Cytochrome b-245 alpha chain

AltitudeomicsDB
Protein Official symbol CYBA
Aliases CYBA
Chromosomal Location 16
Length 195
Uniprot ID P13498
EC number None
Protein family Information(Pfam) PF05038;
PDB id 1WLP;
InterPro ID IPR007732;
dbSNP rs28941476 rs179363891 rs179363891 rs179363890 rs179363893 rs4673 rs104894513 rs179363892 rs104894510 rs104894514 rs179363894 rs119103269 rs104894515 rs72667005 rs1049254 rs72667006

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
NCF2 NCF1 0.9990000000000001
CYBB NCF1 0.998
CYBB NCF2 0.998
NCF1 CYBA 0.997
NCF2 CYBA 0.997
CYBB CYBA 0.997
NOX1 CYBA 0.996
NCF4 CYBB 0.996
NOXO1 NOXA1 0.995
NCF4 CYBA 0.9940000000000001
NOX4 CYBA 0.9940000000000001
NOX1 NOXA1 0.993
NOXA1 NCF1 0.991
NOXO1 CYBA 0.99
NCF2 RAC2 0.9890000000000001
CYBA NOX3 0.9890000000000001
CYBB RAC2 0.987
NOXO1 NOX1 0.986
NOX1 NCF1 0.986
NCF4 RAC2 0.985
NCF1 RAC2 0.9840000000000001
NOXA1 NOX3 0.98
NCF4 NCF2 0.98
NOXA1 CYBA 0.9790000000000001
NCF1 NOX3 0.978
NCF2 NOX3 0.978
NOX1 NCF2 0.977
CYBA RAC2 0.9740000000000001
NCF4 NCF1 0.972
NCF4 NOX1 0.946
NOXO1 NCF2 0.943
NOXO1 CYBB 0.941
CYBB NOXA1 0.9390000000000001
NCF1 NOX4 0.9329999999999999
NCF4 NOXA1 0.9229999999999999
NOX1 RAC2 0.9229999999999999
NCF2 NOX4 0.92
NOXO1 NCF4 0.919
NCF2 NOXA1 0.9179999999999999
CYBB NOX4 0.9129999999999999
NOXO1 NOX3 0.8690000000000001
NOXA1 NOX4 0.8370000000000001
NOXO1 NOX4 0.831
NOX1 NOX4 0.83
NCF4 NOX4 0.8220000000000001
NCF4 NOX3 0.8109999999999999
CYBB NOX1 0.8109999999999999
NOXO1 NCF1 0.797
NOXA1 RAC2 0.685
RAC2 NOX3 0.565
NOX4 RAC2 0.5379999999999999
NOXO1 RAC2 0.489
NOX4 NOX3 0.451
Gene Ontology Semantic Similarity
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# 4688 (NCF2) 1536 (CYBB) 653361 (NCF1) 27035 (NOX1) 4689 (NCF4) 124056 (NOXO1) 50507 (NOX4) 10811 (NOXA1) 1535 (CYBA) 5880 (RAC2)
4688 (NCF2) 1.00 0.70 0.66 0.52 0.60 0.64 0.60 0.67 0.80 0.15
1536 (CYBB) 0.70 1.00 0.69 0.68 0.51 0.55 0.88 0.54 0.84 0.49
653361 (NCF1) 0.66 0.69 1.00 0.55 0.72 0.80 0.65 0.70 0.79 0.24
27035 (NOX1) 0.52 0.68 0.55 1.00 0.45 0.51 0.67 0.62 0.65 0.39
4689 (NCF4) 0.60 0.51 0.72 0.45 1.00 0.83 0.45 0.74 0.57 0.19
124056 (NOXO1) 0.64 0.55 0.80 0.51 0.83 1.00 0.50 0.80 0.59 0.27
50507 (NOX4) 0.60 0.88 0.65 0.67 0.45 0.50 1.00 0.49 0.72 0.49
10811 (NOXA1) 0.67 0.54 0.70 0.62 0.74 0.80 0.49 1.00 0.67 0.15
1535 (CYBA) 0.80 0.84 0.79 0.65 0.57 0.59 0.72 0.67 1.00 0.15
5880 (RAC2) 0.15 0.49 0.24 0.39 0.19 0.27 0.49 0.15 0.15 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
CYBA Human Blood - 3250 m 4 day downregulated -1.77 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
PAX5 5079 CYBA 1535 proximal_filtered 22955619 TRANSFAC
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT044553 hsa-miR-320a Homo sapiens CYBA 1535 Homo sapiens CLASH Functional MTI (Weak) 23622248
MIRT046446 hsa-miR-15b-5p Homo sapiens CYBA 1535 Homo sapiens CLASH Functional MTI (Weak) 23622248
Gene Ontology
ID GO ID GO Term GO Type
1535 GO:0030307 positive regulation of cell growth GOTERM_BP_DIRECT
