ALTITUDEOMICSDB

Apolipoprotein A-IV

AltitudeomicsDB

Protein Official symbol	APOA4
Aliases	APOA4
Chromosomal Location	11
Length	396
Uniprot ID	P06727
EC number	None
Protein family Information(Pfam)	PF01442;
PDB id	3S84;
InterPro ID	IPR000074;
dbSNP	rs12721041 rs5102 rs12721042 rs5104 rs12721043 rs1181852696 rs201861136 rs773492545 rs121909576 rs2238008 rs1042372 rs150264487 rs5108 rs675 rs5110

Protein Protein Interaction

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AltitudeomicsDB

Protein 1	Protein 2	Combine Score
APOA1	APOC3	0.999
APOA1	APOB	0.999
APOA2	APOA1	0.999
APOA2	APOB	0.997
MTTP	APOB	0.997
APOA2	APOC3	0.996
APOB	APOC3	0.996
LDLR	APOE	0.996
APOE	APOB	0.996
LDLR	APOB	0.996
APP	APOE	0.995
LPA	APOB	0.994
GPIHBP1	LPL	0.993
APOC2	APOE	0.993
APOC2	APOC3	0.993
APOC1	APOE	0.992
APOC2	LPL	0.992
APOA5	APOC3	0.991
APOC2	APOA1	0.991
APOE	APOA1	0.991
APOA4	APOC3	0.99
APOE	LRP1	0.989
APOC2	APOB	0.988
APOC2	APOA2	0.988
GPIHBP1	APOA5	0.988
APOA4	APOB	0.988
MTTP	P4HB	0.987
LRP8	APOE	0.987
LPL	APOB	0.986
LPL	APOC3	0.985
APOA2	APOE	0.985
LPA	APOA1	0.985
GPC6	GPC4	0.984
APOE	APOC3	0.984
APOA5	LPL	0.982
APOA4	CREB3L3	0.981
HSPG2	GPC1	0.981
APOA5	APOB	0.981
APOA2	LPA	0.981
SDC1	GPC1	0.98
MTTP	APOA1	0.98
APOC2	APOA5	0.98
LPL	APOE	0.98
GPC4	SDC2	0.978
GPIHBP1	APOC2	0.978
GPC6	SDC2	0.978
HSPG2	GPC2	0.977
SDC2	GPC2	0.976
GPC6	HSPG2	0.976
APOC2	APOC1	0.975
APOC2	APOA4	0.975
SDC1	HSPG2	0.975
HSPG2	GPC4	0.975
SDC2	GPC1	0.974
APOC1	APOB	0.973
HSPG2	SDC2	0.973
SDC4	GPC1	0.973
APOA5	CREB3L3	0.973
GPC5	HSPG2	0.971
LRP2	APOE	0.971
LPL	APOA1	0.971
SDC3	GPC1	0.971
AGRN	GPC1	0.971
APOA5	APOE	0.97
LDLR	APOA1	0.97
APOA5	APOA2	0.969
HSPG2	SDC4	0.969
SDC1	GPC6	0.969
SDC1	GPC4	0.969
SDC1	GPC2	0.968
APOC2	CREB3L3	0.968
SDC3	GPC2	0.967
GPC5	SDC2	0.967
GPC3	HSPG2	0.967
SDC1	GPC5	0.967
LPA	APOC3	0.967
AGRN	GPC2	0.967
AGRN	GPC4	0.967
GPC4	SDC3	0.967
GPC6	SDC3	0.966
APOA2	LPL	0.966
AGRN	GPC5	0.966
AGRN	GPC6	0.966
GPC3	SDC2	0.965
GPC5	SDC3	0.965
GPC3	SDC1	0.965
P4HB	APOB	0.964
APOA2	APOA4	0.964
APOC1	APOC3	0.964
LRP2	APOB	0.964
HSPG2	SDC3	0.963
SDC4	GPC4	0.963
GPC6	SDC4	0.963
SDC4	GPC2	0.962
GPIHBP1	APOC3	0.962
HSPG2	APOB	0.962
LPA	APOE	0.961
MTTP	APOA4	0.96
LDLR	APOC3	0.959
GPC3	AGRN	0.958
SDC1	AGRN	0.958
