ALTITUDEOMICSDB

Urokinase-type plasminogen activator

AltitudeomicsDB

Protein Official symbol	PLAU
Aliases	PLAU
Chromosomal Location	10
Length	431
Uniprot ID	P00749
EC number	3.4.21.73
Protein family Information(Pfam)	PF00051;PF00089;
PDB id	1C5W;1C5X;1C5Y;1C5Z;1EJN;1F5K;1F5L;1F92;1FV9;1GI7;1GI8;1GI9;1GJ7;1GJ8;1GJ9;1GJA;1GJB;1GJC;1GJD;1KDU;1LMW;1O3P;1O5A;1O5B;1O5C;1OWD;1OWE;1OWH;1OWI;1OWJ;1OWK;1SC8;1SQA;1SQO;1SQT;1U6Q;1URK;1VJ9;1VJA;1W0Z;1W10;1W11;1W12;1W13;1W14;2FD6;2I9A;2I9B;2NWN;2O8T;2O8U;2O8W;2R2W;2VIN;2VIO;2VIP;2VIQ;2VIV;2VIW;2VNT;3BT1;3BT2;3IG6;3KGP;3KHV;3KID;3M61;3MHW;3MWI;3OX7;3OY5;3OY6;3PB1;3QN7;3U73;4DVA;4DW2;4FU7;4FU8;4FU9;4FUB;4FUC;4FUD;4FUE;4FUF;4FUG;4FUH;4FUI;4FUJ;4GLY;4H42;4JK5;4JK6;4K24;4MNV;4MNW;4MNX;4MNY;4OS1;4OS2;4OS4;4OS5;4OS6;4OS7;4X0W;4X1N;4X1P;4X1Q;4X1R;4X1S;4XSK;4ZHL;4ZHM;4ZKN;4ZKO;4ZKR;4ZKS;5HGG;5WXF;5WXO;5WXP;5WXQ;5WXR;5WXS;5WXT;5XG4;5YC6;5YC7;5Z1C;5ZA7;5ZA8;5ZA9;5ZAE;5ZAF;5ZAG;5ZAH;5ZAJ;5ZC5;6AG2;6AG3;6AG7;6AG9;6NMB;6XVD;
InterPro ID	IPR013032;IPR000742;IPR000001;IPR013806;IPR018056;IPR038178;IPR009003;IPR001314;IPR001254;IPR018114;IPR033116;IPR034814;
dbSNP	rs2227580 rs2227564 rs1050120 rs2227567

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
FGG	FGB	0.999
FGA	FGB	0.999
FGG	FGA	0.999
PLAU	PLAUR	0.997
PLG	SERPINE1	0.997
CYBB	CYBA	0.994
PLAUR	PLG	0.994
SIRPA	CD47	0.994
PLAU	SERPINE1	0.993
FGG	F2	0.992
F2	FGA	0.991
PLAUR	SERPINE1	0.99
PLG	HRG	0.988
VTN	SERPINE1	0.988
ITGB3	ITGAV	0.986
PLAUR	VTN	0.986
SERPINB2	PLG	0.986
ITGB1	ITGA5	0.986
ITGAV	VTN	0.986
F2	FGB	0.985
FN1	ITGA5	0.985
ITGAM	ITGB2	0.985
FGA	HRG	0.985
FGG	HRG	0.983
ITGB1	FN1	0.982
FGB	HRG	0.982
ITGB1	ITGA3	0.981
ITGB1	ITGAV	0.981
PLG	FGA	0.98
SERPINB2	PLAU	0.98
FN1	PLG	0.979
FN1	SERPINE1	0.979
PLG	FGB	0.979
FGG	PLG	0.978
SRC	HGF	0.977
ITGAM	CYBB	0.977
ITGB5	ITGAV	0.976
ITGB3	ITGA3	0.975
SERPINB2	PLAUR	0.975
SRC	FN1	0.975
SERPINE1	HGF	0.971
SERPINE2	PLAU	0.971
ITGB2	C3AR1	0.97
FN1	ITGAV	0.97
PDGFD	PDGFRB	0.969
ITGAM	C3AR1	0.969
FN1	HGF	0.968
ITGB5	ITGA3	0.967
PLAU	VTN	0.965
ITGB2	CYBB	0.965
ITGB3	FN1	0.962
ITGAM	CD93	0.962
PDGFRB	LRP1	0.961
PLAU	FN1	0.96
ITGAM	SIRPA	0.96
C3AR1	CD93	0.96
SRC	F2	0.959
ITGB3	ITGA5	0.959
SERPINE2	PLAUR	0.958
ITGB3	VTN	0.958
FN1	PLAUR	0.958
SRC	VTN	0.957
FN1	VTN	0.956
PLAUR	PDGFRB	0.956
ITGB2	ITGAV	0.955
ITGB1	HGF	0.954
ADAM8	ITGB2	0.954
PLAUR	EGFR	0.954
SERPINE2	F2	0.953
ITGB2	ITGA3	0.952
PLAU	EGFR	0.951
ITGB5	VTN	0.95
ITGAM	CD47	0.95
HRG	SERPINE1	0.95
CD59	C3AR1	0.95
PLAUR	HGF	0.95
ITGB1	VTN	0.949
ADAM8	TNFRSF1B	0.949
FPR2	ITGAM	0.949
ITGAM	TNFRSF1B	0.948
FPR2	PLAUR	0.948
CYBB	OLR1	0.948
SRC	PLAUR	0.947
LRP1	SERPINE1	0.947
PLAUR	LRP1	0.947
ITGB3	SERPINE1	0.947
ITGB1	SRC	0.947
FPR2	CLEC4D	0.946
ITGB3	FGB	0.946
ITGB1	EGFR	0.946
ITGB3	SRC	0.946
ITGAM	ITGB1	0.945
CYBB	C3AR1	0.944
CD59	PLAUR	0.943
FN1	ADAM10	0.943
ITGAM	CLEC4D	0.943
SRC	PLAU	0.943
ITGB3	CD47	0.942
PLAU	MMP25	0.942
CD59	CD47	0.942
CD47	ITGAV	0.942
VTN	ITGA3	0.941
SRC	ITGAV	0.94
FGB	SERPINE1	0.94
ITGAM	CD59	0.94
PLAUR	ITGAV	0.939
ITGB2	TNFRSF1B	0.939
PLAU	LRP1	0.938
CYBB	RAP2B	0.938
OLR1	CYBA	0.938
PLAU	FGA	0.938
FN1	HRG	0.937
FPR2	CYBB	0.936
ITGB2	CD93	0.936
C3AR1	CLEC4D	0.935
FN1	FGA	0.935
EGFR	ITGA3	0.934
PDGFRB	ITGAV	0.934
ITGAM	PLAUR	0.934
ITGAM	PLG	0.934
ITGB3	FGA	0.934
PLAUR	ITGA5	0.933
PTAFR	PLAU	0.933
ADAM8	ITGAM	0.932
CYBB	TNFRSF1B	0.932
EGFR	HGF	0.932
ITGAM	PTAFR	0.932
SRC	EGFR	0.931
PLAU	ITGAV	0.931
ITGB2	CYBA	0.93
FN1	FGG	0.93
ITGAV	LRP1	0.93
ITGAV	ITGA3	0.93
FN1	FGB	0.93
ITGAV	SERPINE1	0.93
ADAM8	MMP25	0.93
VLDLR	ITGA3	0.929
PLAU	ITGA5	0.929
ITGB3	PLAU	0.929
ADAM8	ADAM10	0.929
VLDLR	SERPINE1	0.929
FGG	SERPINE1	0.929
ITGAM	CYBA	0.929
SRC	PDGFRB	0.929
ADAM8	CLEC4D	0.928
PLAU	PDGFRB	0.928
ITGB1	PLAUR	0.927
ITGB1	PLAU	0.927
FN1	CEACAM1	0.927
MMP25	ADAM10	0.927
ITGB3	PLAUR	0.927
PDGFD	PLG	0.927
RAP2B	CYBA	0.927
CYBB	PTAFR	0.927
PLAUR	ITGA3	0.926
FPR2	PTAFR	0.926
PLAU	F2	0.926
FPR2	PLAU	0.926
FGA	SERPINE1	0.926
ITGAM	LRP1	0.926
FPR2	CD47	0.926
ITGB3	FGG	0.926
VLDLR	PLAU	0.926
ITGB2	CD47	0.926
ITGAM	PLAU	0.926
CD59	ITGAV	0.925
PTAFR	CEACAM1	0.925
ITGB2	FGA	0.925
ITGAM	OLR1	0.925
SERPINB6	ITGAM	0.924
PLAU	PLG	0.924
ITGB2	PTAFR	0.924
SIRPA	CD93	0.924
CD47	PLAUR	0.923
TNFRSF1B	CD93	0.923
PLAU	ITGA3	0.923
ITGAV	ADAM10	0.923
ITGB2	CD59	0.922
TNFRSF1B	ITGAV	0.922
PLAU	ITGB5	0.922
FGA	ITGAV	0.922
ITGB3	PDGFRB	0.922
CYBB	PLAUR	0.922
NCL	VTN	0.922
ITGAM	ITGAV	0.921
CD59	CD93	0.921
ITGB5	ITGA5	0.921
CYBB	CD93	0.921
CYBB	PLAU	0.921
SRC	ITGB5	0.921
CYBB	CLEC4D	0.921
ITGAM	CEACAM1	0.921
ITGAM	ADAM10	0.921
ITGB2	MMP25	0.921
PLAUR	RAP2B	0.921
ITGB3	LRP1	0.921
FPR2	OLR1	0.921
VLDLR	PLAUR	0.921
SRC	FGA	0.92
ITGB1	VLDLR	0.92
FPR2	ITGB2	0.92
PLAU	ADAM10	0.92
PLAU	RAP2B	0.92
PLAUR	MMP25	0.919
FPR2	CD93	0.919
PLAU	UBE2A	0.919
TNFRSF1B	PLAUR	0.919
PTAFR	F2	0.919
PLAU	HGF	0.918
ADAM8	PLAU	0.918
PDGFD	PLAU	0.918
FPR2	CD59	0.918
ITGB2	CLEC4D	0.918
ITGB2	OLR1	0.918
ITGB2	PLAU	0.918
OLR1	CLEC4D	0.918
SERPINB2	SERPINB8	0.917
TNFRSF1B	CEACAM1	0.917
PLAU	FGG	0.917
ITGB5	SERPINE1	0.917
