0.938
ALB	SERPING1	0.938
ALB	ACTN4	0.938
FN1	HRG	0.937
SERPINA1	VWF	0.937
TGFB2	A2M	0.936
PROS1	PLG	0.936
SERPINF2	SERPINE1	0.936
CLU	KNG1	0.936
AHSG	FN1	0.936
MMRN1	F5	0.936
A2M	MMP2	0.936
PPBP	THBS1	0.935
PPBP	EGF	0.935
SERPING1	VWF	0.935
FN1	FGA	0.935
FN1	ACTN4	0.935
CLU	HRG	0.935
F5	FGG	0.935
A2M	TGFB1	0.935
PLG	APP	0.935
ORM2	KNG1	0.935
F5	KNG1	0.935
AHSG	PROS1	0.934
SERPINA1	SERPING1	0.934
CLU	TGFB1	0.934
AHSG	F13A1	0.934
IGF2	PLG	0.934
IGF2	TIMP1	0.934
CLU	A1BG	0.934
SPARC	SERPINE1	0.934
FGG	VWF	0.934
PF4	F13A1	0.934
SPARC	HGF	0.934
PPBP	ALB	0.933
IGF2	TGFB3	0.933
VEGFA	SERPINA1	0.933
F5	FGB	0.933
APP	APOA1	0.933
PROS1	SERPINF2	0.933
AHSG	IGF1	0.933
PROS1	FN1	0.933
TGFB2	SPARC	0.933
PPBP	TIMP1	0.933
AHSG	SERPINE1	0.932
FGB	VWF	0.932
PF4	SRGN	0.932
PPBP	F13A1	0.932
FGG	A1BG	0.932
THBS1	TGFB3	0.932
APOA1	TIMP1	0.932
SERPINA1	F8	0.932
VWF	TGFB1	0.932
A2M	MMP1	0.932
CLU	THBS1	0.932
MMP9	A2M	0.932
SERPINF2	CLU	0.931
F5	APOA1	0.931
VEGFA	HRG	0.931
AHSG	SERPING1	0.931
CLU	PLG	0.931
CLU	SPARC	0.931
IGF2	SERPINE1	0.931
F8	KNG1	0.931
PF4	TGFB1	0.93
FN1	FGG	0.93
A2M	EGF	0.93
PROS1	F13A1	0.93
F5	A2M	0.93
F8	EGF	0.93
A2M	SPARC	0.93
SERPINA1	HGF	0.93
FN1	F13A1	0.93
SERPINA1	EGF	0.93
FN1	FGB	0.93
IGF1	KNG1	0.93
IGF2	APP	0.93
FGG	SERPING1	0.93
F8	F13A1	0.93
FGG	SERPINE1	0.929
IGF1	PF4	0.929
PF4	HGF	0.929
EGF	A1BG	0.929
PROS1	KNG1	0.929
CLU	ORM1	0.929
SERPINF2	SERPING1	0.929
PLG	SPARC	0.929
F5	ALB	0.929
IGF2	THBS1	0.929
CFD	ALB	0.929
FGB	A1BG	0.929
MMRN1	PF4	0.929
PPBP	SRGN	0.929
FGA	A1BG	0.929
PLG	ORM1	0.928
PROS1	SERPINE1	0.928
PPBP	MMP8	0.928
SERPING1	TIMP1	0.928
SERPINF2	F13A1	0.928
IGF2	SPARC	0.928
SERPING1	ORM1	0.928
F5	ORM1	0.927
F8	PF4	0.927
AHSG	IGF2	0.927
ORM2	F5	0.927
SERPINA1	IGF1	0.927
PROS1	VWF	0.927
SERPING1	F13A1	0.927
VWF	HRG	0.927
F8	A2M	0.927
FN1	SERPING1	0.927
FGA	TGFB3	0.926
FGA	PF4	0.926
FGG	CLU	0.926
MMRN1	F13A1	0.926
PROS1	SERPING1	0.926
FN1	SRGN	0.926
F13A1	SERPINE1	0.926
MMRN1	SRGN	0.926
A2M	MMP3	0.926
TGFB2	HGF	0.926
PROS1	F8	0.926
A2M	PPBP	0.926
ORM2	CLU	0.926
FGA	SERPING1	0.926
F5	SERPINF2	0.926
PF4	KNG1	0.926
TGFB2	APP	0.926
PPBP	SERPING1	0.926
CLU	VWF	0.926
VEGFA	A2M	0.926
APP	TIMP1	0.926
FGA	SERPINE1	0.926
CLU	FGA	0.925
SERPINA1	APP	0.925
ORM2	PLG	0.925
F13A1	ORM1	0.925
IGF2	MMP1	0.925
CFD	SPARC	0.925
FGA	PPBP	0.925
APP	VWF	0.925
CFD	IGF1	0.925
ALB	TGFB3	0.925
APP	TGFB1	0.925
CLU	SERPINE1	0.925
IGF2	A2M	0.924
SERPING1	SERPINE1	0.924
F5	EGF	0.924
F13A1	SRGN	0.924
F8	FGG	0.923
PPBP	HGF	0.923
MMP3	MMP2	0.923
A1BG	HGF	0.923
PROS1	ORM1	0.923
VEGFA	CFD	0.923
VWF	TGFB3	0.923
FGB	SERPING1	0.923
TGFB3	SPARC	0.923
VEGFA	ACTN4	0.923
TGFB2	PLG	0.923
SERPINA1	PPBP	0.923
KNG1	F13A1	0.923
IGF2	FGA	0.923
F5	PF4	0.923
IGF2	CLU	0.922
A2M	F13A1	0.922
TGFB2	ALB	0.922
TGFB2	FGA	0.922
IGF2	IGF1	0.922
AHSG	HGF	0.922
PLG	F13A1	0.922
CFD	CLU	0.922
ACTN1	TGFB1	0.922
PPBP	KNG1	0.922
TGFB3	HGF	0.922
MMP1	MMP2	0.922
F13A1	TGFB3	0.922
F5	FN1	0.921
PPBP	TGFB1	0.921
SRGN	HGF	0.921
PPBP	HRG	0.921
APP	SERPINE1	0.921
PF4	SERPING1	0.921
FGA	THBS1	0.921
AHSG	F5	0.921
TGFB2	CLU	0.921
KNG1	TGFB1	0.921
KNG1	TIMP1	0.921
VEGFA	F5	0.921
MMP1	KLKB1	0.92
SERPINA1	F13A1	0.92
ACTN1	THBS1	0.92
AHSG	TIMP1	0.92
EGF	ACTN4	0.919
VEGFA	AHSG	0.919
FGG	EGF	0.919
PF4	SPARC	0.919
SERPING1	THBS1	0.919
A2M	THBS1	0.919
MMRN1	PPBP	0.919
IGF1	F13A1	0.919
MMP9	MMP13	0.919
CLU	FGB	0.919
KNG1	HGF	0.919
MMRN1	THBS1	0.919
ACTN1	EGF	0.919
APP	SPARC	0.919
APP	THBS1	0.919
VEGFA	SERPING1	0.919
SERPINA1	SERPINE1	0.919
IGF1	A1BG	0.919
F8	SERPING1	0.919
CFD	TIMP1	0.918
SERPINF2	A1BG	0.918
SERPING1	SPARC	0.918
F8	THBS1	0.918
IGF1	ACTN4	0.918