GPC3	SDC3	0.958
APP	GPC1	0.958
GPC5	SDC4	0.957
APOC1	APOA2	0.957
APP	APOA1	0.956
APOA4	APOA1	0.956
GPC3	SDC4	0.955
APOA4	LPL	0.954
AGRN	SDC2	0.954
MTTP	APOA2	0.954
HSPG2	APP	0.954
APOC2	LDLR	0.953
APOA5	APOA1	0.953
APOA4	LPA	0.953
APCS	APOA1	0.952
GPIHBP1	APOB	0.952
APOC2	LPA	0.952
HSPG2	APOE	0.951
GPIHBP1	APOE	0.95
LRP10	APOE	0.95
LRP8	APOB	0.95
SAR1B	APOB	0.949
AGRN	HSPG2	0.947
SDC1	SDC2	0.946
GPC3	GPC4	0.946
SDC3	SDC2	0.945
LRP1	APOB	0.945
APOA4	APCS	0.945
SDC4	SDC3	0.945
AGRN	SDC3	0.945
AGRN	SDC4	0.945
LDLR	APOA4	0.944
APOC1	APOA1	0.943
SDC1	SDC3	0.943
AGRN	LRP8	0.942
LDLR	APOA2	0.942
APOA4	RBP2	0.941
APOA4	APOE	0.94
SDC4	SDC2	0.94
GPC3	GPC6	0.939
AGRN	LRP2	0.938
GPC3	GPC2	0.938
GPC3	APOA1	0.938
APOA5	APOA4	0.937
GPC3	APOB	0.937
LRP2	APOA1	0.937
GPC5	GPC2	0.937
LPL	LRP1	0.935
GPC5	GPC6	0.934
HSPG2	LRP1	0.934
AGRN	LRP1	0.933
P4HB	APP	0.932
GPC5	GPC4	0.932
APP	APCS	0.931
HSPG2	LRP2	0.93
GPC3	APOA2	0.93
SDC1	SDC4	0.929
SDC1	APOE	0.929
GPIHBP1	APOA1	0.929
APP	APOB	0.927
SDC1	LRP1	0.925
GPC3	GPC1	0.924
SDC3	APOE	0.924
P4HB	APOE	0.923
AGRN	APOE	0.922
SAR1B	APOA4	0.922
GPIHBP1	APOA4	0.921
SDC1	APOB	0.921
HSPG2	LRP8	0.92
APOA4	APP	0.92
SDC4	APOE	0.92
APOC2	SDC1	0.919
GPC1	LRP1	0.919
GPC3	APOE	0.919
GPC5	APOE	0.919
P4HB	APOA1	0.919
LRP1	APOA1	0.919
APOA1	RBP2	0.919
APOA1	RBP1	0.919
GPC5	GPC1	0.919
LRP8	APOA1	0.919
SDC2	APOE	0.918
APOA2	APP	0.918
HSPG2	LRP10	0.918
HSPG2	APOA4	0.918
GPC1	APOE	0.918
GPC4	APOE	0.918
APOC2	HSPG2	0.917
HSPG2	APCS	0.917
APOC2	LRP1	0.917
AGRN	LRP10	0.917
SDC1	APOC3	0.917
APOA5	LPA	0.917
APOA2	LRP8	0.917
SDC3	LRP8	0.916
APOC2	AGRN	0.915
HSPG2	LRP12	0.915
AGRN	LRP12	0.915
APOA2	LRP2	0.915
SDC3	LRP1	0.915
HSPG2	APOA1	0.915
LRP1	APOC3	0.915
APOA5	GPC3	0.914
LRP10	APOB	0.914
GPC1	LRP2	0.913
LDLR	LRP2	0.913
GPC3	APOC3	0.913
GPC2	APOE	0.912
GPC4	APOB	0.912
LRP12	APOE	0.912
HSPG2	APOA2	0.912
APOC2	LRP8	0.912
SAR1B	APOA1	0.912
GPC6	APOE	0.912
APOB	RBP2	0.912
GPC5	APOB	0.911
LRP8	APOC3	0.911
SDC4	RBP1	0.911
GPC6	APOB	0.911
APOB	RBP1	0.911
GPC1	APOB	0.911
APOA4	LRP2	0.911
GPC2	APOB	0.91
SDC4	APOA1	0.91
GPC3	LRP2	0.91
HSPG2	APOC3	0.91
APOA2	LRP1	0.91
GPC2	LRP2	0.91
APOC1	LPA	0.91
SDC1	APOA1	0.91
SDC4	LRP10	0.91
SDC2	APP	0.91
APOC1	APOA5	0.909
APOE	RBP1	0.909
