ALTITUDEOMICSDB

Apolipoprotein E

AltitudeomicsDB

Protein Official symbol	APOE
Aliases	APOE
Chromosomal Location	19
Length	317
Uniprot ID	P02649
EC number	None
Protein family Information(Pfam)	PF01442;
PDB id	1B68;1BZ4;1EA8;1GS9;1H7I;1LE2;1LE4;1LPE;1NFN;1NFO;1OEF;1OEG;1OR2;1OR3;2KC3;2KNY;2L7B;6IWB;6NCN;6NCO;
InterPro ID	IPR000074;
dbSNP	rs121918392 rs201672011 rs121918399 rs769452 rs28931576 rs370594287 rs1180612218 rs11083750 rs28931577 rs937063425 rs429358 rs267606664 rs28931578 rs121918393 rs121918393 rs387906567 rs769455 rs121918397 rs121918397 rs121918394 rs121918394 rs267606662 rs7412 rs267606663 rs121918395 rs199768005 rs267606661 rs121918398 rs28931579

Protein Protein Interaction

Download Tab separated file

AltitudeomicsDB

Protein 1	Protein 2	Combine Score
LDLR	PCSK9	0.999
APOA2	APOA1	0.999
APOA1	APOB	0.999
APOA1	APOC3	0.999
FGG	FGA	0.999
AHSG	ALB	0.998
APOA2	APOB	0.997
APOE	APOB	0.996
APOB	APOC3	0.996
SERPINC1	FGA	0.996
LDLR	APOB	0.996
APOA2	APOC3	0.996
LDLR	APOE	0.996
AHSG	APOA1	0.996
SERPINC1	FGG	0.995
APP	APOE	0.995
AHSG	APOA2	0.995
LPA	APOB	0.994
GPIHBP1	LPL	0.993
APOC2	APOE	0.993
APOC2	APOC3	0.993
APOC2	LPL	0.992
PCSK9	APOB	0.992
LCAT	APOA1	0.992
APOC1	APOE	0.992
LDLR	LDLRAP1	0.991
ALB	APOA1	0.991
APOA5	APOC3	0.991
APOE	APOA1	0.991
APOC2	APOA1	0.991
AHSG	FGG	0.991
FN1	ALB	0.99
APOA4	APOC3	0.99
FGA	APOA1	0.989
APOA1	CETP	0.989
AHSG	FGA	0.989
APOB	CETP	0.989
APOE	LRP1	0.989
APOC2	APOB	0.988
APP	ADAM10	0.988
APOA4	APOB	0.988
APOC2	APOA2	0.988
GPIHBP1	APOA5	0.988
FN1	PCSK9	0.988
AHSG	SERPINC1	0.987
AHSG	APOB	0.987
LRP8	APOE	0.987
CLU	APP	0.987
SERPINC1	ALB	0.987
ALB	APOB	0.986
LPL	APOB	0.986
LPL	APOC3	0.985
LPA	APOA1	0.985
APOA2	APOE	0.985
AHSG	TF	0.985
APOE	APOC3	0.984
FGG	APOA1	0.984
TF	ALB	0.983
SERPINA1	ALB	0.983
IL6	ALB	0.983
FGA	ALB	0.983
IL6	TIMP1	0.982
LIPC	APOB	0.982
APOA5	LPL	0.982
APOL1	APOA1	0.982
TF	APOA2	0.982
SERPINA1	CP	0.981
APOA2	LPA	0.981
APOA2	ALB	0.981
APOA5	APOB	0.981
LPL	APOE	0.98
ALB	CP	0.98
APOC2	APOA5	0.98
FGG	ALB	0.98
FGG	APOB	0.98
LDLRAP1	LRP2	0.98
HP	APOA1	0.979
ALB	APOE	0.979
TF	APOA1	0.978
SPP1	TIMP1	0.978
SPP1	ALB	0.978
SERPINC1	APOA1	0.978
IL6	SPP1	0.978
CST3	ALB	0.978
GPIHBP1	APOC2	0.978
FGA	APOB	0.977
SPP1	FN1	0.977
IL6	CSF1	0.976
APOC2	APOA4	0.975
SDC1	HSPG2	0.975
APOC2	APOC1	0.975
IL6	KNG1	0.974
SERPINA1	AHSG	0.974
SERPINC1	APOB	0.974
APOC1	APOB	0.973
IL6	SERPINC1	0.973
APLP2	ADAM10	0.973
SERPINC1	KNG1	0.972
ALB	C3	0.972
LCAT	CETP	0.972
APOA2	FGA	0.972
FN1	TIMP1	0.972
SERPINA1	IL6	0.971
IL6	FN1	0.971
LPL	APOA1	0.971
ALB	KNG1	0.971
LRP2	APOE	0.971
IL6	APOA1	0.971
APOA5	APOE	0.97
SERPINA1	APOA1	0.97
APOA2	FGG	0.97
LDLR	APOA1	0.97
APOA5	SERPINC1	0.97
F5	SERPINC1	0.969
LPA	LCAT	0.969
IL6	APOE	0.969
APOA5	APOA2	0.969
TF	C3	0.967
APP	APLP2	0.967
TF	CP	0.967
ADAM10	TIMP1	0.967
LPA	APOC3	0.967
C3	APOA1	0.967
PCSK9	APOE	0.966
AHSG	SPP1	0.966
LIPC	APOE	0.966
FN1	C3	0.966
APOA2	LPL	0.966
APOA2	LCAT	0.966
SERPINA1	TF	0.966
PLTP	APOE	0.965
ALB	APP	0.965
AHSG	CP	0.964
APOC1	APOC3	0.964
LRP2	APOB	0.964
APOA2	APOA4	0.964
LDLRAP1	APOB	0.963
APOA2	SERPINC1	0.963
CP	C3	0.963
SERPINA1	C3	0.963
APOA5	ALB	0.963
APOA5	PCSK9	0.963
GPIHBP1	APOC3	0.962
HSPG2	APOB	0.962
SERPINA1	FN1	0.961
APOA2	C3	0.961
AHSG	KNG1	0.961
APP	KNG1	0.961
LPA	APOE	0.961
PLTP	LCAT	0.96
PCSK9	APOA1	0.96
APOA5	FGA	0.96
SERPINA1	APOA2	0.96
LPA	CETP	0.96
APOA5	AHSG	0.96
CST3	APOE	0.959
C4A	ALB	0.959
APOE	C3	0.959
LDLR	APOC3	0.959
LDLR	LIPC	0.959
CLU	ALB	0.958
C4A	SERPINC1	0.958
IL6	C3	0.958
CP	APOA1	0.957
APOC1	APOA2	0.957
IL6	APOB	0.957
IL6	APP	0.957
SERPINA1	FGA	0.957
SERPINC1	CP	0.956
APOA4	APOA1	0.956
APP	APOA1	0.956
ALB	TIMP1	0.956
CST3	APP	0.956
IL6	CST3	0.956
AHSG	C3	0.956
SERPINC1	C3	0.956
C4A	APOA2	0.955
APOA5	FGG	0.955
TF	APOB	0.955
SERPINA1	FGG	0.955
FGG	CP	0.954
HSPG2	APP	0.954
APOA4	LPL	0.954
SERPINA1	KNG1	0.954
SERPINC1	FN1	0.954
KNG1	C3	0.954
TF	KNG1	0.954
CST3	TIMP1	0.953
TF	FGG	0.953
ALB	LCAT	0.953
APOA4	LPA	0.953
CST3	SPP1	0.953
FGG	KNG1	0.953
APOC2	LDLR	0.953
CLU	APOE	0.953
HP	APOE	0.953
APOA5	APOA1	0.953
APOA5	SERPINA1	0.952
LCAT	APOB	0.952
SERPINA1	APOB	0.952
CSF1	ALB	0.952
GPIHBP1	APOB	0.952
FN1	APOE	0.952
APOC2	LPA	0.952
C4A	APOA1	0.951
LCAT	APOE	0.951
HSPG2	APOE	0.951
SERPINA1	C4A	0.951
SERPINA1	CLU	0.951
KNG1	APOA1	0.951
LRP8	APOB	0.95
FN1	KNG1	0.95
ADAM10	APOE	0.95
FN1	FGA	0.95
LRP10	APOE	0.95
SERPINA1	APOE	0.95
GPIHBP1	APOE	0.95
C4A	FN1	0.95
SPP1	CSF1	0.95
C3	APOB	0.95
TF	SERPINC1	0.95
APOA2	APOL1	0.949
APOL1	APOE	0.949
C4A	KNG1	0.949
CP	APOB	0.949
IL6	CP	0.949
SPP1	APOE	0.949
APOA5	KNG1	0.949
APP	CP	0.948
FGA	KNG1	0.948
FN1	CSF1	0.948
CP	APOE	0.948
AHSG	IL6	0.947
APOA5	C3	0.946
FN1	FGG	0.946
APOA5	TF	0.946
APOA2	CP	0.946
CST3	APOA1	0.946
CSF1	TIMP1	0.946
C4A	CST3	0.946
PLTP	APOA1	0.946
AHSG	CLU	0.946
FN1	APP	0.946
FN1	CLU	0.945
FGA	C3	0.945
FGA	CP	0.945
C4A	TF	0.945
LRP1	APOB	0.945
APOA2	KNG1	0.945
ALB	LRP1	0.945
SERPINA1	F5	0.945
AHSG	CST3	0.944
C4A	IL6	0.944