A2M	SRGN	0.918
SERPINA1	PF4	0.918
A2M	TGFB3	0.918
FGB	THBS1	0.918
ORM1	MMP8	0.918
SERPING1	A1BG	0.918
THBS1	SRGN	0.918
IGF2	FGB	0.918
PROS1	APP	0.918
IGF1	PPBP	0.918
VEGFA	PROS1	0.918
ACTN1	IGF1	0.918
FGA	TGFB1	0.918
KNG1	THBS1	0.918
F13A1	THBS1	0.918
SERPINA1	THBS1	0.918
VEGFA	SERPINF2	0.917
IGF2	VWF	0.917
VEGFA	SRGN	0.917
ACTN1	ALB	0.917
APP	TGFB3	0.917
ALB	SRGN	0.917
A2M	PF4	0.917
PROS1	CLU	0.917
SERPINF2	TIMP1	0.917
SERPINF2	APP	0.917
IGF2	CFD	0.917
FN1	A1BG	0.917
MMP3	KLKB1	0.917
CLU	PF4	0.916
SERPINA1	IGF2	0.916
IGF2	FGG	0.916
A2M	HGF	0.916
PLG	SRGN	0.916
MMRN1	CLU	0.916
CLU	PPBP	0.916
SERPING1	HRG	0.916
PLG	A1BG	0.916
MMP9	ORM1	0.916
CLU	HGF	0.916
ACTN1	TGFB2	0.915
MMRN1	FGB	0.915
F8	IGF1	0.915
EGF	HRG	0.915
TGFB2	VWF	0.915
CFD	VWF	0.915
AHSG	EGF	0.915
A2M	MMP8	0.915
F8	FGA	0.915
AHSG	THBS1	0.915
ORM2	SERPING1	0.915
PROS1	IGF1	0.915
CFD	PF4	0.915
FGB	EGF	0.915
FGA	EGF	0.915
FGA	APP	0.915
IGF2	ACTN4	0.915
CFD	EGF	0.915
EGF	SRGN	0.915
ACTN1	SERPINE1	0.915
VEGFA	A1BG	0.915
ACTN4	SERPINE1	0.915
PLG	TGFB3	0.915
A2M	MMP13	0.914
MMRN1	KNG1	0.914
PROS1	EGF	0.914
PROS1	THBS1	0.914
FN1	CFD	0.914
FGB	IGF1	0.914
ACTN1	CLU	0.914
AHSG	CFD	0.914
EGF	F13A1	0.914
APP	SERPING1	0.914
MMRN1	F8	0.914
MMP12	A2M	0.914
F5	F8	0.914
SERPINA1	CFD	0.914
SRGN	TIMP1	0.914
MMRN1	FN1	0.913
ORM2	CFD	0.913
FN1	ORM1	0.913
FGA	IGF1	0.913
VWF	SRGN	0.913
PROS1	SPARC	0.913
TGFB2	PF4	0.913
F5	SERPING1	0.913
F5	HRG	0.913
ACTN1	A2M	0.913
F5	A1BG	0.913
AHSG	APP	0.913
MMRN1	A2M	0.913
F8	FGB	0.913
SRGN	TGFB1	0.913
PROS1	ACTN4	0.913
A2M	ACTN4	0.913
ORM2	TIMP1	0.912
FGB	TGFB1	0.912
IGF1	SERPING1	0.912
PLG	HGF	0.912
MMRN1	HRG	0.912
ALB	F13A1	0.912
PROS1	A1BG	0.912
F13A1	TGFB1	0.912
ORM2	PROS1	0.912
AHSG	VWF	0.912
F8	HGF	0.912
CFD	A2M	0.912
CLU	SRGN	0.912
IGF2	SERPINF2	0.912
AHSG	PF4	0.912
PROS1	TGFB2	0.911
SERPINA1	SRGN	0.911
F5	PPBP	0.911
IGF2	KNG1	0.911
ORM1	SERPINE1	0.911
MMP3	TIMP1	0.911
PROS1	TIMP1	0.911
FGG	THBS1	0.911
CFD	ORM1	0.911
AHSG	TGFB1	0.911
MMP13	MMP2	0.911
MMRN1	SERPINF2	0.911
F13A1	TIMP1	0.911
ACTN1	SPARC	0.911
TGFB2	PPBP	0.91
TGFB2	TGFB3	0.91
VEGFA	ACTN1	0.91
SERPING1	SRGN	0.91
CFD	SRGN	0.91
MMP3	MMP13	0.91
APP	HRG	0.91
IGF2	PF4	0.91
CFD	TGFB1	0.91
MMRN1	EGF	0.91
PF4	APP	0.91
CFD	KNG1	0.91
SERPINF2	EGF	0.91
ORM1	TIMP1	0.91
MMRN1	ALB	0.91
CFD	PPBP	0.91
CFD	APP	0.91
ACTN1	TIMP1	0.91
SERPING1	TGFB1	0.91
PPBP	SPARC	0.91
IGF2	PROS1	0.909
VEGFA	FGA	0.909
SERPING1	TGFB3	0.909
MMP1	MMP13	0.909
FGG	APP	0.909
ACTN4	TGFB1	0.909
ACTN4	SPARC	0.909
THBS1	ACTN4	0.909
IGF2	SERPING1	0.909
PPBP	TGFB3	0.909
MMRN1	PROS1	0.909
FGG	IGF1	0.909
SERPINF2	TGFB1	0.909
MMP9	MMP2	0.908
APP	SRGN	0.908
ACTN1	APP	0.908
CLU	TGFB3	0.908
SERPINF2	THBS1	0.908
PROS1	TGFB1	0.908
MMRN1	SERPING1	0.908
APP	HGF	0.908
FGB	APP	0.908
THBS1	ORM1	0.908
ACTN1	F13A1	0.908
F5	THBS1	0.908
IGF1	ORM1	0.908
ACTN1	ACTN4	0.908
MMRN1	PLG	0.908
F5	SRGN	0.908
APP	ACTN4	0.908
IGF2	ORM1	0.907
ACTN1	PF4	0.907
ORM2	IGF2	0.907
SERPINF2	HGF	0.907
KNG1	SPARC	0.907
CLU	F13A1	0.907
SERPINF2	IGF1	0.907
SERPINA1	ACTN1	0.907
F5	TGFB1	0.907
CFD	A1BG	0.907
CFD	PLG	0.907
CFD	F13A1	0.907
VEGFA	FGB	0.907
ACTN1	PPBP	0.907
SERPING1	EGF	0.907
VEGFA	FGG	0.907
F13A1	ACTN4	0.907
PROS1	PF4	0.907
VEGFA	ORM1	0.907
PROS1	PPBP	0.907
PF4	TGFB3	0.907
TGFB2	TGFB1	0.907
F13A1	HRG	0.907
KNG1	ACTN4	0.907
AHSG	PPBP	0.907
ACTN4	TIMP1	0.907
F5	HGF	0.907
F5	CLU	0.907
IGF2	A1BG	0.907
F8	TIMP1	0.906
ACTN1	F5	0.906
ACTN1	FGA	0.906
ORM2	F13A1	0.906
TGFB2	ACTN4	0.906
TGFB3	TGFB1	0.906
APP	ORM1	0.906
ORM2	APP	0.906
MMRN1	TGFB1	0.906
F8	HRG	0.906
IGF2	ACTN1	0.906
KNG1	TGFB3	0.906
F8	TGFB1	0.906
MMRN1	CFD	0.906