SDC4	LRP1	0.909
APOA4	LRP8	0.909
GPC4	GPC1	0.908
LRP12	APOB	0.908
SDC2	LRP1	0.908
LRP10	SDC2	0.908
GPC2	GPC1	0.907
GPC4	LRP8	0.907
GPC6	GPC1	0.907
SDC4	APOB	0.907
APOA4	P4HB	0.907
GPC3	APP	0.906
GPC4	LRP2	0.906
APOC2	LRP2	0.906
LRP8	GPC1	0.906
GPC4	GPC2	0.906
GPC6	LRP8	0.906
LRP2	APOC3	0.906
GPC3	GPC5	0.905
GPIHBP1	APOA2	0.905
RBP1	APOC3	0.905
SDC1	LRP2	0.905
GPC6	LRP2	0.905
GPC3	LRP8	0.905
APOC2	GPC3	0.905
SDC3	LRP2	0.904
APOA4	RBP1	0.904
P4HB	SDC2	0.904
GPC5	LRP2	0.904
SDC1	LRP8	0.904
APOA4	LRP1	0.904
SDC4	LRP2	0.904
GPC6	GPC2	0.904
APOC2	SDC4	0.903
APOA5	APP	0.903
APOA2	P4HB	0.903
SDC1	APOA4	0.903
GPC4	LRP1	0.903
GPC6	LRP1	0.903
GPC4	APOC3	0.903
GPC4	APOA4	0.902
APOC2	RBP1	0.902
APOA2	RBP2	0.902
SDC3	LRP12	0.902
AGRN	RBP1	0.902
SDC1	APOA2	0.902
APOA2	RBP1	0.902
APOA5	SDC2	0.902
GPC3	LRP1	0.902
SDC2	APOB	0.902
SDC2	APOC3	0.902
APOA5	P4HB	0.902
GPC4	RBP1	0.902
LRP12	APOC3	0.902
AGRN	APOB	0.902
SDC1	LRP10	0.902
GPC1	APOC3	0.901
APOA2	SDC2	0.901
SAR1B	APOA2	0.901
APOA4	SDC2	0.901
GPC6	APOA1	0.901
GPC6	APOC3	0.901
GPC5	LRP8	0.901
SDC4	APOA4	0.901
SDC2	LRP2	0.901
GPC5	APOC3	0.901
GPC4	APOA1	0.901
SDC2	LRP8	0.901
GPC2	APOC3	0.901
GPC6	APOA4	0.9
GPC3	APOA4	0.9
APOC2	SDC3	0.9
LRP10	SDC3	0.9
SDC4	LRP12	0.9
APOC2	GPC1	0.9
SDC3	APOA1	0.9
SDC1	RBP1	0.9
GPC5	LRP1	0.9
APOA4	SDC3	0.9
APOC2	SDC2	0.9
GPC3	RBP1	0.9
GPC6	LRP12	0.9
SDC3	APOC3	0.9
GPC1	APOA1	0.9
GPC2	APOA1	0.9
GPC3	LRP12	0.9
HSPG2	RBP1	0.9
GPC3	LRP10	0.9
GPC2	RBP1	0.9
GPC6	RBP1	0.9
SDC4	APOC3	0.9
APOC2	GPC6	0.9
APOA2	LRP12	0.9
LRP8	GPC2	0.9
GPC4	LRP10	0.9
GPC5	APOA1	0.9
APOA2	GPC1	0.9
AGRN	APOA1	0.9
SDC2	APOA1	0.9
GPC2	LRP1	0.9
AGRN	APOA4	0.9
SDC3	APOB	0.9
APOC1	APOA4	0.9
APOA4	GPC1	0.9
GPC4	LRP12	0.9
GPC2	LRP12	0.9
SDC4	APOA2	0.9
GPC5	RBP1	0.9
APOA4	LRP12	0.9
LRP10	APOA4	0.9
APOC2	GPC5	0.9
LRP12	GPC1	0.9
GPC5	LRP12	0.9
APOC2	LRP10	0.9
SDC3	RBP1	0.9
LRP10	GPC2	0.9
LRP10	APOA1	0.9
GPC6	LRP10	0.9
APOC2	GPC2	0.9
SDC1	LRP12	0.9
AGRN	APOC3	0.9
GPC4	APOA2	0.9
APOA2	GPC2	0.9
SDC2	RBP1	0.9
GPC6	APOA2	0.9
APOC2	LRP12	0.9
AGRN	APOA2	0.9
APOA2	SDC3	0.9
GPC5	APOA4	0.9
GPC3	P4HB	0.9
SDC4	LRP8	0.9
LRP12	APOA1	0.9
LRP10	APOC3	0.9
SDC2	LRP12	0.9
APOA4	GPC2	0.9
GPC1	RBP1	0.9
GPC5	LRP10	0.9
GPC5	APOA2	0.9
APOC2	GPC4	0.9
APOA2	LRP10	0.9
LRP10	GPC1	0.9