LDLR	APOA4	0.944
C4A	APOE	0.944
TFAP2A	APOE	0.944
APOE	TIMP1	0.944
FN1	APOA1	0.943
FN1	ADAM10	0.943
APOC1	APOA1	0.943
CLU	TIMP1	0.943
PLTP	APOA2	0.943
APOE	CETP	0.942
APOL1	ALB	0.942
TF	FGA	0.942
KNG1	CP	0.942
LDLR	APOA2	0.942
AHSG	APOE	0.942
KNG1	APOE	0.941
CST3	HP	0.941
TF	FN1	0.941
IL6	ADAM10	0.941
APOA4	APOE	0.94
SERPINA1	CST3	0.94
C4A	CP	0.94
APLP2	APOE	0.94
SERPINA1	TIMP1	0.94
SERPINA1	SERPINC1	0.94
FGG	C3	0.94
CSF1	APOE	0.939
F5	FGA	0.939
FN1	CP	0.939
LDLRAP1	APOE	0.939
CST3	APOB	0.939
FN1	APOB	0.938
LPL	CETP	0.938
APOC3	CETP	0.938
C4A	F5	0.938
C4A	FGA	0.938
PCSK9	ALB	0.938
APOA5	C4A	0.938
C4A	C3	0.938
MSR1	APOE	0.938
LRP2	APOA1	0.937
TF	APOE	0.937
C4A	AHSG	0.937
APP	C3	0.937
APOA5	APOA4	0.937
APOL1	APOB	0.937
CST3	C3	0.937
C4A	FGG	0.936
CLU	KNG1	0.936
AHSG	FN1	0.936
FGG	APOE	0.935
F5	FGG	0.935
LPL	LRP1	0.935
F5	KNG1	0.935
HSPG2	LRP1	0.934
CST3	FN1	0.934
SERPINA1	APOL1	0.934
SERPINC1	APOE	0.934
FGA	APOE	0.933
ALB	ADAM10	0.933
KNG1	APOB	0.933
APOC1	CETP	0.932
APOA1	TIMP1	0.932
CST3	APOL1	0.932
F5	APOA1	0.931
SPP1	APOA1	0.931
F5	APOE	0.931
C4A	APOB	0.931
F5	C3	0.93
HSPG2	LRP2	0.93
SPP1	C3	0.93
GPIHBP1	APOA1	0.929
SDC1	APOE	0.929
F5	ALB	0.929
F5	APOB	0.929
IL6	PCSK9	0.929
APOL1	C3	0.927
APOA2	HP	0.927
APOA5	APOL1	0.927
APP	APOB	0.927
C4A	APP	0.927
IL6	APOA2	0.926
APOC1	LCAT	0.926
CST3	CP	0.926
CST3	APOA2	0.926
CSF1	C3	0.926
FGG	CLU	0.926
APP	TIMP1	0.926
LIPC	CETP	0.925
SERPINA1	APP	0.925
SDC1	LRP1	0.925
CLU	FGA	0.925
SPP1	CP	0.925
APOA5	CETP	0.924
APOA2	PCSK9	0.924
APOA2	CETP	0.923
SPP1	KNG1	0.923
CSF1	APP	0.923
CST3	SERPINC1	0.923
FGA	PCSK9	0.922
CST3	APLP2	0.922
KNG1	TIMP1	0.921
AHSG	F5	0.921
C4A	CSF1	0.921
F5	FN1	0.921
PCSK9	APLP2	0.921
FGG	PCSK9	0.921
C3	TIMP1	0.921
MSR1	APOB	0.921
SDC1	APOB	0.921
IL6	FGA	0.921
GPIHBP1	APOA4	0.921
FN1	APLP2	0.92
PLTP	APOB	0.92
APOA4	APP	0.92
SERPINA1	SPP1	0.92
HSPG2	LRP8	0.92
AHSG	TIMP1	0.92
ALB	APLP2	0.92
PCSK9	APP	0.919
LRP1	APOA1	0.919
SERPINC1	APP	0.919
APOB	TIMP1	0.919
C4A	SPP1	0.919
KNG1	APLP2	0.919
TF	CST3	0.919
LRP8	APOA1	0.919
SPP1	APOB	0.919
APOC2	SDC1	0.919
APOA5	IL6	0.918
IL6	FGG	0.918
IL6	APOL1	0.918
HSPG2	APOA4	0.918
HSPG2	LRP10	0.918
SPP1	APP	0.918
TF	IL6	0.918
APOA2	APP	0.918
F5	CP	0.918
TF	F5	0.917
APOA5	LPA	0.917
SERPINC1	TIMP1	0.917
APOC2	LRP1	0.917
SDC1	APOC3	0.917
ADAM10	C3	0.917
APOA2	LRP8	0.917
APOC2	HSPG2	0.917
CP	TIMP1	0.917
SERPINC1	PCSK9	0.915
CSF1	PCSK9	0.915
LRP1	APOC3	0.915
APOA2	LRP2	0.915
FGA	APP	0.915
HSPG2	APOA1	0.915
APOL1	FGA	0.915
IL6	F5	0.914
LRP10	APOB	0.914
PLTP	LPA	0.914
APOA2	F5	0.914
AHSG	PCSK9	0.914
SERPINA1	CSF1	0.913
APOA5	F5	0.913
SPP1	SERPINC1	0.913
FN1	APOL1	0.913
APOA2	FN1	0.913
CST3	FGA	0.913
C4A	TIMP1	0.913
LDLR	LRP2	0.913
AHSG	APP	0.913
CSF1	APOA1	0.913
HSPG2	APOA2	0.912
SERPINA1	PCSK9	0.912
AHSG	APOL1	0.912
APOC2	LRP8	0.912
SERPINC1	APOL1	0.912
CST3	ADAM10	0.912
CSF1	APOB	0.912
TF	APOL1	0.912
C4A	APOL1	0.912
APOL1	CP	0.912
LRP8	APOC3	0.911
TF	APP	0.911
APOA4	LRP2	0.911
TF	SPP1	0.911
CST3	KNG1	0.911
CP	APLP2	0.911
CSF1	ADAM10	0.911
APOA2	LRP1	0.91
KNG1	ADAM10	0.91
APOC1	LPA	0.91
APOA5	CP	0.91
HSPG2	APOC3	0.91
APOL1	KNG1	0.91
APOL1	PCSK9	0.91
SDC1	APOA1	0.91
MSR1	APOA1	0.91
SPP1	ADAM10	0.909
APOA4	LRP8	0.909
APOC1	APOA5	0.909
APLP2	APOB	0.909
FGG	APP	0.909
CST3	CSF1	0.909
SPP1	F5	0.908
TF	TIMP1	0.908
LPL	LIPC	0.908
CST3	HSPG2	0.908
LCAT	APOC3	0.908
SPP1	FGG	0.908
SPP1	FGA	0.908
APLP2	C3	0.907
PCSK9	C3	0.907
C4A	ADAM10	0.907
APOA2	TIMP1	0.907
F5	CLU	0.907
CLU	APOA1	0.906
CSF1	CP	0.906
ADAM10	APOB	0.906
SPP1	APOA2	0.906
PCSK9	CP	0.906
APOC2	LRP2	0.906
LRP2	APOC3	0.906
HP	APOL1	0.906
SERPINC1	APLP2	0.906
AHSG	CSF1	0.905
FGA	TIMP1	0.905
CSF1	KNG1	0.905
SDC1	LRP2	0.905
FGG	TIMP1	0.905
ADAM10	APOA1	0.905
APOC2	LCAT	0.905
APOL1	APP	0.905
SPP1	PCSK9	0.905
GPIHBP1	APOA2	0.905
C4A	APLP2	0.905
FGG	APOL1	0.904
APOA4	LRP1	0.904
F5	APOL1	0.904
CP	ADAM10	0.904
LDLR	TF	0.904
CSF1	FGA	0.904
C4A	PCSK9	0.904
PCSK9	TIMP1	0.904
SERPINA1	ADAM10	0.904
PCSK9	KNG1	0.904
SDC1	LRP8	0.904
LPL	LCAT	0.904
F5	PCSK9	0.904
SDC1	APOA4	0.903
APOA5	FN1	0.903
TF	PCSK9	0.903
PCSK9	ADAM10	0.903
APOA5	APP	0.903
CST3	FGG	0.903
HSPG2	FGA	0.903
APLP2	APOA1	0.903
F5	APP	0.903
APOA2	APLP2	0.903
AHSG	ADAM10	0.903
IL6	APLP2	0.902
FGG	APLP2	0.902
AHSG	APLP2	0.902
APLP2	TIMP1	0.902
FGA	APLP2	0.902
SDC1	LRP10	0.902
APOA5	CSF1	0.902
TF	APLP2	0.902
SERPINC1	ADAM10	0.902
CSF1	APOL1	0.902
SDC1	APOA2	0.902
CST3	PCSK9	0.902
APOL1	TIMP1	0.902
TF	LRP2	0.901
F5	APLP2	0.901
SERPINC1	CSF1	0.901
SERPINC1	LPA	0.901
FGG	CSF1	0.901
APOL1	APLP2	0.901
CSF1	APLP2	0.901
F5	TIMP1	0.9
APOA5	ADAM10	0.9
APOA5	TIMP1	0.9
SPP1	APOL1	0.9
SPP1	APLP2	0.9
APOA5	SPP1	0.9
APOA5	APLP2	0.9
APOA5	CST3	0.9
LRP10	APOC3	0.9
APOA2	LRP10	0.9
APOC2	LRP10	0.9
F5	CSF1	0.9
LRP10	APOA4	0.9
LRP10	APOA1	0.9
FGA	ADAM10	0.9
TF	LDLRAP1	0.9
APOA2	CSF1	0.9
APOC1	APOA4	0.9
FGG	ADAM10	0.9
APOL1	ADAM10	0.9
CST3	F5	0.9
APOA2	ADAM10	0.9
TF	CSF1	0.9
F5	ADAM10	0.9
TF	ADAM10	0.9
SERPINA1	APLP2	0.9