TNFRSF1B	C3AR1	0.917
FPR2	TNFRSF1B	0.917
NBEAL2	CYBA	0.917
CD59	PLAU	0.917
FPR2	C3AR1	0.916
SERPINE2	SERPINE1	0.916
TNFRSF1B	ADAM10	0.915
ITGAM	MMP25	0.915
CLEC4D	CD93	0.915
CD47	ADAM10	0.915
PDGFD	PLAUR	0.914
TNFRSF1B	CYBA	0.914
ITGB2	PLAUR	0.914
ADAM8	CYBB	0.914
C3AR1	CYBA	0.913
OLR1	ADAM10	0.913
SERPINB6	PLAU	0.913
ITGB2	PLG	0.913
PLAUR	CEACAM1	0.913
CYBB	CD47	0.913
ADAM8	C3AR1	0.913
ADAM8	ITGAV	0.913
PLAU	FGB	0.913
PLAU	CD47	0.912
PLG	HGF	0.912
PLAU	HRG	0.912
SERPINB8	PLAUR	0.912
TNFRSF1B	PLAU	0.912
ADAM8	CD47	0.912
ADAM8	CYBA	0.912
SIRPA	ITGB2	0.912
PLAUR	FGA	0.912
PLAUR	CD93	0.912
SERPINB6	PTAFR	0.912
PTAFR	CLEC4D	0.912
TNFRSF1B	CD47	0.912
NBEAL2	PLAU	0.911
PLAUR	ITGB5	0.911
TNFRSF1B	CLEC4D	0.911
NBEAL2	CYBB	0.911
FPR2	CYBA	0.911
ADAM8	NBEAL2	0.911
FPR2	ADAM10	0.911
PLAUR	OLR1	0.911
FPR2	MMP25	0.911
ITGB2	FGG	0.91
PLAUR	ADAM10	0.91
SIRPA	CEACAM1	0.91
ITGB1	ITGB5	0.91
ADAM8	PTAFR	0.91
PTAFR	OLR1	0.91
MMP25	CLEC4D	0.91
NBEAL2	ITGB2	0.91
CD47	CD93	0.91
MMP25	CD93	0.909
ADAM8	PLAUR	0.909
SIRPA	CYBB	0.909
SERPINB6	SERPINB2	0.909
ITGB2	CEACAM1	0.909
ITGAM	NBEAL2	0.909
CD47	OLR1	0.909
ITGB3	ITGB2	0.909
SERPINB8	PLAU	0.909
PLAUR	FGG	0.909
PLAU	CD93	0.909
CD59	OLR1	0.909
PLAU	SLC2A3	0.909
HGF	ITGA3	0.909
PLAU	CLEC4D	0.909
PLAUR	SLC2A3	0.909
PLAU	C3AR1	0.909
TNFRSF1B	OLR1	0.908
ITGB2	RAP2B	0.908
CLEC4D	CYBA	0.908
RAP2B	ADAM10	0.908
ITGB1	CEACAM1	0.908
SERPINB6	ITGB2	0.908
ITGB3	ITGB1	0.908
CYBB	MMP25	0.908
SIRPA	CD59	0.908
FPR2	SIRPA	0.908
SIRPA	CLEC4D	0.908
FPR2	ITGAV	0.908
CYBB	ADAM10	0.907
SIRPA	PLAU	0.907
ITGB2	ITGB1	0.907
MMP25	CYBA	0.907
OLR1	ITGAV	0.907
PLAU	OLR1	0.907
PLAUR	FGB	0.907
ITGB3	ITGB5	0.907
OLR1	C3AR1	0.907
PLAUR	NCL	0.906
PTAFR	CD93	0.906
CYBA	CEACAM1	0.906
ADAM8	CD93	0.906
PLAU	NCL	0.906
FGB	ITGA5	0.906
SRC	FGG	0.906
ADAM8	SIRPA	0.906
ITGAM	SLC2A3	0.906
SERPINB6	CYBB	0.906
CYBB	CEACAM1	0.906
PTAFR	ADAM10	0.906
FPR2	ADAM8	0.906
CD59	CEACAM1	0.906
CD59	ADAM10	0.906
ITGAV	SLC2A3	0.906
PLAU	CYBA	0.906
PLAU	CEACAM1	0.906
HRG	HGF	0.906
CD59	TNFRSF1B	0.906
SRC	FGB	0.906
C3AR1	CEACAM1	0.905
PLAUR	C3AR1	0.905
NBEAL2	RAP2B	0.905
NCL	ITGAV	0.905
SERPINB6	SLC2A3	0.905
ADAM10	SLC2A3	0.905
PLAUR	CYBA	0.905
CD47	C3AR1	0.905
OLR1	CEACAM1	0.905
FGB	ITGAV	0.905
ITGB2	ADAM10	0.905
TNFRSF1B	MMP25	0.905
PLAUR	CLEC4D	0.905
SIRPA	PTAFR	0.905
MMP25	C3AR1	0.905
ITGB1	FGA	0.904
ITGAV	CEACAM1	0.904
MMP25	ITGAV	0.904
CD47	CEACAM1	0.904
ITGB5	LRP1	0.904
MMP25	OLR1	0.904
CYBB	SLC2A3	0.904
NBEAL2	SLC2A3	0.904
CD59	SLC2A3	0.904
MMP25	SLC2A3	0.904
ITGB2	ITGB5	0.904
CYBB	ITGAV	0.904
ITGB2	FGB	0.904
ITGAM	FGG	0.904
CD59	CYBB	0.904
ITGB2	LRP1	0.903
C3AR1	ADAM10	0.903
CLEC4D	SLC2A3	0.903
ADAM8	ITGB1	0.903
FGG	ITGA5	0.903
ITGAM	FGB	0.903
SERPINB6	CEACAM1	0.903
SERPINB6	ADAM8	0.903
CD47	CYBA	0.903
SIRPA	SLC2A3	0.903
CEACAM1	SLC2A3	0.903
NBEAL2	SIRPA	0.902
FGG	ITGAV	0.902
ITGAM	FGA	0.902
SERPINB6	ADAM10	0.902
CD47	MMP25	0.902
ITGA5	CEACAM1	0.902
FGB	HGF	0.902
SERPINB6	CD93	0.902
NBEAL2	CLEC4D	0.902
ADAM8	RAP2B	0.902
ADAM10	CEACAM1	0.902
PTAFR	CD47	0.902
FGG	HGF	0.902
SIRPA	CYBA	0.902
NBEAL2	CD93	0.902
PTAFR	CYBA	0.902
RAP2B	C3AR1	0.902
OLR1	CD93	0.902
PLAUR	HRG	0.902
ITGB1	FGB	0.902
C3AR1	SLC2A3	0.902
SERPINB6	PLAUR	0.902
FGA	HGF	0.902
SERPINB6	SIRPA	0.902
OLR1	SLC2A3	0.902
SIRPA	RAP2B	0.902
PTAFR	SLC2A3	0.902
CYBA	CD93	0.902
ITGB1	FGG	0.902
ITGB2	SLC2A3	0.902
ADAM8	OLR1	0.902
FGA	ITGA5	0.902
C3AR1	ITGAV	0.901
RAP2B	SLC2A3	0.901
RAP2B	ITGAV	0.901
CD59	RAP2B	0.901
SERPINB6	CYBA	0.901
ITGAV	CD93	0.901
SIRPA	OLR1	0.901
SERPINB6	OLR1	0.901
SERPINB6	CD47	0.901
CYBA	ADAM10	0.901
ADAM10	CD93	0.9
CD47	CLEC4D	0.9
MMP25	CEACAM1	0.9
CYBA	ITGAV	0.9
RAP2B	CEACAM1	0.9
TNFRSF1B	RAP2B	0.9
FPR2	F2	0.9
CD59	PTAFR	0.9
ADAM8	CD59	0.9
FPR2	RAP2B	0.9
ADAM8	SLC2A3	0.9
UBE2A	PLG	0.9
CLEC4D	ITGAV	0.9
FPR2	NBEAL2	0.9
NBEAL2	ADAM10	0.9
RAP2B	OLR1	0.9
ADAM8	CEACAM1	0.9
CD47	RAP2B	0.9
FGA	ADAM10	0.9
CD47	SLC2A3	0.9
SERPINB6	CD59	0.9
SERPINB6	RAP2B	0.9
CYBA	SLC2A3	0.9
SERPINB6	CLEC4D	0.9
SIRPA	ADAM10	0.9
FGG	ADAM10	0.9
RAP2B	CLEC4D	0.9
NBEAL2	PTAFR	0.9
FPR2	CEACAM1	0.9
SERPINB6	NBEAL2	0.9
CD93	SLC2A3	0.9
TNFRSF1B	SLC2A3	0.9
ITGB3	NCL	0.9
NBEAL2	CD59	0.9
FPR2	SLC2A3	0.9
CLEC4D	ADAM10	0.9
RAP2B	CD93	0.9
NBEAL2	OLR1	0.9
PTAFR	RAP2B	0.9
CD59	CLEC4D	0.9
CD93	CEACAM1	0.9
MMP25	RAP2B	0.9
CD59	CYBA	0.9
NBEAL2	CD47	0.9
NBEAL2	CEACAM1	0.9
SERPINB6	FPR2	0.9
CLEC4D	CEACAM1	0.9
ITGAM	RAP2B	0.9
CD59	MMP25	0.9

Gene Ontology Semantic Similarity

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#	2266 (FGG)	2243 (FGA)	5328 (PLAU)	5340 (PLG)	1536 (CYBB)	5329 (PLAUR)	140885 (SIRPA)	2147 (F2)	7448 (VTN)	3690 (ITGB3)	5055 (SERPINB2)	3688 (ITGB1)	3685 (ITGAV)	2335 (FN1)	3684 (ITGAM)	2244 (FGB)	6714 (SRC)	3693 (ITGB5)	5054 (SERPINE1)	5270 (SERPINE2)	3689 (ITGB2)	80310 (PDGFD)	5159 (PDGFRB)	719 (C3AR1)	101 (ADAM8)	3273 (HRG)	966 (CD59)	2358 (FPR2)	4035 (LRP1)	961 (CD47)	4973 (OLR1)	1956 (EGFR)	5724 (PTAFR)	7436 (VLDLR)	64386 (MMP25)	5912 (RAP2B)	5269 (SERPINB6)	7133 (TNFRSF1B)	4691 (NCL)	23218 (NBEAL2)	338339 (CLEC4D)	5271 (SERPINB8)	3082 (HGF)	1535 (CYBA)	102 (ADAM10)	634 (CEACAM1)	3678 (ITGA5)	7319 (UBE2A)	22918 (CD93)	3675 (ITGA3)	6515 (SLC2A3)
