ALTITUDEOMICSDB

Retinol-binding protein

AltitudeomicsDB

Protein Official symbol	RBP1
Aliases	RBP1 CRBP1
Chromosomal Location	3
Length	135
Uniprot ID	P09455
EC number	None
Protein family Information(Pfam)	PF00061;
PDB id	5H8T;5H9A;5HA1;5HBS;5LJB;5LJC;5LJD;5LJE;5LJG;5LJH;5LJK;6E5L;6E5T;6E6M;
InterPro ID	IPR012674;IPR031264;IPR000463;IPR031259;IPR000566;
dbSNP	None

Protein Protein Interaction

Download Tab separated file

AltitudeomicsDB

Protein 1	Protein 2	Combine Score
APOA2	APOA1	0.9990000000000001
APOA1	APOC3	0.9990000000000001
APOA1	APOB	0.9990000000000001
RBP4	TTR	0.998
APOA2	APOB	0.997
APOB	APOC3	0.996
APOE	APOB	0.996
APOA2	APOC3	0.996
APOC2	APOE	0.993
APOC2	APOC3	0.993
APOE	APOA1	0.991
APOC2	APOA1	0.991
APOA4	APOC3	0.99
LRAT	RBP1	0.9890000000000001
APOC2	APOA2	0.988
APOA4	APOB	0.988
APOC2	APOB	0.988
STRA6	RBP4	0.986
APOA2	APOE	0.985
GPC6	GPC4	0.9840000000000001
APOE	APOC3	0.9840000000000001
LIPC	APOB	0.982
HSPG2	GPC1	0.981
SDC1	GPC1	0.98
RDH12	LRAT	0.9790000000000001
GPC6	SDC2	0.978
GPC4	SDC2	0.978
HSPG2	GPC2	0.977
GPC6	HSPG2	0.976
SDC2	GPC2	0.976
APOC2	APOA4	0.975
HSPG2	GPC4	0.975
SDC1	HSPG2	0.975
STRA6	RBP1	0.9740000000000001
RDH11	RBP1	0.9740000000000001
SDC2	GPC1	0.9740000000000001
SDC4	GPC1	0.973
HSPG2	SDC2	0.973
AGRN	GPC1	0.971
SDC3	GPC1	0.971
GPC5	HSPG2	0.971
SDC1	GPC4	0.9690000000000001
LRAT	RDH10	0.9690000000000001
SDC1	GPC6	0.9690000000000001
HSPG2	SDC4	0.9690000000000001
RDH10	RBP1	0.968
SDC1	GPC2	0.968
SDC1	GPC5	0.9670000000000001
AGRN	GPC2	0.9670000000000001
GPC3	HSPG2	0.9670000000000001
GPC5	SDC2	0.9670000000000001
GPC4	SDC3	0.9670000000000001
AGRN	GPC4	0.9670000000000001