Gene Ontology Semantic Similarity

Download Tab separated file

#	2266 (FGG)	335 (APOA1)	3949 (LDLR)	336 (APOA2)	197 (AHSG)	338 (APOB)	348 (APOE)	462 (SERPINC1)	351 (APP)	4018 (LPA)	338328 (GPIHBP1)	341 (APOC1)	255738 (PCSK9)	3931 (LCAT)	116519 (APOA5)	213 (ALB)	2335 (FN1)	337 (APOA4)	2243 (FGA)	1191 (CLU)	7804 (LRP8)	4023 (LPL)	3569 (IL6)	5265 (SERPINA1)	7018 (TF)	3990 (LIPC)	8542 (APOL1)	26119 (LDLRAP1)	3240 (HP)	6696 (SPP1)	1471 (CST3)	6382 (SDC1)	334 (APLP2)	4036 (LRP2)	2153 (F5)	102 (ADAM10)	718 (C3)	1356 (CP)	3339 (HSPG2)	720 (C4A)	3827 (KNG1)	1435 (CSF1)	4035 (LRP1)	7020 (TFAP2A)	345 (APOC3)	4481 (MSR1)	1071 (CETP)	7076 (TIMP1)
2266 (FGG)	1.00	0.61	0.64	0.56	0.16	0.63	0.56	0.69	0.73	0.62	0.46	0.25	0.62	0.69	0.48	0.61	0.71	0.52	1.00	0.78	0.56	0.62	0.79	0.70	0.73	0.50	0.67	0.66	0.80	0.76	0.62	0.80	0.74	0.63	1.00	0.63	0.74	0.57	0.80	0.43	0.66	0.78	0.58	0.44	0.46	0.72	0.38	0.71
335 (APOA1)	0.61	1.00	0.57	0.88	0.17	0.72	0.81	0.57	0.64	0.57	0.41	0.46	0.59	0.54	0.81	0.60	0.65	0.78	0.61	0.59	0.50	0.56	0.57	0.61	0.55	0.42	0.58	0.65	0.57	0.56	0.64	0.57	0.58	0.54	1.00	0.55	0.57	0.44	0.57	0.33	0.58	0.58	0.55	0.44	0.65	0.54	0.63	0.57
3949 (LDLR)	0.64	0.57	1.00	0.52	0.12	0.56	0.53	0.64	0.65	0.56	0.53	0.21	0.61	0.58	0.44	0.58	0.68	0.49	0.64	0.65	0.77	0.54	0.62	0.73	0.60	0.55	0.57	0.60	0.64	0.62	0.62	0.64	0.65	0.74	1.00	0.54	0.59	0.47	0.64	0.35	0.56	0.64	0.69	0.43	0.35	0.72	0.34	0.64
336 (APOA2)	0.56	0.88	0.52	1.00	0.22	0.71	0.82	0.54	0.59	0.55	0.38	0.56	0.56	0.50	0.83	0.56	0.59	0.86	0.56	0.55	0.45	0.51	0.53	0.57	0.51	0.38	0.59	0.57	0.53	0.51	0.56	0.53	0.53	0.53	1.00	0.53	0.52	0.40	0.53	0.30	0.56	0.58	0.54	0.44	0.71	0.50	0.73	0.54
197 (AHSG)	0.16	0.17	0.12	0.22	1.00	0.12	0.16	0.50	0.33	0.38	0.10	0.41	0.15	0.13	0.23	0.14	0.11	0.19	0.16	0.13	0.12	0.12	0.13	0.39	0.13	0.11	0.13	0.11	0.14	0.15	0.48	0.14	0.14	0.13	0.16	0.11	0.12	0.11	0.14	0.09	0.38	0.12	0.12	0.10	0.38	0.14	0.12	0.39
338 (APOB)	0.63	0.72	0.56	0.71	0.12	1.00	0.75	0.55	0.62	0.65	0.50	0.33	0.58	0.55	0.74	0.59	0.72	0.63	0.63	0.64	0.46	0.63	0.61	0.60	0.57	0.40	0.58	0.66	0.62	0.59	0.53	0.62	0.59	0.55	1.00	0.52	0.57	0.44	0.62	0.33	0.67	0.61	0.55	0.39	0.54	0.56	0.60	0.57
348 (APOE)	0.56	0.81	0.53	0.82	0.16	0.75	1.00	0.51	0.58	0.57	0.38	0.40	0.57	0.50	0.81	0.63	0.63	0.85	0.56	0.54	0.46	0.56	0.52	0.56	0.53	0.38	0.56	0.63	0.52	0.51	0.59	0.52	0.54	0.52	1.00	0.53	0.51	0.40	0.52	0.30	0.61	0.57	0.57	0.44	0.59	0.49	0.66	0.51
462 (SERPINC1)	0.69	0.57	0.64	0.54	0.50	0.55	0.51	1.00	0.84	0.73	0.44	0.33	0.55	0.61	0.47	0.56	0.69	0.46	0.69	0.72	0.47	0.52	0.67	0.94	0.63	0.42	0.58	0.60	0.73	0.68	0.87	0.73	0.67	0.53	1.00	0.53	0.61	0.49	0.73	0.36	0.72	0.68	0.50	0.38	0.45	0.63	0.33	0.87
351 (APP)	0.73	0.64	0.65	0.59	0.33	0.62	0.58	0.84	1.00	0.72	0.47	0.30	0.65	0.65	0.54	0.70	0.73	0.53	0.73	0.73	0.54	0.60	0.73	0.86	0.68	0.47	0.63	0.63	0.72	0.69	0.81	0.72	0.84	0.60	1.00	0.62	0.69	0.53	0.72	0.39	0.74	0.73	0.61	0.57	0.48	0.66	0.36	0.79
4018 (LPA)	0.62	0.57	0.56	0.55	0.38	0.65	0.57	0.73	0.72	1.00	0.38	0.34	0.66	0.58	0.53	0.57	0.69	0.48	0.62	0.64	0.50	0.67	0.61	0.74	0.57	0.50	0.54	0.58	0.63	0.60	0.74	0.63	0.60	0.50	1.00	0.66	0.74	0.45	0.63	0.56	0.79	0.62	0.52	0.39	0.46	0.57	0.34	0.70
338328 (GPIHBP1)	0.46	0.41	0.53	0.38	0.10	0.50	0.38	0.44	0.47	0.38	1.00	0.16	0.48	0.41	0.38	0.39	0.48	0.36	0.46	0.50	0.33	0.35	0.45	0.46	0.42	0.48	0.46	0.40	0.47	0.45	0.40	0.47	0.44	0.48	0.69	0.37	0.41	0.32	0.47	0.24	0.37	0.45	0.41	0.29	0.24	0.66	0.35	0.44
341 (APOC1)	0.25	0.46	0.21	0.56	0.41	0.33	0.40	0.33	0.30	0.34	0.16	1.00	0.24	0.21	0.56	0.37	0.24	0.51	0.25	0.23	0.18	0.23	0.22	0.31	0.24	0.17	0.28	0.25	0.23	0.24	0.34	0.23	0.23	0.20	0.30	0.19	0.21	0.18	0.23	0.14	0.36	0.22	0.22	0.17	0.67	0.22	0.40	0.30
255738 (PCSK9)	0.62	0.59	0.61	0.56	0.15	0.58	0.57	0.55	0.65	0.66	0.48	0.24	1.00	0.56	0.51	0.58	0.61	0.48	0.62	0.60	0.51	0.58	0.58	0.57	0.56	0.57	0.53	0.60	0.58	0.57	0.54	0.58	0.62	0.51	1.00	0.64	0.69	0.44	0.58	0.46	0.55	0.59	0.61	0.49	0.45	0.65	0.34	0.56
3931 (LCAT)	0.69	0.54	0.58	0.50	0.13	0.55	0.50	0.61	0.65	0.58	0.41	0.21	0.56	1.00	0.41	0.57	0.65	0.45	0.69	0.72	0.49	0.55	0.68	0.65	0.64	0.48	0.58	0.60	0.73	0.68	0.55	0.73	0.67	0.53	1.00	0.53	0.62	0.51	0.73	0.38	0.55	0.68	0.52	0.38	0.36	0.64	0.33	0.62
116519 (APOA5)	0.48	0.81	0.44	0.83	0.23	0.74	0.81	0.47	0.54	0.53	0.38	0.56	0.51	0.41	1.00	0.50	0.58	0.78	0.48	0.46	0.38	0.50	0.46	0.49	0.43	0.32	0.50	0.52	0.44	0.43	0.48	0.44	0.43	0.42	0.82	0.44	0.45	0.33	0.44	0.25	0.56	0.46	0.47	0.35	0.71	0.42	0.64	0.48
213 (ALB)	0.61	0.60	0.58	0.56	0.14	0.59	0.63	0.56	0.70	0.57	0.39	0.37	0.58	0.57	0.50	1.00	0.65	0.64	0.61	0.64	0.51	0.55	0.60	0.61	0.62	0.43	0.57	0.58	0.60	0.59	0.57	0.60	0.72	0.53	1.00	0.54	0.57	0.50	0.60	0.34	0.61	0.61	0.60	0.55	0.43	0.57	0.43	0.57
2335 (FN1)	0.71	0.65	0.68	0.59	0.11	0.72	0.63	0.69	0.73	0.69	0.48	0.24	0.61	0.65	0.58	0.65	1.00	0.54	0.71	0.73	0.57	0.69	0.71	0.73	0.67	0.49	0.63	0.66	0.69	0.68	0.67	0.72	0.70	0.61	1.00	0.67	0.69	0.57	0.72	0.39	0.73	0.71	0.61	0.48	0.43	0.66	0.37	0.70
337 (APOA4)	0.52	0.78	0.49	0.86	0.19	0.63	0.85	0.46	0.53	0.48	0.36	0.51	0.48	0.45	0.78	0.64	0.54	1.00	0.52	0.51	0.41	0.44	0.49	0.51	0.51	0.34	0.54	0.51	0.48	0.46	0.49	0.48	0.48	0.48	1.00	0.49	0.46	0.35	0.48	0.26	0.52	0.55	0.53	0.40	0.56	0.44	0.79	0.48
2243 (FGA)	1.00	0.61	0.64	0.56	0.16	0.63	0.56	0.69	0.73	0.62	0.46	0.25	0.62	0.69	0.48	0.61	0.71	0.52	1.00	0.78	0.56	0.62	0.79	0.70	0.73	0.50	0.67	0.66	0.80	0.76	0.62	0.80	0.74	0.63	1.00	0.63	0.74	0.57	0.80	0.43	0.66	0.78	0.58	0.44	0.46	0.72	0.38	0.71
1191 (CLU)	0.78	0.59	0.65	0.55	0.13	0.64	0.54	0.72	0.73	0.64	0.50	0.23	0.60	0.72	0.46	0.64	0.73	0.51	0.78	1.00	0.57	0.60	0.77	0.73	0.74	0.51	0.70	0.66	0.84	0.80	0.64	0.84	0.77	0.65	1.00	0.60	0.71	0.69	0.84	0.45	0.64	0.76	0.57	0.44	0.40	0.76	0.37	0.71
7804 (LRP8)	0.56	0.50	0.77	0.45	0.12	0.46	0.46	0.47	0.54	0.50	0.33	0.18	0.51	0.49	0.38	0.51	0.57	0.41	0.56	0.57	1.00	0.48	0.53	0.52	0.49	0.40	0.46	0.52	0.53	0.50	0.47	0.53	0.51	0.71	1.00	0.46	0.49	0.37	0.53	0.28	0.45	0.55	0.71	0.36	0.31	0.47	0.29	0.49
4023 (LPL)	0.62	0.56	0.54	0.51	0.12	0.63	0.56	0.52	0.60	0.67	0.35	0.23	0.58	0.55	0.50	0.55	0.69	0.44	0.62	0.60	0.48	1.00	0.61	0.57	0.55	0.82	0.50	0.56	0.58	0.55	0.50	0.58	0.56	0.47	1.00	0.59	0.62	0.44	0.58	0.38	0.64	0.62	0.51	0.38	0.39	0.53	0.33	0.55
3569 (IL6)	0.79	0.57	0.62	0.53	0.13	0.61	0.52	0.67	0.73	0.61	0.45	0.22	0.58	0.68	0.46	0.60	0.71	0.49	0.79	0.77	0.53	0.61	1.00	0.69	0.71	0.48	0.66	0.63	0.79	0.75	0.61	0.79	0.73	0.61	1.00	0.61	0.73	0.56	0.79	0.42	0.66	0.88	0.55	0.42	0.44	0.71	0.35	0.76
5265 (SERPINA1)	0.70	0.61	0.73	0.57	0.39	0.60	0.56	0.94	0.86	0.74	0.46	0.31	0.57	0.65	0.49	0.61	0.73	0.51	0.70	0.73	0.52	0.57	0.69	1.00	0.66	0.46	0.63	0.62	0.74	0.70	0.88	0.74	0.74	0.58	1.00	0.57	0.65	0.53	0.74	0.39	0.73	0.71	0.54	0.43	0.45	0.67	0.35	0.85
7018 (TF)	0.73	0.55	0.60	0.51	0.13	0.57	0.53	0.63	0.68	0.57	0.42	0.24	0.56	0.64	0.43	0.62	0.67	0.51	0.73	0.74	0.49	0.55	0.71	0.66	1.00	0.44	0.61	0.61	0.76	0.71	0.57	0.76	0.69	0.55	1.00	0.56	0.66	0.51	0.76	0.38	0.68	0.70	0.55	0.39	0.40	0.67	0.35	0.64