Gene Ontology Semantic Similarity

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#	345 (APOC3)	338 (APOB)	335 (APOA1)	348 (APOE)	4023 (LPL)	4035 (LRP1)	336 (APOA2)	116519 (APOA5)	5034 (P4HB)	2239 (GPC4)	84699 (CREB3L3)	2817 (GPC1)	4018 (LPA)	6383 (SDC2)	344 (APOC2)	221914 (GPC2)	3339 (HSPG2)	341 (APOC1)	337 (APOA4)	6385 (SDC4)	10082 (GPC6)	9672 (SDC3)	6382 (SDC1)	375790 (AGRN)	351 (APP)	3949 (LDLR)	325 (APCS)	7804 (LRP8)	5948 (RBP2)	4036 (LRP2)	5947 (RBP1)	29967 (LRP12)	2719 (GPC3)	4547 (MTTP)	338328 (GPIHBP1)	51128 (SAR1B)
345 (APOC3)	1.00	0.54	0.65	0.57	0.39	0.37	0.69	0.71	0.31	0.14	0.31	0.31	0.46	0.40	0.62	0.60	0.43	0.67	0.60	0.37	0.35	0.40	0.41	0.40	0.48	0.35	0.35	0.31	0.45	0.36	0.33	0.35	0.50	0.34	0.24	0.13
338 (APOB)	0.54	1.00	0.73	0.73	0.63	0.54	0.69	0.74	0.45	0.14	0.48	0.46	0.65	0.63	0.45	1.00	0.66	0.33	0.69	0.57	0.54	0.62	0.64	0.60	0.62	0.54	0.52	0.46	0.45	0.56	0.31	0.54	0.54	0.67	0.50	0.13
335 (APOA1)	0.65	0.73	1.00	0.80	0.57	0.54	0.84	0.79	0.50	0.18	0.52	0.43	0.58	0.62	0.56	1.00	0.59	0.41	0.80	0.59	0.55	0.62	0.63	0.55	0.66	0.58	0.53	0.51	0.45	0.56	0.31	0.55	0.58	0.63	0.43	0.17
348 (APOE)	0.57	0.73	0.80	1.00	0.56	0.59	0.80	0.79	0.47	0.18	0.52	0.42	0.57	0.56	0.57	1.00	0.59	0.38	0.86	0.54	0.50	0.55	0.56	0.62	0.58	0.54	0.55	0.48	0.69	0.56	0.32	0.50	0.52	0.63	0.41	0.17
4023 (LPL)	0.39	0.63	0.57	0.56	1.00	0.50	0.50	0.50	0.46	0.14	0.46	0.42	0.67	0.59	0.38	1.00	0.56	0.23	0.48	0.54	0.50	0.58	0.60	0.57	0.60	0.52	0.49	0.48	0.41	0.51	0.25	0.50	0.50	0.50	0.36	0.26
4035 (LRP1)	0.37	0.54	0.54	0.59	0.50	1.00	0.52	0.47	0.48	0.71	0.46	0.40	0.51	0.50	0.37	1.00	0.51	0.22	0.51	0.61	0.56	0.49	0.51	0.58	0.55	0.69	0.52	0.70	0.41	0.75	0.24	0.64	0.45	0.51	0.41	0.13
336 (APOA2)	0.69	0.69	0.84	0.80	0.50	0.52	1.00	0.81	0.47	0.14	0.52	0.39	0.55	0.54	0.64	1.00	0.52	0.54	0.86	0.51	0.48	0.53	0.54	0.50	0.58	0.53	0.52	0.45	0.69	0.53	0.33	0.48	0.54	0.66	0.45	0.13
116519 (APOA5)	0.71	0.74	0.79	0.79	0.50	0.47	0.81	1.00	0.38	0.14	0.39	0.33	0.53	0.44	0.67	0.82	0.49	0.56	0.80	0.42	0.40	0.44	0.45	0.48	0.54	0.43	0.41	0.38	0.69	0.45	0.31	0.40	0.47	0.49	0.38	0.13
5034 (P4HB)	0.31	0.45	0.50	0.47	0.46	0.48	0.47	0.38	1.00	0.14	0.48	0.36	0.45	0.51	0.36	1.00	0.48	0.18	0.42	0.46	0.43	0.49	0.52	0.43	0.58	0.47	0.45	0.40	0.41	0.45	0.22	0.43	0.43	0.49	0.31	0.15
2239 (GPC4)	0.14	0.14	0.18	0.18	0.14	0.71	0.14	0.14	0.14	1.00	0.14	0.10	0.14	0.14	0.14	0.14	0.14	0.10	0.18	0.60	1.00	0.14	0.14	0.14	0.14	0.29	0.14	0.55	0.10	0.29	0.10	0.29	0.14	0.14	0.10	0.06