2266 (FGG)	1.00	1.00	0.63	0.66	0.58	0.68	0.52	0.61	0.88	0.67	0.15	0.69	0.63	0.77	0.71	0.98	0.63	0.69	0.70	0.64	0.67	0.73	0.51	0.15	0.61	0.57	0.72	0.45	0.52	0.64	0.72	0.50	0.25	0.56	0.21	0.57	0.44	0.69	0.62	1.00	1.00	0.63	0.56	0.64	0.60	0.69	0.69	0.59	0.64	0.70	0.27
2243 (FGA)	1.00	1.00	0.63	0.66	0.58	0.68	0.52	0.61	0.88	0.67	0.15	0.69	0.63	0.77	0.71	0.98	0.63	0.69	0.70	0.64	0.67	0.73	0.51	0.15	0.61	0.57	0.72	0.45	0.52	0.64	0.72	0.50	0.25	0.56	0.21	0.57	0.44	0.69	0.62	1.00	1.00	0.63	0.56	0.64	0.60	0.69	0.69	0.59	0.64	0.70	0.27
5328 (PLAU)	0.63	0.63	1.00	0.83	0.49	0.62	0.52	0.71	0.58	0.62	0.12	0.64	0.61	0.61	0.71	0.65	0.58	0.66	0.62	0.55	0.61	0.60	0.43	0.12	0.76	0.50	0.73	0.33	0.45	0.60	0.73	0.45	0.20	0.50	0.55	0.49	0.40	0.68	0.60	1.00	1.00	0.56	0.63	0.58	0.71	0.65	0.64	0.54	0.59	0.70	0.21
5340 (PLG)	0.66	0.66	0.83	1.00	0.58	0.70	0.57	0.77	0.63	0.68	0.12	0.66	0.64	0.70	0.66	0.69	0.67	0.65	0.67	0.63	0.65	0.73	0.56	0.11	0.77	0.60	0.67	0.43	0.55	0.62	0.67	0.55	0.24	0.59	0.73	0.59	0.47	0.66	0.63	1.00	1.00	0.62	0.71	0.63	0.82	0.69	0.66	0.62	0.62	0.67	0.23
1536 (CYBB)	0.58	0.58	0.49	0.58	1.00	0.56	0.45	0.51	0.51	0.59	0.15	0.63	0.57	0.58	0.65	0.60	0.61	0.54	0.54	0.52	0.60	0.60	0.44	0.13	0.50	0.58	0.58	0.33	0.48	0.53	0.58	0.49	0.25	0.49	0.21	0.56	0.34	0.56	0.60	1.00	1.00	0.49	0.47	0.84	0.50	0.64	0.54	0.51	0.52	0.64	0.24
5329 (PLAUR)	0.68	0.68	0.62	0.70	0.56	1.00	0.54	0.76	0.63	0.75	0.12	0.76	0.73	0.68	0.69	0.70	0.65	0.68	0.70	0.63	0.75	0.73	0.69	0.40	0.57	0.57	0.71	0.67	0.68	0.82	0.71	0.61	0.49	0.70	0.16	0.57	0.49	0.69	0.64	1.00	1.00	0.62	0.54	0.63	0.60	0.69	0.68	0.60	0.88	0.71	0.24
140885 (SIRPA)	0.52	0.52	0.52	0.57	0.45	0.54	1.00	0.45	0.51	0.50	0.30	0.51	0.51	0.51	0.56	0.52	0.47	0.55	0.56	0.51	0.54	0.43	0.44	0.09	0.45	0.46	0.58	0.31	0.38	0.69	0.58	0.46	0.19	0.44	0.11	0.48	0.46	0.56	0.50	0.71	0.71	0.56	0.44	0.49	0.50	0.63	0.54	0.48	0.51	0.57	0.19
2147 (F2)	0.61	0.61	0.71	0.77	0.51	0.76	0.45	1.00	0.54	0.66	0.12	0.66	0.64	0.69	0.60	0.63	0.59	0.57	0.61	0.71	0.63	0.73	0.58	0.27	0.66	0.63	0.59	0.54	0.60	0.70	0.59	0.52	0.43	0.58	0.55	0.52	0.36	0.58	0.56	1.00	1.00	0.52	0.63	0.54	0.68	0.61	0.59	0.52	0.67	0.59	0.22
7448 (VTN)	0.88	0.88	0.58	0.63	0.51	0.63	0.51	0.54	1.00	0.67	0.12	0.70	0.66	0.78	0.70	0.87	0.62	0.85	0.64	0.58	0.70	0.60	0.45	0.13	0.55	0.52	0.72	0.37	0.46	0.60	0.72	0.46	0.22	0.51	0.16	0.51	0.41	0.68	0.60	1.00	1.00	0.58	0.48	0.59	0.61	0.65	0.64	0.55	0.60	0.69	0.23
3690 (ITGB3)	0.67	0.67	0.62	0.68	0.59	0.75	0.50	0.66	0.67	1.00	0.12	0.81	0.85	0.72	0.66	0.68	0.67	0.69	0.68	0.63	0.72	1.00	0.66	0.18	0.62	0.60	0.66	0.51	0.62	0.68	0.68	0.62	0.33	0.64	0.20	0.60	0.48	0.65	0.65	1.00	1.00	0.62	0.59	0.62	0.65	0.68	0.73	0.62	0.69	0.69	0.24
5055 (SERPINB2)	0.15	0.15	0.12	0.12	0.15	0.12	0.30	0.12	0.12	0.12	1.00	0.12	0.12	0.12	0.12	0.15	0.12	0.12	1.00	1.00	0.12	0.07	0.22	0.07	0.12	1.00	0.12	0.10	0.12	0.12	0.12	0.37	0.08	0.12	0.07	0.12	1.00	0.12	0.12	0.12	0.12	1.00	0.22	0.15	0.12	0.21	0.12	0.12	0.12	0.12	0.10
3688 (ITGB1)	0.69	0.69	0.64	0.66	0.63	0.76	0.51	0.66	0.70	0.81	0.12	1.00	0.79	0.72	0.72	0.69	0.66	0.73	0.69	0.63	0.78	0.60	0.62	0.20	0.63	0.60	0.68	0.52	0.66	0.71	0.68	0.65	0.35	0.65	0.16	0.61	0.49	0.67	0.64	1.00	1.00	0.64	0.57	0.67	0.64	0.69	0.66	0.61	0.73	0.75	0.24
3685 (ITGAV)	0.63	0.63	0.61	0.64	0.57	0.73	0.51	0.64	0.66	0.85	0.12	0.79	1.00	0.68	0.66	0.64	0.63	0.69	0.66	0.60	0.73	0.60	0.63	0.19	0.59	0.57	0.65	0.49	0.61	0.68	0.65	0.58	0.33	0.63	0.16	0.58	0.48	0.64	0.61	1.00	1.00	0.61	0.55	0.61	0.64	0.67	0.63	0.59	0.70	0.68	0.24
2335 (FN1)	0.77	0.77	0.61	0.70	0.58	0.68	0.51	0.69	0.78	0.72	0.12	0.72	0.68	1.00	0.66	0.79	0.68	0.71	0.70	0.72	0.68	0.73	0.55	0.11	0.59	0.68	0.66	0.43	0.55	0.62	0.69	0.55	0.26	0.57	0.16	0.61	0.50	0.66	0.67	1.00	1.00	0.61	0.58	0.61	0.65	0.69	0.65	0.60	0.62	0.70	0.24
3684 (ITGAM)	0.71	0.71	0.71	0.66	0.65	0.69	0.56	0.60	0.70	0.66	0.12	0.72	0.66	0.66	1.00	0.72	0.61	0.77	0.72	0.65	0.81	0.60	0.49	0.12	0.61	0.58	0.84	0.41	0.51	0.70	0.82	0.52	0.24	0.58	0.16	0.63	0.49	0.77	0.67	1.00	1.00	0.71	0.54	0.73	0.59	0.70	0.74	0.64	0.75	0.87	0.24
2244 (FGB)	0.98	0.98	0.65	0.69	0.60	0.70	0.52	0.63	0.87	0.68	0.15	0.69	0.64	0.79	0.72	1.00	0.64	0.71	0.71	0.65	0.68	0.73	0.53	0.15	0.62	0.59	0.73	0.46	0.53	0.66	0.73	0.51	0.26	0.58	0.21	0.60	0.45	0.70	0.64	1.00	1.00	0.65	0.58	0.66	0.62	0.70	0.71	0.61	0.66	0.71	0.27
6714 (SRC)	0.63	0.63	0.58	0.67	0.61	0.65	0.47	0.59	0.62	0.67	0.12	0.66	0.63	0.68	0.61	0.64	1.00	0.63	0.63	0.60	0.64	0.86	0.76	0.10	0.58	0.62	0.60	0.42	0.53	0.58	0.60	0.73	0.23	0.55	0.24	0.56	0.42	0.60	0.63	1.00	1.00	0.57	0.74	0.59	0.64	0.65	0.62	0.63	0.58	0.61	0.23
3693 (ITGB5)	0.69	0.69	0.66	0.65	0.54	0.68	0.55	0.57	0.85	0.69	0.12	0.73	0.69	0.71	0.77	0.71	0.63	1.00	0.71	0.62	0.73	0.60	0.46	0.12	0.58	0.55	0.83	0.40	0.48	0.66	0.83	0.47	0.22	0.54	0.16	0.56	0.46	0.76	0.64	1.00	1.00	0.66	0.50	0.63	0.65	0.67	0.72	0.59	0.66	0.78	0.23