3990 (LIPC)	0.50	0.42	0.55	0.38	0.11	0.40	0.38	0.42	0.47	0.50	0.48	0.17	0.57	0.48	0.32	0.43	0.49	0.34	0.50	0.51	0.40	0.82	0.48	0.46	0.44	1.00	0.40	0.45	0.49	0.46	0.40	0.49	0.46	0.37	0.82	0.47	0.48	0.36	0.49	0.33	0.40	0.49	0.42	0.30	0.27	0.65	0.26	0.44
8542 (APOL1)	0.67	0.58	0.57	0.59	0.13	0.58	0.56	0.58	0.63	0.54	0.46	0.28	0.53	0.58	0.50	0.57	0.63	0.54	0.67	0.70	0.46	0.50	0.66	0.63	0.61	0.40	1.00	0.60	0.70	0.65	0.54	0.70	0.64	0.53	1.00	0.51	0.59	0.47	0.70	0.35	0.53	0.66	0.50	0.37	0.44	0.61	0.52	0.59
26119 (LDLRAP1)	0.66	0.65	0.60	0.57	0.11	0.66	0.63	0.60	0.63	0.58	0.40	0.25	0.60	0.60	0.52	0.58	0.66	0.51	0.66	0.66	0.52	0.56	0.63	0.62	0.61	0.45	0.60	1.00	0.65	0.63	0.64	0.65	0.62	0.56	1.00	0.56	0.61	0.48	0.65	0.36	0.58	0.64	0.58	0.44	0.44	0.61	0.38	0.60
3240 (HP)	0.80	0.57	0.64	0.53	0.14	0.62	0.52	0.73	0.72	0.63	0.47	0.23	0.58	0.73	0.44	0.60	0.69	0.48	0.80	0.84	0.53	0.58	0.79	0.74	0.76	0.49	0.70	0.65	1.00	0.85	0.62	0.91	0.80	0.63	1.00	0.58	0.71	0.61	0.91	0.46	0.63	0.77	0.54	0.41	0.40	0.79	0.36	0.72
6696 (SPP1)	0.76	0.56	0.62	0.51	0.15	0.59	0.51	0.68	0.69	0.60	0.45	0.24	0.57	0.68	0.43	0.59	0.68	0.46	0.76	0.80	0.50	0.55	0.75	0.70	0.71	0.46	0.65	0.63	0.85	1.00	0.59	0.85	0.75	0.59	1.00	0.56	0.68	0.57	0.85	0.42	0.59	0.74	0.53	0.39	0.38	0.74	0.37	0.68
1471 (CST3)	0.62	0.64	0.62	0.56	0.48	0.53	0.59	0.87	0.81	0.74	0.40	0.34	0.54	0.55	0.48	0.57	0.67	0.49	0.62	0.64	0.47	0.50	0.61	0.88	0.57	0.40	0.54	0.64	0.62	0.59	1.00	0.62	0.64	0.50	1.00	0.52	0.56	0.44	0.62	0.33	0.75	0.63	0.49	0.40	0.45	0.56	0.33	0.82
6382 (SDC1)	0.80	0.57	0.64	0.53	0.14	0.62	0.52	0.73	0.72	0.63	0.47	0.23	0.58	0.73	0.44	0.60	0.72	0.48	0.80	0.84	0.53	0.58	0.79	0.74	0.76	0.49	0.70	0.65	0.91	0.85	0.62	1.00	0.80	0.63	1.00	0.58	0.71	0.61	1.00	0.46	0.63	0.77	0.54	0.41	0.40	0.79	0.36	0.72
334 (APLP2)	0.74	0.58	0.65	0.53	0.14	0.59	0.54	0.67	0.84	0.60	0.44	0.23	0.62	0.67	0.43	0.72	0.70	0.48	0.74	0.77	0.51	0.56	0.73	0.74	0.69	0.46	0.64	0.62	0.80	0.75	0.64	0.80	1.00	0.59	1.00	0.57	0.67	0.55	0.80	0.41	0.59	0.74	0.59	0.56	0.39	0.71	0.36	0.67
4036 (LRP2)	0.63	0.54	0.74	0.53	0.13	0.55	0.52	0.53	0.60	0.50	0.48	0.20	0.51	0.53	0.42	0.53	0.61	0.48	0.63	0.65	0.71	0.47	0.61	0.58	0.55	0.37	0.53	0.56	0.63	0.59	0.50	0.63	0.59	1.00	1.00	0.48	0.54	0.41	0.63	0.31	0.49	0.62	0.78	0.36	0.33	0.54	0.43	0.55
2153 (F5)	1.00	1.00	1.00	1.00	0.16	1.00	1.00	1.00	1.00	1.00	0.69	0.30	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	0.61	1.00	1.00	1.00	1.00	0.60	1.00	0.59	1.00
102 (ADAM10)	0.63	0.55	0.54	0.53	0.11	0.52	0.53	0.53	0.62	0.66	0.37	0.19	0.64	0.53	0.44	0.54	0.67	0.49	0.63	0.60	0.46	0.59	0.61	0.57	0.56	0.47	0.51	0.56	0.58	0.56	0.52	0.58	0.57	0.48	1.00	1.00	0.76	0.44	0.58	0.54	0.54	0.68	0.51	0.43	0.37	0.53	0.31	0.55
718 (C3)	0.74	0.57	0.59	0.52	0.12	0.57	0.51	0.61	0.69	0.74	0.41	0.21	0.69	0.62	0.45	0.57	0.69	0.46	0.74	0.71	0.49	0.62	0.73	0.65	0.66	0.48	0.59	0.61	0.71	0.68	0.56	0.71	0.67	0.54	1.00	0.76	1.00	0.51	0.71	0.67	0.61	0.72	0.53	0.40	0.41	0.64	0.33	0.64
1356 (CP)	0.57	0.44	0.47	0.40	0.11	0.44	0.40	0.49	0.53	0.45	0.32	0.18	0.44	0.51	0.33	0.50	0.57	0.35	0.57	0.69	0.37	0.44	0.56	0.53	0.51	0.36	0.47	0.48	0.61	0.57	0.44	0.61	0.55	0.41	0.82	0.44	0.51	1.00	0.61	0.33	0.44	0.55	0.40	0.30	0.29	0.52	0.27	0.50
3339 (HSPG2)	0.80	0.57	0.64	0.53	0.14	0.62	0.52	0.73	0.72	0.63	0.47	0.23	0.58	0.73	0.44	0.60	0.72	0.48	0.80	0.84	0.53	0.58	0.79	0.74	0.76	0.49	0.70	0.65	0.91	0.85	0.62	1.00	0.80	0.63	1.00	0.58	0.71	0.61	1.00	0.46	0.63	0.77	0.54	0.41	0.40	0.79	0.36	0.72
720 (C4A)	0.43	0.33	0.35	0.30	0.09	0.33	0.30	0.36	0.39	0.56	0.24	0.14	0.46	0.38	0.25	0.34	0.39	0.26	0.43	0.45	0.28	0.38	0.42	0.39	0.38	0.33	0.35	0.36	0.46	0.42	0.33	0.46	0.41	0.31	0.61	0.54	0.67	0.33	0.46	1.00	0.33	0.41	0.30	0.22	0.22	0.39	0.20	0.37
3827 (KNG1)	0.66	0.58	0.56	0.56	0.38	0.67	0.61	0.72	0.74	0.79	0.37	0.36	0.55	0.55	0.56	0.61	0.73	0.52	0.66	0.64	0.45	0.64	0.66	0.73	0.68	0.40	0.53	0.58	0.63	0.59	0.75	0.63	0.59	0.49	1.00	0.54	0.61	0.44	0.63	0.33	1.00	0.66	0.54	0.38	0.51	0.56	0.34	0.72
1435 (CSF1)	0.78	0.58	0.64	0.58	0.12	0.61	0.57	0.68	0.73	0.62	0.45	0.22	0.59	0.68	0.46	0.61	0.71	0.55	0.78	0.76	0.55	0.62	0.88	0.71	0.70	0.49	0.66	0.64	0.77	0.74	0.63	0.77	0.74	0.62	1.00	0.68	0.72	0.55	0.77	0.41	0.66	1.00	0.56	0.47	0.44	0.71	0.36	0.75
4035 (LRP1)	0.58	0.55	0.69	0.54	0.12	0.55	0.57	0.50	0.61	0.52	0.41	0.22	0.61	0.52	0.47	0.60	0.61	0.53	0.58	0.57	0.71	0.51	0.55	0.54	0.55	0.42	0.50	0.58	0.54	0.53	0.49	0.54	0.59	0.78	1.00	0.51	0.53	0.40	0.54	0.30	0.54	0.56	1.00	0.46	0.39	0.51	0.41	0.52
7020 (TFAP2A)	0.44	0.44	0.43	0.44	0.10	0.39	0.44	0.38	0.57	0.39	0.29	0.17	0.49	0.38	0.35	0.55	0.48	0.40	0.44	0.44	0.36	0.38	0.42	0.43	0.39	0.30	0.37	0.44	0.41	0.39	0.40	0.41	0.56	0.36	1.00	0.43	0.40	0.30	0.41	0.22	0.38	0.47	0.46	1.00	0.27	0.39	0.28	0.40
345 (APOC3)	0.46	0.65	0.35	0.71	0.38	0.54	0.59	0.45	0.48	0.46	0.24	0.67	0.45	0.36	0.71	0.43	0.43	0.56	0.46	0.40	0.31	0.39	0.44	0.45	0.40	0.27	0.44	0.44	0.40	0.38	0.45	0.40	0.39	0.33	0.60	0.37	0.41	0.29	0.40	0.22	0.51	0.44	0.39	0.27	1.00	0.36	0.48	0.45
4481 (MSR1)	0.72	0.54	0.72	0.50	0.14	0.56	0.49	0.63	0.66	0.57	0.66	0.22	0.65	0.64	0.42	0.57	0.66	0.44	0.72	0.76	0.47	0.53	0.71	0.67	0.67	0.65	0.61	0.61	0.79	0.74	0.56	0.79	0.71	0.54	1.00	0.53	0.64	0.52	0.79	0.39	0.56	0.71	0.51	0.39	0.36	1.00	0.34	0.64
1071 (CETP)	0.38	0.63	0.34	0.73	0.12	0.60	0.66	0.33	0.36	0.34	0.35	0.40	0.34	0.33	0.64	0.43	0.37	0.79	0.38	0.37	0.29	0.33	0.35	0.35	0.35	0.26	0.52	0.38	0.36	0.37	0.33	0.36	0.36	0.43	0.59	0.31	0.33	0.27	0.36	0.20	0.34	0.36	0.41	0.28	0.48	0.34	1.00	0.33
7076 (TIMP1)	0.71	0.57	0.64	0.54	0.39	0.57	0.51	0.87	0.79	0.70	0.44	0.30	0.56	0.62	0.48	0.57	0.70	0.48	0.71	0.71	0.49	0.55	0.76	0.85	0.64	0.44	0.59	0.60	0.72	0.68	0.82	0.72	0.67	0.55	1.00	0.55	0.64	0.50	0.72	0.37	0.72	0.75	0.52	0.40	0.45	0.64	0.33	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
APOE	Rat	Plasma	-	7620 m	12 hours	downregulated	0.76	2-DE	Northern indo-australian plate	Sprague-dawley rats	1	Male SD rats weighing 220g	24842778
APOE	Human	Serum	-	2400 m	0.5 hours	downregulated	0.026	2-DE	Western Europe	Germans	0.037	Healthy adults never had ear surgery or problems with pressure equalization	28858246
APOE	Rat	Plasma	-	7620 m	24 hours	upregulated	0.52	2-DE	Northern indo-australian plate	Sprague-dawley rats	1	Male SD rats weighing 220g	24842778
APOE	Toad	Liver	-	3464 m	33 day	upregulated	4.102412189	RNA-seq	Tibetan Plateau	Asiatic toad	1	Zoige (High altitute Toad) Vs Chengdu (Low altitude toad) -	28673260
APOE	Rat	Plasma	-	7619 m	24 hours	downregulated	1.24	2-DE	Northern indo-australian plate	Male sprague-dawley	1	8 weeks old male SD rats kept at standard conditions	26882918
APOE	Human	Serum	-	2400 m	0.5 hours	upregulated	0.056	2-DE	Western Europe	Germans	0.043	Healthy adults never had ear surgery or problems with pressure equalization	28858246