MMRN1	ACTN1	0.906
PROS1	SRGN	0.906
KNG1	SRGN	0.906
ACTN1	SERPINF2	0.906
F8	APP	0.906
HRG	HGF	0.906
HRG	SPARC	0.906
CLU	APOA1	0.906
SERPINA1	TGFB2	0.906
CFD	FGA	0.905
TGFB2	SERPING1	0.905
IGF2	PPBP	0.905
FGB	TIMP1	0.905
ORM2	MMRN1	0.905
F13A1	SPARC	0.905
ORM2	MMP8	0.905
FGA	TIMP1	0.905
ORM1	HGF	0.905
FGG	TGFB3	0.905
F5	TGFB3	0.905
IGF2	SRGN	0.905
CFD	THBS1	0.905
PROS1	CFD	0.905
F8	SRGN	0.905
SERPINA1	TGFB3	0.905
SERPINA1	ACTN4	0.905
MMRN1	ORM1	0.905
SERPINA1	SPARC	0.905
PF4	ORM1	0.905
FGG	TIMP1	0.905
VEGFA	MMRN1	0.905
TGFB2	FGB	0.905
ACTN1	PROS1	0.905
CFD	HGF	0.905
ACTN1	FGB	0.905
HRG	TIMP1	0.905
CFD	FGB	0.905
F13A1	HGF	0.905
A1BG	THBS1	0.905
ORM2	SERPINE1	0.904
MMRN1	SPARC	0.904
FGG	PPBP	0.904
F5	SPARC	0.904
SERPING1	HGF	0.904
IGF2	F13A1	0.904
ACTN1	VWF	0.904
MMRN1	APP	0.904
PROS1	HGF	0.904
F13A1	A1BG	0.904
SRGN	SPARC	0.904
FGB	TGFB3	0.904
F5	IGF1	0.904
ACTN1	F8	0.904
ACTN1	KNG1	0.904
PPBP	APP	0.904
EGF	ORM1	0.904
PROS1	TGFB3	0.904
ACTN1	TGFB3	0.904
FGA	ACTN4	0.904
CFD	SERPINF2	0.904
ORM2	HGF	0.904
VWF	ORM1	0.904
IGF1	HRG	0.903
FGB	SPARC	0.903
AHSG	F8	0.903
F8	TGFB3	0.903
CLU	ACTN4	0.903
MMRN1	TIMP1	0.903
FGG	TGFB1	0.903
A1BG	TIMP1	0.903
SERPINF2	SRGN	0.903
APP	A1BG	0.903
ORM1	SRGN	0.903
SERPINF2	ACTN4	0.903
MMRN1	HGF	0.903
FGG	SPARC	0.903
PF4	A1BG	0.903
SERPINA1	MMRN1	0.903
ORM2	SRGN	0.903
ORM2	PF4	0.903
F5	APP	0.903
ORM2	FN1	0.903
F8	CLU	0.903
MMRN1	TGFB2	0.903
FGG	CFD	0.903
PPBP	A1BG	0.902
IGF2	F5	0.902
SERPINF2	TGFB3	0.902
ORM2	IGF1	0.902
MMRN1	SERPINE1	0.902
AHSG	TGFB2	0.902
MMRN1	IGF1	0.902
F8	SPARC	0.902
TGFB2	F8	0.902
FGG	HGF	0.902
TGFB2	SERPINF2	0.902
F5	TGFB2	0.902
FGB	HGF	0.902
IGF2	HRG	0.902
PF4	ACTN4	0.902
ORM1	ACTN4	0.902
FGB	PPBP	0.902
MMRN1	TGFB3	0.902
FGB	SRGN	0.902
ACTN1	PLG	0.902
SRGN	TGFB3	0.902
A1BG	SERPINE1	0.902
TGFB2	KNG1	0.902
SERPING1	ACTN4	0.902
TGFB2	F13A1	0.902
FGA	HGF	0.902
ACTN1	SERPING1	0.902
CFD	HRG	0.902
MMRN1	ACTN4	0.902
FGA	SPARC	0.902
VWF	ACTN4	0.902
ACTN4	HRG	0.902
APP	F13A1	0.901
TGFB2	CFD	0.901
F8	ACTN4	0.901
F8	CFD	0.901
ORM2	TGFB2	0.901
ACTN1	HGF	0.901
AHSG	ACTN1	0.901
ACTN1	ORM1	0.901
ORM1	TGFB1	0.901
AHSG	SRGN	0.901
VEGFA	ORM2	0.901
ACTN1	SRGN	0.901
A1BG	SPARC	0.901
A1BG	ACTN4	0.901
PPBP	ORM1	0.901
ORM2	VWF	0.901
ACTN4	HGF	0.901
A1BG	TGFB1	0.901
TGFB2	ORM1	0.9
ORM2	F8	0.9
MMRN1	FGG	0.9
FGB	PF4	0.9
FGG	PF4	0.9
A1BG	SRGN	0.9
ORM2	PPBP	0.9
TGFB3	HRG	0.9
ACTN1	A1BG	0.9
PPBP	ACTN4	0.9
F5	CFD	0.9
TGFB2	FGG	0.9
ACTN4	TGFB3	0.9
IGF2	F8	0.9
IGF1	SRGN	0.9
ORM1	SPARC	0.9
ACTN4	SRGN	0.9
ORM2	ACTN4	0.9
CFD	ACTN4	0.9
F8	ORM1	0.9
F5	TIMP1	0.9
CFD	TGFB3	0.9
SERPINF2	SPARC	0.9
A1BG	TGFB3	0.9
HRG	TGFB1	0.9
MMRN1	A1BG	0.9
A1BG	VWF	0.9
FGB	ACTN4	0.9
AHSG	ACTN4	0.9
TGFB2	A1BG	0.9
ORM2	ACTN1	0.9
ORM2	TGFB1	0.9
AHSG	TGFB3	0.9
F5	ACTN4	0.9
F8	A1BG	0.9
ORM2	TGFB3	0.9
FGG	SRGN	0.9
ACTN1	FGG	0.9
MMRN1	FGA	0.9
ACTN1	HRG	0.9
FGG	ACTN4	0.9
ORM1	TGFB3	0.9
ORM2	EGF	0.9
TGFB2	HRG	0.9
ORM2	SPARC	0.9
SRGN	HRG	0.9
ORM2	THBS1	0.9
FGA	SRGN	0.9
ACTN1	CFD	0.9
IGF2	MMRN1	0.9

Gene Ontology Semantic Similarity

Download Tab separated file

#	2243 (FGA)	2266 (FGG)	197 (AHSG)	5340 (PLG)	2157 (F8)	4318 (MMP9)	3827 (KNG1)	7422 (VEGFA)	5345 (SERPINF2)	5265 (SERPINA1)	3479 (IGF1)	213 (ALB)	2335 (FN1)	1950 (EGF)	2244 (FGB)	1191 (CLU)	2 (A2M)	5196 (PF4)	7040 (TGFB1)	5054 (SERPINE1)	710 (SERPING1)	7057 (THBS1)	7450 (VWF)	7042 (TGFB2)	3082 (HGF)	5473 (PPBP)	3481 (IGF2)	5004 (ORM1)	7043 (TGFB3)	4312 (MMP1)	4313 (MMP2)	1675 (CFD)	4321 (MMP12)	2162 (F13A1)	3273 (HRG)	351 (APP)	6678 (SPARC)	5627 (PROS1)	1 (A1BG)	2153 (F5)	87 (ACTN1)	5552 (SRGN)	22915 (MMRN1)	335 (APOA1)	4314 (MMP3)	81 (ACTN4)	4322 (MMP13)	7076 (TIMP1)	3818 (KLKB1)	4317 (MMP8)
2243 (FGA)	1.00	1.00	0.20	0.66	1.00	0.52	0.62	0.67	0.58	0.66	0.73	0.60	0.77	0.54	0.98	0.68	0.67	0.63	0.71	0.70	0.63	0.69	0.80	0.71	0.56	0.62	0.67	1.00	0.71	0.16	0.53	0.15	0.34	0.21	0.57	0.69	0.64	0.16	0.64	1.00	0.57	1.00	0.91	0.62	0.50	0.57	0.36	0.59	0.63	0.23