5054 (SERPINE1)	0.70	0.70	0.62	0.67	0.54	0.70	0.56	0.61	0.64	0.68	1.00	0.69	0.66	0.70	0.72	0.71	0.63	0.71	1.00	0.83	0.64	0.73	0.51	0.12	0.56	0.70	0.74	0.43	0.49	0.64	0.74	0.50	0.22	0.54	0.16	0.56	0.87	0.70	0.63	1.00	1.00	0.92	0.53	0.62	0.59	0.66	0.71	0.58	0.63	0.80	0.23
5270 (SERPINE2)	0.64	0.64	0.55	0.63	0.52	0.63	0.51	0.71	0.58	0.63	1.00	0.63	0.60	0.72	0.65	0.65	0.60	0.62	0.83	1.00	0.60	0.73	0.48	0.12	0.53	0.78	0.65	0.39	0.50	0.58	0.65	0.48	0.28	0.51	0.16	0.55	0.64	0.63	0.58	1.00	1.00	0.80	0.49	0.56	0.55	0.63	0.63	0.53	0.57	0.64	0.23
3689 (ITGB2)	0.67	0.67	0.61	0.65	0.60	0.75	0.54	0.63	0.70	0.72	0.12	0.78	0.73	0.68	0.81	0.68	0.64	0.73	0.64	0.60	1.00	0.60	0.67	0.29	0.60	0.56	0.69	0.56	0.59	0.69	0.67	0.62	0.42	0.65	0.16	0.57	0.44	0.66	0.62	1.00	1.00	0.61	0.53	0.65	0.67	0.69	0.64	0.59	0.73	0.72	0.23
80310 (PDGFD)	0.73	0.73	0.60	0.73	0.60	0.73	0.43	0.73	0.60	1.00	0.07	0.60	0.60	0.73	0.60	0.73	0.86	0.60	0.73	0.73	0.60	1.00	1.00	0.09	0.60	0.73	0.60	0.60	0.60	0.60	0.60	0.60	0.23	0.60	0.09	0.60	0.40	0.60	0.60	0.60	0.60	0.60	0.60	0.60	0.73	0.60	1.00	0.60	0.60	0.60	0.22
5159 (PDGFRB)	0.51	0.51	0.43	0.56	0.44	0.69	0.44	0.58	0.45	0.66	0.22	0.62	0.63	0.55	0.49	0.53	0.76	0.46	0.51	0.48	0.67	1.00	1.00	0.36	0.45	0.47	0.47	0.56	0.56	0.58	0.47	0.81	0.46	0.60	0.16	0.42	0.34	0.48	0.49	1.00	1.00	0.44	0.72	0.47	0.51	0.58	0.51	0.50	0.61	0.49	0.19
719 (C3AR1)	0.15	0.15	0.12	0.11	0.13	0.40	0.09	0.27	0.13	0.18	0.07	0.20	0.19	0.11	0.12	0.15	0.10	0.12	0.12	0.12	0.29	0.09	0.36	1.00	0.11	0.10	0.13	0.67	0.28	0.36	0.13	0.25	0.73	0.35	0.09	0.10	0.09	0.12	0.11	0.14	0.14	0.12	0.12	0.14	0.10	0.13	0.12	0.11	0.47	0.12	0.09
101 (ADAM8)	0.61	0.61	0.76	0.77	0.50	0.57	0.45	0.66	0.55	0.62	0.12	0.63	0.59	0.59	0.61	0.62	0.58	0.58	0.56	0.53	0.60	0.60	0.45	0.11	1.00	0.64	0.60	0.33	0.54	0.55	0.60	0.47	0.24	0.50	1.00	0.49	0.36	0.59	0.56	1.00	1.00	0.52	0.61	0.55	0.75	0.61	0.57	0.54	0.54	0.60	0.22
3273 (HRG)	0.57	0.57	0.50	0.60	0.58	0.57	0.46	0.63	0.52	0.60	1.00	0.60	0.57	0.68	0.58	0.59	0.62	0.55	0.70	0.78	0.56	0.73	0.47	0.10	0.64	1.00	0.57	0.36	0.60	0.53	0.57	0.48	0.30	0.49	0.16	0.51	0.51	0.56	0.58	1.00	1.00	0.66	0.48	0.52	0.52	0.59	0.56	0.50	0.52	0.57	0.22
966 (CD59)	0.72	0.72	0.73	0.67	0.58	0.71	0.58	0.59	0.72	0.66	0.12	0.68	0.65	0.66	0.84	0.73	0.60	0.83	0.74	0.65	0.69	0.60	0.47	0.13	0.60	0.57	1.00	0.40	0.49	0.71	0.91	0.48	0.24	0.57	0.16	0.63	0.51	0.82	0.68	1.00	1.00	0.73	0.52	0.67	0.58	0.69	0.78	0.63	0.75	0.84	0.25
2358 (FPR2)	0.45	0.45	0.33	0.43	0.33	0.67	0.31	0.54	0.37	0.51	0.10	0.52	0.49	0.43	0.41	0.46	0.42	0.40	0.43	0.39	0.56	0.60	0.56	0.67	0.33	0.36	0.40	1.00	0.58	0.56	0.40	0.45	0.66	0.62	0.13	0.30	0.23	0.39	0.37	0.69	0.69	0.33	0.33	0.37	0.38	0.43	0.42	0.33	0.63	0.40	0.15
4035 (LRP1)	0.52	0.52	0.45	0.55	0.48	0.68	0.38	0.60	0.46	0.62	0.12	0.66	0.61	0.55	0.51	0.53	0.53	0.48	0.49	0.50	0.59	0.60	0.56	0.28	0.54	0.60	0.49	0.58	1.00	0.61	0.49	0.56	0.41	0.71	0.16	0.45	0.31	0.49	0.59	1.00	1.00	0.45	0.45	0.49	0.47	0.57	0.48	0.46	0.63	0.50	0.25
961 (CD47)	0.64	0.64	0.60	0.62	0.53	0.82	0.69	0.70	0.60	0.68	0.12	0.71	0.68	0.62	0.70	0.66	0.58	0.66	0.64	0.58	0.69	0.60	0.58	0.36	0.55	0.53	0.71	0.56	0.61	1.00	0.71	0.54	0.44	0.64	0.16	0.54	0.42	0.68	0.61	1.00	1.00	0.60	0.50	0.60	0.54	0.65	0.65	0.57	0.81	0.69	0.22
4973 (OLR1)	0.72	0.72	0.73	0.67	0.58	0.71	0.58	0.59	0.72	0.68	0.12	0.68	0.65	0.69	0.82	0.73	0.60	0.83	0.74	0.65	0.67	0.60	0.47	0.13	0.60	0.57	0.91	0.40	0.49	0.71	1.00	0.50	0.24	0.57	0.16	0.63	0.51	0.82	0.72	1.00	1.00	0.73	0.56	0.67	0.59	0.73	0.78	0.63	0.73	0.84	0.25
1956 (EGFR)	0.50	0.50	0.45	0.55	0.49	0.61	0.46	0.52	0.46	0.62	0.37	0.65	0.58	0.55	0.52	0.51	0.73	0.47	0.50	0.48	0.62	0.60	0.81	0.25	0.47	0.48	0.48	0.45	0.56	0.54	0.50	1.00	0.36	0.55	0.16	0.44	0.37	0.52	0.55	1.00	1.00	0.47	0.70	0.50	0.47	0.61	0.47	0.53	0.56	0.52	0.20
5724 (PTAFR)	0.25	0.25	0.20	0.24	0.25	0.49	0.19	0.43	0.22	0.33	0.08	0.35	0.33	0.26	0.24	0.26	0.23	0.22	0.22	0.28	0.42	0.23	0.46	0.73	0.24	0.30	0.24	0.66	0.41	0.44	0.24	0.36	1.00	0.43	0.10	0.24	0.15	0.23	0.24	0.38	0.38	0.20	0.20	0.23	0.20	0.26	0.22	0.21	0.52	0.24	0.14
7436 (VLDLR)	0.56	0.56	0.50	0.59	0.49	0.70	0.44	0.58	0.51	0.64	0.12	0.65	0.63	0.57	0.58	0.58	0.55	0.54	0.54	0.51	0.65	0.60	0.60	0.35	0.50	0.49	0.57	0.62	0.71	0.64	0.57	0.55	0.43	1.00	0.16	0.47	0.35	0.56	0.54	1.00	1.00	0.50	0.47	0.53	0.49	0.62	0.54	0.50	0.67	0.57	0.26
64386 (MMP25)	0.21	0.21	0.55	0.73	0.21	0.16	0.11	0.55	0.16	0.20	0.07	0.16	0.16	0.16	0.16	0.21	0.24	0.16	0.16	0.16	0.16	0.09	0.16	0.09	1.00	0.16	0.16	0.13	0.16	0.16	0.16	0.16	0.10	0.16	1.00	0.16	0.11	0.16	0.16	0.16	0.16	0.16	0.55	0.21	1.00	0.28	0.16	0.24	0.16	0.16	0.13
5912 (RAP2B)	0.57	0.57	0.49	0.59	0.56	0.57	0.48	0.52	0.51	0.60	0.12	0.61	0.58	0.61	0.63	0.60	0.56	0.56	0.56	0.55	0.57	0.60	0.42	0.10	0.49	0.51	0.63	0.30	0.45	0.54	0.63	0.44	0.24	0.47	0.16	1.00	0.35	0.60	0.58	1.00	1.00	0.49	0.43	0.52	0.48	0.61	0.57	0.49	0.52	0.62	0.22