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
EP300	2033	APOE	348	distal	22955619	TRANSFAC
GTF2B	2959	APOE	348	distal	22955619	TRANSFAC
NFYB	4801	APOE	348	distal	22955619	TRANSFAC
TAL1	6886	APOE	348	distal	22955619	TRANSFAC
USF1	7391	APOE	348	distal	22955619	TRANSFAC
HEY1	23462	APOE	348	distal	22955619	TRANSFAC
FOS	2353	APOE	348	distal	22955619	TRANSFAC
MAX	4149	APOE	348	distal	22955619	TRANSFAC
NFYA	4800	APOE	348	distal	22955619	TRANSFAC
E2F6	1876	APOE	348	distal	22955619	TRANSFAC
EGR1	1958	APOE	348	distal	22955619	TRANSFAC
IRF1	3659	APOE	348	distal	22955619	TRANSFAC
USF2	7392	APOE	348	distal	22955619	TRANSFAC
RFX5	5993	APOE	348	proximal_filtered	22955619	TRANSFAC
SP1	6667	APOE	348	Unknown	22334592	TRUSST
FOXM1	2305	APOE	348	Unknown	17124180	TRUSST
ATF4	468	APOE	348	Unknown	14739605	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT053558	hsa-miR-199a-3p	Homo sapiens	APOE	348	Homo sapiens	ELISA//Luciferase reporter assay//Microarray	Functional MTI	23142051
MIRT053554	hsa-miR-1908-5p	Homo sapiens	APOE	348	Homo sapiens	ELISA//Luciferase reporter assay//Microarray	Functional MTI	23142051
MIRT053553	hsa-miR-199a-5p	Homo sapiens	APOE	348	Homo sapiens	ELISA//Luciferase reporter assay//Microarray	Functional MTI	23142051