84699 (CREB3L3)	0.31	0.48	0.52	0.52	0.46	0.46	0.52	0.39	0.48	0.14	1.00	0.39	0.48	0.57	0.45	1.00	0.52	0.19	0.48	0.52	0.47	0.56	0.59	0.46	0.62	0.51	0.50	0.42	0.41	0.48	0.24	0.47	0.47	0.53	0.33	0.13
2817 (GPC1)	0.31	0.46	0.43	0.42	0.42	0.40	0.39	0.33	0.36	0.10	0.39	1.00	0.45	0.58	0.33	0.71	0.51	0.21	0.47	0.52	0.51	0.60	0.60	0.53	0.50	0.45	0.52	0.38	0.29	0.50	0.25	0.51	0.51	0.46	0.33	0.09
4018 (LPA)	0.46	0.65	0.58	0.57	0.67	0.51	0.55	0.53	0.45	0.14	0.48	0.45	1.00	0.63	0.47	1.00	0.58	0.34	0.51	0.58	0.54	0.63	0.65	0.59	0.72	0.54	0.52	0.50	0.41	0.53	0.27	0.54	0.68	0.53	0.38	0.21
6383 (SDC2)	0.40	0.63	0.62	0.56	0.59	0.50	0.54	0.44	0.51	0.14	0.57	0.58	0.63	1.00	0.49	1.00	0.73	0.23	0.54	0.81	0.73	0.94	0.92	0.56	0.75	0.67	0.68	0.55	0.41	0.61	0.34	0.73	0.73	0.66	0.47	0.13
344 (APOC2)	0.62	0.45	0.56	0.57	0.38	0.37	0.64	0.67	0.36	0.14	0.45	0.33	0.47	0.49	1.00	0.69	0.42	0.59	0.61	0.46	0.40	0.50	0.50	0.39	0.56	0.45	0.45	0.35	0.69	0.41	0.33	0.40	0.54	0.41	0.35	0.13
221914 (GPC2)	0.60	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	0.14	1.00	0.71	1.00	1.00	0.69	1.00	1.00	0.30	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	0.82	1.00	0.41	1.00	0.41	1.00	1.00	1.00	0.69	0.13
3339 (HSPG2)	0.43	0.66	0.59	0.59	0.56	0.51	0.52	0.49	0.48	0.14	0.52	0.51	0.58	0.73	0.42	1.00	1.00	0.22	0.49	0.66	0.63	0.74	0.80	0.64	0.67	0.59	0.57	0.51	0.41	0.57	0.30	0.63	0.63	0.59	0.42	0.13
341 (APOC1)	0.67	0.33	0.41	0.38	0.23	0.22	0.54	0.56	0.18	0.10	0.19	0.21	0.34	0.23	0.59	0.30	0.22	1.00	0.50	0.22	0.21	0.23	0.23	0.31	0.30	0.20	0.25	0.18	0.37	0.23	0.27	0.21	0.40	0.21	0.16	0.08
337 (APOA4)	0.60	0.69	0.80	0.86	0.48	0.51	0.86	0.80	0.42	0.18	0.48	0.47	0.51	0.54	0.61	1.00	0.49	0.50	1.00	0.51	0.45	0.53	0.55	0.51	0.56	0.51	0.54	0.43	0.69	0.55	0.35	0.45	0.48	0.63	0.37	0.17
6385 (SDC4)	0.37	0.57	0.59	0.54	0.54	0.61	0.51	0.42	0.46	0.60	0.52	0.52	0.58	0.81	0.46	1.00	0.66	0.22	0.51	1.00	0.80	0.84	0.83	0.52	0.70	0.69	0.64	0.71	0.41	0.60	0.31	0.71	0.63	0.58	0.42	0.13
10082 (GPC6)	0.35	0.54	0.55	0.50	0.50	0.56	0.48	0.40	0.43	1.00	0.47	0.51	0.54	0.73	0.40	1.00	0.63	0.21	0.45	0.80	1.00	0.74	0.75	0.49	0.64	0.60	0.56	0.62	0.41	0.56	0.29	0.64	0.57	0.54	0.40	0.13
9672 (SDC3)	0.40	0.62	0.62	0.55	0.58	0.49	0.53	0.44	0.49	0.14	0.56	0.60	0.63	0.94	0.50	1.00	0.74	0.23	0.53	0.84	0.74	1.00	0.96	0.55	0.76	0.67	0.69	0.53	0.41	0.61	0.35	0.74	0.74	0.65	0.47	0.13
6382 (SDC1)	0.41	0.64	0.63	0.56	0.60	0.51	0.54	0.45	0.52	0.14	0.59	0.60	0.65	0.92	0.50	1.00	0.80	0.23	0.55	0.83	0.75	0.96	1.00	0.58	0.76	0.69	0.69	0.56	0.41	0.63	0.35	0.76	0.76	0.67	0.48	0.13