2266 (FGG)	1.00	1.00	0.20	0.66	1.00	0.52	0.62	0.67	0.58	0.66	0.73	0.60	0.77	0.54	0.98	0.68	0.67	0.63	0.71	0.70	0.63	0.69	0.80	0.71	0.56	0.62	0.67	1.00	0.71	0.16	0.53	0.15	0.34	0.21	0.57	0.69	0.64	0.16	0.64	1.00	0.57	1.00	0.91	0.62	0.50	0.57	0.36	0.59	0.63	0.23
197 (AHSG)	0.20	0.20	1.00	0.16	0.16	0.16	0.42	0.20	0.46	0.42	0.16	0.20	0.16	0.35	0.20	0.16	0.42	0.16	0.16	0.42	0.42	0.16	0.16	0.16	0.29	0.16	0.42	0.16	0.16	0.09	0.16	0.09	0.10	0.09	0.42	0.42	0.16	0.46	0.27	0.16	0.16	0.16	0.16	0.42	0.16	0.16	0.10	0.57	0.16	0.09
5340 (PLG)	0.66	0.66	0.16	1.00	1.00	0.82	0.62	0.65	0.60	0.65	0.68	0.61	0.70	0.56	0.69	0.69	0.68	0.62	0.71	0.67	0.62	0.61	0.70	0.68	0.71	0.61	0.65	1.00	0.67	0.45	0.83	0.41	0.62	0.20	0.60	0.70	0.65	0.13	0.48	1.00	0.59	1.00	0.63	0.63	0.85	0.58	0.62	0.60	0.83	0.51
2157 (F8)	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.16	1.00	0.15	0.62	0.16	1.00	1.00	1.00	0.13	0.48	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.62	1.00	1.00	0.32
4318 (MMP9)	0.52	0.52	0.16	0.82	1.00	1.00	0.56	0.57	0.46	0.53	0.54	0.57	0.60	0.43	0.54	0.55	0.55	0.46	0.58	0.50	0.44	0.59	0.64	0.55	0.65	0.44	0.51	1.00	0.56	0.66	0.88	0.53	0.82	0.20	0.57	0.55	0.60	0.13	0.48	1.00	0.49	1.00	0.46	0.52	0.90	0.49	0.87	0.55	0.76	0.80
3827 (KNG1)	0.62	0.62	0.42	0.62	1.00	0.56	1.00	0.70	0.74	0.73	0.66	0.62	0.70	0.49	0.64	0.63	0.72	0.71	0.67	0.77	0.72	0.67	0.63	0.67	0.48	0.53	0.62	1.00	0.66	0.12	0.44	0.11	0.44	0.16	0.86	0.74	0.64	0.90	0.48	1.00	0.52	1.00	0.55	0.60	0.41	0.53	0.50	0.81	0.53	0.37
7422 (VEGFA)	0.67	0.67	0.20	0.65	1.00	0.57	0.70	1.00	0.62	0.64	0.63	0.62	0.72	0.61	0.68	0.63	0.66	0.67	0.70	0.67	0.60	0.67	0.68	0.74	0.66	0.60	0.67	1.00	0.70	0.12	0.56	0.11	0.35	0.21	0.67	0.69	0.65	0.17	0.64	1.00	0.60	1.00	0.61	0.62	0.54	0.59	0.37	0.61	0.60	0.21
5345 (SERPINF2)	0.58	0.58	0.46	0.60	1.00	0.46	0.74	0.62	1.00	0.94	0.60	0.55	0.64	0.48	0.61	0.62	0.81	0.53	0.64	0.93	0.89	0.56	0.71	0.66	0.49	0.51	0.57	1.00	0.62	0.11	0.44	0.11	0.30	0.16	0.68	0.84	0.57	1.00	0.48	1.00	0.57	1.00	0.54	0.58	0.41	0.55	0.31	0.80	0.52	0.18
5265 (SERPINA1)	0.66	0.66	0.42	0.65	1.00	0.53	0.73	0.64	0.94	1.00	0.67	0.60	0.69	0.51	0.67	0.68	0.81	0.61	0.72	0.95	0.92	0.60	0.75	0.67	0.54	0.60	0.62	1.00	0.69	0.12	0.50	0.12	0.33	0.16	0.68	0.87	0.65	0.90	0.48	1.00	0.57	1.00	0.65	0.62	0.47	0.55	0.35	0.80	0.62	0.20
3479 (IGF1)	0.73	0.73	0.16	0.68	1.00	0.54	0.66	0.63	0.60	0.67	1.00	0.59	0.73	0.53	0.73	0.69	0.69	0.63	0.69	0.74	0.65	0.66	0.77	0.71	0.53	0.63	0.84	1.00	0.68	0.12	0.54	0.11	0.39	0.16	0.61	0.72	0.70	0.13	0.48	1.00	0.66	1.00	0.67	0.59	0.50	0.63	0.44	0.59	0.65	0.20
213 (ALB)	0.60	0.60	0.20	0.61	1.00	0.57	0.62	0.62	0.55	0.60	0.59	1.00	0.64	0.50	0.63	0.63	0.60	0.57	0.63	0.58	0.55	0.63	0.65	0.60	0.54	0.55	0.56	1.00	0.62	0.14	0.50	0.13	0.49	0.21	0.62	0.70	0.61	0.16	0.64	1.00	0.58	1.00	0.57	0.61	0.49	0.61	0.43	0.58	0.55	0.31
2335 (FN1)	0.77	0.77	0.16	0.70	1.00	0.60	0.70	0.72	0.64	0.69	0.73	0.64	1.00	0.55	0.79	0.68	0.70	0.70	0.72	0.70	0.61	0.78	0.87	0.69	0.58	0.61	0.69	1.00	0.69	0.11	0.55	0.11	0.42	0.16	0.68	0.71	0.68	0.13	0.48	1.00	0.64	1.00	0.73	0.65	0.53	0.62	0.45	0.63	0.61	0.21
1950 (EGF)	0.54	0.54	0.35	0.56	1.00	0.43	0.49	0.61	0.48	0.51	0.53	0.50	0.55	1.00	0.56	0.55	0.59	0.47	0.56	0.53	0.47	0.51	0.56	0.56	0.77	0.45	0.60	1.00	0.54	0.13	0.41	0.12	0.28	0.27	0.48	0.56	0.49	0.23	0.48	1.00	0.47	1.00	0.46	0.53	0.39	0.47	0.29	0.48	0.45	0.18
