Plasminogen activator inhibitor 1

AltitudeomicsDB
Protein Official symbol SERPINE1
Aliases SERPINE1 PAI1 PLANH1
Chromosomal Location  7
Length 402
Uniprot ID P05121
EC number None
Protein family Information(Pfam) PF00079;
PDB id 1A7C;1B3K;1C5G;1DB2;1DVM;1DVN;1LJ5;1OC0;3CVM;3EOX;3PB1;3Q02;3Q03;3R4L;3UT3;4AQH;4G8O;4G8R;4IC0;5BRR;5ZLZ;6GWN;6GWP;6GWQ;6I8S;9PAI;
InterPro ID IPR023795;IPR023796;IPR000215;IPR036186;IPR042178;IPR042185;
dbSNP rs6092 rs6090 rs2227647 rs2227669 rs2227685

Protein Protein Interaction

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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
FGA FGB 0.999
FGG FGB 0.999
FGG FGA 0.999
AHSG ALB 0.998
PLG SERPINE1 0.997
PLAU PLAUR 0.997
F8 VWF 0.996
SERPINE1 PLAT 0.995
PLAUR PLG 0.994
VEGFA TGFB1 0.993
PLAU SERPINE1 0.993
SERPINF2 PLG 0.993
VEGFA EGF 0.993
VEGFA IGF1 0.993
IGF1 EGF 0.992
VEGFA HGF 0.992
AHSG FGG 0.991
PLAUR SERPINE1 0.99
AHSG FGA 0.989
FN1 ALB 0.989
PLG HRG 0.988
VTN SERPINE1 0.988
VEGFA FN1 0.988
FN1 EGF 0.988
AHSG HRG 0.987
VEGFA ALB 0.986
PLAUR VTN 0.986
ITGB3 ITGAV 0.986
ITGAV VTN 0.986
VEGFA VWF 0.986
SMAD2 TGFB1 0.986
FGA HRG 0.985
FN1 TGFB1 0.985
VEGFA THBS1 0.984
EGF HGF 0.984
FGG HRG 0.983
PLG VWF 0.983
SERPINF2 PLAT 0.982
FGB HRG 0.982
FGA ALB 0.982
SMAD3 TGFB1 0.982
VEGFA SERPINE1 0.982
VEGFA PDGFB 0.981
FN1 VWF 0.98
A2M SERPINF2 0.98
VEGFA IGF2 0.98
PF4 PPBP 0.98
FGG ALB 0.98
PLG FGA 0.98
TGFB1 TIMP1 0.98
ALB EGF 0.98
SERPINE1 TGFB1 0.979
ALB SERPINE1 0.979
FN1 SERPINE1 0.979
PLG FGB 0.979
ALB HGF 0.979
FN1 PLG 0.979
VWF THBS1 0.978
FGG PLG 0.978
VWF SERPINE1 0.978
IGF1 HGF 0.978
PLG ALB 0.978
THBS1 TIMP1 0.978
EGF SERPINE1 0.978
SMAD7 TGFB1 0.976
TGFB2 FN1 0.976
VEGFC FN1 0.975
FN1 SPARC 0.974
A2M ALB 0.974
PLG KNG1 0.974
SERPINE1 TIMP1 0.974
SMAD2 SERPINE1 0.974
EGF TIMP1 0.974
IGF1 ALB 0.974
ALB VWF 0.973
VEGFA TIMP1 0.973
THBS1 HGF 0.973
VEGFA KNG1 0.973
VEGFA PF4 0.973
AHSG FGB 0.973
EGF THBS1 0.972
FN1 THBS1 0.972
FN1 TIMP1 0.972
ALB KNG1 0.971
KNG1 HRG 0.971
A2M PLG 0.971
SERPINE1 HGF 0.971
THBS1 TGFB1 0.971
EGF KNG1 0.97
HGF TGFB1 0.97
IGF1 SERPINE1 0.97
VEGFC THBS1 0.97
FN1 ITGAV 0.97
KNG1 SERPINE1 0.969
VEGFA PLG 0.969
FGB ALB 0.969
SMAD3 SERPINE1 0.969
THBS1 SERPINE1 0.969
IGF1 TGFB1 0.969
PLG TIMP1 0.969
FN1 IGF1 0.968
FN1 HGF 0.968
FN1 TGFB3 0.967
PF4 VWF 0.967
ITGB3 VWF 0.967
TGFB2 SMAD3 0.967
PPBP VWF 0.966
TGFB2 SMAD2 0.966
F8 PLG 0.966
EGF VWF 0.965
IGF2 EGF 0.965
PLAU VTN 0.965
EGF TGFB1 0.965
CLU IGF1 0.964
SMAD7 SERPINE1 0.964
SMAD7 TGFB3 0.964
PLG EGF 0.964
VEGFA VTN 0.963
TGFB3 SERPINE1 0.962
SMAD4 SERPINE1 0.962
SERPINF2 ALB 0.962
ITGB3 FN1 0.962
FIGF THBS1 0.961
SERPINF2 FGA 0.961
FGG SERPINF2 0.961
CLU EGF 0.961
AHSG KNG1 0.961
SERPINF2 HRG 0.961
AHSG A2M 0.96
SMAD4 TGFB1 0.96
PLAU FN1 0.96
ALB TGFB1 0.959
THBS1 HRG 0.959
AHSG PLG 0.958
FN1 PLAUR 0.958
ITGB3 VTN 0.958
IGF2 ALB 0.958
SMAD2 TGFB3 0.958
F8 ALB 0.958
PLG THBS1 0.958
A2M KNG1 0.958
CLU ALB 0.958
SMAD3 TGFB3 0.957
FN1 A2M 0.957
PLG PPBP 0.957
HGF TIMP1 0.957
PDGFB EGF 0.957
AHSG SERPINF2 0.957
THBS1 SPARC 0.957
ALB TIMP1 0.956
PLG IGF1 0.956
FGB F13A1 0.956
FGA F13A1 0.956
CLOCK SERPINE1 0.956
SERPINF2 PPBP 0.956
SERPINF2 VWF 0.956
LRP1 PLAT 0.956
FN1 VTN 0.956
PF4 THBS1 0.955
PLG TGFB1 0.955
A2M CLU 0.955
F8 SERPINE1 0.954
VEGFC PDGFB 0.954
PLG PF4 0.954
VEGFC EGF 0.954
VEGFC HGF 0.954
TGFB2 SMAD4 0.954
FGG KNG1 0.953
IGF1 TIMP1 0.953
VEGFA TGFB2 0.953
IGF2 FN1 0.953
TGFB2 EGF 0.952
SERPINF2 PF4 0.952
FIGF HGF 0.952
SERPINF2 FGB 0.952
A2M VWF 0.952
FGG F13A1 0.952
CFD SERPINE1 0.952
A2M HRG 0.952
FN1 PF4 0.952
PPBP SERPINE1 0.951
IGF1 VWF 0.951
VEGFA SPARC 0.951
A2M IGF1 0.951
KNG1 VWF 0.951
TGFB2 IGF1 0.951
PLAUR HGF 0.95
F13A1 VWF 0.95
HRG SERPINE1 0.95
ALB SPARC 0.95
PDGFB IGF1 0.95
A2M FGA 0.95
PDGFB TGFB1 0.95
IGF2 HGF 0.95
FN1 KNG1 0.95
FGG A2M 0.95
SERPINF2 KNG1 0.95
IGF1 TGFB3 0.949
FIGF TGFB1 0.949
FN1 PDGFB 0.949
VWF HGF 0.948
SMAD4 TGFB3 0.948
A2M TIMP1 0.948
FGA KNG1 0.948
ITGB3 SERPINE1 0.947
PLAUR LRP1 0.947
VWF TIMP1 0.947
SPARC TIMP1 0.947
A2M FGB 0.947
FGB KNG1 0.947
LRP1 SERPINE1 0.947
TGFB2 THBS1 0.947
PDGFB HGF 0.946
TGFB2 SERPINE1 0.946
ALB HRG 0.946
EGF SPARC 0.946
ITGB3 FGB 0.946
F8 SERPINF2 0.946
FIGF EGF 0.946
AHSG CLU 0.946
PF4 SERPINE1 0.946
IGF2 TGFB1 0.946
ALB LRP1 0.945
FN1 CLU 0.945
IGF1 FIGF 0.945
VEGFC SERPINE1 0.945
PROS1 HRG 0.945
VEGFC IGF1 0.945
F5 PLG 0.944
PF4 HRG 0.944
VEGFA F13A1 0.944
CLU TIMP1 0.943
EGF TGFB3 0.943
VEGFA ITGAV 0.943
PROS1 FGB 0.943
PROS1 ALB 0.943
IGF1 THBS1 0.943
PROS1 F5 0.943
ITGB3 THBS1 0.942
PROS1 A2M 0.942
PDGFB FIGF 0.942
PF4 ALB 0.942
ALB THBS1 0.942
PROS1 FGG 0.942
FGA VWF 0.942
AHSG SPARC 0.942
IGF1 SPARC 0.941
VEGFA TGFB3 0.941
VWF SPARC 0.941
VEGFC ALB 0.941
PF4 TIMP1 0.941
VEGFA CLU 0.941
F5 F13A1 0.941
TGFB2 TIMP1 0.941
SPARC TGFB1 0.941
FN1 SERPINF2 0.941
FN1 PPBP 0.941
TGFB2 PDGFB 0.941
IGF2 TGFB2 0.941
FGB SERPINE1 0.94
VEGFA PPBP 0.94
SRGN SERPINE1 0.94