375790 (AGRN)	0.40	0.60	0.55	0.62	0.57	0.58	0.50	0.48	0.43	0.14	0.46	0.53	0.59	0.56	0.39	1.00	0.64	0.31	0.51	0.52	0.49	0.55	0.58	1.00	0.56	0.51	0.57	0.45	0.41	0.58	0.26	0.49	0.49	0.49	0.35	0.13
351 (APP)	0.48	0.62	0.66	0.58	0.60	0.55	0.58	0.54	0.58	0.14	0.62	0.50	0.72	0.75	0.56	1.00	0.67	0.30	0.56	0.70	0.64	0.76	0.76	0.56	1.00	0.65	0.61	0.54	0.41	0.60	0.30	0.64	0.75	0.61	0.47	0.13
3949 (LDLR)	0.35	0.54	0.58	0.54	0.52	0.69	0.53	0.43	0.47	0.29	0.51	0.45	0.54	0.67	0.45	1.00	0.59	0.20	0.51	0.69	0.60	0.67	0.69	0.51	0.65	1.00	0.66	0.77	0.41	0.70	0.27	0.81	0.56	0.54	0.54	0.13
325 (APCS)	0.35	0.52	0.53	0.55	0.49	0.52	0.52	0.41	0.45	0.14	0.50	0.52	0.52	0.68	0.45	0.82	0.57	0.25	0.54	0.64	0.56	0.69	0.69	0.57	0.61	0.66	1.00	0.47	0.41	0.62	0.31	0.56	0.56	0.53	0.53	0.13
7804 (LRP8)	0.31	0.46	0.51	0.48	0.48	0.70	0.45	0.38	0.40	0.55	0.42	0.38	0.50	0.55	0.35	1.00	0.51	0.18	0.43	0.71	0.62	0.53	0.56	0.45	0.54	0.77	0.47	1.00	0.41	0.67	0.23	0.77	0.45	0.45	0.33	0.13
5948 (RBP2)	0.45	0.45	0.45	0.69	0.41	0.41	0.69	0.69	0.41	0.10	0.41	0.29	0.41	0.41	0.69	0.41	0.41	0.37	0.69	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	1.00	0.41	1.00	0.41	0.41	0.41	0.27	0.08
4036 (LRP2)	0.36	0.56	0.56	0.56	0.51	0.75	0.53	0.45	0.45	0.29	0.48	0.50	0.53	0.61	0.41	1.00	0.57	0.23	0.55	0.60	0.56	0.61	0.63	0.58	0.60	0.70	0.62	0.67	0.41	1.00	0.28	0.72	0.53	0.61	0.44	0.13
5947 (RBP1)	0.33	0.31	0.31	0.32	0.25	0.24	0.33	0.31	0.22	0.10	0.24	0.25	0.27	0.34	0.33	0.41	0.30	0.27	0.35	0.31	0.29	0.35	0.35	0.26	0.30	0.27	0.31	0.23	1.00	0.28	1.00	0.30	0.29	0.27	0.22	0.08
29967 (LRP12)	0.35	0.54	0.55	0.50	0.50	0.64	0.48	0.40	0.43	0.29	0.47	0.51	0.54	0.73	0.40	1.00	0.63	0.21	0.45	0.71	0.64	0.74	0.76	0.49	0.64	0.81	0.56	0.77	0.41	0.72	0.30	1.00	0.58	0.54	0.40	0.13
2719 (GPC3)	0.50	0.54	0.58	0.52	0.50	0.45	0.54	0.47	0.43	0.14	0.47	0.51	0.68	0.73	0.54	1.00	0.63	0.40	0.48	0.63	0.57	0.74	0.76	0.49	0.75	0.56	0.56	0.45	0.41	0.53	0.29	0.58	1.00	0.54	0.40	0.13
4547 (MTTP)	0.34	0.67	0.63	0.63	0.50	0.51	0.66	0.49	0.49	0.14	0.53	0.46	0.53	0.66	0.41	1.00	0.59	0.21	0.63	0.58	0.54	0.65	0.67	0.49	0.61	0.54	0.53	0.45	0.41	0.61	0.27	0.54	0.54	1.00	0.48	0.13
338328 (GPIHBP1)	0.24	0.50	0.43	0.41	0.36	0.41	0.45	0.38	0.31	0.10	0.33	0.33	0.38	0.47	0.35	0.69	0.42	0.16	0.37	0.42	0.40	0.47	0.48	0.35	0.47	0.54	0.53	0.33	0.27	0.44	0.22	0.40	0.40	0.48	1.00	0.08
51128 (SAR1B)	0.13	0.13	0.17	0.17	0.26	0.13	0.13	0.13	0.15	0.06	0.13	0.09	0.21	0.13	0.13	0.13	0.13	0.08	0.17	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.08	0.13	0.08	0.13	0.13	0.13	0.08	1.00