SDC3	GPC2	0.9670000000000001
AGRN	GPC6	0.966
GPC6	SDC3	0.966
RDH11	LRAT	0.966
LIPC	APOE	0.966
AGRN	GPC5	0.966
GPC3	SDC2	0.965
GPC5	SDC3	0.965
GPC3	SDC1	0.965
APOA2	APOA4	0.9640000000000001
STRA6	TTR	0.9640000000000001
RBP4	RBP1	0.963
SDC4	GPC4	0.963
GPC6	SDC4	0.963
HSPG2	SDC3	0.963
HSPG2	APOB	0.9620000000000001
SDC4	GPC2	0.9620000000000001
SDC1	AGRN	0.958
GPC3	SDC3	0.958
GPC3	AGRN	0.958
GPC5	SDC4	0.9570000000000001
APOA4	APOA1	0.956
GPC3	SDC4	0.955
TTR	RBP1	0.955
AGRN	SDC2	0.9540000000000001
DHRS9	RBP1	0.953
DHRS9	LRAT	0.953
HSPG2	APOE	0.951
RDH8	LRAT	0.95
RDH12	RBP1	0.9490000000000001
RDH16	LRAT	0.9490000000000001
RDH16	RBP1	0.948
AGRN	HSPG2	0.9470000000000001
HSPG2	TTR	0.946
SDC1	SDC2	0.946
GPC3	GPC4	0.946
DHRS3	LRAT	0.945
AGRN	SDC3	0.945
SDC4	SDC3	0.945
SDC3	SDC2	0.945
AGRN	SDC4	0.945
SDC1	SDC3	0.943
RDH8	RBP1	0.9420000000000001
APOA4	APOE	0.94
SDC4	SDC2	0.94
DHRS3	RBP1	0.94
GPC3	GPC6	0.9390000000000001
GPC3	GPC2	0.938
GPC3	APOA1	0.938
GPC3	APOB	0.937
GPC5	GPC2	0.937
GPC5	GPC6	0.934
GPC5	GPC4	0.932
GPC3	APOA2	0.93
SDC1	APOE	0.929
SDC1	SDC4	0.929
SDC3	APOE	0.924
GPC3	GPC1	0.924
AGRN	APOE	0.922
LRAT	SDR16C5	0.9209999999999999
SDC1	APOB	0.9209999999999999
SDC4	APOE	0.92
GPC3	APOE	0.919
APOA1	RBP1	0.919
APOC2	SDC1	0.919
GPC5	APOE	0.919
GPC5	GPC1	0.919
GPC1	APOE	0.9179999999999999
GPC4	APOE	0.9179999999999999
HSPG2	APOA4	0.9179999999999999
SDC2	APOE	0.9179999999999999
PNLIP	RBP1	0.917
APOC2	HSPG2	0.917
AKT1	RBP1	0.917
SDC1	APOC3	0.917
HSPG2	APOA1	0.915
APOC2	AGRN	0.915
DHRS4	RBP1	0.914
GPC3	APOC3	0.9129999999999999
GPC2	APOE	0.912
GPC4	APOB	0.912
GPC6	APOE	0.912
HSPG2	APOA2	0.912