Gene Ontology

ID	GO ID	GO Term	GO Type
348	GO:0032489	regulation of Cdc42 protein signal transduction	GOTERM_BP_DIRECT
348	GO:0044794	positive regulation by host of viral process	GOTERM_BP_DIRECT
348	GO:0055089	fatty acid homeostasis	GOTERM_BP_DIRECT
348	GO:0008203	cholesterol metabolic process	GOTERM_BP_DIRECT
348	GO:0010877	lipid transport involved in lipid storage	GOTERM_BP_DIRECT
348	GO:0019934	cGMP-mediated signaling	GOTERM_BP_DIRECT
348	GO:0051000	positive regulation of nitric-oxide synthase activity	GOTERM_BP_DIRECT
348	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	GOTERM_BP_DIRECT
348	GO:0051651	maintenance of location in cell	GOTERM_BP_DIRECT
348	GO:1901631	positive regulation of presynaptic membrane organization	GOTERM_BP_DIRECT
348	GO:0006869	lipid transport	GOTERM_BP_DIRECT
348	GO:0010875	positive regulation of cholesterol efflux	GOTERM_BP_DIRECT
348	GO:0031102	neuron projection regeneration	GOTERM_BP_DIRECT
348	GO:0051055	negative regulation of lipid biosynthetic process	GOTERM_BP_DIRECT
348	GO:0061000	negative regulation of dendritic spine development	GOTERM_BP_DIRECT
348	GO:0002021	response to dietary excess	GOTERM_BP_DIRECT
348	GO:0030516	regulation of axon extension	GOTERM_BP_DIRECT
348	GO:0042157	lipoprotein metabolic process	GOTERM_BP_DIRECT
348	GO:0006898	receptor-mediated endocytosis	GOTERM_BP_DIRECT
348	GO:0007263	nitric oxide mediated signal transduction	GOTERM_BP_DIRECT
348	GO:0034372	very-low-density lipoprotein particle remodeling	GOTERM_BP_DIRECT
348	GO:0097113	AMPA glutamate receptor clustering	GOTERM_BP_DIRECT
348	GO:1900221	regulation of beta-amyloid clearance	GOTERM_BP_DIRECT
348	GO:0010873	positive regulation of cholesterol esterification	GOTERM_BP_DIRECT
348	GO:0043691	reverse cholesterol transport	GOTERM_BP_DIRECT
348	GO:0046889	positive regulation of lipid biosynthetic process	GOTERM_BP_DIRECT
348	GO:0010544	negative regulation of platelet activation	GOTERM_BP_DIRECT
348	GO:0017038	protein import	GOTERM_BP_DIRECT
348	GO:0034374	low-density lipoprotein particle remodeling	GOTERM_BP_DIRECT
348	GO:0034375	high-density lipoprotein particle remodeling	GOTERM_BP_DIRECT
348	GO:0042158	lipoprotein biosynthetic process	GOTERM_BP_DIRECT
348	GO:0042159	lipoprotein catabolic process	GOTERM_BP_DIRECT
348	GO:0097114	NMDA glutamate receptor clustering	GOTERM_BP_DIRECT
348	GO:0098869	cellular oxidant detoxification	GOTERM_BP_DIRECT
348	GO:0007010	cytoskeleton organization	GOTERM_BP_DIRECT
348	GO:0007186	G-protein coupled receptor signaling pathway	GOTERM_BP_DIRECT
348	GO:0030828	positive regulation of cGMP biosynthetic process	GOTERM_BP_DIRECT
348	GO:0042311	vasodilation	GOTERM_BP_DIRECT
348	GO:0048844	artery morphogenesis	GOTERM_BP_DIRECT
348	GO:1901214	regulation of neuron death	GOTERM_BP_DIRECT
348	GO:1901630	negative regulation of presynaptic membrane organization	GOTERM_BP_DIRECT
348	GO:0007271	synaptic transmission	GOTERM_BP_DIRECT
348	GO:0015909	long-chain fatty acid transport	GOTERM_BP_DIRECT
348	GO:0033344	cholesterol efflux	GOTERM_BP_DIRECT
348	GO:0048168	regulation of neuronal synaptic plasticity	GOTERM_BP_DIRECT
348	GO:0006641	triglyceride metabolic process	GOTERM_BP_DIRECT
348	GO:0006707	cholesterol catabolic process	GOTERM_BP_DIRECT
348	GO:0030195	negative regulation of blood coagulation	GOTERM_BP_DIRECT
348	GO:0034384	high-density lipoprotein particle clearance	GOTERM_BP_DIRECT
348	GO:0046907	intracellular transport	GOTERM_BP_DIRECT
348	GO:0001937	negative regulation of endothelial cell proliferation	GOTERM_BP_DIRECT
348	GO:1901215	negative regulation of neuron death	GOTERM_BP_DIRECT
348	GO:0000302	response to reactive oxygen species	GOTERM_BP_DIRECT
348	GO:0006874	cellular calcium ion homeostasis	GOTERM_BP_DIRECT
348	GO:0034447	very-low-density lipoprotein particle clearance	GOTERM_BP_DIRECT
348	GO:0042632	cholesterol homeostasis	GOTERM_BP_DIRECT
348	GO:0045541	negative regulation of cholesterol biosynthetic process	GOTERM_BP_DIRECT
348	GO:0090370	negative regulation of cholesterol efflux	GOTERM_BP_DIRECT
348	GO:1901216	positive regulation of neuron death	GOTERM_BP_DIRECT
348	GO:0019433	triglyceride catabolic process	GOTERM_BP_DIRECT
348	GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	GOTERM_BP_DIRECT
348	GO:0034380	high-density lipoprotein particle assembly	GOTERM_BP_DIRECT
348	GO:0001523	retinoid metabolic process	GOTERM_BP_DIRECT
348	GO:0006979	response to oxidative stress	GOTERM_BP_DIRECT
348	GO:0033700	phospholipid efflux	GOTERM_BP_DIRECT
348	GO:0043407	negative regulation of MAP kinase activity	GOTERM_BP_DIRECT
348	GO:0043537	negative regulation of blood vessel endothelial cell migration	GOTERM_BP_DIRECT
348	GO:0060999	positive regulation of dendritic spine development	GOTERM_BP_DIRECT
348	GO:0010468	regulation of gene expression	GOTERM_BP_DIRECT
348	GO:0019068	virion assembly	GOTERM_BP_DIRECT
348	GO:0043524	negative regulation of neuron apoptotic process	GOTERM_BP_DIRECT
348	GO:0034382	chylomicron remnant clearance	GOTERM_BP_DIRECT
348	GO:0050728	negative regulation of inflammatory response	GOTERM_BP_DIRECT
348	GO:0070328	triglyceride homeostasis	GOTERM_BP_DIRECT
348	GO:0090090	negative regulation of canonical Wnt signaling pathway	GOTERM_BP_DIRECT
348	GO:1901627	negative regulation of postsynaptic membrane organization	GOTERM_BP_DIRECT
348	GO:1901628	positive regulation of postsynaptic membrane organization	GOTERM_BP_DIRECT
348	GO:1903001	negative regulation of lipid transport across blood brain barrier	GOTERM_BP_DIRECT
348	GO:0008201	ferric iron binding	GOTERM_MF_DIRECT
348	GO:0016209	AMP binding	GOTERM_MF_DIRECT
348	GO:0050750	androgen receptor binding	GOTERM_MF_DIRECT
348	GO:0070326	thyroid hormone binding	GOTERM_MF_DIRECT
348	GO:0030425	dendrite	GOTERM_CC_DIRECT
348	GO:0042627	chylomicron	GOTERM_CC_DIRECT
348	GO:0034364	high-density lipoprotein particle	GOTERM_CC_DIRECT
348	GO:1902952	positive regulation of dendritic spine maintenance	GOTERM_BP_DIRECT
348	GO:0005319	L-glutamate transmembrane transporter activity	GOTERM_MF_DIRECT
348	GO:0005515	protein binding	GOTERM_MF_DIRECT
348	GO:1902951	negative regulation of dendritic spine maintenance	GOTERM_BP_DIRECT
348	GO:1902999	negative regulation of phospholipid efflux	GOTERM_BP_DIRECT
348	GO:0042803	protein homodimerization activity	GOTERM_MF_DIRECT
348	GO:0048156	cofactor binding	GOTERM_MF_DIRECT
348	GO:0042802	identical protein binding	GOTERM_MF_DIRECT
348	GO:0008289	lipid binding	GOTERM_MF_DIRECT
348	GO:0015485	potassium channel regulator activity	GOTERM_MF_DIRECT
348	GO:0005769	early endosome	GOTERM_CC_DIRECT
348	GO:0034362	low-density lipoprotein particle	GOTERM_CC_DIRECT
348	GO:1902947	regulation of tau-protein kinase activity	GOTERM_BP_DIRECT
348	GO:0071813	medium-chain-acyl-CoA dehydrogenase activity	GOTERM_MF_DIRECT
348	GO:0005576	extracellular region	GOTERM_CC_DIRECT
348	GO:1902004	positive regulation of beta-amyloid formation	GOTERM_BP_DIRECT
348	GO:0017127	SH3 domain binding	GOTERM_MF_DIRECT
348	GO:0060228	large conductance calcium-activated potassium channel activity	GOTERM_MF_DIRECT
348	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
348	GO:0072562	blood microparticle	GOTERM_CC_DIRECT
348	GO:0005543	phospholipid binding	GOTERM_MF_DIRECT
348	GO:0046911	metal ion binding	GOTERM_MF_DIRECT
348	GO:1902998	positive regulation of neurofibrillary tangle assembly	GOTERM_BP_DIRECT
348	GO:0005615	extracellular space	GOTERM_CC_DIRECT
348	GO:0005623	cell	GOTERM_CC_DIRECT
348	GO:0070062	extracellular exosome	GOTERM_CC_DIRECT
348	GO:0043025	neuronal cell body	GOTERM_CC_DIRECT
348	GO:1903561	extracellular vesicle	GOTERM_CC_DIRECT
348	GO:0001540	N-acetylglucosamine 6-O-sulfotransferase activity	GOTERM_MF_DIRECT
348	GO:0005634	nucleus	GOTERM_CC_DIRECT
348	GO:0016020	membrane	GOTERM_CC_DIRECT
348	GO:0005886	plasma membrane	GOTERM_CC_DIRECT
348	GO:0005783	endoplasmic reticulum	GOTERM_CC_DIRECT
348	GO:0005794	Golgi apparatus	GOTERM_CC_DIRECT
348	GO:0031012	extracellular matrix	GOTERM_CC_DIRECT
348	GO:0071682	endocytic vesicle lumen	GOTERM_CC_DIRECT
348	GO:1902995	positive regulation of phospholipid efflux	GOTERM_BP_DIRECT
348	GO:0034361	very-low-density lipoprotein particle	GOTERM_CC_DIRECT
348	GO:1902430	negative regulation of beta-amyloid formation	GOTERM_BP_DIRECT
348	GO:1903002	positive regulation of lipid transport across blood brain barrier	GOTERM_BP_DIRECT
348	GO:0034363	intermediate-density lipoprotein particle	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term
348	hsa05010	Alzheimer's disease

