Ficolin-2

AltitudeomicsDB
Protein Official symbol FCN2
Aliases FCN2 FCNL
Chromosomal Location  9
Length 313
Uniprot ID Q15485
EC number None
Protein family Information(Pfam) PF01391;PF00147;
PDB id 2J0G;2J0H;2J0Y;2J1G;2J2P;2J3F;2J3G;2J3O;2J3U;2J61;4NYT;4R9J;4R9T;
InterPro ID IPR008160;IPR036056;IPR014716;IPR014715;IPR002181;IPR020837;
dbSNP rs17549179 rs12684476 rs17549193 rs7851696

Protein Protein Interaction

0%
Download Tab separated file
AltitudeomicsDB
Protein 1 Protein 2 Combine Score
MBL2 FCN2 0.991
MASP1 FCN2 0.989
FCN1 MASP1 0.986
MBL2 FCN3 0.986
MASP2 MBL2 0.986
MBL2 MASP1 0.984
MASP1 FCN3 0.979
C4B C4A 0.976
COLEC11 MASP1 0.976
C4A MBL2 0.97
C4B MBL2 0.97
COLEC11 FCN3 0.969
C4A MASP1 0.967
C4B FCN2 0.967
C4A FCN2 0.966
C4B MASP1 0.966
COLEC10 MASP1 0.965
COLEC10 FCN2 0.963
C4B C2 0.962
C4A C2 0.962
C4A FCN3 0.958
C4B FCN3 0.958
COLEC10 FCN3 0.957
MBL2 C2 0.955
C4A FCN1 0.95
C4B FCN1 0.95
COLEC11 C4A 0.947
C4B COLEC11 0.947
C2 FCN2 0.938
C4B MASP2 0.935
C4A MASP2 0.935
COLEC11 FCN2 0.931
COLEC11 FCN1 0.93
MBL2 FCN1 0.93
FCN1 COLEC10 0.927
C2 FCN3 0.925
COLEC11 MBL2 0.92
C2 MASP1 0.92
C4B COLEC10 0.919
C4A COLEC10 0.919
MBL2 COLEC10 0.918
FCN1 C2 0.915
MASP2 FCN2 0.914
FCN2 FCN3 0.911
COLEC11 C2 0.91
COLEC11 COLEC10 0.91
MASP2 MASP1 0.909
FCN1 FCN3 0.906
COLEC10 C2 0.906
FCN1 FCN2 0.906
Gene Ontology Semantic Similarity
Download Tab separated file
# 4153 (MBL2) 5648 (MASP1) 2219 (FCN1) 10747 (MASP2) 721 (C4B) 78989 (COLEC11) 720 (C4A) 10584 (COLEC10) 717 (C2) 2220 (FCN2) 8547 (FCN3)
4153 (MBL2) 1.00 0.86 0.70 0.79 0.73 0.81 0.58 0.66 0.79 0.76 0.77
5648 (MASP1) 0.86 1.00 0.68 0.87 0.70 0.67 0.61 0.50 0.79 0.76 0.77
2219 (FCN1) 0.70 0.68 1.00 0.71 0.66 0.54 0.56 0.49 0.74 0.69 0.72
10747 (MASP2) 0.79 0.87 0.71 1.00 0.77 0.60 0.74 0.52 0.85 0.79 0.82
721 (C4B) 0.73 0.70 0.66 0.77 1.00 0.66 0.77 0.68 0.84 0.74 0.80
78989 (COLEC11) 0.81 0.67 0.54 0.60 0.66 1.00 0.42 0.67 0.58 0.60 0.58
720 (C4A) 0.58 0.61 0.56 0.74 0.77 0.42 1.00 0.49 0.80 0.58 0.71
10584 (COLEC10) 0.66 0.50 0.49 0.52 0.68 0.67 0.49 1.00 0.59 0.51 0.57
717 (C2) 0.79 0.79 0.74 0.85 0.84 0.58 0.80 0.59 1.00 0.80 0.92
2220 (FCN2) 0.76 0.76 0.69 0.79 0.74 0.60 0.58 0.51 0.80 1.00 0.87
8547 (FCN3) 0.77 0.77 0.72 0.82 0.80 0.58 0.71 0.57 0.92 0.87 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
FCN2 Human Blood - 3600 m Native upregulated - TMT-based proteomic analysis/LC-MS Central Asia Tibetans - High altitude native vs. low Lander 30908922
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT029624 hsa-miR-26b-5p Homo sapiens FCN2 2220 Homo sapiens Microarray Functional MTI (Weak) 19088304
MIRT610902 hsa-miR-8485 Homo sapiens FCN2 2220 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT610901 hsa-miR-501-3p Homo sapiens FCN2 2220 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT610900 hsa-miR-502-3p Homo sapiens FCN2 2220 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT610898 hsa-miR-5589-3p Homo sapiens FCN2 2220 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT610899 hsa-miR-8064 Homo sapiens FCN2 2220 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT614115 hsa-miR-764 Homo sapiens FCN2 2220 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
MIRT614114 hsa-miR-3665 Homo sapiens FCN2 2220 Homo sapiens HITS-CLIP Functional MTI (Weak) 23824327
Gene Ontology
ID GO ID GO Term GO Type
2220 GO:0046872 metal ion binding GOTERM_MF_DIRECT
2220 GO:0072562 blood microparticle GOTERM_CC_DIRECT
2220 GO:0008228 opsonization GOTERM_BP_DIRECT
2220 GO:0004252 serine-type endopeptidase activity GOTERM_MF_DIRECT
2220 GO:0005515 protein binding GOTERM_MF_DIRECT
2220 GO:0001867 complement activation GOTERM_BP_DIRECT
2220 GO:0006508 proteolysis GOTERM_BP_DIRECT
2220 GO:0050830 defense response to Gram-positive bacterium GOTERM_BP_DIRECT
2220 GO:0006956 complement activation GOTERM_BP_DIRECT
2220 GO:0005581 collagen trimer GOTERM_CC_DIRECT
2220 GO:0043394 glutathione binding GOTERM_MF_DIRECT
2220 GO:0005576 extracellular region GOTERM_CC_DIRECT
2220 GO:0043654 recognition of apoptotic cell GOTERM_BP_DIRECT
2220 GO:0050829 defense response to Gram-negative bacterium GOTERM_BP_DIRECT
2220 GO:2001065 sequence-specific mRNA binding GOTERM_MF_DIRECT
2220 GO:0070062 extracellular exosome GOTERM_CC_DIRECT
2220 GO:0003823 lysozyme activity GOTERM_MF_DIRECT
2220 GO:0048306 calcium-dependent protein binding GOTERM_MF_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
FCN2 2220 Malignant mesothelioma C0345967 Neoplastic Process 0.3 0.584 0.793 disease
FCN2 2220 Colorectal Cancer C1527249 Neoplastic Process 0.3 0.584 0.793 disease
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types