APOB	RBP1	0.9109999999999999
GPC6	APOB	0.9109999999999999
SDC4	RBP1	0.9109999999999999
GPC1	APOB	0.9109999999999999
GPC5	APOB	0.9109999999999999
HSPG2	APOC3	0.91
SDC4	APOA1	0.91
SDC1	APOA1	0.91
LRAT	DHRS4	0.91
GPC2	APOB	0.91
APOE	RBP1	0.909
GPC4	GPC1	0.9079999999999999
SDC4	APOB	0.907
GPC2	GPC1	0.907
GPC6	GPC1	0.907
DHRS9	DHRS4	0.907
GPC4	GPC2	0.9059999999999999
LIPC	RBP1	0.9059999999999999
XDH	RBP1	0.9059999999999999
RBP1	APOC3	0.905
GPC3	GPC5	0.905
APOC2	GPC3	0.905
GPC6	GPC2	0.904
APOA4	RBP1	0.904
APOC2	SDC4	0.903
GPC4	APOC3	0.903
SDC1	APOA4	0.903
GPC4	RBP1	0.902
SDC2	APOC3	0.902
SDC1	APOA2	0.902
APOA2	RBP1	0.902
AGRN	RBP1	0.902
APOC2	RBP1	0.902
GPC4	APOA4	0.902
AGRN	APOB	0.902
SDC2	APOB	0.902
SDR16C5	RBP1	0.902
GPC4	APOA1	0.9009999999999999
GPC5	APOC3	0.9009999999999999
APOA2	SDC2	0.9009999999999999
GPC6	APOA1	0.9009999999999999
GPC2	APOC3	0.9009999999999999
APOA4	SDC2	0.9009999999999999
GPC6	APOC3	0.9009999999999999
GPC1	APOC3	0.9009999999999999
SDC4	APOA4	0.9009999999999999
GPC6	APOA2	0.9
APOA4	GPC2	0.9
GPC6	APOA4	0.9
GPC5	APOA4	0.9
SDC2	APOA1	0.9
APOC2	GPC5	0.9
GPC5	APOA2	0.9
GPC5	RBP1	0.9
SDC3	APOA1	0.9
GPC3	RBP1	0.9
SDC4	APOC3	0.9
SDC3	RBP1	0.9
GPC2	RBP1	0.9
AGRN	APOA1	0.9
AGRN	APOA4	0.9
GPC4	APOA2	0.9
APOC2	GPC4	0.9
APOA2	GPC1	0.9
GPC1	RBP1	0.9
GPC5	APOA1	0.9
APOA4	GPC1	0.9
SDC3	APOC3	0.9
APOC2	SDC3	0.9
SDC4	APOA2	0.9
GPC6	RBP1	0.9
AGRN	APOA2	0.9
APOA2	GPC2	0.9
APOC2	GPC6	0.9
GPC1	APOA1	0.9
APOC2	GPC2	0.9
APOA4	SDC3	0.9
HSPG2	RBP1	0.9
GPC2	APOA1	0.9
APOC2	GPC1	0.9
SDC2	RBP1	0.9
AGRN	APOC3	0.9
SDC3	APOB	0.9
APOC2	SDC2	0.9
GPC3	APOA4	0.9
APOA2	SDC3	0.9
SDC1	RBP1	0.9