2244 (FGB)	0.98	0.98	0.20	0.69	1.00	0.54	0.64	0.68	0.61	0.67	0.73	0.63	0.79	0.56	1.00	0.72	0.68	0.65	0.72	0.71	0.65	0.69	0.82	0.72	0.58	0.64	0.68	1.00	0.72	0.16	0.56	0.15	0.35	0.21	0.59	0.70	0.66	0.16	0.64	1.00	0.59	1.00	0.90	0.63	0.53	0.58	0.37	0.61	0.65	0.23
1191 (CLU)	0.68	0.68	0.16	0.69	1.00	0.55	0.63	0.63	0.62	0.68	0.69	0.63	0.68	0.55	0.72	1.00	0.68	0.65	0.69	0.69	0.66	0.62	0.70	0.75	0.56	0.64	0.64	1.00	0.68	0.12	0.58	0.12	0.37	0.16	0.59	0.69	0.68	0.13	0.48	1.00	0.60	1.00	0.68	0.68	0.55	0.59	0.40	0.61	0.66	0.22
2 (A2M)	0.67	0.67	0.42	0.68	1.00	0.55	0.72	0.66	0.81	0.81	0.69	0.60	0.70	0.59	0.68	0.68	1.00	0.63	0.72	0.84	0.77	0.62	0.69	0.69	0.58	0.62	0.69	1.00	0.70	0.11	0.56	0.11	0.35	0.16	0.69	0.80	0.64	0.90	0.48	1.00	0.59	1.00	0.64	0.67	0.54	0.58	0.37	0.76	0.63	0.20
5196 (PF4)	0.63	0.63	0.16	0.62	1.00	0.46	0.71	0.67	0.53	0.61	0.63	0.57	0.70	0.47	0.65	0.65	0.63	1.00	0.66	0.63	0.56	0.64	0.64	0.65	0.47	0.73	0.57	1.00	0.65	0.11	0.45	0.11	0.32	0.16	0.64	0.64	0.60	0.13	0.48	1.00	0.53	1.00	0.58	0.57	0.42	0.52	0.34	0.54	0.56	0.20
7040 (TGFB1)	0.71	0.71	0.16	0.71	1.00	0.58	0.67	0.70	0.64	0.72	0.69	0.63	0.72	0.56	0.72	0.69	0.72	0.66	1.00	0.74	0.66	0.62	0.72	0.88	0.59	0.66	0.64	1.00	0.94	0.12	0.58	0.11	0.36	0.16	0.62	0.76	0.67	0.13	0.48	1.00	0.61	1.00	0.67	0.64	0.55	0.58	0.38	0.66	0.66	0.21
5054 (SERPINE1)	0.70	0.70	0.42	0.67	1.00	0.50	0.77	0.67	0.93	0.95	0.74	0.58	0.70	0.53	0.71	0.69	0.84	0.63	0.74	1.00	0.92	0.59	0.72	0.72	0.53	0.61	0.68	1.00	0.72	0.12	0.50	0.12	0.33	0.16	0.70	0.87	0.65	0.90	0.48	1.00	0.57	1.00	0.65	0.63	0.47	0.56	0.35	0.82	0.62	0.20
710 (SERPING1)	0.63	0.63	0.42	0.62	1.00	0.44	0.72	0.60	0.89	0.92	0.65	0.55	0.61	0.47	0.65	0.66	0.77	0.56	0.66	0.92	1.00	0.56	0.66	0.64	0.46	0.54	0.59	1.00	0.65	0.13	0.42	0.12	0.30	0.16	0.66	0.83	0.61	0.90	0.48	1.00	0.52	1.00	0.60	0.57	0.38	0.51	0.32	0.74	0.56	0.18
7057 (THBS1)	0.69	0.69	0.16	0.61	1.00	0.59	0.67	0.67	0.56	0.60	0.66	0.63	0.78	0.51	0.69	0.62	0.62	0.64	0.62	0.59	0.56	1.00	0.76	0.61	0.54	0.56	0.63	1.00	0.65	0.11	0.52	0.10	0.48	0.16	0.69	0.62	0.70	0.13	0.48	1.00	0.60	1.00	0.66	0.60	0.50	0.59	0.52	0.57	0.56	0.24
7450 (VWF)	0.80	0.80	0.16	0.70	1.00	0.64	0.63	0.68	0.71	0.75	0.77	0.65	0.87	0.56	0.82	0.70	0.69	0.64	0.72	0.72	0.66	0.76	1.00	0.71	0.60	0.64	0.71	1.00	0.70	0.12	0.58	0.11	0.45	0.16	0.64	0.72	0.74	0.13	0.48	1.00	0.70	1.00	0.79	0.64	0.55	0.66	0.49	0.65	0.66	0.21
7042 (TGFB2)	0.71	0.71	0.16	0.68	1.00	0.55	0.67	0.74	0.66	0.67	0.71	0.60	0.69	0.56	0.72	0.75	0.69	0.65	0.88	0.72	0.64	0.61	0.71	1.00	0.57	0.64	0.67	1.00	0.88	0.11	0.56	0.11	0.35	0.16	0.62	0.72	0.65	0.13	0.48	1.00	0.63	1.00	0.65	0.67	0.53	0.62	0.37	0.63	0.64	0.20
3082 (HGF)	0.56	0.56	0.29	0.71	1.00	0.65	0.48	0.66	0.49	0.54	0.53	0.54	0.58	0.77	0.58	0.56	0.58	0.47	0.59	0.53	0.46	0.54	0.60	0.57	1.00	0.46	0.55	1.00	0.57	0.40	0.63	0.38	0.46	0.27	0.48	0.58	0.50	0.23	0.64	1.00	0.49	1.00	0.48	0.55	0.63	0.49	0.46	0.48	0.63	0.42
5473 (PPBP)	0.62	0.62	0.16	0.61	1.00	0.44	0.53	0.60	0.51	0.60	0.63	0.55	0.61	0.45	0.64	0.64	0.62	0.73	0.66	0.61	0.54	0.56	0.64	0.64	0.46	1.00	0.56	1.00	0.65	0.12	0.42	0.11	0.30	0.16	0.51	0.63	0.59	0.13	0.48	1.00	0.51	1.00	0.57	0.55	0.39	0.51	0.32	0.53	0.54	0.18
3481 (IGF2)	0.67	0.67	0.42	0.65	1.00	0.51	0.62	0.67	0.57	0.62	0.84	0.56	0.69	0.60	0.68	0.64	0.69	0.57	0.64	0.68	0.59	0.63	0.71	0.67	0.55	0.56	1.00	1.00	0.63	0.11	0.49	0.10	0.37	0.16	0.58	0.68	0.63	0.22	0.48	1.00	0.62	1.00	0.59	0.59	0.47	0.59	0.40	0.58	0.57	0.18
