NADPH oxidase 1

AltitudeomicsDB
Protein Official symbol NOX1
Aliases NOX1 MOX1 NOH1
Chromosomal Location X
Length 564
Uniprot ID Q9Y5S8
EC number 1.-.-.-
Protein family Information(Pfam) PF08022;PF01794;PF08030;
PDB id None
InterPro ID IPR000778;IPR013112;IPR017927;IPR013130;IPR013121;IPR039261;IPR029650;IPR017938;
dbSNP rs2071756 rs34688635 rs35404864

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
NCF2 NCF1 0.9990000000000001
NCF1 CYBA 0.997
NCF2 CYBA 0.997
NOX1 CYBA 0.996
NOXO1 NOXA1 0.995
NCF4 CYBA 0.9940000000000001
NOX1 NOXA1 0.993
NOXA1 NCF1 0.991
NOXO1 CYBA 0.99
NCF2 RAC2 0.9890000000000001
NOX1 NCF1 0.986
NOXO1 NOX1 0.986
NCF4 RAC2 0.985
NCF1 RAC2 0.9840000000000001
NCF4 NCF2 0.98
NOXA1 CYBA 0.9790000000000001
NOX1 NCF2 0.977
CYBA RAC2 0.9740000000000001
RAC1 NOXA1 0.972
NCF4 NCF1 0.972
RAC1 NCF1 0.9690000000000001
NCF2 RAC1 0.961
RAC1 CYBA 0.953
NOXO1 RAC1 0.95
NCF4 NOX1 0.946
NCF4 RAC1 0.9440000000000001
NOXO1 NCF2 0.943
NOX1 DECR1 0.9390000000000001
NOX1 RAC1 0.935
NOX1 RAC2 0.9229999999999999
NCF4 NOXA1 0.9229999999999999
NCF1 DECR1 0.92
NOXO1 NCF4 0.919
NCF2 NOXA1 0.9179999999999999
RAC1 RAC2 0.9059999999999999
Gene Ontology Semantic Similarity
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# 4688 (NCF2) 653361 (NCF1) 27035 (NOX1) 124056 (NOXO1) 4689 (NCF4) 10811 (NOXA1) 1535 (CYBA) 5879 (RAC1) 5880 (RAC2) 1666 (DECR1)
4688 (NCF2) 1.00 0.66 0.52 0.64 0.60 0.67 0.80 0.63 0.15 0.24
653361 (NCF1) 0.66 1.00 0.55 0.80 0.72 0.70 0.79 0.51 0.24 0.36
27035 (NOX1) 0.52 0.55 1.00 0.51 0.45 0.62 0.65 0.54 0.39 0.48
124056 (NOXO1) 0.64 0.80 0.51 1.00 0.83 0.80 0.59 0.64 0.27 0.26
4689 (NCF4) 0.60 0.72 0.45 0.83 1.00 0.74 0.57 0.55 0.19 0.21
10811 (NOXA1) 0.67 0.70 0.62 0.80 0.74 1.00 0.67 0.66 0.15 0.18
1535 (CYBA) 0.80 0.79 0.65 0.59 0.57 0.67 1.00 0.58 0.15 0.36
5879 (RAC1) 0.63 0.51 0.54 0.64 0.55 0.66 0.58 1.00 1.00 0.24
5880 (RAC2) 0.15 0.24 0.39 0.27 0.19 0.15 0.15 1.00 1.00 0.46
1666 (DECR1) 0.24 0.36 0.48 0.26 0.21 0.18 0.36 0.24 0.46 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
NOX1 Human Blood - 3250 m 4 day upregulated 3.6 Microarray Himalayas Indians 1 Sea level healthy individuals 24465776
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
STAT3 6774 NOX1 27035 Activation 20068066 TRUSST
STAT1 6772 NOX1 27035 Unknown 21741415 TRUSST
HIPK2 28996 NOX1 27035 Activation 19396168 TRUSST
STAT4 6775 NOX1 27035 Repression 20473547 TRUSST
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
27035 GO:0008284 positive regulation of cell proliferation GOTERM_BP_DIRECT
27035 GO:0005769 early endosome GOTERM_CC_DIRECT
27035 GO:0030171 pyridoxal phosphate binding GOTERM_MF_DIRECT
27035 GO:0001525 angiogenesis GOTERM_BP_DIRECT
27035 GO:0051454 intracellular pH elevation GOTERM_BP_DIRECT
27035 GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin GOTERM_BP_DIRECT