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
APOE	348	Carotid Stenosis	C0007282	Disease or Syndrome	0.33	0.352	0.931	disease
APOE	348	Abortion, Tubal	C0000822	Pathologic Function	0.3	0.352	0.931	disease
APOE	348	Hypertensive disease	C0020538	Disease or Syndrome	0.6	0.352	0.931	group
APOE	348	Adenocarcinoma	C0001418	Neoplastic Process	0.31	0.352	0.931	group
APOE	348	Cognition Disorders	C0009241	Mental or Behavioral Dysfunction	0.4	0.352	0.931	group
APOE	348	Cardiovascular Diseases	C0007222	Disease or Syndrome	0.4	0.352	0.931	group
APOE	348	Mercury Poisoning	C0025427	Injury or Poisoning	0.3	0.352	0.931	disease
APOE	348	Arteriosclerosis	C0003850	Disease or Syndrome	0.4	0.352	0.931	disease
APOE	348	Atherosclerosis	C0004153	Disease or Syndrome	0.5	0.352	0.931	disease
APOE	348	Carotid Artery Diseases	C0007273	Disease or Syndrome	0.34	0.352	0.931	group
APOE	348	Pathological accumulation of air in tissues	C0013990	Pathologic Function	0.3	0.352	0.931	phenotype
APOE	348	Amyloidosis	C0002726	Disease or Syndrome	0.4	0.352	0.931	disease
APOE	348	Coronary heart disease	C0010068	Disease or Syndrome	0.5	0.352	0.931	disease
APOE	348	Jacksonian Seizure	C0022333	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Myocardial Infarction	C0027051	Disease or Syndrome	0.5	0.352	0.931	disease
APOE	348	Nerve Degeneration	C0027746	Cell or Molecular Dysfunction	0.3	0.352	0.931	phenotype
APOE	348	Obesity	C0028754	Disease or Syndrome	0.5	0.352	0.931	disease
APOE	348	Proteinuria	C0033687	Finding	0.4	0.352	0.931	phenotype
APOE	348	Hyperlipidemia	C0020473	Disease or Syndrome	0.6	0.352	0.931	disease
APOE	348	Spontaneous abortion	C0000786	Pathologic Function	0.3	0.352	0.931	phenotype
APOE	348	Multiple Sclerosis	C0026769	Disease or Syndrome	0.4	0.352	0.931	disease
APOE	348	Alzheimer's Disease	C0002395	Disease or Syndrome	0.7	0.352	0.931	disease
APOE	348	Lung Neoplasms	C0024121	Neoplastic Process	0.31	0.352	0.931	group
APOE	348	Pustulosis of Palms and Soles	C0030246	Disease or Syndrome	0.31	0.352	0.931	disease
APOE	348	Psoriasis	C0033860	Disease or Syndrome	0.36	0.352	0.931	disease
APOE	348	Presenile dementia	C0011265	Mental or Behavioral Dysfunction	0.4	0.352	0.931	disease
APOE	348	Hepatolenticular Degeneration	C0019202	Disease or Syndrome	0.33	0.352	0.931	disease
APOE	348	Hypercholesterolemia	C0020443	Disease or Syndrome	0.5	0.352	0.931	disease
APOE	348	Arterial Fatty Streak	C0015697	Acquired Abnormality	0.3	0.352	0.931	phenotype
APOE	348	Hepatitis, Toxic	C0019193	Injury or Poisoning	0.3	0.352	0.931	disease
APOE	348	Seizures, Clonic	C0234535	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Arterial Diseases, Common Carotid	C0750987	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	External Carotid Artery Stenosis	C0751636	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Hyperlipoproteinemia Type IIb	C1704417	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Nonepileptic Seizures	C3495874	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Carcinoma, Cribriform	C0205643	Neoplastic Process	0.3	0.352	0.931	disease
APOE	348	External Carotid Artery Diseases	C0600178	Disease or Syndrome	0.3	0.352	0.931	group
APOE	348	Carotid Artery Plaque	C0751633	Acquired Abnormality	0.31	0.352	0.931	phenotype
APOE	348	Splenomegaly	C0038002	Finding	0.4	0.352	0.931	phenotype
APOE	348	Complex partial seizures	C0149958	Disease or Syndrome	0.31	0.352	0.931	disease
APOE	348	Dyslipidemias	C0242339	Disease or Syndrome	0.5	0.352	0.931	group
APOE	348	Visual seizure	C0270824	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Adenocarcinoma, Basal Cell	C0205641	Neoplastic Process	0.3	0.352	0.931	disease
APOE	348	Single Seizure	C0751110	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Drug-Induced Acute Liver Injury	C3658290	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Carcinoma, Granular Cell	C0205644	Neoplastic Process	0.3	0.352	0.931	disease
APOE	348	Generalized seizures	C0234533	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Familial Alzheimer Disease (FAD)	C0276496	Disease or Syndrome	0.4	0.352	0.931	disease
APOE	348	Lipidemias	C1706412	Finding	0.3	0.352	0.931	phenotype
APOE	348	Macular Degeneration, Age-Related, 1	C1864205	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Kidney Failure	C0035078	Disease or Syndrome	0.46	0.352	0.931	disease
APOE	348	Seizures	C0036572	Sign or Symptom	0.4	0.352	0.931	phenotype
APOE	348	Non-epileptic convulsion	C0751056	Sign or Symptom	0.3	0.352	0.931	phenotype
APOE	348	Seizures, Sensory	C0751496	Sign or Symptom	0.3	0.352	0.931	phenotype
APOE	348	Epileptic drop attack	C0270846	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Internal Carotid Artery Stenosis	C0340569	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Seizures, Focal	C0751495	Disease or Syndrome	0.3	0.352	0.931	phenotype
APOE	348	Chemical and Drug Induced Liver Injury	C4277682	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Generalized Absence Seizures	C4505436	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.4	0.352	0.931	disease
APOE	348	Sporadic Cerebral Amyloid Angiopathy	C0338582	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Olfactory seizure	C0422853	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Alzheimer Disease, Late Onset	C0494463	Mental or Behavioral Dysfunction	0.4	0.352	0.931	disease
APOE	348	Carotid Atherosclerosis	C0577631	Disease or Syndrome	0.4	0.352	0.931	disease
APOE	348	Convulsive Seizures	C0751494	Sign or Symptom	0.3	0.352	0.931	phenotype
APOE	348	Carotid Ulcer	C0751634	Acquired Abnormality	0.3	0.352	0.931	phenotype
APOE	348	Cerebral Amyloid Angiopathy	C0085220	Disease or Syndrome	0.5	0.352	0.931	disease
APOE	348	Adenocarcinoma, Oxyphilic	C0205642	Neoplastic Process	0.3	0.352	0.931	disease
APOE	348	Malignant neoplasm of lung	C0242379	Neoplastic Process	0.31	0.352	0.931	disease
APOE	348	Vertiginous seizure	C0422855	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Acute Confusional Senile Dementia	C0546126	Mental or Behavioral Dysfunction	0.3	0.352	0.931	disease
APOE	348	Multiple Sclerosis, Acute Fulminating	C0751324	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Multiple Sclerosis, Acute Relapsing	C0393664	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Atonic Absence Seizures	C0751123	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	ALZHEIMER DISEASE 4	C1847200	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Convulsions	C4048158	Sign or Symptom	0.3	0.352	0.931	phenotype
APOE	348	Epileptic Seizures	C4317109	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Myoclonic Seizures	C4317123	Sign or Symptom	0.3	0.352	0.931	phenotype
APOE	348	Dyslipoproteinemias	C0598784	Pathologic Function	0.3	0.352	0.931	group
APOE	348	Common Carotid Artery Stenosis	C0751635	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	hearing impairment	C1384666	Disease or Syndrome	0.3	0.352	0.931	phenotype
APOE	348	Chemically-Induced Liver Toxicity	C4279912	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Age related macular degeneration	C0242383	Disease or Syndrome	0.5	0.352	0.931	disease
APOE	348	Multiple Sclerosis, Relapsing-Remitting	C0751967	Disease or Syndrome	0.32	0.352	0.931	disease
APOE	348	Drug-Induced Liver Disease	C0860207	Disease or Syndrome	0.31	0.352	0.931	disease
APOE	348	Renal Insufficiency	C1565489	Disease or Syndrome	0.44	0.352	0.931	disease
APOE	348	Internal Carotid Artery Diseases	C0750986	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Seizures, Somatosensory	C0422850	Pathologic Function	0.3	0.352	0.931	phenotype
APOE	348	Tonic - clonic seizures	C0494475	Disease or Syndrome	0.31	0.352	0.931	disease
APOE	348	Hepatitis, Drug-Induced	C1262760	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Adenocarcinoma, Tubular	C0205645	Neoplastic Process	0.3	0.352	0.931	disease
APOE	348	Disease Exacerbation	C0235874	Finding	0.3	0.352	0.931	phenotype
APOE	348	Atheroma	C0264956	Pathologic Function	0.3	0.352	0.931	phenotype
APOE	348	Tonic Seizures	C0270844	Sign or Symptom	0.3	0.352	0.931	phenotype
APOE	348	Atherogenesis	C1563937	Pathologic Function	0.3	0.352	0.931	phenotype
APOE	348	Absence Seizures	C4316903	Sign or Symptom	0.3	0.352	0.931	phenotype
APOE	348	Seizures, Auditory	C0422852	Pathologic Function	0.3	0.352	0.931	phenotype
APOE	348	Gustatory seizure	C0422854	Sign or Symptom	0.3	0.352	0.931	phenotype
APOE	348	Alzheimer's Disease, Focal Onset	C0750900	Mental or Behavioral Dysfunction	0.3	0.352	0.931	disease
APOE	348	Alzheimer Disease, Early Onset	C0750901	Disease or Syndrome	0.4	0.352	0.931	disease
APOE	348	Hepatic Form of Wilson Disease	C1527352	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Fibroatheroma	C2936351	Acquired Abnormality	0.3	0.352	0.931	phenotype
APOE	348	Hypercholesterolemia, Familial	C0020445	Disease or Syndrome	0.6	0.352	0.931	disease
APOE	348	Sea-Blue Histiocyte Syndrome	C0036489	Disease or Syndrome	0.6	0.352	0.931	disease
APOE	348	LIPOPROTEIN GLOMERULOPATHY	C2673196	Disease or Syndrome	0.8	0.352	0.931	disease
APOE	348	Hyperlipoproteinemia Type III	C0020479	Disease or Syndrome	0.8	0.352	0.931	disease
APOE	348	Hyperlipoproteinemia Type IIa	C0745103	Disease or Syndrome	0.6	0.352	0.931	disease
APOE	348	ALZHEIMER DISEASE 2	C1863051	Disease or Syndrome	0.7	0.352	0.931	disease
APOE	348	Alcoholic Intoxication, Chronic	C0001973	Mental or Behavioral Dysfunction	0.35	0.352	0.931	disease
APOE	348	Delirium	C0011206	Mental or Behavioral Dysfunction	0.4	0.352	0.931	disease
APOE	348	Bipolar Disorder	C0005586	Mental or Behavioral Dysfunction	0.34	0.352	0.931	disease
APOE	348	Alcohol abuse	C0085762	Mental or Behavioral Dysfunction	0.31	0.352	0.931	disease
APOE	348	Floating-Betalipoproteinemia	C1862562	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Broad-Betalipoproteinemia	C1862561	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Dysbetalipoproteinemia due to Defect in Apolipoprotein E-d	C1862557	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 2	C3276941	Finding	0.3	0.352	0.931	phenotype
APOE	348	Apolipoprotein E, Deficiency or Defect of	C1862556	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	Familial Hyperbeta- and Prebetalipoproteinemia	C1862558	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 5	C2676098	Finding	0.3	0.352	0.931	phenotype
APOE	348	Hyperlipemia with Familial Hypercholesterolemic Xanthomatosis	C1862560	Disease or Syndrome	0.3	0.352	0.931	disease
APOE	348	CORONARY ARTERY DISEASE, SEVERE, SUSCEPTIBILITY TO	C1862591	Finding	0.3	0.352	0.931	phenotype