5004 (ORM1)	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.16	1.00	0.15	0.62	0.16	1.00	1.00	1.00	0.13	0.48	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.62	1.00	1.00	0.32
7043 (TGFB3)	0.71	0.71	0.16	0.67	1.00	0.56	0.66	0.70	0.62	0.69	0.68	0.62	0.69	0.54	0.72	0.68	0.70	0.65	0.94	0.72	0.65	0.65	0.70	0.88	0.57	0.65	0.63	1.00	1.00	0.11	0.56	0.10	0.35	0.16	0.61	0.73	0.66	0.13	0.48	1.00	0.59	1.00	0.66	0.61	0.53	0.57	0.37	0.64	0.65	0.19
4312 (MMP1)	0.16	0.16	0.09	0.45	0.16	0.66	0.12	0.12	0.11	0.12	0.12	0.14	0.11	0.13	0.16	0.12	0.11	0.11	0.12	0.12	0.13	0.11	0.12	0.11	0.40	0.12	0.11	0.16	0.11	1.00	0.82	0.83	0.58	0.20	0.11	0.12	0.13	0.07	0.28	0.16	0.10	0.16	0.14	0.13	0.87	0.10	0.63	0.11	0.70	0.87
4313 (MMP2)	0.53	0.53	0.16	0.83	1.00	0.88	0.44	0.56	0.44	0.50	0.54	0.50	0.55	0.41	0.56	0.58	0.56	0.45	0.58	0.50	0.42	0.52	0.58	0.56	0.63	0.42	0.49	1.00	0.56	0.82	1.00	0.71	0.67	0.20	0.45	0.55	0.50	0.13	0.48	1.00	0.46	1.00	0.44	0.51	0.98	0.47	0.75	0.44	0.86	0.78
1675 (CFD)	0.15	0.15	0.09	0.41	0.15	0.53	0.11	0.11	0.11	0.12	0.11	0.13	0.11	0.12	0.15	0.12	0.11	0.11	0.11	0.12	0.12	0.10	0.11	0.11	0.38	0.11	0.10	0.15	0.10	0.83	0.71	1.00	0.46	0.20	0.10	0.11	0.12	0.07	0.24	0.15	0.10	0.15	0.14	0.12	0.71	0.10	0.53	0.11	0.74	0.71
4321 (MMP12)	0.34	0.34	0.10	0.62	0.62	0.82	0.44	0.35	0.30	0.33	0.39	0.49	0.42	0.28	0.35	0.37	0.35	0.32	0.36	0.33	0.30	0.48	0.45	0.35	0.46	0.30	0.37	0.62	0.35	0.58	0.67	0.46	1.00	0.20	0.52	0.45	0.55	0.08	0.28	0.62	0.39	0.62	0.31	0.34	0.71	0.44	0.86	0.42	0.58	0.76
2162 (F13A1)	0.21	0.21	0.09	0.20	0.16	0.20	0.16	0.21	0.16	0.16	0.16	0.21	0.16	0.27	0.21	0.16	0.16	0.16	0.16	0.16	0.16	0.16	0.16	0.16	0.27	0.16	0.16	0.16	0.16	0.20	0.20	0.20	0.20	1.00	0.16	0.16	0.16	0.07	0.28	0.16	0.16	0.16	0.16	0.21	0.20	0.16	0.16	0.16	0.16	0.20
3273 (HRG)	0.57	0.57	0.42	0.60	1.00	0.57	0.86	0.67	0.68	0.68	0.61	0.62	0.68	0.48	0.59	0.59	0.69	0.64	0.62	0.70	0.66	0.69	0.64	0.62	0.48	0.51	0.58	1.00	0.61	0.11	0.45	0.10	0.52	0.16	1.00	0.72	0.65	0.90	0.48	1.00	0.53	1.00	0.52	0.57	0.43	0.56	0.54	0.74	0.50	0.36
351 (APP)	0.69	0.69	0.42	0.70	1.00	0.55	0.74	0.69	0.84	0.87	0.72	0.70	0.71	0.56	0.70	0.69	0.80	0.64	0.76	0.87	0.83	0.62	0.72	0.72	0.58	0.63	0.68	1.00	0.73	0.12	0.55	0.11	0.45	0.16	0.72	1.00	0.65	0.90	0.48	1.00	0.63	1.00	0.65	0.66	0.52	0.67	0.37	0.75	0.64	0.21
6678 (SPARC)	0.64	0.64	0.16	0.65	1.00	0.60	0.64	0.65	0.57	0.65	0.70	0.61	0.68	0.49	0.66	0.68	0.64	0.60	0.67	0.65	0.61	0.70	0.74	0.65	0.50	0.59	0.63	1.00	0.66	0.13	0.50	0.12	0.55	0.16	0.65	0.65	1.00	0.13	0.48	1.00	0.57	1.00	0.64	0.57	0.46	0.55	0.65	0.61	0.61	0.31
5627 (PROS1)	0.16	0.16	0.46	0.13	0.13	0.13	0.90	0.17	1.00	0.90	0.13	0.16	0.13	0.23	0.16	0.13	0.90	0.13	0.13	0.90	0.90	0.13	0.13	0.13	0.23	0.13	0.22	0.13	0.13	0.07	0.13	0.07	0.08	0.07	0.90	0.90	0.13	1.00	0.22	0.13	0.13	0.13	0.13	0.33	0.13	0.13	0.08	0.81	0.13	0.07
1 (A1BG)	0.64	0.64	0.27	0.48	0.48	0.48	0.48	0.64	0.48	0.48	0.48	0.64	0.48	0.48	0.64	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.64	0.48	0.48	0.48	0.48	0.28	0.48	0.24	0.28	0.28	0.48	0.48	0.48	0.22	1.00	0.48	0.48	0.48	0.48	0.64	0.48	0.48	0.28	0.48	0.48	0.28
2153 (F5)	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.16	1.00	0.15	0.62	0.16	1.00	1.00	1.00	0.13	0.48	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.62	1.00	1.00	0.32
87 (ACTN1)	0.57	0.57	0.16	0.59	1.00	0.49	0.52	0.60	0.57	0.57	0.66	0.58	0.64	0.47	0.59	0.60	0.59	0.53	0.61	0.57	0.52	0.60	0.70	0.63	0.49	0.51	0.62	1.00	0.59	0.10	0.46	0.10	0.39	0.16	0.53	0.63	0.57	0.13	0.48	1.00	1.00	1.00	0.53	0.54	0.44	0.80	0.36	0.51	0.52	0.17
5552 (SRGN)	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.16	1.00	0.15	0.62	0.16	1.00	1.00	1.00	0.13	0.48	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.62	1.00	1.00	0.32