Gene Ontology Semantic Similarity

Download Tab separated file

#	336 (APOA2)	335 (APOA1)	5950 (RBP4)	338 (APOB)	348 (APOE)	337 (APOA4)	9227 (LRAT)	10082 (GPC6)	3990 (LIPC)	3339 (HSPG2)	6382 (SDC1)	145226 (RDH12)	2239 (GPC4)	6383 (SDC2)	51109 (RDH11)	6385 (SDC4)	375790 (AGRN)	157506 (RDH10)	2719 (GPC3)	7276 (TTR)	10170 (DHRS9)	50700 (RDH8)	8608 (RDH16)	9249 (DHRS3)
336 (APOA2)	1.00	0.88	0.60	0.71	0.82	0.86	0.15	0.14	0.38	0.53	0.53	0.47	0.14	0.52	0.13	0.49	0.51	0.11	0.55	0.53	0.15	0.16	0.24	0.28	0.39	0.14	0.55	0.38	0.39	0.69	0.40	0.71
335 (APOA1)	0.88	1.00	0.59	0.72	0.81	0.78	0.16	0.18	0.42	0.57	0.57	0.51	0.18	0.56	0.14	0.53	0.55	0.12	0.55	0.59	0.17	0.21	0.26	0.29	0.42	0.18	0.59	0.43	0.38	0.45	0.44	0.65
5950 (RBP4)	0.60	0.59	1.00	0.60	0.57	0.57	0.16	0.14	0.38	0.65	0.65	0.46	0.14	0.63	0.14	0.52	0.50	0.13	0.52	0.62	0.16	0.16	0.24	0.28	0.46	0.14	0.43	0.31	0.31	0.66	0.43	0.39
338 (APOB)	0.71	0.72	0.60	1.00	0.75	0.63	0.15	0.14	0.40	0.62	0.62	0.49	0.14	0.60	0.13	0.54	0.62	0.12	0.54	0.60	0.15	0.16	0.23	0.25	0.46	0.14	0.54	0.37	0.35	0.45	0.44	0.54
348 (APOE)	0.82	0.81	0.57	0.75	1.00	0.85	0.16	0.18	0.38	0.52	0.52	0.47	0.18	0.51	0.14	0.49	0.58	0.12	0.50	0.54	0.17	0.21	0.26	0.29	0.42	0.18	0.55	0.38	0.39	0.69	0.40	0.59
337 (APOA4)	0.86	0.78	0.57	0.63	0.85	1.00	0.17	0.18	0.34	0.48	0.48	0.41	0.18	0.47	0.15	0.43	0.49	0.13	0.46	0.49	0.17	0.21	0.26	0.31	0.47	0.18	0.48	0.31	0.38	0.69	0.37	0.56
9227 (LRAT)	0.15	0.16	0.16	0.15	0.16	0.17	1.00	0.11	0.21	0.17	0.17	0.22	0.11	0.17	0.26	0.17	0.15	0.23	0.16	0.17	0.30	0.28	0.24	0.21	0.13	0.25	0.28	0.26	0.23	0.15	0.20	0.15
10082 (GPC6)	0.14	0.18	0.14	0.14	0.18	0.18	0.11	1.00	0.11	0.14	0.14	0.14	1.00	0.14	0.10	0.60	0.14	0.08	0.14	0.14	0.11	0.08	0.18	0.18	0.10	0.07	0.14	0.11	0.11	0.10	0.11	0.14
3990 (LIPC)	0.38	0.42	0.38	0.40	0.38	0.34	0.21	0.11	1.00	0.49	0.49	0.39	0.11	0.47	0.18	0.40	0.40	0.16	0.40	0.48	0.21	0.20	0.22	0.23	0.35	1.00	0.37	0.30	0.30	0.33	0.36	0.27
3339 (HSPG2)	0.53	0.57	0.65	0.62	0.52	0.48	0.17	0.14	0.49	1.00	1.00	0.62	0.14	0.88	0.16	0.75	0.58	0.14	0.74	0.82	0.18	0.16	0.28	0.29	0.60	0.14	0.48	0.38	0.36	0.41	0.55	0.40
6382 (SDC1)	0.53	0.57	0.65	0.62	0.52	0.48	0.17	0.14	0.49	1.00	1.00	0.62	0.14	0.88	0.16	0.75	0.58	0.14	0.74	0.82	0.18	0.16	0.28	0.29	0.60	0.14	0.48	0.38	0.36	0.41	0.55	0.40