F5 SERPINE1 0.94
TGFB2 SRGN 0.94
VEGFC VWF 0.94
PDGFB VWF 0.94
VEGFC VEGFA 0.94
A2M SERPINE1 0.94
VEGFC TIMP1 0.939
F8 FN1 0.939
PLAUR ITGAV 0.939
PROS1 FGA 0.939
PF4 EGF 0.939
VEGFA ITGB3 0.939
F5 VWF 0.939
IGF2 PDGFB 0.939
F5 FGA 0.939
TGFB3 TIMP1 0.938
PDGFB ALB 0.938
VEGFA F8 0.938
F8 PPBP 0.938
PLAU LRP1 0.938
PLAU FGA 0.938
PDGFB TIMP1 0.937
PDGFB THBS1 0.937
FN1 HRG 0.937
PDGFB SERPINE1 0.937
ITGB3 TGFB1 0.937
SMAD4 SMAD7 0.936
AHSG FN1 0.936
PROS1 PLG 0.936
TGFB2 A2M 0.936
SERPINF2 SERPINE1 0.936
CLU KNG1 0.936
FN1 FIGF 0.936
PPBP EGF 0.935
FN1 FGA 0.935
A2M TGFB1 0.935
PPBP THBS1 0.935
F5 FGG 0.935
F5 KNG1 0.935
CLU HRG 0.935
ARNTL CLOCK 0.935
VEGFC PLG 0.934
PF4 F13A1 0.934
FGG VWF 0.934
AHSG PROS1 0.934
CLU TGFB1 0.934
IGF2 PLG 0.934
SPARC SERPINE1 0.934
SPARC HGF 0.934
IGF2 TIMP1 0.934
ITGB3 FGA 0.934
VEGFA FIGF 0.934
AHSG F13A1 0.934
HRG PLAT 0.933
IGF2 TGFB3 0.933
PROS1 FN1 0.933
F5 FGB 0.933
AHSG IGF1 0.933
VEGFC TGFB1 0.933
TGFB2 SPARC 0.933
PPBP ALB 0.933
VEGFC TGFB2 0.933
PPBP TIMP1 0.933
PROS1 SERPINF2 0.933
SMAD2 SMAD7 0.932
PPBP F13A1 0.932
PF4 SRGN 0.932
ARNTL SERPINE1 0.932
AHSG SERPINE1 0.932
VWF TGFB1 0.932
THBS1 TGFB3 0.932
CLU THBS1 0.932
FIGF VWF 0.932
FGB VWF 0.932
IGF2 FIGF 0.932
VEGFC IGF2 0.932
IGF2 SERPINE1 0.931
CLU PLG 0.931
VEGFA HRG 0.931
CLU SPARC 0.931
PDGFB TGFB3 0.931
SERPINF2 CLU 0.931
PDGFB PLG 0.931
CLOCK ARNTL2 0.931
PLAU ITGAV 0.931
F8 KNG1 0.931
PROS1 F13A1 0.93
F8 F13A1 0.93
SMAD3 SMAD7 0.93
ITGAV LRP1 0.93
F8 EGF 0.93
F5 A2M 0.93
IGF1 KNG1 0.93
ITGAV SERPINE1 0.93
A2M EGF 0.93
FN1 F13A1 0.93
FN1 FGG 0.93
PF4 TGFB1 0.93
FN1 FGB 0.93
A2M SPARC 0.93
PF4 HGF 0.929
IGF1 PF4 0.929
FGG SERPINE1 0.929
PPBP SRGN 0.929
PROS1 KNG1 0.929
CFD ALB 0.929
IGF2 THBS1 0.929
PLG SPARC 0.929
F5 ALB 0.929
PLG FIGF 0.929
FIGF TIMP1 0.929
ITGB3 PLAU 0.929
VLDLR SERPINE1 0.929
IGF2 SPARC 0.928
PROS1 SERPINE1 0.928
SERPINF2 F13A1 0.928
PROS1 VWF 0.927
ITGB3 PLAUR 0.927
ARNTL2 SERPINE1 0.927
VWF HRG 0.927
VEGFC PF4 0.927
F8 A2M 0.927
AHSG IGF2 0.927
F8 PF4 0.927
FGG CLU 0.926
VLDLR PLAU 0.926
ITGAV TGFB1 0.926
PROS1 F8 0.926
ITGB3 FGG 0.926
F13A1 SERPINE1 0.926
CLU VWF 0.926
FGA PF4 0.926
TGFB2 HGF 0.926
FGA SERPINE1 0.926
PF4 KNG1 0.926
FN1 SRGN 0.926
A2M PPBP 0.926
F5 SERPINF2 0.926
VEGFA A2M 0.926
FGA TGFB3 0.926
PDGFB FGA 0.925
CFD SPARC 0.925
CFD IGF1 0.925
ALB TGFB3 0.925
CLU SERPINE1 0.925
FGA PPBP 0.925
FIGF ALB 0.925
CLU FGA 0.925
PLG PLAT 0.924
ITGB3 IGF1 0.924
F5 EGF 0.924
IGF2 A2M 0.924
PLAU PLG 0.924
FIGF SERPINE1 0.924
F13A1 SRGN 0.924
IGF1 ITGAV 0.924
PPBP HGF 0.923
TGFB3 SPARC 0.923
IGF2 FGA 0.923
TGFB2 PLG 0.923
F5 PF4 0.923
VWF TGFB3 0.923
F8 FGG 0.923
ITGB3 PDGFB 0.923
VEGFA CFD 0.923
PDGFB SPARC 0.923
KNG1 F13A1 0.923
IGF2 CLU 0.922
PLG F13A1 0.922
A2M F13A1 0.922
PPBP KNG1 0.922
TGFB2 FGA 0.922
TGFB2 ALB 0.922
CFD CLU 0.922
TGFB3 HGF 0.922
FGA ITGAV 0.922
AHSG HGF 0.922
IGF2 IGF1 0.922
F13A1 TGFB3 0.922
FGA THBS1 0.921
ITGB3 LRP1 0.921
PPBP HRG 0.921
VLDLR PLAUR 0.921
SRGN HGF 0.921
KNG1 TGFB1 0.921
PPBP TGFB1 0.921
TGFB2 CLU 0.921
F5 FN1 0.921
VEGFA F5 0.921
AHSG F5 0.921
KNG1 TIMP1 0.921
PDGFB PPBP 0.92
ITGAV TGFB3 0.92
AHSG TIMP1 0.92
VEGFC SPARC 0.92
PF4 SPARC 0.919
FGG EGF 0.919
CLU FGB 0.919
VEGFA AHSG 0.919
PDGFB PF4 0.919
KNG1 HGF 0.919
PDGFB LRP1 0.919
A2M THBS1 0.919
IGF1 F13A1 0.919
THBS1 SRGN 0.918
IGF2 FGB 0.918
FGB THBS1 0.918
A2M TGFB3 0.918
KNG1 THBS1 0.918
A2M SRGN 0.918
SMAD4 SMAD2 0.918
F8 THBS1 0.918
CFD TIMP1 0.918
F13A1 THBS1 0.918
PLAU HGF 0.918
CFD PDGFB 0.918
FGA TGFB1 0.918
IGF1 PPBP 0.918
VEGFA PROS1 0.918
FGG PDGFB 0.917
PLAU FGG 0.917
IGF2 CFD 0.917
A2M PF4 0.917
SERPINF2 TIMP1 0.917
PDGFB FGB 0.917
VEGFA SRGN 0.917
ALB SRGN 0.917
PDGFB ITGAV 0.917
VEGFC TGFB3 0.917
IGF2 VWF 0.917
VEGFA SERPINF2 0.917
PROS1 CLU 0.917
PLG SRGN 0.916
VEGFC PPBP 0.916
CLU HGF 0.916
CLU PPBP 0.916
CLU PF4 0.916
SMAD4 SMAD3 0.916
A2M HGF 0.916
IGF2 FGG 0.916
TGFB2 FIGF 0.915
PROS1 IGF1 0.915
EGF SRGN 0.915
FGA EGF 0.915
PLG TGFB3 0.915
FIGF TGFB3 0.915
FIGF PF4 0.915
F8 FGA 0.915
F8 IGF1 0.915
EGF HRG 0.915
AHSG EGF 0.915
TGFB2 VWF 0.915
AHSG THBS1 0.915
FGB EGF 0.915
CFD PF4 0.915
CFD EGF 0.915
CFD VWF 0.915
EGF F13A1 0.914
FGB IGF1 0.914
AHSG CFD 0.914
PROS1 THBS1 0.914
FN1 CFD 0.914
PROS1 EGF 0.914
SRGN TIMP1 0.914
F5 F8 0.914
F5 HRG 0.913
SRGN TGFB1 0.913
VWF SRGN 0.913
PROS1 SPARC 0.913
PLAU FGB 0.913
TGFB2 PF4 0.913
F8 FGB 0.913
FGA IGF1 0.913
F13A1 TGFB1 0.912
VEGFC FIGF 0.912
CFD A2M 0.912
ALB F13A1 0.912
PLG HGF 0.912
PLAU HRG 0.912
CLU SRGN 0.912
F8 HGF 0.912
PLAUR FGA 0.912
AHSG VWF 0.912
FGB TGFB1 0.912
AHSG PF4 0.912
IGF2 SERPINF2 0.912
AHSG TGFB1 0.911
FGG THBS1 0.911
IGF2 KNG1 0.911
PROS1 TIMP1 0.911
F5 PPBP 0.911
F13A1 TIMP1 0.911
PROS1 TGFB2 0.911
TGFB2 TGFB3 0.91
PDGFB KNG1 0.91
IGF2 PF4 0.91
PPBP SPARC 0.91
TGFB2 PPBP 0.91
CFD TGFB1 0.91
CFD KNG1 0.91
SERPINF2 EGF 0.91
VEGFC KNG1 0.91
CFD SRGN 0.91
FIGF SPARC 0.91
CFD PPBP 0.91
PLAUR FGG 0.909
IGF2 PROS1 0.909