5269 (SERPINB6)	0.44	0.44	0.40	0.47	0.34	0.49	0.46	0.36	0.41	0.48	1.00	0.49	0.48	0.50	0.49	0.45	0.42	0.46	0.87	0.64	0.44	0.40	0.34	0.09	0.36	0.51	0.51	0.23	0.31	0.42	0.51	0.37	0.15	0.35	0.11	0.35	1.00	0.51	0.44	0.69	0.69	0.85	0.33	0.40	0.37	0.49	0.44	0.40	0.41	0.66	0.15
7133 (TNFRSF1B)	0.69	0.69	0.68	0.66	0.56	0.69	0.56	0.58	0.68	0.65	0.12	0.67	0.64	0.66	0.77	0.70	0.60	0.76	0.70	0.63	0.66	0.60	0.48	0.12	0.59	0.56	0.82	0.39	0.49	0.68	0.82	0.52	0.23	0.56	0.16	0.60	0.51	1.00	0.66	1.00	1.00	0.68	0.52	0.65	0.57	0.68	0.73	0.71	0.68	0.78	0.23
4691 (NCL)	0.62	0.62	0.60	0.63	0.60	0.64	0.50	0.56	0.60	0.65	0.12	0.64	0.61	0.67	0.67	0.64	0.63	0.64	0.63	0.58	0.62	0.60	0.49	0.11	0.56	0.58	0.68	0.37	0.59	0.61	0.72	0.55	0.24	0.54	0.16	0.58	0.44	0.66	1.00	1.00	1.00	0.60	0.54	0.60	0.56	0.67	0.64	0.57	0.61	0.67	0.24
23218 (NBEAL2)	1.00	1.00	1.00	1.00	1.00	1.00	0.71	1.00	1.00	1.00	0.12	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.60	1.00	0.14	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	0.38	1.00	0.16	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.37
338339 (CLEC4D)	1.00	1.00	1.00	1.00	1.00	1.00	0.71	1.00	1.00	1.00	0.12	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.60	1.00	0.14	1.00	1.00	1.00	0.69	1.00	1.00	1.00	1.00	0.38	1.00	0.16	1.00	0.69	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.37
5271 (SERPINB8)	0.63	0.63	0.56	0.62	0.49	0.62	0.56	0.52	0.58	0.62	1.00	0.64	0.61	0.61	0.71	0.65	0.57	0.66	0.92	0.80	0.61	0.60	0.44	0.12	0.52	0.66	0.73	0.33	0.45	0.60	0.73	0.47	0.20	0.50	0.16	0.49	0.85	0.68	0.60	1.00	1.00	1.00	0.46	0.58	0.51	0.65	0.64	0.53	0.59	0.70	0.21
3082 (HGF)	0.56	0.56	0.63	0.71	0.47	0.54	0.44	0.63	0.48	0.59	0.22	0.57	0.55	0.58	0.54	0.58	0.74	0.50	0.53	0.49	0.53	0.60	0.72	0.12	0.61	0.48	0.52	0.33	0.45	0.50	0.56	0.70	0.20	0.47	0.55	0.43	0.33	0.52	0.54	1.00	1.00	0.46	1.00	0.52	0.62	0.63	0.50	0.52	0.48	0.53	0.22
1535 (CYBA)	0.64	0.64	0.58	0.63	0.84	0.63	0.49	0.54	0.59	0.62	0.15	0.67	0.61	0.61	0.73	0.66	0.59	0.63	0.62	0.56	0.65	0.60	0.47	0.14	0.55	0.52	0.67	0.37	0.49	0.60	0.67	0.50	0.23	0.53	0.21	0.52	0.40	0.65	0.60	1.00	1.00	0.58	0.52	1.00	0.54	0.68	0.62	0.57	0.59	0.74	0.25
102 (ADAM10)	0.60	0.60	0.71	0.82	0.50	0.60	0.50	0.68	0.61	0.65	0.12	0.64	0.64	0.65	0.59	0.62	0.64	0.65	0.59	0.55	0.67	0.73	0.51	0.10	0.75	0.52	0.58	0.38	0.47	0.54	0.59	0.47	0.20	0.49	1.00	0.48	0.37	0.57	0.56	1.00	1.00	0.51	0.62	0.54	1.00	0.69	0.57	0.53	0.53	0.58	0.20
634 (CEACAM1)	0.69	0.69	0.65	0.69	0.64	0.69	0.63	0.61	0.65	0.68	0.21	0.69	0.67	0.69	0.70	0.70	0.65	0.67	0.66	0.63	0.69	0.60	0.58	0.13	0.61	0.59	0.69	0.43	0.57	0.65	0.73	0.61	0.26	0.62	0.28	0.61	0.49	0.68	0.67	1.00	1.00	0.65	0.63	0.68	0.69	1.00	0.66	0.63	0.65	0.70	0.29
3678 (ITGA5)	0.69	0.69	0.64	0.66	0.54	0.68	0.54	0.59	0.64	0.73	0.12	0.66	0.63	0.65	0.74	0.71	0.62	0.72	0.71	0.63	0.64	1.00	0.51	0.12	0.57	0.56	0.78	0.42	0.48	0.65	0.78	0.47	0.22	0.54	0.16	0.57	0.44	0.73	0.64	1.00	1.00	0.64	0.50	0.62	0.57	0.66	1.00	0.59	0.65	0.75	0.22
7319 (UBE2A)	0.59	0.59	0.54	0.62	0.51	0.60	0.48	0.52	0.55	0.62	0.12	0.61	0.59	0.60	0.64	0.61	0.63	0.59	0.58	0.53	0.59	0.60	0.50	0.11	0.54	0.50	0.63	0.33	0.46	0.57	0.63	0.53	0.21	0.50	0.24	0.49	0.40	0.71	0.57	1.00	1.00	0.53	0.52	0.57	0.53	0.63	0.59	1.00	0.55	0.62	0.21
22918 (CD93)	0.64	0.64	0.59	0.62	0.52	0.88	0.51	0.67	0.60	0.69	0.12	0.73	0.70	0.62	0.75	0.66	0.58	0.66	0.63	0.57	0.73	0.60	0.61	0.47	0.54	0.52	0.75	0.63	0.63	0.81	0.73	0.56	0.52	0.67	0.16	0.52	0.41	0.68	0.61	1.00	1.00	0.59	0.48	0.59	0.53	0.65	0.65	0.55	1.00	0.70	0.22
3675 (ITGA3)	0.70	0.70	0.70	0.67	0.64	0.71	0.57	0.59	0.69	0.69	0.12	0.75	0.68	0.70	0.87	0.71	0.61	0.78	0.80	0.64	0.72	0.60	0.49	0.12	0.60	0.57	0.84	0.40	0.50	0.69	0.84	0.52	0.24	0.57	0.16	0.62	0.66	0.78	0.67	1.00	1.00	0.70	0.53	0.74	0.58	0.70	0.75	0.62	0.70	1.00	0.24
6515 (SLC2A3)	0.27	0.27	0.21	0.23	0.24	0.24	0.19	0.22	0.23	0.24	0.10	0.24	0.24	0.24	0.24	0.27	0.23	0.23	0.23	0.23	0.23	0.22	0.19	0.09	0.22	0.22	0.25	0.15	0.25	0.22	0.25	0.20	0.14	0.26	0.13	0.22	0.15	0.23	0.24	0.37	0.37	0.21	0.22	0.25	0.20	0.29	0.22	0.21	0.22	0.24	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
PLAU	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	2.2	RT-qPCR	Western US	C57BL/6 mice	–7.4	7600m mice(8% oxygen with no Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776
PLAU	Mice	Blood	8% Oxygen	7600 m	24 hours	upregulated	3.2	RT-qPCR	Western US	C57BL/6 mice	–7.4	7600m mice(8% oxygen with Fenofibrate injections Vs Baseline normoxia mice (21% oxygen)	24183776

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
HIF1A	3091	PLAU	5328	Unknown	12032322	TRUSST
RARA	5914	PLAU	5328	Repression	12032779	TRUSST
FOS	2353	PLAU	5328	Unknown	12734418	TRUSST
ILF3	3609	PLAU	5328	Repression	12947005	TRUSST
POU2F1	5451	PLAU	5328	Activation	19568426	TRUSST
HOXD3	3232	PLAU	5328	Repression	12032779	TRUSST
EGR1	1958	PLAU	5328	Unknown	24512546	TRUSST
GATA6	2627	PLAU	5328	Unknown	9797456	TRUSST
RUNX2	860	PLAU	5328	Unknown	17724465	TRUSST
ATF2	1386	PLAU	5328	Activation	20549547	TRUSST
CREB1	1385	PLAU	5328	Repression	16510874	TRUSST
