Coagulation factor XI

AltitudeomicsDB
Protein Official symbol F11
Aliases F11
Chromosomal Location  4
Length 625
Uniprot ID P03951
EC number 3.4.21.27
Protein family Information(Pfam) PF00024;PF00089;
PDB id 1XX9;1XXD;1XXF;1ZHM;1ZHP;1ZHR;1ZJD;1ZLR;1ZMJ;1ZML;1ZMN;1ZOM;1ZPB;1ZPC;1ZPZ;1ZRK;1ZSJ;1ZSK;1ZSL;1ZTJ;1ZTK;1ZTL;2F83;2FDA;2J8J;2J8L;3BG8;3SOR;3SOS;4CR5;4CR9;4CRA;4CRB;4CRC;4CRD;4CRE;4CRF;4CRG;4D76;4D7F;4D7G;4NA7;4NA8;4TY6;4TY7;4WXI;4X6M;4X6N;4X6O;4X6P;4Y8X;4Y8Y;4Y8Z;5E2O;5E2P;5EOD;5EOK;5EXL;5EXM;5EXN;5I25;5Q0D;5Q0E;5Q0F;5Q0G;5Q0H;5QCK;5QCL;5QCM;5QCN;5QQO;5QQP;5QTT;5QTV;5QTW;5QTY;5TKS;5TKT;5TKU;5WB6;6AOD;6C0S;6HHC;6I58;6R8X;
InterPro ID IPR000177;IPR003609;IPR009003;IPR001314;IPR001254;IPR018114;IPR033116;
dbSNP rs281875259 rs281875267 rs281875264 rs281875271 rs281875252 rs281875243 rs281875261 rs121965069 rs281875244 rs5968 rs281875272 rs768474112 rs281875256 rs281875273 rs281875245 rs281875246 rs281875265 rs5969 rs281875279 rs281875260 rs281875277 rs281875274 rs145168351 rs121965070 rs281875247 rs281875248 rs121965064 rs5972 rs281875257 rs281875268 rs281875269 rs28934608 rs281875253 rs5967 rs281875270 rs281875254 rs1800439 rs281875262 rs281875266 rs121965067 rs121965071 rs121965068 rs281875241 rs121965065 rs281875242 rs1554083754 rs140068026 rs281875258 rs281875278 rs281875249 rs281875263 rs139695003 rs142952627 rs369935706 rs281875275 rs281875250 rs121965072 rs28934609 rs281875251 rs281875255 rs281875276

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
SERPINC1 F2 0.998
KNG1 KLKB1 0.993
SERPINC1 F9 0.992
GP1BA GP9 0.991
GP5 GP9 0.99
F8 F9 0.989
F2 SERPIND1 0.989
SERPINC1 PROC 0.988
F11 F8 0.988
GP1BB GP1BA 0.986
F11 SERPINC1 0.985
F10 SERPINC1 0.985
F8 F2 0.985
GP5 GP1BB 0.982
KNG1 F12 0.979
SERPINC1 F8 0.979
F10 F8 0.975
SERPINC1 KNG1 0.972
F11 KNG1 0.972
F11 F9 0.966
F2 PROC 0.963
F2 KNG1 0.961
F10 SERPIND1 0.961
F12 F9 0.961
KLKB1 F12 0.961
SERPINC1 SERPIND1 0.96
F11 F12 0.959
SERPINA5 F2 0.955
SERPINC1 F12 0.954
SERPINE2 F2 0.953
PROC SERPIND1 0.953
KNG1 SERPIND1 0.952
KNG1 C1QBP 0.951
F11 F2 0.951
GP5 SERPIND1 0.951
F11 PROC 0.95
F11 SERPIND1 0.949
SERPINA5 PROC 0.947
F2 F9 0.946
GP1BA F2 0.945
GP5 F8 0.944
F8 GP1BA 0.944
F8 GP9 0.942
GP5 GP1BA 0.94
F8 PROC 0.938
F11 F10 0.938
F10 F2 0.938
F2 GP9 0.935
F10 SERPINA5 0.933
GP1BB F8 0.932
F8 KNG1 0.931
KLKB1 C1QBP 0.93