PPBP TGFB3 0.909
VEGFC F5 0.909
VEGFA FGA 0.909
SMAD3 SMAD2 0.909
FGG IGF1 0.909
ITGB3 TGFB3 0.909
FIGF PPBP 0.909
SERPINF2 TGFB1 0.909
PDGFB A2M 0.908
VEGFC F8 0.908
CLU TGFB3 0.908
F5 THBS1 0.908
SERPINF2 THBS1 0.908
VEGFC AHSG 0.908
PROS1 TGFB1 0.908
F5 SRGN 0.908
CFD F13A1 0.907
PF4 TGFB3 0.907
PLAUR FGB 0.907
CLU F13A1 0.907
PROS1 PF4 0.907
KNG1 SPARC 0.907
VEGFA FGB 0.907
F5 HGF 0.907
SERPINF2 IGF1 0.907
F13A1 HRG 0.907
VEGFA FGG 0.907
AHSG PPBP 0.907
F5 CLU 0.907
PROS1 PPBP 0.907
SERPINF2 HGF 0.907
F5 TGFB1 0.907
CFD PLG 0.907
TGFB2 TGFB1 0.907
KNG1 SRGN 0.906
A2M FIGF 0.906
PDGFB HRG 0.906
TGFB3 TGFB1 0.906
F8 TGFB1 0.906
HRG HGF 0.906
F8 TIMP1 0.906
F8 HRG 0.906
KNG1 TGFB3 0.906
HRG SPARC 0.906
PROS1 SRGN 0.906
FGG TGFB3 0.905
TGFB2 FGB 0.905
F13A1 HGF 0.905
F5 TGFB3 0.905
PROS1 CFD 0.905
CFD HGF 0.905
PDGFB SERPINF2 0.905
FGG TIMP1 0.905
F13A1 SPARC 0.905
FGB ITGAV 0.905
FGB TIMP1 0.905
CFD THBS1 0.905
F8 SRGN 0.905
IGF2 SRGN 0.905
VEGFC A2M 0.905
FGA TIMP1 0.905
CFD FGB 0.905
HRG TIMP1 0.905
CFD FGA 0.905
FIGF KNG1 0.905
IGF2 PPBP 0.905
VEGFC CLU 0.904
PROS1 TGFB3 0.904
VEGFC SERPINF2 0.904
CFD SERPINF2 0.904
F5 IGF1 0.904
FGB TGFB3 0.904
F8 FIGF 0.904
FIGF F13A1 0.904
SRGN SPARC 0.904
PROS1 PDGFB 0.904
F5 SPARC 0.904
FIGF HRG 0.904
PROS1 HGF 0.904
F8 PDGFB 0.904
IGF2 F13A1 0.904
FGG PPBP 0.904
FGG TGFB1 0.903
VEGFC HRG 0.903
F8 TGFB3 0.903
FGG CFD 0.903
AHSG F8 0.903
SERPINF2 SRGN 0.903
FGB SPARC 0.903
IGF1 HRG 0.903
F5 FIGF 0.903
PDGFB CLU 0.903
F8 CLU 0.903
VEGFC F13A1 0.903
VEGFC PROS1 0.903
FGG SPARC 0.903
VEGFC FGG 0.903
F8 SPARC 0.902
CFD HRG 0.902
SRGN TGFB3 0.902
SERPINF2 TGFB3 0.902
FGB SRGN 0.902
AHSG TGFB2 0.902
TGFB2 KNG1 0.902
FGA HGF 0.902
PDGFB SRGN 0.902
TGFB2 F8 0.902
FGG HGF 0.902
TGFB2 F13A1 0.902
CLU FIGF 0.902
FGG ITGAV 0.902
IGF2 F5 0.902
FGB HGF 0.902
FGB PPBP 0.902
IGF2 HRG 0.902
TGFB2 SERPINF2 0.902
FGA SPARC 0.902
PDGFB F13A1 0.902
PLAUR HRG 0.902
F5 TGFB2 0.902
F8 CFD 0.901
AHSG SRGN 0.901
TGFB2 CFD 0.901
CFD FIGF 0.901
PROS1 FIGF 0.901
F5 CFD 0.9
IGF2 F8 0.9
FGA FIGF 0.9
IGF1 SRGN 0.9
VEGFC FGA 0.9
VEGFC SRGN 0.9
AHSG TGFB3 0.9
FGG SRGN 0.9
AHSG PDGFB 0.9
SERPINF2 FIGF 0.9
FGB PF4 0.9
FGG FIGF 0.9
HRG TGFB1 0.9
F5 TIMP1 0.9
SRGN HRG 0.9
FGA SRGN 0.9
FIGF SRGN 0.9
VEGFC FGB 0.9
FGB FIGF 0.9
VEGFC CFD 0.9
F5 PDGFB 0.9
AHSG FIGF 0.9
TGFB3 HRG 0.9
FGG PF4 0.9
CFD TGFB3 0.9
TGFB2 HRG 0.9
TGFB2 FGG 0.9
SERPINF2 SPARC 0.9
Gene Ontology Semantic Similarity
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# 2243 (FGA) 2266 (FGG) 197 (AHSG) 5340 (PLG) 5328 (PLAU) 2157 (F8) 5054 (SERPINE1) 5329 (PLAUR) 7422 (VEGFA) 5345 (SERPINF2) 3479 (IGF1) 2335 (FN1) 7448 (VTN) 3690 (ITGB3) 3685 (ITGAV) 4087 (SMAD2) 1950 (EGF) 2244 (FGB) 4088 (SMAD3) 2 (A2M) 5196 (PF4) 7040 (TGFB1) 213 (ALB) 7450 (VWF) 7057 (THBS1) 4092 (SMAD7) 7042 (TGFB2) 7424 (VEGFC) 3827 (KNG1) 3082 (HGF) 5473 (PPBP) 3481 (IGF2) 1191 (CLU) 7043 (TGFB3) 4089 (SMAD4) 2277 (FIGF) 5155 (PDGFB) 9575 (CLOCK) 4035 (LRP1) 1675 (CFD) 2162 (F13A1) 3273 (HRG) 6678 (SPARC) 5627 (PROS1) 2153 (F5) 5552 (SRGN) 406 (ARNTL) 7436 (VLDLR) 56938 (ARNTL2) 5327 (PLAT) 7076 (TIMP1)
2243 (FGA) 1.00 1.00 0.20 0.66 0.63 1.00 0.70 0.68 0.67 0.58 0.73 0.77 0.88 0.67 0.63 0.52 0.54 0.98 0.52 0.67 0.63 0.71 0.60 0.80 0.69 0.60 0.71 0.70 0.62 0.56 0.62 0.67 0.68 0.71 0.48 0.70 0.62 0.42 0.52 0.15 0.21 0.57 0.64 0.16 1.00 1.00 0.53 0.56 0.26 0.71 0.59
2266 (FGG) 1.00 1.00 0.20 0.66 0.63 1.00 0.70 0.68 0.67 0.58 0.73 0.77 0.88 0.67 0.63 0.52 0.54 0.98 0.52 0.67 0.63 0.71 0.60 0.80 0.69 0.60 0.71 0.70 0.62 0.56 0.62 0.67 0.68 0.71 0.48 0.70 0.62 0.42 0.52 0.15 0.21 0.57 0.64 0.16 1.00 1.00 0.53 0.56 0.26 0.71 0.59
197 (AHSG) 0.20 0.20 1.00 0.16 0.16 0.16 0.42 0.16 0.20 0.46 0.16 0.16 0.16 0.16 0.16 0.16 0.35 0.20 0.16 0.42 0.16 0.16 0.20 0.16 0.16 0.16 0.16 0.20 0.42 0.29 0.16 0.42 0.16 0.16 0.16 0.20 0.42 0.16 0.16 0.09 0.09 0.42 0.16 0.46 0.16 0.16 0.16 0.16 0.16 0.16 0.57
5340 (PLG) 0.66 0.66 0.16 1.00 0.83 1.00 0.67 0.70 0.65 0.60 0.68 0.70 0.63 0.68 0.64 0.54 0.56 0.69 0.55 0.68 0.62 0.71 0.61 0.70 0.61 0.62 0.68 0.65 0.62 0.71 0.61 0.65 0.69 0.67 0.50 0.66 0.62 0.47 0.55 0.41 0.20 0.60 0.65 0.13 1.00 1.00 0.55 0.59 0.20 0.85 0.60
5328 (PLAU) 0.63 0.63 0.16 0.83 1.00 1.00 0.62 0.62 0.60 0.52 0.65 0.61 0.58 0.62 0.61 0.48 0.45 0.65 0.48 0.63 0.56 0.66 0.55 0.66 0.56 0.55 0.64 0.61 0.53 0.63 0.54 0.57 0.66 0.65 0.42 0.60 0.55 0.34 0.45 0.74 0.16 0.50 0.61 0.13 1.00 1.00 0.47 0.50 0.21 0.94 0.51
2157 (F8) 1.00 1.00 0.16 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.15 0.16 1.00 1.00 0.13 1.00 1.00 1.00 1.00 0.26 1.00 1.00
5054 (SERPINE1) 0.70 0.70 0.42 0.67 0.62 1.00 1.00 0.70 0.67 0.93 0.74 0.70 0.64 0.68 0.66 0.51 0.53 0.71 0.51 0.84 0.63 0.74 0.58 0.72 0.59 0.59 0.72 0.68 0.77 0.53 0.61 0.68 0.69 0.72 0.46 0.68 0.61 0.40 0.49 0.12 0.16 0.70 0.65 0.90 1.00 1.00 0.52 0.54 0.21 0.72 0.82