22915 (MMRN1)	0.91	0.91	0.16	0.63	1.00	0.46	0.55	0.61	0.54	0.65	0.67	0.57	0.73	0.46	0.90	0.68	0.64	0.58	0.67	0.65	0.60	0.66	0.79	0.65	0.48	0.57	0.59	1.00	0.66	0.14	0.44	0.14	0.31	0.16	0.52	0.65	0.64	0.13	0.48	1.00	0.53	1.00	1.00	0.56	0.40	0.52	0.33	0.53	0.60	0.20
335 (APOA1)	0.62	0.62	0.42	0.63	1.00	0.52	0.60	0.62	0.58	0.62	0.59	0.61	0.65	0.53	0.63	0.68	0.67	0.57	0.64	0.63	0.57	0.60	0.64	0.67	0.55	0.55	0.59	1.00	0.61	0.13	0.51	0.12	0.34	0.21	0.57	0.66	0.57	0.33	0.64	1.00	0.54	1.00	0.56	1.00	0.49	0.54	0.34	0.58	0.55	0.21
4314 (MMP3)	0.50	0.50	0.16	0.85	1.00	0.90	0.41	0.54	0.41	0.47	0.50	0.49	0.53	0.39	0.53	0.55	0.54	0.42	0.55	0.47	0.38	0.50	0.55	0.53	0.63	0.39	0.47	1.00	0.53	0.87	0.98	0.71	0.71	0.20	0.43	0.52	0.46	0.13	0.48	1.00	0.44	1.00	0.40	0.49	1.00	0.45	0.75	0.41	0.84	0.83
81 (ACTN4)	0.57	0.57	0.16	0.58	1.00	0.49	0.53	0.59	0.55	0.55	0.63	0.61	0.62	0.47	0.58	0.59	0.58	0.52	0.58	0.56	0.51	0.59	0.66	0.62	0.49	0.51	0.59	1.00	0.57	0.10	0.47	0.10	0.44	0.16	0.56	0.67	0.55	0.13	0.48	1.00	0.80	1.00	0.52	0.54	0.45	1.00	0.36	0.50	0.51	0.18
4322 (MMP13)	0.36	0.36	0.10	0.62	0.62	0.87	0.50	0.37	0.31	0.35	0.44	0.43	0.45	0.29	0.37	0.40	0.37	0.34	0.38	0.35	0.32	0.52	0.49	0.37	0.46	0.32	0.40	0.62	0.37	0.63	0.75	0.53	0.86	0.16	0.54	0.37	0.65	0.08	0.28	0.62	0.36	0.62	0.33	0.34	0.75	0.36	1.00	0.47	0.64	0.85
7076 (TIMP1)	0.59	0.59	0.57	0.60	1.00	0.55	0.81	0.61	0.80	0.80	0.59	0.58	0.63	0.48	0.61	0.61	0.76	0.54	0.66	0.82	0.74	0.57	0.65	0.63	0.48	0.53	0.58	1.00	0.64	0.11	0.44	0.11	0.42	0.16	0.74	0.75	0.61	0.81	0.48	1.00	0.51	1.00	0.53	0.58	0.41	0.50	0.47	1.00	0.51	0.33
3818 (KLKB1)	0.63	0.63	0.16	0.83	1.00	0.76	0.53	0.60	0.52	0.62	0.65	0.55	0.61	0.45	0.65	0.66	0.63	0.56	0.66	0.62	0.56	0.56	0.66	0.64	0.63	0.54	0.57	1.00	0.65	0.70	0.86	0.74	0.58	0.16	0.50	0.64	0.61	0.13	0.48	1.00	0.52	1.00	0.60	0.55	0.84	0.51	0.64	0.51	1.00	0.66
4317 (MMP8)	0.23	0.23	0.09	0.51	0.32	0.80	0.37	0.21	0.18	0.20	0.20	0.31	0.21	0.18	0.23	0.22	0.20	0.20	0.21	0.20	0.18	0.24	0.21	0.20	0.42	0.18	0.18	0.32	0.19	0.87	0.78	0.71	0.76	0.20	0.36	0.21	0.31	0.07	0.28	0.32	0.17	0.32	0.20	0.21	0.83	0.18	0.85	0.33	0.66	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
A2M	Human	Blood	-	3600 m	Native	upregulated	-	TMT-based proteomic analysis/LC-MS	Central Asia	Tibetans	-	High altitude native vs. low Lander	30908922

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
EP300	2033	A2M	2	distal	22955619	TRANSFAC
FOXA1	3169	A2M	2	proximal_filtered	22955619	TRANSFAC
TCF4	6925	A2M	2	proximal_filtered	22955619	TRANSFAC
FOXA2	3170	A2M	2	proximal_filtered	22955619	TRANSFAC
STAT3	6774	A2M	2	Unknown	11466367	TRUSST
TFCP2	7024	A2M	2	Unknown	10455131	TRUSST
NFKB1	4790	A2M	2	Unknown	11466367	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT021948	hsa-miR-128-3p	Homo sapiens	A2M	2	Homo sapiens	Microarray	Functional MTI (Weak)	17612493
MIRT023224	hsa-miR-122-5p	Homo sapiens	A2M	2	Homo sapiens	Microarray	Functional MTI (Weak)	17612493
MIRT027430	hsa-miR-98-5p	Homo sapiens	A2M	2	Homo sapiens	Microarray	Functional MTI (Weak)	19088304

Gene Ontology

ID	GO ID	GO Term	GO Type
2	GO:0007597	blood coagulation	GOTERM_BP_DIRECT
2	GO:0043547	positive regulation of GTPase activity	GOTERM_BP_DIRECT
2	GO:0051056	regulation of small GTPase mediated signal transduction	GOTERM_BP_DIRECT
2	GO:0002020	fibronectin binding	GOTERM_MF_DIRECT
2	GO:0031093	platelet alpha granule lumen	GOTERM_CC_DIRECT
2	GO:0072562	blood microparticle	GOTERM_CC_DIRECT
2	GO:0004866	cAMP-dependent protein kinase inhibitor activity	GOTERM_MF_DIRECT