1535 GO:0033864 positive regulation of NAD GOTERM_BP_DIRECT
1535 GO:0017124 Rab guanyl-nucleotide exchange factor activity GOTERM_MF_DIRECT
1535 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
1535 GO:0048010 vascular endothelial growth factor receptor signaling pathway GOTERM_BP_DIRECT
1535 GO:0005789 endoplasmic reticulum membrane GOTERM_CC_DIRECT
1535 GO:0045087 innate immune response GOTERM_BP_DIRECT
1535 GO:0045730 respiratory burst GOTERM_BP_DIRECT
1535 GO:0051279 regulation of release of sequestered calcium ion into cytosol GOTERM_BP_DIRECT
1535 GO:0071356 cellular response to tumor necrosis factor GOTERM_BP_DIRECT
1535 GO:1903428 positive regulation of reactive oxygen species biosynthetic process GOTERM_BP_DIRECT
1535 GO:1904385 cellular response to angiotensin GOTERM_BP_DIRECT
1535 GO:0016324 apical plasma membrane GOTERM_CC_DIRECT
1535 GO:0042493 response to drug GOTERM_BP_DIRECT
1535 GO:0001666 response to hypoxia GOTERM_BP_DIRECT
1535 GO:0014895 smooth muscle hypertrophy GOTERM_BP_DIRECT
1535 GO:0070555 response to interleukin-1 GOTERM_BP_DIRECT
1535 GO:0046872 metal ion binding GOTERM_MF_DIRECT
1535 GO:0030141 secretory granule GOTERM_CC_DIRECT
1535 GO:0030670 phagocytic vesicle membrane GOTERM_CC_DIRECT
1535 GO:0043025 neuronal cell body GOTERM_CC_DIRECT
1535 GO:0032760 positive regulation of tumor necrosis factor production GOTERM_BP_DIRECT
1535 GO:1904845 cellular response to L-glutamine GOTERM_BP_DIRECT
1535 GO:0005515 protein binding GOTERM_MF_DIRECT
1535 GO:0048661 positive regulation of smooth muscle cell proliferation GOTERM_BP_DIRECT
1535 GO:0071407 cellular response to organic cyclic compound GOTERM_BP_DIRECT
1535 GO:0005634 nucleus GOTERM_CC_DIRECT
1535 GO:1900426 positive regulation of defense response to bacterium GOTERM_BP_DIRECT
1535 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I GOTERM_BP_DIRECT
1535 GO:0006954 inflammatory response GOTERM_BP_DIRECT
1535 GO:0032755 positive regulation of interleukin-6 production GOTERM_BP_DIRECT
1535 GO:0001725 stress fiber GOTERM_CC_DIRECT
1535 GO:0005739 mitochondrion GOTERM_CC_DIRECT
1535 GO:0005886 plasma membrane GOTERM_CC_DIRECT
1535 GO:0043020 NADPH oxidase complex GOTERM_CC_DIRECT
1535 GO:0006801 superoxide metabolic process GOTERM_BP_DIRECT
1535 GO:0034137 positive regulation of toll-like receptor 2 signaling pathway GOTERM_BP_DIRECT
1535 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
1535 GO:0009055 electron carrier activity GOTERM_MF_DIRECT
1535 GO:0097038 perinuclear endoplasmic reticulum GOTERM_CC_DIRECT
1535 GO:0017004 cytochrome complex assembly GOTERM_BP_DIRECT
1535 GO:0001938 positive regulation of endothelial cell proliferation GOTERM_BP_DIRECT
1535 GO:0071333 cellular response to glucose stimulus GOTERM_BP_DIRECT
1535 GO:0071480 cellular response to gamma radiation GOTERM_BP_DIRECT
1535 GO:0000302 response to reactive oxygen species GOTERM_BP_DIRECT
1535 GO:0050766 positive regulation of phagocytosis GOTERM_BP_DIRECT
1535 GO:0071260 cellular response to mechanical stimulus GOTERM_BP_DIRECT