5329 (PLAUR) 0.68 0.68 0.16 0.70 0.62 1.00 0.70 1.00 0.66 0.60 0.71 0.68 0.63 0.75 0.73 0.54 0.64 0.70 0.54 0.69 0.62 0.73 0.59 0.68 0.59 0.62 0.71 0.67 0.62 0.54 0.61 0.67 0.69 0.70 0.49 0.68 0.60 0.42 0.68 0.12 0.16 0.57 0.64 0.13 1.00 1.00 0.53 0.70 0.22 0.69 0.60
7422 (VEGFA) 0.67 0.67 0.20 0.65 0.60 1.00 0.67 0.66 1.00 0.62 0.63 0.72 0.61 0.76 0.65 0.55 0.61 0.68 0.57 0.66 0.67 0.70 0.62 0.68 0.67 0.59 0.74 0.81 0.70 0.66 0.60 0.67 0.63 0.70 0.57 0.86 0.76 0.49 0.55 0.11 0.21 0.67 0.65 0.17 1.00 1.00 0.55 0.57 0.20 0.67 0.61
5345 (SERPINF2) 0.58 0.58 0.46 0.60 0.52 1.00 0.93 0.60 0.62 1.00 0.60 0.64 0.54 0.64 0.62 0.48 0.48 0.61 0.50 0.81 0.53 0.64 0.55 0.71 0.56 0.53 0.66 0.57 0.74 0.49 0.51 0.57 0.62 0.62 0.47 0.57 0.62 0.37 0.45 0.11 0.16 0.68 0.57 1.00 1.00 1.00 0.47 0.49 0.19 0.59 0.80
3479 (IGF1) 0.73 0.73 0.16 0.68 0.65 1.00 0.74 0.71 0.63 0.60 1.00 0.73 0.80 0.70 0.69 0.51 0.53 0.73 0.51 0.69 0.63 0.69 0.59 0.77 0.66 0.62 0.71 0.67 0.66 0.53 0.63 0.84 0.69 0.68 0.47 0.65 0.61 0.42 0.51 0.11 0.16 0.61 0.70 0.13 1.00 1.00 0.53 0.56 0.20 0.75 0.59
2335 (FN1) 0.77 0.77 0.16 0.70 0.61 1.00 0.70 0.68 0.72 0.64 0.73 1.00 0.78 0.72 0.68 0.60 0.55 0.79 0.55 0.70 0.70 0.72 0.64 0.87 0.78 0.62 0.69 0.65 0.70 0.58 0.61 0.69 0.68 0.69 0.54 0.65 0.66 0.47 0.55 0.11 0.16 0.68 0.68 0.13 1.00 1.00 0.55 0.57 0.20 0.67 0.63
7448 (VTN) 0.88 0.88 0.16 0.63 0.58 1.00 0.64 0.63 0.61 0.54 0.80 0.78 1.00 0.67 0.66 0.49 0.47 0.87 0.49 0.64 0.57 0.66 0.56 0.85 0.71 0.57 0.65 0.63 0.56 0.48 0.55 0.70 0.66 0.65 0.44 0.61 0.57 0.36 0.46 0.13 0.16 0.52 0.64 0.13 1.00 1.00 0.48 0.51 0.22 0.66 0.53
3690 (ITGB3) 0.67 0.67 0.16 0.68 0.62 1.00 0.68 0.75 0.76 0.64 0.70 0.72 0.67 1.00 0.85 0.56 0.61 0.68 0.56 0.70 0.61 0.69 0.61 0.74 0.70 0.63 0.66 0.66 0.62 0.59 0.61 0.67 0.65 0.66 0.54 0.71 0.66 0.50 0.62 0.12 0.20 0.60 0.69 0.13 1.00 1.00 0.56 0.64 0.19 0.66 0.62
3685 (ITGAV) 0.63 0.63 0.16 0.64 0.61 1.00 0.66 0.73 0.65 0.62 0.69 0.68 0.66 0.85 1.00 0.54 0.59 0.64 0.54 0.69 0.60 0.65 0.59 0.70 0.69 0.60 0.63 0.62 0.59 0.55 0.61 0.66 0.64 0.67 0.51 0.62 0.59 0.48 0.61 0.10 0.16 0.57 0.67 0.13 1.00 1.00 0.55 0.63 0.19 0.64 0.61
4087 (SMAD2) 0.52 0.52 0.16 0.54 0.48 1.00 0.51 0.54 0.55 0.48 0.51 0.60 0.49 0.56 0.54 1.00 0.47 0.53 0.85 0.55 0.49 0.62 0.60 0.54 0.51 0.79 0.58 0.51 0.49 0.47 0.48 0.50 0.58 0.60 0.81 0.52 0.51 0.76 0.53 0.10 0.16 0.51 0.50 0.13 1.00 1.00 0.74 0.48 0.49 0.52 0.48
1950 (EGF) 0.54 0.54 0.35 0.56 0.45 1.00 0.53 0.64 0.61 0.48 0.53 0.55 0.47 0.61 0.59 0.47 1.00 0.56 0.47 0.59 0.47 0.56 0.50 0.56 0.51 0.50 0.56 0.56 0.49 0.77 0.45 0.60 0.55 0.54 0.42 0.59 0.74 0.36 0.51 0.12 0.27 0.48 0.49 0.23 1.00 1.00 0.44 0.55 0.19 0.53 0.48
2244 (FGB) 0.98 0.98 0.20 0.69 0.65 1.00 0.71 0.70 0.68 0.61 0.73 0.79 0.87 0.68 0.64 0.53 0.56 1.00 0.53 0.68 0.65 0.72 0.63 0.82 0.69 0.61 0.72 0.71 0.64 0.58 0.64 0.68 0.72 0.72 0.49 0.71 0.63 0.45 0.53 0.15 0.21 0.59 0.66 0.16 1.00 1.00 0.55 0.58 0.25 0.72 0.61
4088 (SMAD3) 0.52 0.52 0.16 0.55 0.48 1.00 0.51 0.54 0.57 0.50 0.51 0.55 0.49 0.56 0.54 0.85 0.47 0.53 1.00 0.54 0.49 0.60 0.61 0.56 0.53 0.74 0.58 0.51 0.53 0.49 0.48 0.50 0.54 0.58 0.83 0.52 0.53 0.74 0.53 0.10 0.16 0.55 0.51 0.13 1.00 1.00 0.73 0.48 0.47 0.51 0.52
2 (A2M) 0.67 0.67 0.42 0.68 0.63 1.00 0.84 0.69 0.66 0.81 0.69 0.70 0.64 0.70 0.69 0.55 0.59 0.68 0.54 1.00 0.63 0.72 0.60 0.69 0.62 0.61 0.69 0.66 0.72 0.58 0.62 0.69 0.68 0.70 0.50 0.67 0.66 0.47 0.53 0.11 0.16 0.69 0.64 0.90 1.00 1.00 0.56 0.59 0.20 0.68 0.76
5196 (PF4) 0.63 0.63 0.16 0.62 0.56 1.00 0.63 0.62 0.67 0.53 0.63 0.70 0.57 0.61 0.60 0.49 0.47 0.65 0.49 0.63 1.00 0.66 0.57 0.64 0.64 0.55 0.65 0.59 0.71 0.47 0.73 0.57 0.65 0.65 0.47 0.60 0.55 0.37 0.49 0.11 0.16 0.64 0.60 0.13 1.00 1.00 0.48 0.51 0.19 0.65 0.54
7040 (TGFB1) 0.71 0.71 0.16 0.71 0.66 1.00 0.74 0.73 0.70 0.64 0.69 0.72 0.66 0.69 0.65 0.62 0.56 0.72 0.60 0.72 0.66 1.00 0.63 0.72 0.62 0.71 0.88 0.67 0.67 0.59 0.66 0.64 0.69 0.94 0.53 0.68 0.63 0.47 0.53 0.11 0.16 0.62 0.67 0.13 1.00 1.00 0.56 0.59 0.20 0.73 0.66
213 (ALB) 0.60 0.60 0.20 0.61 0.55 1.00 0.58 0.59 0.62 0.55 0.59 0.64 0.56 0.61 0.59 0.60 0.50 0.63 0.61 0.60 0.57 0.63 1.00 0.65 0.63 0.60 0.60 0.58 0.62 0.54 0.55 0.56 0.63 0.62 0.62 0.58 0.59 0.59 0.56 0.13 0.21 0.62 0.61 0.16 1.00 1.00 0.65 0.53 0.32 0.59 0.58
7450 (VWF) 0.80 0.80 0.16 0.70 0.66 1.00 0.72 0.68 0.68 0.71 0.77 0.87 0.85 0.74 0.70 0.54 0.56 0.82 0.56 0.69 0.64 0.72 0.65 1.00 0.76 0.64 0.71 0.67 0.63 0.60 0.64 0.71 0.70 0.70 0.55 0.66 0.71 0.48 0.54 0.11 0.16 0.64 0.74 0.13 1.00 1.00 0.56 0.59 0.20 0.69 0.65
7057 (THBS1) 0.69 0.69 0.16 0.61 0.56 1.00 0.59 0.59 0.67 0.56 0.66 0.78 0.71 0.70 0.69 0.51 0.51 0.69 0.53 0.62 0.64 0.62 0.63 0.76 1.00 0.58 0.61 0.58 0.67 0.54 0.56 0.63 0.62 0.65 0.53 0.58 0.61 0.45 0.58 0.10 0.16 0.69 0.70 0.13 1.00 1.00 0.52 0.55 0.19 0.60 0.57
4092 (SMAD7) 0.60 0.60 0.16 0.62 0.55 1.00 0.59 0.62 0.59 0.53 0.62 0.62 0.57 0.63 0.60 0.79 0.50 0.61 0.74 0.61 0.55 0.71 0.60 0.64 0.58 1.00 0.66 0.58 0.54 0.50 0.54 0.58 0.66 0.70 0.75 0.59 0.57 0.70 0.51 0.11 0.16 0.55 0.60 0.13 1.00 1.00 0.73 0.52 0.50 0.60 0.53