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types
APOE	348	ACE INHIBITOR	None	None	None
APOE	348	ANTIDEPRESSANT	None	None	None
APOE	348	ANTI-INFLAMMATORY DRUGS	None	None	None
APOE	348	BPDE	None	None	None
APOE	348	BUTHIONINE SULFOXIMINE	BUTHIONINE SULFOXIMINE	CHEMBL1609891	None
APOE	348	CORTICOSTEROIDS	None	None	None
APOE	348	CYTOKINES	None	None	None
APOE	348	GANCICLOVIR	GANCICLOVIR	CHEMBL182	None
APOE	348	GINKGO BILOBA	GINKGO	CHEMBL2108466	None
APOE	348	HUMAN CHORIONIC GONADOTROPIN	GONADOTROPIN, CHORIONIC	CHEMBL1201509	None
APOE	348	IMMUNOSUPPRESSANT	None	None	None
APOE	348	IRBESARTAN	IRBESARTAN	CHEMBL1513	None
APOE	348	INTRALIPID	SOYBEAN OIL	CHEMBL1201485	None
APOE	348	LORAZEPAM	LORAZEPAM	CHEMBL580	None
APOE	348	LUTEIN	LUTEIN	CHEMBL173929	None
APOE	348	NORETHISTERONE ACETATE	None	None	None
APOE	348	PLANT STEROL	None	None	None
APOE	348	PREDNISONE	PREDNISONE	CHEMBL635	None
APOE	348	RETINOIC ACID	TRETINOIN	CHEMBL38	None
APOE	348	SOY PROTEIN	None	None	None
APOE	348	STAUROSPORINE	STAUROSPORINE	CHEMBL388978	None
APOE	348	TRIAMCINOLONE	TRIAMCINOLONE	CHEMBL1451	None
APOE	348	TROGLITAZONE	TROGLITAZONE	CHEMBL408	None
APOE	348	VITAMIN E	VITAMIN E	CHEMBL47	None