145226 (RDH12)	0.47	0.51	0.46	0.49	0.47	0.41	0.22	0.14	0.39	0.62	0.62	1.00	0.14	0.60	0.84	0.49	0.48	0.83	0.49	0.60	0.63	1.00	0.65	0.60	0.44	0.18	0.43	0.77	0.42	0.41	0.72	0.32
2239 (GPC4)	0.14	0.18	0.14	0.14	0.18	0.18	0.11	1.00	0.11	0.14	0.14	0.14	1.00	0.14	0.10	0.60	0.14	0.08	0.14	0.14	0.11	0.08	0.18	0.18	0.10	0.07	0.14	0.11	0.11	0.10	0.11	0.14
6383 (SDC2)	0.52	0.56	0.63	0.60	0.51	0.47	0.17	0.14	0.47	0.88	0.88	0.60	0.14	1.00	0.15	0.72	0.57	0.14	0.71	0.80	0.17	0.16	0.27	0.28	0.58	0.14	0.47	0.37	0.35	0.41	0.54	0.39
51109 (RDH11)	0.13	0.14	0.14	0.13	0.14	0.15	0.26	0.10	0.18	0.16	0.16	0.84	0.10	0.15	1.00	0.15	0.13	0.97	0.15	0.16	0.76	1.00	0.73	0.60	0.11	0.21	0.17	0.75	0.32	0.12	0.54	0.14
6385 (SDC4)	0.49	0.53	0.52	0.54	0.49	0.43	0.17	0.60	0.40	0.75	0.75	0.49	0.60	0.72	0.15	1.00	0.52	0.14	0.58	0.69	0.17	0.16	0.27	0.28	0.51	0.14	0.44	0.32	0.32	0.41	0.47	0.36
375790 (AGRN)	0.51	0.55	0.50	0.62	0.58	0.49	0.15	0.14	0.40	0.58	0.58	0.48	0.14	0.57	0.13	0.52	1.00	0.12	0.52	0.57	0.15	0.16	0.23	0.27	0.56	0.14	0.47	0.35	0.35	0.41	0.43	0.41
157506 (RDH10)	0.11	0.12	0.13	0.12	0.12	0.13	0.23	0.08	0.16	0.14	0.14	0.83	0.08	0.14	0.97	0.14	0.12	1.00	0.13	0.14	0.70	1.00	0.69	0.57	0.10	0.18	0.14	0.68	0.27	0.11	0.48	0.12
2719 (GPC3)	0.55	0.55	0.52	0.54	0.50	0.46	0.16	0.14	0.40	0.74	0.74	0.49	0.14	0.71	0.15	0.58	0.52	0.13	1.00	0.69	0.17	0.16	0.26	0.27	0.51	0.14	0.47	0.32	0.32	0.41	0.46	0.50
7276 (TTR)	0.53	0.59	0.62	0.60	0.54	0.49	0.17	0.14	0.48	0.82	0.82	0.60	0.14	0.80	0.16	0.69	0.57	0.14	0.69	1.00	0.18	0.16	0.28	0.29	0.56	0.14	0.51	0.39	0.39	0.41	0.53	0.39
10170 (DHRS9)	0.15	0.17	0.16	0.15	0.17	0.17	0.30	0.11	0.21	0.18	0.18	0.63	0.11	0.17	0.76	0.17	0.15	0.70	0.17	0.18	1.00	1.00	0.65	0.40	0.13	0.25	0.20	0.57	0.31	0.15	0.51	0.15
50700 (RDH8)	0.16	0.21	0.16	0.16	0.21	0.21	0.28	0.08	0.20	0.16	0.16	1.00	0.08	0.16	1.00	0.16	0.16	1.00	0.16	0.16	1.00	1.00	1.00	0.56	0.11	0.18	0.24	0.73	0.48	0.11	1.00	0.16
8608 (RDH16)	0.24	0.26	0.24	0.23	0.26	0.26	0.24	0.18	0.22	0.28	0.28	0.65	0.18	0.27	0.73	0.27	0.23	0.69	0.26	0.28	0.65	1.00	1.00	0.66	0.20	0.18	0.23	0.55	0.30	0.23	0.50	0.24
9249 (DHRS3)	0.28	0.29	0.28	0.25	0.29	0.31	0.21	0.18	0.23	0.29	0.29	0.60	0.18	0.28	0.60	0.28	0.27	0.57	0.27	0.29	0.40	0.56	0.66	1.00	0.22	0.18	0.27	0.54	0.40	0.25	0.35	0.29