7042 (TGFB2) 0.71 0.71 0.16 0.68 0.64 1.00 0.72 0.71 0.74 0.66 0.71 0.69 0.65 0.66 0.63 0.58 0.56 0.72 0.58 0.69 0.65 0.88 0.60 0.71 0.61 0.66 1.00 0.67 0.67 0.57 0.64 0.67 0.75 0.88 0.53 0.68 0.68 0.46 0.53 0.11 0.16 0.62 0.65 0.13 1.00 1.00 0.56 0.57 0.19 0.73 0.63
7424 (VEGFC) 0.70 0.70 0.20 0.65 0.61 1.00 0.68 0.67 0.81 0.57 0.67 0.65 0.63 0.66 0.62 0.51 0.56 0.71 0.51 0.66 0.59 0.67 0.58 0.67 0.58 0.58 0.67 1.00 0.60 0.67 0.59 0.66 0.67 0.66 0.47 0.95 0.70 0.40 0.50 0.14 0.21 0.56 0.64 0.16 1.00 1.00 0.51 0.55 0.24 0.70 0.56
3827 (KNG1) 0.62 0.62 0.42 0.62 0.53 1.00 0.77 0.62 0.70 0.74 0.66 0.70 0.56 0.62 0.59 0.49 0.49 0.64 0.53 0.72 0.71 0.67 0.62 0.63 0.67 0.54 0.67 0.60 1.00 0.48 0.53 0.62 0.63 0.66 0.46 0.62 0.57 0.37 0.52 0.11 0.16 0.86 0.64 0.90 1.00 1.00 0.48 0.49 0.20 0.63 0.81
3082 (HGF) 0.56 0.56 0.29 0.71 0.63 1.00 0.53 0.54 0.66 0.49 0.53 0.58 0.48 0.59 0.55 0.47 0.77 0.58 0.49 0.58 0.47 0.59 0.54 0.60 0.54 0.50 0.57 0.67 0.48 1.00 0.46 0.55 0.56 0.57 0.45 0.66 0.82 0.37 0.45 0.38 0.27 0.48 0.50 0.23 1.00 1.00 0.45 0.47 0.22 0.68 0.48
5473 (PPBP) 0.62 0.62 0.16 0.61 0.54 1.00 0.61 0.61 0.60 0.51 0.63 0.61 0.55 0.61 0.61 0.48 0.45 0.64 0.48 0.62 0.73 0.66 0.55 0.64 0.56 0.54 0.64 0.59 0.53 0.46 1.00 0.56 0.64 0.65 0.43 0.59 0.55 0.35 0.47 0.11 0.16 0.51 0.59 0.13 1.00 1.00 0.47 0.52 0.20 0.63 0.53
3481 (IGF2) 0.67 0.67 0.42 0.65 0.57 1.00 0.68 0.67 0.67 0.57 0.84 0.69 0.70 0.67 0.66 0.50 0.60 0.68 0.50 0.69 0.57 0.64 0.56 0.71 0.63 0.58 0.67 0.66 0.62 0.55 0.56 1.00 0.64 0.63 0.46 0.65 0.64 0.41 0.49 0.10 0.16 0.58 0.63 0.22 1.00 1.00 0.50 0.53 0.19 0.68 0.58
1191 (CLU) 0.68 0.68 0.16 0.69 0.66 1.00 0.69 0.69 0.63 0.62 0.69 0.68 0.66 0.65 0.64 0.58 0.55 0.72 0.54 0.68 0.65 0.69 0.63 0.70 0.62 0.66 0.75 0.67 0.63 0.56 0.64 0.64 1.00 0.68 0.50 0.66 0.61 0.48 0.58 0.12 0.16 0.59 0.68 0.13 1.00 1.00 0.56 0.59 0.21 0.70 0.61
7043 (TGFB3) 0.71 0.71 0.16 0.67 0.65 1.00 0.72 0.70 0.70 0.62 0.68 0.69 0.65 0.66 0.67 0.60 0.54 0.72 0.58 0.70 0.65 0.94 0.62 0.70 0.65 0.70 0.88 0.66 0.66 0.57 0.65 0.63 0.68 1.00 0.51 0.67 0.62 0.46 0.52 0.10 0.16 0.61 0.66 0.13 1.00 1.00 0.55 0.57 0.19 0.73 0.64
4089 (SMAD4) 0.48 0.48 0.16 0.50 0.42 1.00 0.46 0.49 0.57 0.47 0.47 0.54 0.44 0.54 0.51 0.81 0.42 0.49 0.83 0.50 0.47 0.53 0.62 0.55 0.53 0.75 0.53 0.47 0.46 0.45 0.43 0.46 0.50 0.51 1.00 0.48 0.52 0.79 0.50 0.10 0.16 0.50 0.45 0.13 1.00 1.00 0.77 0.44 0.61 0.46 0.43
2277 (FIGF) 0.70 0.70 0.20 0.66 0.60 1.00 0.68 0.68 0.86 0.57 0.65 0.65 0.61 0.71 0.62 0.52 0.59 0.71 0.52 0.67 0.60 0.68 0.58 0.66 0.58 0.59 0.68 0.95 0.62 0.66 0.59 0.65 0.66 0.67 0.48 1.00 0.74 0.42 0.50 0.13 0.21 0.57 0.62 0.16 1.00 1.00 0.52 0.55 0.22 0.70 0.56
5155 (PDGFB) 0.62 0.62 0.42 0.62 0.55 1.00 0.61 0.60 0.76 0.62 0.61 0.66 0.57 0.66 0.59 0.51 0.74 0.63 0.53 0.66 0.55 0.63 0.59 0.71 0.61 0.57 0.68 0.70 0.57 0.82 0.55 0.64 0.61 0.62 0.52 0.74 1.00 0.44 0.50 0.12 0.25 0.56 0.62 0.33 1.00 1.00 0.51 0.53 0.21 0.60 0.57
9575 (CLOCK) 0.42 0.42 0.16 0.47 0.34 1.00 0.40 0.42 0.49 0.37 0.42 0.47 0.36 0.50 0.48 0.76 0.36 0.45 0.74 0.47 0.37 0.47 0.59 0.48 0.45 0.70 0.46 0.40 0.37 0.37 0.35 0.41 0.48 0.46 0.79 0.42 0.44 1.00 0.45 0.10 0.31 0.43 0.39 0.13 1.00 1.00 0.85 0.38 0.77 0.40 0.37
4035 (LRP1) 0.52 0.52 0.16 0.55 0.45 1.00 0.49 0.68 0.55 0.45 0.51 0.55 0.46 0.62 0.61 0.53 0.51 0.53 0.53 0.53 0.49 0.53 0.56 0.54 0.58 0.51 0.53 0.50 0.52 0.45 0.47 0.49 0.58 0.52 0.50 0.50 0.50 0.45 1.00 0.11 0.16 0.60 0.55 0.13 1.00 1.00 0.51 0.71 0.24 0.50 0.48
1675 (CFD) 0.15 0.15 0.09 0.41 0.74 0.15 0.12 0.12 0.11 0.11 0.11 0.11 0.13 0.12 0.10 0.10 0.12 0.15 0.10 0.11 0.11 0.11 0.13 0.11 0.10 0.11 0.11 0.14 0.11 0.38 0.11 0.10 0.12 0.10 0.10 0.13 0.12 0.10 0.11 1.00 0.20 0.10 0.12 0.07 0.15 0.15 0.10 0.11 0.11 0.54 0.11
2162 (F13A1) 0.21 0.21 0.09 0.20 0.16 0.16 0.16 0.16 0.21 0.16 0.16 0.16 0.16 0.20 0.16 0.16 0.27 0.21 0.16 0.16 0.16 0.16 0.21 0.16 0.16 0.16 0.16 0.21 0.16 0.27 0.16 0.16 0.16 0.16 0.16 0.21 0.25 0.31 0.16 0.20 1.00 0.16 0.16 0.07 0.16 0.16 0.16 0.16 0.16 0.16 0.16
3273 (HRG) 0.57 0.57 0.42 0.60 0.50 1.00 0.70 0.57 0.67 0.68 0.61 0.68 0.52 0.60 0.57 0.51 0.48 0.59 0.55 0.69 0.64 0.62 0.62 0.64 0.69 0.55 0.62 0.56 0.86 0.48 0.51 0.58 0.59 0.61 0.50 0.57 0.56 0.43 0.60 0.10 0.16 1.00 0.65 0.90 1.00 1.00 0.52 0.49 0.22 0.58 0.74
6678 (SPARC) 0.64 0.64 0.16 0.65 0.61 1.00 0.65 0.64 0.65 0.57 0.70 0.68 0.64 0.69 0.67 0.50 0.49 0.66 0.51 0.64 0.60 0.67 0.61 0.74 0.70 0.60 0.65 0.64 0.64 0.50 0.59 0.63 0.68 0.66 0.45 0.62 0.62 0.39 0.55 0.12 0.16 0.65 1.00 0.13 1.00 1.00 0.51 0.54 0.22 0.66 0.61
5627 (PROS1) 0.16 0.16 0.46 0.13 0.13 0.13 0.90 0.13 0.17 1.00 0.13 0.13 0.13 0.13 0.13 0.13 0.23 0.16 0.13 0.90 0.13 0.13 0.16 0.13 0.13 0.13 0.13 0.16 0.90 0.23 0.13 0.22 0.13 0.13 0.13 0.16 0.33 0.13 0.13 0.07 0.07 0.90 0.13 1.00 0.13 0.13 0.13 0.13 0.13 0.13 0.81