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
APOA4	Rat	Plasma	-	7619 m	24 hours	downregulated	1.47	2-DE	Northern indo-australian plate	SD rats	1	8 weeks old male SD rats kept at standard conditions	26882918
APOA4	Rat	Plasma	-	7620 m	24 hours	upregulated	0.71	2-DE	Northern indo-australian plate	Sprague-dawley rats	1	Male SD rats weighing 220g	24842778

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database
HNF4G	3174	APOA4	337	proximal_filtered	22955619	TRANSFAC
EP300	2033	APOA4	337	proximal_filtered	22955619	TRANSFAC
HNF4A	3172	APOA4	337	proximal_filtered	22955619	TRANSFAC
PPARA	5465	APOA4	337	Unknown	11751382	TRUSST

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)

Gene Ontology

ID	GO ID	GO Term	GO Type

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
APOA4	337	Hepatoma, Morris	C0019207	Experimental Model of Disease; Neoplastic Process	0.3	0.596	0.517	disease
APOA4	337	Hepatoma, Novikoff	C0019208	Experimental Model of Disease; Neoplastic Process	0.3	0.596	0.517	disease
APOA4	337	Liver Cirrhosis, Experimental	C0023893	Experimental Model of Disease	0.3	0.596	0.517	disease
APOA4	337	Hyperlipoproteinemia Type IIa	C0745103	Disease or Syndrome	0.31	0.596	0.517	disease
APOA4	337	Atherogenesis	C1563937	Pathologic Function	0.3	0.596	0.517	phenotype
APOA4	337	Liver Neoplasms, Experimental	C0023904	Experimental Model of Disease; Neoplastic Process	0.3	0.596	0.517	group
APOA4	337	Atherosclerosis	C0004153	Disease or Syndrome	0.39	0.596	0.517	disease
APOA4	337	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.3	0.596	0.517	disease
APOA4	337	Experimental Hepatoma	C0086404	Experimental Model of Disease; Neoplastic Process	0.3	0.596	0.517	disease
APOA4	337	Hypercholesterolemia, Familial	C0020445	Disease or Syndrome	0.32	0.596	0.517	disease
APOA4	337	Hyperlipoproteinemia Type IIb	C1704417	Disease or Syndrome	0.3	0.596	0.517	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types