F11 SERPINA5 0.93
F8 SERPIND1 0.929
F8 SERPINA5 0.928
SERPINE2 F11 0.927
F11 GP1BA 0.926
SERPINC1 GP1BA 0.925
GP1BB GP9 0.925
KNG1 PROC 0.924
F11 C1QBP 0.923
GP5 SERPINC1 0.923
F10 PROC 0.919
F10 GP1BA 0.917
GP1BA KNG1 0.917
F10 F9 0.916
SERPINE2 F10 0.915
GP9 KNG1 0.913
F11 GP9 0.913
GP1BA F9 0.913
GP1BA PROC 0.913
F11 GP1BB 0.913
GP5 F2 0.913
SERPINE2 F8 0.912
GP9 F9 0.912
GP5 SERPINA5 0.911
F11 KLKB1 0.911
F11 GP5 0.91
GP1BB KLKB1 0.91
GP1BA C1QBP 0.909
SERPINC1 GP9 0.909
GP9 C1QBP 0.909
GP1BB F2 0.908
GP1BB F12 0.908
GP1BA SERPIND1 0.908
GP1BA F12 0.906
GP1BA KLKB1 0.906
F10 GP9 0.905
GP1BB SERPIND1 0.904
GP1BB KNG1 0.904
SERPINA5 GP1BA 0.904
GP1BB F9 0.903
GP9 KLKB1 0.902
GP5 KNG1 0.902
GP9 PROC 0.902
F12 C1QBP 0.901
GP1BB F10 0.901
GP5 F12 0.9
SERPINE2 GP5 0.9
SERPINA5 GP9 0.9
GP5 C1QBP 0.9
GP1BB SERPINA5 0.9
GP1BB SERPINC1 0.9
SERPINE2 GP1BB 0.9
GP9 F12 0.9
GP5 F10 0.9
GP1BB C1QBP 0.9
SERPINE2 GP9 0.9
GP5 PROC 0.9
GP1BB PROC 0.9
GP9 SERPIND1 0.9
SERPINE2 GP1BA 0.9
GP5 F9 0.9
GP5 KLKB1 0.9
Gene Ontology Semantic Similarity
Download Tab separated file
# 462 (SERPINC1) 3827 (KNG1) 2811 (GP1BA) 2814 (GP5) 2157 (F8) 2147 (F2) 2160 (F11) 2812 (GP1BB) 2159 (F10) 2161 (F12) 3818 (KLKB1) 5104 (SERPINA5) 5270 (SERPINE2) 5624 (PROC) 2815 (GP9) 2158 (F9) 3053 (SERPIND1) 708 (C1QBP)
462 (SERPINC1) 1.00 0.73 0.62 1.00 1.00 0.56 0.62 0.71 0.59 0.65 0.62 0.73 0.79 0.62 1.00 0.53 0.54 0.57
3827 (KNG1) 0.73 1.00 0.53 1.00 1.00 0.67 0.53 0.57 0.55 0.56 0.53 0.73 0.86 0.53 1.00 0.53 0.43 0.56
2811 (GP1BA) 0.62 0.53 1.00 1.00 1.00 0.60 0.56 0.85 0.52 0.61 0.56 0.49 0.55 0.56 1.00 0.46 0.11 0.54
2814 (GP5) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00
2157 (F8) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00
2147 (F2) 0.56 0.67 0.60 1.00 1.00 1.00 0.71 0.66 0.72 0.72 0.71 0.61 0.71 0.71 1.00 0.68 0.10 0.56
2160 (F11) 0.62 0.53 0.56 1.00 1.00 0.71 1.00 0.62 0.88 0.96 1.00 0.49 0.55 1.00 1.00 0.85 0.11 0.54
2812 (GP1BB) 0.71 0.57 0.85 1.00 1.00 0.66 0.62 1.00 0.58 0.65 0.62 0.52 0.59 0.62 1.00 0.52 0.11 0.57
2159 (F10) 0.59 0.55 0.52 1.00 1.00 0.72 0.88 0.58 1.00 0.87 0.88 0.58 0.57 0.88 1.00 0.79 0.11 0.53
2161 (F12) 0.65 0.56 0.61 1.00 1.00 0.72 0.96 0.65 0.87 1.00 0.96 0.52 0.58 0.96 1.00 0.84 0.11 0.56
3818 (KLKB1) 0.62 0.53 0.56 1.00 1.00 0.71 1.00 0.62 0.88 0.96 1.00 0.49 0.55 1.00 1.00 0.85 0.11 0.54