2153 (F5) 1.00 1.00 0.16 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.15 0.16 1.00 1.00 0.13 1.00 1.00 1.00 1.00 0.26 1.00 1.00
5552 (SRGN) 1.00 1.00 0.16 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.15 0.16 1.00 1.00 0.13 1.00 1.00 1.00 1.00 0.26 1.00 1.00
406 (ARNTL) 0.53 0.53 0.16 0.55 0.47 1.00 0.52 0.53 0.55 0.47 0.53 0.55 0.48 0.56 0.55 0.74 0.44 0.55 0.73 0.56 0.48 0.56 0.65 0.56 0.52 0.73 0.56 0.51 0.48 0.45 0.47 0.50 0.56 0.55 0.77 0.52 0.51 0.85 0.51 0.10 0.16 0.52 0.51 0.13 1.00 1.00 1.00 0.47 0.65 0.53 0.47
7436 (VLDLR) 0.56 0.56 0.16 0.59 0.50 1.00 0.54 0.70 0.57 0.49 0.56 0.57 0.51 0.64 0.63 0.48 0.55 0.58 0.48 0.59 0.51 0.59 0.53 0.59 0.55 0.52 0.57 0.55 0.49 0.47 0.52 0.53 0.59 0.57 0.44 0.55 0.53 0.38 0.71 0.11 0.16 0.49 0.54 0.13 1.00 1.00 0.47 1.00 0.20 0.55 0.49
56938 (ARNTL2) 0.26 0.26 0.16 0.20 0.21 0.26 0.21 0.22 0.20 0.19 0.20 0.20 0.22 0.19 0.19 0.49 0.19 0.25 0.47 0.20 0.19 0.20 0.32 0.20 0.19 0.50 0.19 0.24 0.20 0.22 0.20 0.19 0.21 0.19 0.61 0.22 0.21 0.77 0.24 0.11 0.16 0.22 0.22 0.13 0.26 0.26 0.65 0.20 1.00 0.21 0.19
5327 (PLAT) 0.71 0.71 0.16 0.85 0.94 1.00 0.72 0.69 0.67 0.59 0.75 0.67 0.66 0.66 0.64 0.52 0.53 0.72 0.51 0.68 0.65 0.73 0.59 0.69 0.60 0.60 0.73 0.70 0.63 0.68 0.63 0.68 0.70 0.73 0.46 0.70 0.60 0.40 0.50 0.54 0.16 0.58 0.66 0.13 1.00 1.00 0.53 0.55 0.21 1.00 0.59
7076 (TIMP1) 0.59 0.59 0.57 0.60 0.51 1.00 0.82 0.60 0.61 0.80 0.59 0.63 0.53 0.62 0.61 0.48 0.48 0.61 0.52 0.76 0.54 0.66 0.58 0.65 0.57 0.53 0.63 0.56 0.81 0.48 0.53 0.58 0.61 0.64 0.43 0.56 0.57 0.37 0.48 0.11 0.16 0.74 0.61 0.81 1.00 1.00 0.47 0.49 0.19 0.59 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
SERPINE1 Human Blood - 4000 m 24 hours upregulated 2.6 RT-qPCR The South Atlantic States, USA Americans 1 Soldier exposed to high altitude compared to their low altitude profile 24183776
SERPINE1 Human Blood - 3500 m 24 hours upregulated 2.4 RT-qPCR The South Atlantic States, USA Americans 1 Soldier exposed to high altitude compared to their low altitude profile 24183776
SERPINE1 Human Blood - 3000m 24 hours upregulated 1.6 RT-qPCR The South Atlantic States, USA Americans 1 Soldier exposed to high altitude compared to their low altitude profile 24183776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
EP300 2033 SERPINE1 5054 distal 22955619 TRANSFAC
FOXA1 3169 SERPINE1 5054 proximal_filtered 22955619 TRANSFAC
JUN 3725 SERPINE1 5054 proximal_filtered 22955619 TRANSFAC
NR3C1 2908 SERPINE1 5054 proximal_filtered 22955619 TRANSFAC
GATA2 2624 SERPINE1 5054 proximal_filtered 22955619 TRANSFAC
RXRA 6256 SERPINE1 5054 proximal_filtered 22955619 TRANSFAC
MYC 4609 SERPINE1 5054 proximal_filtered 22955619 TRANSFAC
FOS 2353 SERPINE1 5054 proximal_filtered 22955619 TRANSFAC
E2F1 1869 SERPINE1 5054 Activation 17498959 TRUSST
NR4A1 3164 SERPINE1 5054 Activation 12654640 TRUSST
TGIF1 7050 SERPINE1 5054 Activation 20646316 TRUSST
SMAD3 4088 SERPINE1 5054 Unknown 10506168 TRUSST
EPAS1 2034 SERPINE1 5054 Activation 22551568 TRUSST
NFKB1 4790 SERPINE1 5054 Unknown 15317818 TRUSST
SP1 6667 SERPINE1 5054 Activation 10029407 TRUSST
KLF10 7071 SERPINE1 5054 Unknown 10506168 TRUSST
SRF 6722 SERPINE1 5054 Unknown 19853299 TRUSST
USF1 7391 SERPINE1 5054 Activation 20646316 TRUSST
ESR1 2099 SERPINE1 5054 Unknown 17047041 TRUSST
HIF1A 3091 SERPINE1 5054 Activation 22641097 TRUSST
PPARG 5468 SERPINE1 5054 Repression 17533737 TRUSST
PARP1 142 SERPINE1 5054 Unknown 15781633 TRUSST
SMAD4 4089 SERPINE1 5054 Unknown 19853299 TRUSST
PPARA 5465 SERPINE1 5054 Activation 17533737 TRUSST
RELA 5970 SERPINE1 5054 Unknown 16540670 TRUSST
ARNTL2 56938 SERPINE1 5054 Repression 22846578 TRUSST
ESR2 2100 SERPINE1 5054 Activation 17498959 TRUSST
HSF1 3297 SERPINE1 5054 Activation 21469139 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT005844 hsa-miR-204-5p Homo sapiens SERPINE1 5054 Homo sapiens Microarray Functional MTI (Weak) 21282569
MIRT005971 hsa-miR-30c-5p Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT005971 hsa-miR-30c-5p Homo sapiens SERPINE1 5054 Homo sapiens Luciferase reporter assay Functional MTI 21175428
MIRT005971 hsa-miR-30c-5p Homo sapiens SERPINE1 5054 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27819307
MIRT005972 hsa-miR-301a-3p Homo sapiens SERPINE1 5054 Homo sapiens Luciferase reporter assay Functional MTI 21175428
MIRT005973 hsa-miR-99a-5p Homo sapiens SERPINE1 5054 Homo sapiens Luciferase reporter assay Non-Functional MTI 21175428
MIRT006316 hsa-miR-143-3p Homo sapiens SERPINE1 5054 Homo sapiens Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 22108519
MIRT006316 hsa-miR-143-3p Homo sapiens SERPINE1 5054 Homo sapiens Luciferase reporter assay//Western blot Functional MTI 26817521
MIRT006317 hsa-miR-145-5p Homo sapiens SERPINE1 5054 Homo sapiens Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 22108519
MIRT006317 hsa-miR-145-5p Homo sapiens SERPINE1 5054 Homo sapiens qRT-PCR Functional MTI (Weak) 23312222