1535 GO:1904044 response to aldosterone GOTERM_BP_DIRECT
1535 GO:0016175 phospholipase A2 activator activity GOTERM_MF_DIRECT
1535 GO:0005768 endosome GOTERM_CC_DIRECT
1535 GO:0003106 negative regulation of glomerular filtration by angiotensin GOTERM_BP_DIRECT
1535 GO:0045454 cell redox homeostasis GOTERM_BP_DIRECT
1535 GO:0005925 focal adhesion GOTERM_CC_DIRECT
1535 GO:0032930 positive regulation of superoxide anion generation GOTERM_BP_DIRECT
1535 GO:0042554 superoxide anion generation GOTERM_BP_DIRECT
1535 GO:0046982 protein heterodimerization activity GOTERM_MF_DIRECT
1535 GO:0005794 Golgi apparatus GOTERM_CC_DIRECT
1535 GO:0030425 dendrite GOTERM_CC_DIRECT
1535 GO:0014823 response to activity GOTERM_BP_DIRECT
1535 GO:0031667 response to nutrient levels GOTERM_BP_DIRECT
1535 GO:0050665 hydrogen peroxide biosynthetic process GOTERM_BP_DIRECT
1535 GO:0070257 positive regulation of mucus secretion GOTERM_BP_DIRECT
1535 GO:0020037 heme binding GOTERM_MF_DIRECT
1535 GO:0016020 membrane GOTERM_CC_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
1535 hsa04145 Phagosome
1535 hsa04380 Osteoclast differentiation
1535 hsa04670 Leukocyte transendothelial migration
1535 hsa05140 Leishmaniasis
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
CYBA 1535 Kidney Failure C0035078 Disease or Syndrome 0.3 0.55 0.655 disease
CYBA 1535 Diabetes Mellitus, Non-Insulin-Dependent C0011860 Disease or Syndrome 0.4 0.55 0.655 disease
CYBA 1535 Kidney Failure, Chronic C0022661 Disease or Syndrome 0.53 0.55 0.655 disease
CYBA 1535 Fibrosis, Liver C0239946 Disease or Syndrome 0.3 0.55 0.655 disease
CYBA 1535 Streptozotocin Diabetes C0038433 Experimental Model of Disease 0.3 0.55 0.655 disease
CYBA 1535 Diabetes Mellitus, Experimental C0011853 Experimental Model of Disease 0.3 0.55 0.655 disease
CYBA 1535 Heart Diseases C0018799 Disease or Syndrome 0.31 0.55 0.655 group
CYBA 1535 Hepatomegaly C0019209 Finding 0.4 0.55 0.655 phenotype
CYBA 1535 Atherogenesis C1563937 Pathologic Function 0.3 0.55 0.655 phenotype
CYBA 1535 Renal Insufficiency C1565489 Disease or Syndrome 0.3 0.55 0.655 disease
CYBA 1535 Alloxan Diabetes C0002152 Experimental Model of Disease 0.3 0.55 0.655 disease
CYBA 1535 Hypertensive disease C0020538 Disease or Syndrome 0.6 0.55 0.655 group
CYBA 1535 Granulomatous Disease, Chronic, X-Linked C1844376 Disease or Syndrome 0.31 0.55 0.655 disease
CYBA 1535 Liver Cirrhosis, Experimental C0023893 Experimental Model of Disease 0.3 0.55 0.655 disease
CYBA 1535 Atherosclerosis C0004153 Disease or Syndrome 0.4 0.55 0.655 disease
CYBA 1535 Liver Cirrhosis C0023890 Disease or Syndrome 0.3 0.55 0.655 disease
CYBA 1535 Autosomal Recessive Chronic Granulomatous Disease C3661525 Disease or Syndrome 0.33 0.55 0.655 disease
CYBA 1535 Chronic granulomatous disease C0018203 Disease or Syndrome 0.7 0.55 0.655 group
CYBA 1535 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative C1856255 Disease or Syndrome 0.6 0.55 0.655 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types