5104 (SERPINA5) 0.73 0.73 0.49 1.00 1.00 0.61 0.49 0.52 0.58 0.52 0.49 1.00 0.84 0.49 1.00 0.46 0.35 0.57
5270 (SERPINE2) 0.79 0.86 0.55 1.00 1.00 0.71 0.55 0.59 0.57 0.58 0.55 0.84 1.00 0.55 1.00 0.49 0.47 0.62
5624 (PROC) 0.62 0.53 0.56 1.00 1.00 0.71 1.00 0.62 0.88 0.96 1.00 0.49 0.55 1.00 1.00 0.85 0.11 0.54
2815 (GP9) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.13 1.00
2158 (F9) 0.53 0.53 0.46 1.00 1.00 0.68 0.85 0.52 0.79 0.84 0.85 0.46 0.49 0.85 1.00 1.00 0.10 0.50
3053 (SERPIND1) 0.54 0.43 0.11 0.13 0.13 0.10 0.11 0.11 0.11 0.11 0.11 0.35 0.47 0.11 0.13 0.10 1.00 0.09
708 (C1QBP) 0.57 0.56 0.54 1.00 1.00 0.56 0.54 0.57 0.53 0.56 0.54 0.57 0.62 0.54 1.00 0.50 0.09 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
F11 Human Blood - 3600 m Native downregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
Gene Ontology
ID GO ID GO Term GO Type
2160 GO:0005886 plasma membrane GOTERM_CC_DIRECT
2160 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2160 GO:0005515 protein binding GOTERM_MF_DIRECT
2160 GO:0016020 membrane GOTERM_CC_DIRECT
2160 GO:0031639 plasminogen activation GOTERM_BP_DIRECT
2160 GO:0070009 ubiquitin conjugating enzyme activity GOTERM_MF_DIRECT
2160 GO:0005576 extracellular region GOTERM_CC_DIRECT
2160 GO:0051919 positive regulation of fibrinolysis GOTERM_BP_DIRECT
2160 GO:0006508 proteolysis GOTERM_BP_DIRECT
2160 GO:0005615 extracellular space GOTERM_CC_DIRECT
2160 GO:0008201 heparin binding GOTERM_MF_DIRECT
2160 GO:0007597 blood coagulation GOTERM_BP_DIRECT
2160 GO:0007596 blood coagulation GOTERM_BP_DIRECT
2160 GO:0004252 serine-type endopeptidase activity GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
2160 hsa04610 Complement and coagulation cascades
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
F11 2160 Hypertensive disease C0020538 Disease or Syndrome 0.3 0.656 0.414 group
F11 2160 Hereditary Factor XI Deficiency C0015523 Disease or Syndrome 1 0.656 0.414 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types
F11 2160 ALPHA-KETOTHIAZOLE ANALOGUE 36 CHEMBL273653 CHEMBL273653 inhibitor
F11 2160 ANTITHROMBIN None None None
F11 2160 DEXTRAN SULFATE DEXTRAN SULFATE SODIUM CHEMBL2108952 None
F11 2160 ISIS-FXI None None antisense
F11 2160 ISIS-FXIRX None None None
F11 2160 THROMBIN THROMBIN CHEMBL2108110 None