MIRT021688 hsa-miR-138-5p Homo sapiens SERPINE1 5054 Homo sapiens qRT-PCR Functional MTI (Weak) 21770894
MIRT022189 hsa-miR-124-3p Homo sapiens SERPINE1 5054 Homo sapiens Microarray Functional MTI (Weak) 18668037
MIRT053477 hsa-miR-148a-3p Homo sapiens SERPINE1 5054 Homo sapiens Luciferase reporter assay//Microarray//qRT-PCR Functional MTI 21703006
MIRT054106 hsa-miR-486-5p Homo sapiens SERPINE1 5054 Homo sapiens qRT-PCR Functional MTI (Weak) 22995304
MIRT054139 hsa-miR-30b-5p Homo sapiens SERPINE1 5054 Homo sapiens GFP reporter assay//Luciferase reporter assay//Northern blot//qRT-PCR//Western blot Functional MTI 25170877
MIRT054139 hsa-miR-30b-5p Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT244297 hsa-miR-6882-5p Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT244292 hsa-miR-30a-5p Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT244295 hsa-miR-30e-5p Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT244294 hsa-miR-224-5p Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT244293 hsa-miR-30d-5p Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT534386 hsa-miR-3145-5p Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT534387 hsa-miR-1273d Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT534384 hsa-miR-3977 Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT534385 hsa-miR-519d-5p Homo sapiens SERPINE1 5054 Homo sapiens PAR-CLIP Functional MTI (Weak) 22012620
MIRT731180 hsa-miR-10a-5p Homo sapiens SERPINE1 5054 Homo sapiens qRT-PCR//ELISA//Luciferase reporter assay//Western blot Functional MTI 25554417
MIRT735499 hsa-miR-192-5p Homo sapiens SERPINE1 5054 Homo sapiens Luciferase reporter assay//qRT-PCR//Western blot Functional MTI 27216198
Gene Ontology
ID GO ID GO Term GO Type
5054 GO:0030198 extracellular matrix organization GOTERM_BP_DIRECT
5054 GO:0032757 positive regulation of interleukin-8 production GOTERM_BP_DIRECT
5054 GO:2000098 negative regulation of smooth muscle cell-matrix adhesion GOTERM_BP_DIRECT
5054 GO:0051918 negative regulation of fibrinolysis GOTERM_BP_DIRECT
5054 GO:0005615 extracellular space GOTERM_CC_DIRECT
5054 GO:0045766 positive regulation of angiogenesis GOTERM_BP_DIRECT
5054 GO:0061045 negative regulation of wound healing GOTERM_BP_DIRECT
5054 GO:0031093 platelet alpha granule lumen GOTERM_CC_DIRECT
5054 GO:0010469 regulation of receptor activity GOTERM_BP_DIRECT
5054 GO:2000352 negative regulation of endothelial cell apoptotic process GOTERM_BP_DIRECT
5054 GO:0061044 negative regulation of vascular wound healing GOTERM_BP_DIRECT
5054 GO:0004867 serine-type endopeptidase inhibitor activity GOTERM_MF_DIRECT
5054 GO:0005102 receptor binding GOTERM_MF_DIRECT
5054 GO:0005515 protein binding GOTERM_MF_DIRECT
5054 GO:0005576 extracellular region GOTERM_CC_DIRECT
5054 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
5054 GO:0030336 negative regulation of cell migration GOTERM_BP_DIRECT
5054 GO:0071222 cellular response to lipopolysaccharide GOTERM_BP_DIRECT
5054 GO:0010757 negative regulation of plasminogen activation GOTERM_BP_DIRECT
5054 GO:0050729 positive regulation of inflammatory response GOTERM_BP_DIRECT
5054 GO:0001300 chronological cell aging GOTERM_BP_DIRECT
5054 GO:0030194 positive regulation of blood coagulation GOTERM_BP_DIRECT
5054 GO:0002020 protease binding GOTERM_MF_DIRECT
5054 GO:0030195 negative regulation of blood coagulation GOTERM_BP_DIRECT
5054 GO:0045944 positive regulation of transcription from RNA polymerase II promoter GOTERM_BP_DIRECT
5054 GO:0007623 circadian rhythm GOTERM_BP_DIRECT
5054 GO:0033629 negative regulation of cell adhesion mediated by integrin GOTERM_BP_DIRECT
5054 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GOTERM_BP_DIRECT
5054 GO:0001525 angiogenesis GOTERM_BP_DIRECT
5054 GO:0048260 positive regulation of receptor-mediated endocytosis GOTERM_BP_DIRECT
5054 GO:0014912 negative regulation of smooth muscle cell migration GOTERM_BP_DIRECT
5054 GO:0042730 fibrinolysis GOTERM_BP_DIRECT
5054 GO:0005886 plasma membrane GOTERM_CC_DIRECT
5054 GO:0031012 extracellular matrix GOTERM_CC_DIRECT
5054 GO:0010951 negative regulation of endopeptidase activity GOTERM_BP_DIRECT
5054 GO:0035491 positive regulation of leukotriene production involved in inflammatory response GOTERM_BP_DIRECT
5054 GO:0090026 positive regulation of monocyte chemotaxis GOTERM_BP_DIRECT
5054 GO:0002576 platelet degranulation GOTERM_BP_DIRECT
5054 GO:0050829 defense response to Gram-negative bacterium GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
5054 hsa04066 HIF-1 signaling pathway
5054 hsa04115 p53 signaling pathway
5054 hsa04610 Complement and coagulation cascades
5054 hsa04390 Hippo signaling pathway
5054 hsa05142 Chagas disease
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
SERPINE1 5054 Left-Sided Heart Failure C0023212 Disease or Syndrome 0.3 0.384 0.793 disease