SRF	6722	PLAU	5328	Activation	11705881	TRUSST
JUN	3725	PLAU	5328	Unknown	16949368	TRUSST
SP1	6667	PLAU	5328	Activation	19497851	TRUSST
ATF4	468	PLAU	5328	Unknown	11114727	TRUSST
NFKB1	4790	PLAU	5328	Unknown	23774591	TRUSST
RELA	5970	PLAU	5328	Unknown	24725430	TRUSST
RFWD2	64326	PLAU	5328	Activation	20300972	TRUSST
ETS1	2113	PLAU	5328	Activation	21394099	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT004413	hsa-miR-193b-3p	Homo sapiens	PLAU	5328	Homo sapiens	Western blot//Luciferase reporter assay	Functional MTI	19701247
MIRT004413	hsa-miR-193b-3p	Homo sapiens	PLAU	5328	Homo sapiens	Microarray//qRT-PCR//Western blot	Functional MTI	23372348
MIRT004413	hsa-miR-193b-3p	Homo sapiens	PLAU	5328	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT004291	hsa-miR-23b-3p	Homo sapiens	PLAU	5328	Homo sapiens	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	19490101
MIRT004291	hsa-miR-23b-3p	Homo sapiens	PLAU	5328	Homo sapiens	qRT-PCR//Western blot	Functional MTI	21242962
MIRT024290	hsa-miR-215-5p	Homo sapiens	PLAU	5328	Homo sapiens	Microarray	Functional MTI (Weak)	19074876
MIRT026220	hsa-miR-192-5p	Homo sapiens	PLAU	5328	Homo sapiens	Microarray	Functional MTI (Weak)	19074876
MIRT127249	hsa-miR-193a-3p	Homo sapiens	PLAU	5328	Homo sapiens	Luciferase reporter assay//Microarray//qRT-PCR//Western blot	Functional MTI	27307030
MIRT127204	hsa-miR-19b-3p	Homo sapiens	PLAU	5328	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT127249	hsa-miR-193a-3p	Homo sapiens	PLAU	5328	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208
MIRT127203	hsa-miR-19a-3p	Homo sapiens	PLAU	5328	Homo sapiens	HITS-CLIP	Functional MTI (Weak)	22473208

Gene Ontology

ID	GO ID	GO Term	GO Type
5328	GO:0007165	signal transduction	GOTERM_BP_DIRECT
5328	GO:0014909	smooth muscle cell migration	GOTERM_BP_DIRECT
5328	GO:0005515	protein binding	GOTERM_MF_DIRECT
5328	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
5328	GO:0005925	focal adhesion	GOTERM_CC_DIRECT
5328	GO:0030335	positive regulation of cell migration	GOTERM_BP_DIRECT
5328	GO:0042730	fibrinolysis	GOTERM_BP_DIRECT
5328	GO:0006935	chemotaxis	GOTERM_BP_DIRECT
5328	GO:0001666	response to hypoxia	GOTERM_BP_DIRECT
5328	GO:0061041	regulation of wound healing	GOTERM_BP_DIRECT
5328	GO:0006508	proteolysis	GOTERM_BP_DIRECT
5328	GO:0010469	regulation of receptor activity	GOTERM_BP_DIRECT
5328	GO:0042127	regulation of cell proliferation	GOTERM_BP_DIRECT
5328	GO:0005576	extracellular region	GOTERM_CC_DIRECT
5328	GO:0005615	extracellular space	GOTERM_CC_DIRECT
5328	GO:0014910	regulation of smooth muscle cell migration	GOTERM_BP_DIRECT
5328	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
5328	GO:2000097	regulation of smooth muscle cell-matrix adhesion	GOTERM_BP_DIRECT
5328	GO:0016301	kinase activity	GOTERM_MF_DIRECT
5328	GO:0007596	blood coagulation	GOTERM_BP_DIRECT
5328	GO:0009986	cell surface	GOTERM_CC_DIRECT
5328	GO:0033628	regulation of cell adhesion mediated by integrin	GOTERM_BP_DIRECT
5328	GO:0004252	serine-type endopeptidase activity	GOTERM_MF_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
5328	hsa04064	NF-kappa B signaling pathway
5328	hsa04610	Complement and coagulation cascades
5328	hsa05202	Transcriptional misregulation in cancer
5328	hsa05206	MicroRNAs in cancer
5328	hsa05205	Proteoglycans in cancer

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
PLAU	5328	Graft Occlusion, Vascular	C0018128	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Pulmonary Embolism	C0034065	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Vasculitis, Hemorrhagic	C0042386	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Myocardial Preinfarction Syndrome	C0086666	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Malignant neoplasm of prostate	C0376358	Neoplastic Process	0.4	0.434	0.69	disease
PLAU	5328	Alzheimer Disease, Late Onset	C0494463	Mental or Behavioral Dysfunction	0.33	0.434	0.69	disease
PLAU	5328	Middle Cerebral Artery Occlusion	C0740391	Acquired Abnormality	0.3	0.434	0.69	phenotype
PLAU	5328	Adenocarcinoma	C0001418	Neoplastic Process	0.38	0.434	0.69	group
PLAU	5328	Carcinoma, Transitional Cell	C0007138	Neoplastic Process	0.31	0.434	0.69	disease
PLAU	5328	Middle Cerebral Artery Syndrome	C0238281	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Cytotoxic Cerebral Edema	C0472388	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Middle Cerebral Artery Thrombosis	C0740376	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Alzheimer Disease, Early Onset	C0750901	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Acute Cerebrovascular Accidents	C0751956	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Arterial Occlusive Diseases	C0003838	Disease or Syndrome	0.3	0.434	0.69	group
PLAU	5328	Brain Ischemia	C0007786	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Hemorrhage	C0019080	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Neoplasm Recurrence, Local	C0027643	Neoplastic Process	0.3	0.434	0.69	phenotype