2	GO:0005576	extracellular region	GOTERM_CC_DIRECT
2	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
2	GO:0001869	negative regulation of complement activation	GOTERM_BP_DIRECT
2	GO:0022617	extracellular matrix disassembly	GOTERM_BP_DIRECT
2	GO:0005829	cytosol	GOTERM_CC_DIRECT
2	GO:0010951	negative regulation of endopeptidase activity	GOTERM_BP_DIRECT
2	GO:0005096	GTPase activator activity	GOTERM_MF_DIRECT
2	GO:0019899	enzyme binding	GOTERM_MF_DIRECT
2	GO:0048306	activin binding	GOTERM_MF_DIRECT
2	GO:0002576	platelet degranulation	GOTERM_BP_DIRECT
2	GO:0019966	syntaxin binding	GOTERM_MF_DIRECT
2	GO:0048863	stem cell differentiation	GOTERM_BP_DIRECT
2	GO:0019838	oxygen sensor activity	GOTERM_MF_DIRECT
2	GO:0005102	receptor binding	GOTERM_MF_DIRECT
2	GO:0005515	protein binding	GOTERM_MF_DIRECT
2	GO:0004867	endopeptidase inhibitor activity	GOTERM_MF_DIRECT
2	GO:0019959	protein domain specific binding	GOTERM_MF_DIRECT
2	GO:0043120	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GOTERM_MF_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
2	hsa04610	Complement and coagulation cascades

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
A2M	2	Hepatolenticular Degeneration	C0019202	Disease or Syndrome	0.3	0.564	0.724	disease
A2M	2	Lung Neoplasms	C0024121	Neoplastic Process	0.3	0.564	0.724	group
A2M	2	Nephrotic Syndrome	C0027726	Disease or Syndrome	0.51	0.564	0.724	group
A2M	2	Alzheimer Disease, Late Onset	C0494463	Mental or Behavioral Dysfunction	0.31	0.564	0.724	disease
A2M	2	alpha-2-Macroglobulin Deficiency	C3279661	Disease or Syndrome	0.31	0.564	0.724	disease
A2M	2	Colonic Neoplasms	C0009375	Neoplastic Process	0.3	0.564	0.724	group
A2M	2	Kidney Failure, Acute	C0022660	Disease or Syndrome	0.3	0.564	0.724	disease
A2M	2	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.564	0.724	disease
A2M	2	Lung diseases	C0024115	Disease or Syndrome	0.32	0.564	0.724	group
A2M	2	Familial Alzheimer Disease (FAD)	C0276496	Disease or Syndrome	0.3	0.564	0.724	disease
A2M	2	Liver Cirrhosis	C0023890	Disease or Syndrome	0.3	0.564	0.724	disease
A2M	2	Alzheimer's Disease	C0002395	Disease or Syndrome	0.4	0.564	0.724	disease
A2M	2	Malignant neoplasm of lung	C0242379	Neoplastic Process	0.3	0.564	0.724	disease
A2M	2	Alzheimer Disease, Early Onset	C0750901	Disease or Syndrome	0.3	0.564	0.724	disease
A2M	2	Hepatic Form of Wilson Disease	C1527352	Disease or Syndrome	0.3	0.564	0.724	disease
A2M	2	Acute kidney injury	C2609414	Injury or Poisoning	0.3	0.564	0.724	disease
A2M	2	Liver carcinoma	C2239176	Neoplastic Process	0.33	0.564	0.724	disease
A2M	2	Hepatocellular Adenoma	C0206669	Neoplastic Process	0.5	0.564	0.724	disease
A2M	2	Fibrosis, Liver	C0239946	Disease or Syndrome	0.3	0.564	0.724	disease
A2M	2	Presenile dementia	C0011265	Mental or Behavioral Dysfunction	0.3	0.564	0.724	disease
A2M	2	Alzheimer's Disease, Focal Onset	C0750900	Mental or Behavioral Dysfunction	0.3	0.564	0.724	disease
A2M	2	Acute Kidney Insufficiency	C1565662	Disease or Syndrome	0.3	0.564	0.724	disease
A2M	2	Malignant tumor of colon	C0007102	Neoplastic Process	0.3	0.564	0.724	disease
A2M	2	Acute Confusional Senile Dementia	C0546126	Mental or Behavioral Dysfunction	0.3	0.564	0.724	disease
A2M	2	Mental Depression	C0011570	Mental or Behavioral Dysfunction	0.31	0.564	0.724	disease
A2M	2	Depressive disorder	C0011581	Mental or Behavioral Dysfunction	0.31	0.564	0.724	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
A2M	2	COBALT	None	None	None
A2M	2	PROSTAGLANDIN E1	ALPROSTADIL	CHEMBL495	None
A2M	2	THROMBIN	THROMBIN	CHEMBL2108110	None