SERPINE1 5054 Atherogenesis C1563937 Pathologic Function 0.3 0.384 0.793 phenotype
SERPINE1 5054 Alloxan Diabetes C0002152 Experimental Model of Disease 0.3 0.384 0.793 disease
SERPINE1 5054 Cholestasis C0008370 Disease or Syndrome 0.3 0.384 0.793 disease
SERPINE1 5054 Focal glomerulosclerosis C0017668 Disease or Syndrome 0.5 0.384 0.793 disease
SERPINE1 5054 Congestive heart failure C0018802 Disease or Syndrome 0.3 0.384 0.793 disease
SERPINE1 5054 Streptozotocin Diabetes C0038433 Experimental Model of Disease 0.3 0.384 0.793 disease
SERPINE1 5054 Hereditary Diffuse Gastric Cancer C1708349 Neoplastic Process 0.3 0.384 0.793 disease
SERPINE1 5054 Heart failure C0018801 Disease or Syndrome 0.31 0.384 0.793 disease
SERPINE1 5054 Prostatic Neoplasms C0033578 Neoplastic Process 0.32 0.384 0.793 group
SERPINE1 5054 Myocardial Failure C1959583 Disease or Syndrome 0.3 0.384 0.793 disease
SERPINE1 5054 Liver neoplasms C0023903 Neoplastic Process 0.4 0.384 0.793 group
SERPINE1 5054 Hyalinosis, Segmental Glomerular C0086432 Disease or Syndrome 0.3 0.384 0.793 disease
SERPINE1 5054 Heart Decompensation C1961112 Pathologic Function 0.3 0.384 0.793 phenotype
SERPINE1 5054 Diabetes Mellitus, Experimental C0011853 Experimental Model of Disease 0.3 0.384 0.793 disease
SERPINE1 5054 Obesity C0028754 Disease or Syndrome 0.4 0.384 0.793 disease
SERPINE1 5054 Stomach Neoplasms C0038356 Neoplastic Process 0.32 0.384 0.793 group
SERPINE1 5054 Malignant neoplasm of liver C0345904 Neoplastic Process 0.3 0.384 0.793 disease
SERPINE1 5054 Behcet Syndrome C0004943 Disease or Syndrome 0.31 0.384 0.793 disease
SERPINE1 5054 Fatty Liver C0015695 Disease or Syndrome 0.32 0.384 0.793 disease
SERPINE1 5054 Heart Failure, Right-Sided C0235527 Disease or Syndrome 0.3 0.384 0.793 disease
SERPINE1 5054 Diabetic Nephropathy C0011881 Disease or Syndrome 0.4 0.384 0.793 disease
SERPINE1 5054 Respiratory Hypersensitivity C0035228 Pathologic Function 0.3 0.384 0.793 phenotype
SERPINE1 5054 Nephrotic Syndrome C0027726 Disease or Syndrome 0.32 0.384 0.793 group
SERPINE1 5054 Thrombosis C0040053 Pathologic Function 0.34 0.384 0.793 phenotype
SERPINE1 5054 Malignant neoplasm of prostate C0376358 Neoplastic Process 0.38 0.384 0.793 disease
SERPINE1 5054 Nodular glomerulosclerosis C0017667 Disease or Syndrome 0.3 0.384 0.793 disease
SERPINE1 5054 Malignant neoplasm of stomach C0024623 Neoplastic Process 0.4 0.384 0.793 disease
SERPINE1 5054 Pre-Eclampsia C0032914 Pathologic Function 0.33 0.384 0.793 phenotype
SERPINE1 5054 Hypertensive disease C0020538 Disease or Syndrome 0.6 0.384 0.793 group
SERPINE1 5054 Atherosclerosis C0004153 Disease or Syndrome 0.4 0.384 0.793 disease
SERPINE1 5054 Autistic Disorder C0004352 Mental or Behavioral Dysfunction 0.31 0.384 0.793 group
SERPINE1 5054 Thrombus C0087086 Pathologic Function 0.3 0.384 0.793 phenotype
SERPINE1 5054 nervous system disorder C0027765 Disease or Syndrome 0.3 0.384 0.793 group
SERPINE1 5054 Steatohepatitis C2711227 Disease or Syndrome 0.3 0.384 0.793 disease
SERPINE1 5054 Kidney Failure, Chronic C0022661 Disease or Syndrome 0.51 0.384 0.793 disease
SERPINE1 5054 Plasminogen Activator Inhibitor-1 Deficiency C2750067 Disease or Syndrome 0.5 0.384 0.793 disease
SERPINE1 5054 Depressive Symptoms C0086132 Sign or Symptom 0.31 0.384 0.793 phenotype
SERPINE1 5054 Unipolar Depression C0041696 Mental or Behavioral Dysfunction 0.31 0.384 0.793 disease
SERPINE1 5054 Major Depressive Disorder C1269683 Mental or Behavioral Dysfunction 0.31 0.384 0.793 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
SERPINE1 5054 5-BROMODEOXYURIDINE None None None
SERPINE1 5054 9-CIS RETINOIC ACID None None None
SERPINE1 5054 ALEPLASININ ALEPLASININ CHEMBL325424 inhibitor
SERPINE1 5054 ARSENIC TRIOXIDE ARSENIC TRIOXIDE CHEMBL1200978 None
SERPINE1 5054 AZA None None None
SERPINE1 5054 CAPTOPRIL CAPTOPRIL CHEMBL1560 None
SERPINE1 5054 CETRORELIX CETRORELIX CHEMBL1200490 None
SERPINE1 5054 DALTEPARIN DALTEPARIN SODIUM CHEMBL1201460 None
SERPINE1 5054 DEFIBROTIDE DEFIBROTIDE CHEMBL2108396 None
SERPINE1 5054 EPIRUBICIN EPIRUBICIN CHEMBL417 None
SERPINE1 5054 GM-CSF REGRAMOSTIM CHEMBL2107881 None
SERPINE1 5054 GLYCYRRHETINIC ACID GLYCYRRHIZIN CHEMBL441687 None
SERPINE1 5054 HYDROCHLOROTHIAZIDE HYDROCHLOROTHIAZIDE CHEMBL435 None
SERPINE1 5054 LEVOTHYROXINE LEVOTHYROXINE CHEMBL1624 None
SERPINE1 5054 MCP-1 None None None
SERPINE1 5054 NIMODIPINE NIMODIPINE CHEMBL1428 None
SERPINE1 5054 NORETHISTERONE ACETATE None None None
SERPINE1 5054 ORAL CONTRACEPTIVE None None None
SERPINE1 5054 ORLISTAT ORLISTAT CHEMBL175247 None
SERPINE1 5054 PREMARIN ESTROGENS, CONJUGATED CHEMBL1201649 None
SERPINE1 5054 RECOMBINANT INTERLEUKIN None None None
SERPINE1 5054 RETINOID ETRETINATE CHEMBL464 None
SERPINE1 5054 THROMBOLYTIC AGENT None None None
SERPINE1 5054 URIDINE URIDINE CHEMBL100259 None
SERPINE1 5054 UROKINASE UROKINASE CHEMBL1201420 None
SERPINE1 5054 VASOPRESSIN VASOPRESSIN CHEMBL373742 None