PLAU	5328	Thrombosis	C0040053	Pathologic Function	0.5	0.434	0.69	phenotype
PLAU	5328	Adenocarcinoma, Tubular	C0205645	Neoplastic Process	0.3	0.434	0.69	disease
PLAU	5328	Sagittal Sinus Thrombosis	C0338575	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Pulmonary Thromboembolisms	C0524702	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Acute Confusional Senile Dementia	C0546126	Mental or Behavioral Dysfunction	0.3	0.434	0.69	disease
PLAU	5328	Cerebral Infarction, Left Hemisphere	C0751010	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Right Middle Cerebral Artery Infarction	C0751849	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Idiopathic Pulmonary Fibrosis	C1800706	Disease or Syndrome	0.31	0.434	0.69	disease
PLAU	5328	Ischemia	C0022116	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Myocardial Infarction	C0027051	Disease or Syndrome	0.51	0.434	0.69	disease
PLAU	5328	Venous Thrombosis	C0042487	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Malignant Bone Neoplasm	C0279530	Neoplastic Process	0.3	0.434	0.69	disease
PLAU	5328	Asthenozoospermia	C0403823	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Prostatic Neoplasms	C0033578	Neoplastic Process	0.36	0.434	0.69	group
PLAU	5328	Cerebrovascular accident	C0038454	Disease or Syndrome	0.3	0.434	0.69	group
PLAU	5328	Deep Vein Thrombosis	C0149871	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Brain hemorrhage	C0553692	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Brain Edema	C1527311	Disease or Syndrome	0.5	0.434	0.69	disease
PLAU	5328	Coronary heart disease	C0010068	Disease or Syndrome	0.31	0.434	0.69	disease
PLAU	5328	Presenile dementia	C0011265	Mental or Behavioral Dysfunction	0.3	0.434	0.69	disease
PLAU	5328	Ventricular Fibrillation	C0042510	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Infarction, Middle Cerebral Artery	C0740392	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Subcortical Infarction	C0751014	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Posterior Fossa Hemorrhage	C0751893	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Cerebral Embolism and Thrombosis	C0877855	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Carotid Artery Diseases	C0007273	Disease or Syndrome	0.3	0.434	0.69	group
PLAU	5328	IGA Glomerulonephritis	C0017661	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Rheumatoid Purpura	C0086922	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Adenocarcinoma, Basal Cell	C0205641	Neoplastic Process	0.3	0.434	0.69	disease
PLAU	5328	Vasogenic Brain Edema	C0750969	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Internal Carotid Artery Diseases	C0750986	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Intracranial Hemorrhages	C0151699	Disease or Syndrome	0.3	0.434	0.69	group
PLAU	5328	Fibrosis, Liver	C0239946	Disease or Syndrome	0.33	0.434	0.69	disease
PLAU	5328	Malignant neoplasm of pancreas	C0346647	Neoplastic Process	0.36	0.434	0.69	disease
PLAU	5328	External Carotid Artery Diseases	C0600178	Disease or Syndrome	0.3	0.434	0.69	group
PLAU	5328	Left Middle Cerebral Artery Infarction	C0751846	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Angina Pectoris	C0002962	Sign or Symptom	0.3	0.434	0.69	phenotype
PLAU	5328	Liver Cirrhosis	C0023890	Disease or Syndrome	0.31	0.434	0.69	disease
PLAU	5328	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.434	0.69	disease
PLAU	5328	Pancreatic Neoplasm	C0030297	Neoplastic Process	0.35	0.434	0.69	disease
PLAU	5328	Angina, Unstable	C0002965	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.4	0.434	0.69	disease
PLAU	5328	Reperfusion Injury	C0035126	Injury or Poisoning	0.3	0.434	0.69	disease
PLAU	5328	Asthma	C0004096	Disease or Syndrome	0.34	0.434	0.69	disease
PLAU	5328	Intracranial Embolism and Thrombosis	C0007781	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Cerebral Edema	C0006114	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Cerebrovascular Disorders	C0007820	Disease or Syndrome	0.3	0.434	0.69	group
PLAU	5328	Neoplasm Metastasis	C0027627	Neoplastic Process	0.4	0.434	0.69	phenotype
PLAU	5328	Nephritis	C0027697	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Alzheimer's Disease	C0002395	Disease or Syndrome	0.58	0.434	0.69	disease
PLAU	5328	Bone neoplasms	C0005967	Neoplastic Process	0.31	0.434	0.69	group
PLAU	5328	Cerebral Infarction	C0007785	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Thromboembolism	C0040038	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Anuria	C0003460	Disease or Syndrome	0.3	0.434	0.69	phenotype
PLAU	5328	Heart Rupture, Post-Infarction	C0018814	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Hematuria	C0018965	Disease or Syndrome	0.3	0.434	0.69	phenotype
