Retinol dehydrogenase 16 (all-trans and 13-cis)

AltitudeomicsDB
Protein Official symbol RDH16
Aliases RDH16 RODH4 SDR9C8
Chromosomal Location  12
Length 317
Uniprot ID O75452
EC number 1.1.1.105; 1.1.1.209; 1.1.1.315; 1.1.1.53
Protein family Information(Pfam) PF00106;
PDB id None
InterPro ID IPR036291;IPR020904;IPR002347;
dbSNP None

Protein Protein Interaction

0%
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AltitudeomicsDB
Protein 1 Protein 2 Combine Score
ALDH1A2 CYP26A1 0.991
LRAT RBP1 0.989
LRAT CYP26A1 0.97
ALDH1A1 CYP26A1 0.967
RDH16 CYP26A1 0.953
RDH16 LRAT 0.949
RDH16 RBP1 0.948
RDH16 ALDH1A2 0.943
LRAT RBP5 0.942
LRAT RETSAT 0.937
RETSAT CYP26A1 0.935
ALDH1A1 BCO1 0.934
BCO1 ALDH1A2 0.932
RDH16 ALDH1A3 0.932
RDH16 AOX1 0.93
RDH16 ALDH1A1 0.926
AOX1 BCO1 0.923
RDH16 BCO1 0.921
RDH16 RLBP1 0.919
AOX1 CYP26A1 0.912
RDH16 RETSAT 0.904
RDH16 RBP5 0.903
PNPLA4 RETSAT 0.9
RDH16 PNPLA4 0.9
PNPLA4 CYP26A1 0.9
Gene Ontology Semantic Similarity
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# 8854 (ALDH1A2) 9227 (LRAT) 216 (ALDH1A1) 8608 (RDH16) 54884 (RETSAT) 53630 (BCO1) 316 (AOX1) 8228 (PNPLA4) 1592 (CYP26A1) 5947 (RBP1) 83758 (RBP5) 220 (ALDH1A3)
8854 (ALDH1A2) 1.00 0.23 0.66 0.29 0.49 0.27 0.32 0.18 0.37 0.41 0.37 0.73
9227 (LRAT) 0.23 1.00 0.20 0.24 0.38 0.26 0.18 0.23 0.21 0.11 0.17 0.23
216 (ALDH1A1) 0.66 0.20 1.00 0.26 0.40 0.23 0.42 0.15 0.33 0.21 0.25 0.63
8608 (RDH16) 0.29 0.24 0.26 1.00 0.49 0.28 0.25 0.20 0.30 0.18 0.27 0.29
54884 (RETSAT) 0.49 0.38 0.40 0.49 1.00 0.48 0.32 0.32 0.39 0.15 0.22 0.49
53630 (BCO1) 0.27 0.26 0.23 0.28 0.48 1.00 0.19 0.21 0.24 0.10 0.15 0.27
316 (AOX1) 0.32 0.18 0.42 0.25 0.32 0.19 1.00 0.13 0.40 0.23 0.42 0.50
8228 (PNPLA4) 0.18 0.23 0.15 0.20 0.32 0.21 0.13 1.00 0.16 0.09 0.14 0.18
1592 (CYP26A1) 0.37 0.21 0.33 0.30 0.39 0.24 0.40 0.16 1.00 0.36 0.43 0.32
5947 (RBP1) 0.41 0.11 0.21 0.18 0.15 0.10 0.23 0.09 0.36 1.00 0.76 0.16
83758 (RBP5) 0.37 0.17 0.25 0.27 0.22 0.15 0.42 0.14 0.43 0.76 1.00 0.32
220 (ALDH1A3) 0.73 0.23 0.63 0.29 0.49 0.27 0.50 0.18 0.32 0.16 0.32 1.00
Association with High Altitude
Protein Official symbol Source Organism Tissue of Expression Level of hypoxia Altitude Duration of experiment Level of expression Fold change Experiment details geographical location ethnicity of the patients Control group Control (Fold change) Reference (PMID)
RDH16 Human Blood - 3650 m 48 hours downregulated 0.625 Microarray Himalayas Indians 1 HAPE Pateints Vs Normal http://medind.nic.in/iab/t12/i1/iabt12i1p1.pdf
Association with TF
TF TF Entrez Gene Gene Entrez Type PMID Database
Association with miRNA
miRTarBase ID miRNA Species (miRNA) Protein Official Symbol Human Entrez ID Species (Target Gene) Experiments Support Type References (PMID)
MIRT025909 hsa-miR-7-5p Homo sapiens RDH16 8608 Homo sapiens Microarray Functional MTI (Weak) 17612493
Gene Ontology
ID GO ID GO Term GO Type
8608 GO:0005789 endoplasmic reticulum membrane GOTERM_CC_DIRECT
8608 GO:0031090 organelle membrane GOTERM_CC_DIRECT
8608 GO:0043231 intracellular membrane-bounded organelle GOTERM_CC_DIRECT
8608 GO:0016021 integral component of membrane GOTERM_CC_DIRECT
8608 GO:0009055 electron carrier activity GOTERM_MF_DIRECT
8608 GO:0004745 pyruvate kinase activity GOTERM_MF_DIRECT
8608 GO:0055114 oxidation-reduction process GOTERM_BP_DIRECT
8608 GO:0006629 lipid metabolic process GOTERM_BP_DIRECT
Pathways
Human Entrez ID KEGG ID KEGG Term
8608 hsa00830 Retinol metabolism
8608 hsa01100 Metabolic pathways
Association with Disease
Protein Official Symbol Human Entrez ID Disease Name Disease Id Disease Semantic Type Semantic score DSI DPI Disease Type
Association with Drug
Protein Official Symbol Human Entrez ID drug_claim_primary_name drug_name drug_chembl_id interaction_types