Association with High Altitude

Protein Official symbol	Source Organism	Tissue of Expression	Level of hypoxia	Altitude	Duration of experiment	Level of expression	Fold change	Experiment details	geographical location	ethnicity of the patients	Control group	Control (Fold change)	Reference (PMID)
RBP1	Rat	Plasma	-	7620 m	12 hours	upregulated	0.66	2-DE	Northern indo-australian plate	Sprague-dawley rats	1	Male SD rats weighing 220g	24842778

Association with TF

TF	TF Entrez	Gene	Gene Entrez	Type	PMID	Database

Association with miRNA

miRTarBase ID	miRNA	Species (miRNA)	Protein Official Symbol	Human Entrez ID	Species (Target Gene)	Experiments	Support Type	References (PMID)
MIRT018800	hsa-miR-335-5p	Homo sapiens	RBP1	5947	Homo sapiens	Microarray	Functional MTI (Weak)	18185580

Gene Ontology

ID	GO ID	GO Term	GO Type
5947	GO:0016918	ATPase activity	GOTERM_MF_DIRECT
5947	GO:0033189	response to vitamin A	GOTERM_BP_DIRECT
5947	GO:0002138	retinoic acid biosynthetic process	GOTERM_BP_DIRECT
5947	GO:0005215	transporter activity	GOTERM_MF_DIRECT
5947	GO:0030852	regulation of granulocyte differentiation	GOTERM_BP_DIRECT
5947	GO:0019841	oxygen sensor activity	GOTERM_MF_DIRECT
5947	GO:0001523	retinoid metabolic process	GOTERM_BP_DIRECT
5947	GO:0005501	SNAP receptor activity	GOTERM_MF_DIRECT
5947	GO:0008289	lipid binding	GOTERM_MF_DIRECT
5947	GO:0005654	nucleoplasm	GOTERM_CC_DIRECT
5947	GO:0005737	cytoplasm	GOTERM_CC_DIRECT
5947	GO:0044297	cell body	GOTERM_CC_DIRECT
5947	GO:0042572	retinol metabolic process	GOTERM_BP_DIRECT
5947	GO:0006776	vitamin A metabolic process	GOTERM_BP_DIRECT
5947	GO:0006810	transport	GOTERM_BP_DIRECT
5947	GO:0005829	cytosol	GOTERM_CC_DIRECT

Pathways

Human Entrez ID	KEGG ID	KEGG Term

Association with Disease

Protein Official Symbol	Human Entrez ID	Disease Name	Disease Id	Disease Semantic Type	Semantic score	DSI	DPI	Disease Type
RBP1	5947	Drug-Induced Liver Disease	C0860207	Disease or Syndrome	0.3	0.58	0.552	disease
RBP1	5947	Hepatitis, Toxic	C0019193	Injury or Poisoning	0.3	0.58	0.552	disease
RBP1	5947	Mammary Neoplasms, Experimental	C0024668	Experimental Model of Disease; Neoplastic Process	0.3	0.58	0.552	group
RBP1	5947	Malignant neoplasm of stomach	C0024623	Neoplastic Process	0.3	0.58	0.552	disease
RBP1	5947	Stomach Neoplasms	C0038356	Neoplastic Process	0.3	0.58	0.552	group
RBP1	5947	Mammary Carcinoma, Animal	C1257925	Neoplastic Process	0.3	0.58	0.552	disease
RBP1	5947	Undifferentiated carcinoma	C0205698	Neoplastic Process	0.3	0.58	0.552	phenotype
RBP1	5947	Chemically-Induced Liver Toxicity	C4279912	Disease or Syndrome	0.3	0.58	0.552	disease
RBP1	5947	Drug-Induced Acute Liver Injury	C3658290	Disease or Syndrome	0.3	0.58	0.552	disease
RBP1	5947	Carcinoma, Spindle-Cell	C0205697	Neoplastic Process	0.3	0.58	0.552	disease
RBP1	5947	Hereditary Diffuse Gastric Cancer	C1708349	Neoplastic Process	0.3	0.58	0.552	disease
RBP1	5947	Fetal Growth Retardation	C0015934	Pathologic Function	0.3	0.58	0.552	phenotype
RBP1	5947	Hepatitis, Drug-Induced	C1262760	Disease or Syndrome	0.3	0.58	0.552	disease
RBP1	5947	Carcinomatosis	C0205699	Neoplastic Process	0.3	0.58	0.552	phenotype
RBP1	5947	Carcinoma	C0007097	Neoplastic Process	0.3	0.58	0.552	group
RBP1	5947	Animal Mammary Neoplasms	C0024667	Neoplastic Process	0.3	0.58	0.552	group
RBP1	5947	Anaplastic carcinoma	C0205696	Neoplastic Process	0.3	0.58	0.552	disease
RBP1	5947	Chemical and Drug Induced Liver Injury	C4277682	Disease or Syndrome	0.3	0.58	0.552	disease
RBP1	5947	Schizophrenia	C0036341	Mental or Behavioral Dysfunction	0.31	0.58	0.552	disease

Association with Drug

Protein Official Symbol	Human Entrez ID	drug_claim_primary_name	drug_name	drug_chembl_id	interaction_types