PLAU	5328	Henoch-Schoenlein Purpura	C0034152	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Cholesterol Embolism	C0149649	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Familial Alzheimer Disease (FAD)	C0276496	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Vasogenic Cerebral Edema	C0472387	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Septic Phlebitis, Sagittal Sinus	C0751823	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Sagittal Sinus Thrombophlebitis	C0751824	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Middle Cerebral Artery Embolus	C0751845	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Posterior Choroidal Artery Infarction	C0887799	Disease or Syndrome	0.3	0.434	0.69	phenotype
PLAU	5328	Brain Embolism and Thrombosis	C0936247	Disease or Syndrome	0.3	0.434	0.69	phenotype
PLAU	5328	Carcinoma, Cribriform	C0205643	Neoplastic Process	0.3	0.434	0.69	disease
PLAU	5328	Purpura, Nonthrombocytopenic	C0242461	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Purpura Hemorrhagica	C0376362	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Anterior Choroidal Artery Infarction	C0751012	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.434	0.69	disease
PLAU	5328	Thrombus	C0087086	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Cerebrovascular Insufficiency	C0241832	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Carotid Atherosclerosis	C0577631	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Alzheimer's Disease, Focal Onset	C0750900	Mental or Behavioral Dysfunction	0.3	0.434	0.69	disease
PLAU	5328	Stomach Neoplasms	C0038356	Neoplastic Process	0.31	0.434	0.69	group
PLAU	5328	Hypotension	C0020649	Finding	0.3	0.434	0.69	phenotype
PLAU	5328	Cerebral Hemorrhage	C2937358	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Adenocarcinoma, Oxyphilic	C0205642	Neoplastic Process	0.3	0.434	0.69	disease
PLAU	5328	Carcinoma, Granular Cell	C0205644	Neoplastic Process	0.3	0.434	0.69	disease
PLAU	5328	Arterial Diseases, Common Carotid	C0750987	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Neoplasm Invasiveness	C0027626	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Cytotoxic Brain Edema	C0750970	Pathologic Function	0.3	0.434	0.69	phenotype
PLAU	5328	Embolic Infarction, Middle Cerebral Artery	C0751847	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Cerebral Ischemia	C0917798	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Cerebrovascular Occlusion	C0596298	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Cerebral Infarction, Right Hemisphere	C0751011	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Thrombotic Infarction, Middle Cerebral Artery	C0751848	Disease or Syndrome	0.3	0.434	0.69	disease
PLAU	5328	Quebec platelet disorder	C1866423	Disease or Syndrome	0.55	0.434	0.69	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
PLAU	5328	17 BETA-ESTRADIOL	ESTRADIOL	CHEMBL135	None
PLAU	5328	ALENDRONATE	ALENDRONIC ACID	CHEMBL870	None
PLAU	5328	AMEDIPLASE	AMEDIPLASE	CHEMBL2108361	activator
PLAU	5328	ANTIBIOTIC	ANTIBIOTIC	CHEMBL606111	None
PLAU	5328	ANTIINFLAMMATORY DRUGS	None	None	None
PLAU	5328	ANTIOXIDANT	None	None	None
PLAU	5328	AZACYTIDINE	AZACITIDINE	CHEMBL1489	None
PLAU	5328	BCNU	CARMUSTINE	CHEMBL513	None
PLAU	5328	BLM	None	None	None
PLAU	5328	BISPHOSPHONATES	MEDRONIC ACID	CHEMBL180570	None
PLAU	5328	CALCITRIOL	CALCITRIOL	CHEMBL846	None
PLAU	5328	CELECOXIB	CELECOXIB	CHEMBL118	None
PLAU	5328	CISPLATIN	None	None	None
PLAU	5328	CLODRONATE	None	None	None
PLAU	5328	COMPOUND 4 [PMID: 18163548]	CHEMBL252937	CHEMBL252937	inhibitor
PLAU	5328	CORTISOL	HYDROCORTISONE	CHEMBL389621	None
PLAU	5328	DACARBAZINE	DACARBAZINE	CHEMBL476	None
PLAU	5328	DEXTRAN SULFATE	DEXTRAN SULFATE SODIUM	CHEMBL2108952	None
PLAU	5328	DIFFERENTIATION INDUCER	None	None	None
PLAU	5328	G-CSF	FILGRASTIM	CHEMBL1201567	None
PLAU	5328	GELDANAMYCIN	GELDANAMYCIN	CHEMBL278315	None
PLAU	5328	HERBIMYCIN A	HERBIMYCIN	CHEMBL479533	None
PLAU	5328	IONOMYCIN	IONOMYCIN	CHEMBL501617	None
PLAU	5328	IRESSA	GEFITINIB	CHEMBL939	None
PLAU	5328	LIF	None	None	None
PLAU	5328	MRX-801	None	None	None
PLAU	5328	NORDIHYDROGUAIARETIC ACID	NORDIHYDROGUAIARETIC ACID	CHEMBL52	None
PLAU	5328	OESTRADIOL	ESTRADIOL	CHEMBL135	None
PLAU	5328	PAPAVERINE	PAPAVERINE	CHEMBL19224	None
PLAU	5328	PHOSPHODIESTERASE INHIBITOR	None	None	None
PLAU	5328	PMSG	GONADOTROPIN, CHORIONIC	CHEMBL1201509	None
PLAU	5328	PROTEIN KINASE INHIBITOR	None	None	None
PLAU	5328	PROTEIN KINASE C INHIBITOR	None	None	None
PLAU	5328	RAPAMYCIN	SIROLIMUS	CHEMBL413	None
PLAU	5328	RANTES	None	None	None
PLAU	5328	RAZOXANE	RAZOXANE	CHEMBL444186	None
PLAU	5328	RETINOL	RETINOL	CHEMBL986	None
PLAU	5328	RU 486	MIFEPRISTONE	CHEMBL1276308	None
PLAU	5328	TRICHOSTATIN A	TRICHOSTATIN	CHEMBL99	None
PLAU	5328	TYROSINE KINASE INHIBITOR	None	None	None
PLAU	5328	UK-356202	CHEMBL111576	CHEMBL111576	inhibitor
PLAU	5328	UPAMOSTAT	None	None	inhibitor
PLAU	5328	UROKINASE	UROKINASE	CHEMBL1201420	None
PLAU	5328	VERAPAMIL	VERAPAMIL	CHEMBL6966	None
PLAU	5328	WX-UK1	CHEMBL108468	CHEMBL108468	inhibitor
PLAU	5328	WX-671	None	None	None
PLAU	5328	WX-UK1	CHEMBL108468	CHEMBL108468	None
PLAU	5328	ZOLEDRONATE	ZOLEDRONIC ACID	CHEMBL924	None