27035 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
27035 GO:0043020 NADPH oxidase complex GOTERM_CC_DIRECT
27035 GO:0008217 regulation of blood pressure GOTERM_BP_DIRECT
27035 GO:0045730 respiratory burst GOTERM_BP_DIRECT
27035 GO:0046330 positive regulation of JNK cascade GOTERM_BP_DIRECT
27035 GO:0005515 protein binding GOTERM_MF_DIRECT
27035 GO:0050661 flavin adenine dinucleotide binding GOTERM_MF_DIRECT
27035 GO:0071438 invadopodium membrane GOTERM_CC_DIRECT
27035 GO:0016477 cell migration GOTERM_BP_DIRECT
27035 GO:0034765 regulation of ion transmembrane transport GOTERM_BP_DIRECT
27035 GO:0042554 superoxide anion generation GOTERM_BP_DIRECT
27035 GO:0046872 metal ion binding GOTERM_MF_DIRECT
27035 GO:0005886 plasma membrane GOTERM_CC_DIRECT
27035 GO:0006954 inflammatory response GOTERM_BP_DIRECT
27035 GO:0007165 signal transduction GOTERM_BP_DIRECT
27035 GO:0072592 oxygen metabolic process GOTERM_BP_DIRECT
27035 GO:0030054 cell junction GOTERM_CC_DIRECT
27035 GO:0015992 proton transport GOTERM_BP_DIRECT
27035 GO:0016175 phospholipase activator activity GOTERM_MF_DIRECT
27035 GO:0006801 superoxide metabolic process GOTERM_BP_DIRECT
27035 GO:0071455 cellular response to hyperoxia GOTERM_BP_DIRECT
27035 GO:0048365 calcium-dependent protein binding GOTERM_MF_DIRECT
27035 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
27035 GO:0048661 positive regulation of smooth muscle cell proliferation GOTERM_BP_DIRECT
27035 GO:1990451 cellular stress response to acidic pH GOTERM_BP_DIRECT
27035 GO:0006739 NADP metabolic process GOTERM_BP_DIRECT
27035 GO:0010575 positive regulation of vascular endothelial growth factor production GOTERM_BP_DIRECT
27035 GO:0042743 hydrogen peroxide metabolic process GOTERM_BP_DIRECT
27035 GO:0045726 positive regulation of integrin biosynthetic process GOTERM_BP_DIRECT
27035 GO:0030198 extracellular matrix organization GOTERM_BP_DIRECT
27035 GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
27035 hsa04380 Osteoclast differentiation
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
NOX1 27035 Colonic Neoplasms C0009375 Neoplastic Process 0.31 0.607 0.586 group
NOX1 27035 Left-Sided Heart Failure C0023212 Disease or Syndrome 0.3 0.607 0.586 disease
NOX1 27035 Hypercholesterolemia C0020443 Disease or Syndrome 0.3 0.607 0.586 disease
NOX1 27035 Myocardial Failure C1959583 Disease or Syndrome 0.3 0.607 0.586 disease
NOX1 27035 Congestive heart failure C0018802 Disease or Syndrome 0.3 0.607 0.586 disease
NOX1 27035 Heart Decompensation C1961112 Pathologic Function 0.3 0.607 0.586 phenotype
NOX1 27035 Heart failure C0018801 Disease or Syndrome 0.3 0.607 0.586 disease
NOX1 27035 Malignant tumor of colon C0007102 Neoplastic Process 0.36 0.607 0.586 disease
NOX1 27035 Heart Failure, Right-Sided C0235527 Disease or Syndrome 0.3 0.607 0.586 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types